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Brief Communication

Trichinella spiralis Infection Suppressed Gut Inflammation with CD4+CD25+Foxp3+ T Cell Recruitment

Min Kyoung Cho1, Mi Kyung Park1, Shin Ae Kang1, Seon Hee Choi1, Soon Cheol Ahn2, Hak Sun Yu1
The Korean Journal of Parasitology 2012;50(4):385-390.
Published online: November 26, 2012

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Corresponding author (hsyu@pusan.ac.kr)
• Received: June 1, 2012   • Revised: July 12, 2012   • Accepted: August 2, 2012

© 2012, Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Trichinella spiralis Infection Suppressed Gut Inflammation with CD4+CD25+Foxp3+ T Cell Recruitment
Korean J Parasitol. 2012;50(4):385-390.   Published online November 26, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.4.385
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Trichinella spiralis Infection Suppressed Gut Inflammation with CD4+CD25+Foxp3+ T Cell Recruitment
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DOI: https://doi.org/10.3347/kjp.2012.50.4.385
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Trichinella spiralis Infection Suppressed Gut Inflammation with CD4+CD25+Foxp3+ T Cell Recruitment
Image Image Image
Fig. 1 T. spiralis infection could inhibit DSS-induced intestinal inflammation. Four weeks after T. spiralis infection or uninfection, mice were treated with 4% DSS for a period of 4 days. Weight change during experimental period was expressed as percentage change from day 0 (A). Colon lengths after 4 days of DSS treatment was measured (B). Scoring of weight loss, stool consistency, and fecal blood was performed in order to provide DAI for each group (C). Histopathological changes in large intestines from colon are shown in (D). Uninfected mice, a and c; infected mice, b and d; DSS untreated mice, a and b; DSS treated mice, c and d. Inflammatory score for the colon was calculated (E). *P<0.05, **P<0.01, ***P<0.001, n=5 mice/group, 3 independent experiments.
Fig. 2 Comparison of Th1 and regulatory cytokines level between spleen and MLN of T. spiralis infected and uninfected mice. After isolation of lymphocytes from spleen and MLN, the cells were stimulated with anti-CD3 antibody. After 72 hr, cytokines levels in the supernatant were measured. *P<0.05, **P<0.01, ***P<0.001, n=5 mice/group, 3 independent experiments.
Fig. 3 Treg cell recruitment in spleen and MLN by T. spiralis infection and Th1 & Treg cell related gene expression levels in large intestinal tissue. The populations of Treg cell were calculated in MLN and spleen of T. spiralis-infected and uninfected mice after inflammation induction (A). *P<0.05, **P<0.01, ***P<0.001, n=5 mice/group, 3 independent experiments. Total RNAs were isolated from T. spiralis-infected and uninfected mice colon to real time-PCR analysis for evaluation of the expression of Th1 related genes (IFN-γ and TNF-α) and Treg cell related genes (IL-10, TGF-β, and Foxp3) (B).

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Trichinella spiralis Infection Suppressed Gut Inflammation with CD4+CD25+Foxp3+ T Cell Recruitment
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