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Original Article

Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand

Srivicha Krudsood1, Noppadon Tangpukdee1, Sant Muangnoicharoen1, Vipa Thanachartwet1, Nutthanej Luplertlop1, Siripan Srivilairit1, Polrat Wilairatana1, Shigeyuki Kano2, Pascal Ringwald3, Sornchai Looareesuwan1
The Korean Journal of Parasitology 2007;45(2):111-114.
Published online: June 20, 2007

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Corresponding author (tmsks@mahidol.ac.th)
• Received: November 9, 2007   • Accepted: May 9, 2007

Copyright © 2007 by The Korean Society for Parasitology

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Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand
Korean J Parasitol. 2007;45(2):111-114.   Published online June 20, 2007
DOI: https://doi.org/10.3347/kjp.2007.45.2.111
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Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand
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DOI: https://doi.org/10.3347/kjp.2007.45.2.111
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Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand
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Fig. 1 Percentage of parasite reduction after treatment.

Fig. 1

Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand
Group I Artemether-lumefantrine (n = 47) Group II Chloroquine (n = 51) Male/Female 35/12 35/16 Age (yr)  Mean (SD) 25.1 (6.9) 24.3 (6.3)  Range 15-65 15-65 Mean (SD) height in cm 162.3 (6.4) 161.4 (7.0) Mean (SD) weight in kg 52.9 (5.1) 53.8 (6.3) Highest fever before treatment (°C) 37.5 (0.8) 37.8 (0.9) No. of patients with splenomegaly 1 2 No. of patients with hepatomegaly 12 11 Geometric mean parasite count per μl 4,347.9 6,125.5  Range 40-95,800 111-47,400 Laboratory data; mean (SD)  Packed cell volume (%) 36.2 (5.9) 37.4 (6.1)  Platelet count (/μl) 91.3 (62.5) 98.8 (62.0)  Blood urea (mg/dL) 16.0 (20.1) 17.1 (18.9)  Serum creatinine (mg/dL) 0.8 (0.2) 0.9 (0.1)  Total bilirubin (mg/dL) 1.1 (0.5) 1.4 (0.8)  Aspartate aminotrans-ferases (U/L) 26.6 (14.5) 29.8 (19.6)  Alamine aminotrans-ferases (U/L) 27.5 (16.7) 32.7 (29.5)  Albumin (g/L) 3.7 (0.4) 3.9 (0.5)  Alkaline phosphatase (U/L) 88.3 (49.0) 90.6 (29.0) Group I Artemether-lumefantrine (n = 47) Group II Chloroquine (n = 51) No. of patients lost to follow-up 9 (19.1%) 9 (18%) No. of patients with 28 days follow-up 38 (80.9%) 42 (82.0%) No. (%) cured at day 28 37 (97.4%) 42 (100%) Fever clearance time (hr)  Mean (SD) 21.8 (11.2) 25.3 (10.8)  Range 4-70 4-90 Parasite clearance time (hr)  Mean (SD)* 41.6 (7.2) 55.8 (7.8)  Range 14-71 23-106
Table 1. Clinical and laboratory characteristics of study groups before treatments
Table 2. Therapeutic responses

Significant difference between groups at P < 0.001.

Table 1.

Table 2.

PHD : Parasites, Hosts and Diseases

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