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Original Article

Effects of Excretory/Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells

Eun-Min Kim1,2, June-Sung Kim1, Min-Ho Choi1,2, Sung-Tae Hong1,2, Young Mee Bae1,2
The Korean Journal of Parasitology 2008;46(3):127-132.
Published online: September 20, 2008

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Corresponding author (ymbae@snu.ac.kr)
• Received: June 5, 2008   • Accepted: August 25, 2008

Copyright © 2008 by The Korean Society for Parasitology

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Effects of Excretory/Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells
Korean J Parasitol. 2008;46(3):127-132.   Published online September 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.3.127
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Effects of Excretory/Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells
Korean J Parasitol. 2008;46(3):127-132.   Published online September 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.3.127
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Effects of Excretory/Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells
Image Image Image Image
Fig. 1 Effects of ESP of C. sinensis and DMN on the proliferation of human embryonic kidney cells (HEK293T). Cellular proliferation in each treatment was determined using the XTT assay. Bars and whiskers indicate cell growth as the percentage of the control ± standard deviation (n = 4).
Fig. 2 Effects of ESP of C. sinensis and DMN on the cell cycle distribution of HEK293T. Bars and whiskers indicate cell growth as the percentage of the control ± standard deviation (n = 4).
Fig. 3 Expression of cell-cycle-related proteins in response to the ESP and DMN in HEK293T. Each sample was subjected to immunoblotting and probed with the indicated antibodies. Quantitative densitometry confirmed the observations presented in each blot and is shown as numbers.
Fig. 4 Treatment of ESP and DMN upregulated dhfr promoter-driven luciferase activity in HEK293T cells transfected with the luciferase reporter gene dhfr-luc (DHFR) or pXP2-luc (XP2, control). Bars and whiskers indicate the mean ± standard deviation (n = 3).

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Effects of Excretory/Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells
PHD : Parasites, Hosts and Diseases

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