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Original Article

Nested-PCR and a New ELISA-Based NovaLisa Test Kit for Malaria Diagnosis in an Endemic Area of Thailand

Pimwan Thongdee1,2, Wanna Chaijaroenkul1,3, Jiraporn Kuesap1, Kesara Na-Bangchang1,3
The Korean Journal of Parasitology 2014;52(4):377-381.
Published online: August 29, 2014

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Corresponding author (kesaratmu@yahoo.com)
• Received: April 21, 2014   • Revised: June 17, 2014   • Accepted: June 24, 2014

© 2014, Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nested-PCR and a New ELISA-Based NovaLisa Test Kit for Malaria Diagnosis in an Endemic Area of Thailand
Korean J Parasitol. 2014;52(4):377-381.   Published online August 29, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.4.377
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Nested-PCR and a New ELISA-Based NovaLisa Test Kit for Malaria Diagnosis in an Endemic Area of Thailand
Korean J Parasitol. 2014;52(4):377-381.   Published online August 29, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.4.377
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Nested-PCR and a New ELISA-Based NovaLisa Test Kit for Malaria Diagnosis in an Endemic Area of Thailand
Nested-PCR and a New ELISA-Based NovaLisa Test Kit for Malaria Diagnosis in an Endemic Area of Thailand
Microscopy (no. of samples) Nested PCR NovaLisa test kit Plasmodium spp. 97a  P. falciparum (35) 25  P. vivax (51) 53  P. falciparum and P. vivax mixed (8) 16 Healthy subjects (Control) (91) 91 93 Patients with other fever-related infections (Control) (60) 60 55 Total (245) 245 245 Nested-PCR
NovaLisa test kit (%) P. falciparum(%) P. vivax (%) P. falciparum and P. vivax mixed (%) Sensitivity 71.4 (53.5-84.8) 100.0 (91.3-100.0) 100.0 (59.8-100.0) 89.0 (80.7-94.6) Specificity 100.0 (96.9-100.0) 98.7 (94.9-99.8) 95.0 (90.0-97.6) 91.6 (86.0- 95.4) Positive predictive value (PPV) 100.0 (83.4-100.0) 96.2 (85.9-99.3) 50.0 (25.5-74.5) 86.2 (77.5-92.4) Negative predictive value (NPV) 93.8 (88.6-96.8) 100.0 (96.9-100.0) 100.0 (96.9-100.0) 93.4 (88.2-96.7) False positive rate 0.0 (0.0-16.6) 3.8 (0.7-14.1) 50.0 (25.5-74.5) 13.8 (7.8-22.8) False negative rate 6.2 (3.2-11.4) 0.0 (0.0-3.1) 0.0 (0.0-3.1) 6.6 (3.4-12.2) Detection limit (parasites/µl) 1-5 parasites/µl 1-5 parasites/µl 1-5 parasites/µl Detection of antibodies against Plasmodium Agreement between tests kappa 0.80 (0.69-0.92) 0.97 (0.94-1.01) 0.64 (0.42-0.87) 0.80 (0.69-0.92)
Table 1. Detection of P. falciparum and P. vivax by nested-PCR and a new ELISA-based NovaLisa test kita in comparison with the microscopic method

ELISA-based NovaLisa test detects only the Plasmodium genus.

Table 2. The test performance of nested-PCR and a new ELISA-based NovaLisa test kit for detection of P. falciparum and P. vivax in comparison with the microscopic method

Data are presented as percentage (95% confidence interval; CI) for all parameters except the detection limit (parasites/μl).

Table 1.

Table 2.

PHD : Parasites, Hosts and Diseases

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