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Original Article

Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment

Kyoung-Ho Pyo1, Bong-Kwang Jung1, Chun-Feng Xin1, You-Won Lee1, Jong-Yil Chai1, Eun-Hee Shin1,2
The Korean Journal of Parasitology 2014;52(6):605-612.
Published online: December 23, 2014

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Corresponding author (ehshin@snu.ac.kr)
• Received: September 18, 2014   • Revised: October 12, 2014   • Accepted: October 13, 2014

© 2014, Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment
Korean J Parasitol. 2014;52(6):605-612.   Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.605
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Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment
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DOI: https://doi.org/10.3347/kjp.2014.52.6.605
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Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment
Image Image Image Image
Fig. 1 Effects of TLA treatment on CT26 tumor growth. When the tumor mass was about 40 mm3, mice were given PBS or TLA through an intratumoral injection in euthymic (A, n=6) and athymic (B, n=8) tumor groups. In athymic mice (B), tumor growth in TLA-treated mice was significantly lower from day 6 after TLA treatment than that in PBS-treated mice (*P<0.05). Images of tumors isolated in athymic mice on day 8 of an intratumoral injection with PBS or the TLA are shown (C). Because the EGFP gene was stably expressed in CT26 cells, the metastasis of inoculated CT26 cells was observed using an imaging system (D).
Fig. 2 Cytokine profiles of euthymic (A) and athymic (B) mice sera after PBS or TLA treatment. The results are shown as the relative expression rate (%) of each cytokine expression value in PBS- or TLA-treated mice in comparison to that in non-tumor euthymic (A) and athymic (B) mice. M-CSF, macrophage colony-stimulating factor; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; PF-4, platelet factor-4; TIMP-1, tissue inhibitor of metalloproteinase-1.
Fig. 3 An increase of IL-12 after TLA treatment regardless of the presence of a tumor in athymic mice. The results show the relative expression rate (%) between the values of IL-12p40 in each experimental group (pooled sera) based on the value of IL-12p40 in PBS-treated mice with no tumor.
Fig. 4 The induction of IL-12p40 and MyD88/NF-κB signals in BMMs after TLA treatment. There was a significant increase in IL-12p40 after TLA treatment in a dose-dependent manner (A) (*P<0.05). The activation signal of macrophages for IL-12 induction, namely MyD88, also increased after TLA treatment (B). "Con" refers to control with no treatment. Images from lanes 1 to 2 show the results for signals in control; lanes 3 to 4 in LPS treatment; lanes 5 to 6 in TLA treatment. The bar graph shows the mean fold values for signals after each stimulant treatment compared to β-actin signals.

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Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment
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