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Original Article

Immunopathological Changes in the Brain of Immunosuppressed Mice Experimentally Infected with Toxocara canis

Mohamed M. Eid1, Samy I. El-Kowrany1, Ahmad A. Othman1,*, Dina I. El Gendy1, Eman M. Saied2
The Korean Journal of Parasitology 2015;53(1):51-58.
Published online: February 27, 2015

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*Corresponding author (ahmed_ali44@hotmail.com)
• Received: May 23, 2014   • Revised: October 9, 2014   • Accepted: October 20, 2014

© 2015, Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Immunopathological Changes in the Brain of Immunosuppressed Mice Experimentally Infected with Toxocara canis
Korean J Parasitol. 2015;53(1):51-58.   Published online February 27, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.1.51
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Immunopathological Changes in the Brain of Immunosuppressed Mice Experimentally Infected with Toxocara canis
Korean J Parasitol. 2015;53(1):51-58.   Published online February 27, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.1.51
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Immunopathological Changes in the Brain of Immunosuppressed Mice Experimentally Infected with Toxocara canis
Image Image Image
Fig. 1. IL-5 mRNA expression in the brain tissues at different time points post-infection (PI). Vertical bars represent the mean (±SD) of these results for each group (n=5). (A) Significant increase (P<0.05) was noted in levels of IL-5 mRNA expression in immunocompetent infected group at week 5 and 12 PI as compared to normal controls. (B) Significant difference (P<0.05) was noted in levels of IL-5 mRNA expression in both infected groups at all durations PI.
Fig. 2. Photomicrographs of brain sections showing (A) Numerous tangential and cross-sectional profiles of Toxocara larvae (arrows) deposited within the cerebral tissue. No apparent inflammation was noticed (H&E, ×400). (B) PAS-positive material deposited in the wall of blood vessels (arrows) (PAS, ×400).
Fig. 3. GFAP staining of activated astrocytes. (A) Immunocompetent infected group at week 2 post-infection (PI) showing grade 1 immunoreactivity. (B) Immunosuppressed infected group at week 2 PI showing grade 2 immunoreactivity. (C) Immunocompetent infected group at week 12 PI showing grade 3 immunoreactivity. (D) Immunosuppressed infected group at week 12 PI showing grade 3 immunoreactivity (immunoperoxidase stain, ×400).

Fig. 1.

Fig. 2.

Fig. 3.

Immunopathological Changes in the Brain of Immunosuppressed Mice Experimentally Infected with Toxocara canis
Group Week 2 PI Week 5 PI Week 12 PI P-valuec
Immnuocompetent infected 65.0 ± 4.8 90.9 ± 23.9 106.9 ± 3.8 0.001b
%a 6.5 9.09 10.69
Immunosuppressed infected 97 ± 5.033 137.20 ± 5.11 154.8 ± 3.91 0.001b
%a 9.7 13.72 15.48
P-valued 0.001b 0.001b 0.001b
Groups Grade 1 GFAP staining
 Grade 2 GFAP staining
 Grade 3 GFAP staining
No. mice % No. mice % No. mice %
Normal (immunocompetent) controla 5 100 0 0 0 0
Immunocompetent infecteda
Week 2 PI 9 90 1 10 0 0
Week 5 PI 6 60 3 30 1 10
Week 12 PI 2 20 3 30 5 50
Immunosuppressed (control)a 5 100 0 0 0 0
Immunosuppressed infectedb
Week 2 PI 7 70 2 20 1 10
Week 5 PI 4 40 4 40 2 20
Week 12 PI 0 0 2 20 8 80
Table 1. Larval counts (mean±SD) in the brains of infected mice at weeks post-infection (PI)

Number of larvae expressed as % of the original dose.

Significant.

Comparison between larval counts at week 2 and 12 PI in each group.

Comparison between immnuocompetent infected and immunosuppressed infected groups.

Table 2. GFAP immunoreactivity in the brains of studied mice (n=10 for infected groups)

Both control groups showed the same patterns of immunoreactivity at all time points post-infection.

Significant increase (P<0.05) was found in both infected groups with increased duration of infection, and significant difference (P<0.05) was found between both infected groups at different time points post-infection.

Table 1.

Table 2.

PHD : Parasites, Hosts and Diseases

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