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Case Report

Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea

Hea Yoon Kwon1, Jae Hyoung Im1, Yun-Kyu Park2, Areum Durey3, Jin-Soo Lee1, Ji Hyeon Baek1,*
The Korean Journal of Parasitology 2018;56(6):609-613.
Published online: December 31, 2018

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*Corresponding author (jhbaek@inha.ac.kr)
• Received: August 13, 2018   • Revised: October 8, 2018   • Accepted: October 14, 2018

Copyright © 2018 by The Korean Society for Parasitology and Tropical Medicine

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  • Babesiosis, caused by Babesia microti and B. divergens, is transmitted by Ixodid ticks. Symptoms of babesiosis vary from a mild flu-like illness to acute, severe, and sometimes fatal and fulminant disease. In Korea, 7 imported babesiosis cases and 1 endemic case have been reported. We report 2 cases of severe babesiosis initially mistaken as malaria. The first patient was complicated by shock and splenic infarction, the other co-infected with Lyme disease. As the population traveling abroad increases every year, physicians should be aware of babesiosis which mimics malaria, co-infection with other diseases, and its complications.
  • Key words: Babesia microti, babesiosis, splenic infarction, co-infection, Lyme disease
Babesiosis is a tick-mediated zoonosis caused by intraerythrocytic protozoa. The main species that cause disease in humans are Babesia microti and B. divergens, which are endemic to the northeastern and midwestern areas of the United States and Europe, respectively [1]. The symptoms of babesiosis are diverse, ranging from a subclinical flu-like illness to acute, severe disease occasionally resulting in fatality [2]. The patient usually presents with malaise, fever, fatigue, and headache. Hemolytic anemia and thrombocytopenia may be accompanied. If severe, organ dysfunction, mental change, pulmonary edema, renal failure, and splenic rupture can be present [3,4].
Although not endemic, babesiosis in Korea has been continuously reported. Since the first imported case of babesiosis in Korea was reported in 1988, 11 cases of babesiosis have been reported until now [5–11]. Among them, only 1 case was endemic; the other cases were imported from Africa or the United States [11]. Although endemic babesiosis in Korea is not common, physicians should be aware of this disease because of increased travel to other countries and the increasing incidence of babesiosis worldwide [12,13]. The symptoms and appearance of infected erythrocytes on blood smears are similar to erythrocytes infected by Plasmodium species. However, the treatment and course of babesiosis and malaria are different; therefore, awareness of the disease should be highlighted.
It is also noteworthy that babesiosis often occurs as a co-infection with other tick-borne diseases. Ixodes scapularis, the ticks which maintain B. microti, also transmit Borrelia burgdorferi and Anaplasma phagocytophilum [14]. Previous epidemiologic studies documented that 2/3 of patients with babesiosis experience concurrent Lyme disease [14,15]. Since co-infection with Lyme disease or anaplasmosis may lead to severe disease, suspicion of and early treatment for concurrent diseases are crucial when patients are in a fatal condition.
Here, we report 2 cases of babesiosis in Korea. Both cases were imported from the United States. They were first mistaken as malaria since malaria is endemic to the northern provinces of South Korea. Both patients presented severe symptoms and unusual complications; the first case was complicated by splenic infarction and the second case by co-infection with Lyme disease.
Case 1
A 50-year-old woman, a house-wife, visited our hospital complaining of fever, abdominal pain, and nausea. She had a history of suboccipital craniectomy due to right trigeminal nerve irritability 15 years ago. She also had right middle cerebral artery clipping because of a cerebral artery aneurysm rupture 2 years before.
She was residing in Incheon, South Korea. She visited New Jersey in the United States 4 weeks before the symptoms developed. In New Jersey, she went to a forest. Although she did not remember getting bitten by ticks or insects, she had an erythematous lesion on the right proximal calf area after visiting the forest, which was suspicious for a tick bite. Two days after detecting the skin lesion, headache, myalgia, fever, and chills developed.
On admission, her vital signs were: blood pressure 148/73 mmHg, heart rate 120 beats per minute, respiratory rate 18 breaths per minute, and body temperature 40.7°C. Laboratory examination showed white blood cells 5,610 cells/μl (normal range 4,000–10,000 cells/μl), hemoglobin 11.2 g/dl (normal range 12.0–15.3 g/dl), platelets 53,000 cells/μl (normal range 150,000–400,000 cells/μl), erythrocyte sedimentation rate 69 mm/hr (normal range 1–22 mm/hr), and C-reactive protein 9.52 mg/dl (normal range 0.0–0.3 mg/dl). Blood smear showed erythrocyte-containing organisms suspicious for Plasmodium species (Fig. 1). Abdomen-pelvis computed tomography revealed findings consistent with splenic infarction.
Suspecting malaria complicated with splenic infarction, treatment with hydroxychloroquine (800 mg loading and 400 mg 3 times after 6, 24, and 48 hr) was initiated. However, tests for detecting malaria antigens and polymerase chain reaction (PCR) for Plasmodium species failed to confirm malaria [16]. When the blood smear slide was re-examined, 4 Plasmodium-like organisms in 1 erythrocyte emulating Maltese cross forms were observed (Fig. 2A). We prescribed atovaquone 250 mg/proguanil hydrochloride 100 mg and azithromycin 500 mg to treat babesiosis. PCR for B. microti confirmed the diagnosis of babesiosis. A day after treatment, fever and abdominal discomfort subsided, and laboratory findings returned to normal.
Case 2
A 72-year-old woman without underlying disease visited our hospital for a fever that started 2 weeks before. She had been in Boston in the United States for 2 months previously. Vital signs were: blood pressure 93/67 mmHg, heart rate 76 beats per minute, respiratory rate 18 breaths per minute, and body temperature 37.7°C. Laboratory findings showed white blood cells 5,480 cells/μl, hemoglobin 10.8 g/dl, platelets 52,000 cells/μl, erythrocyte sedimentation rate 105 mm/hr, and C-reactive protein 15.1 mg/dl. Malaria-like organisms were seen on the observation of blood smear; however, the malaria antigen test was negative. When the blood smear morphology was closely observed, Maltese cross forms were visible in the red blood cells; therefore, babesiosis was diagnosed (Fig. 1B). Atovaquone 250 mg/proguanil 100 mg and azithromycin 500 mg were prescribed. However, fever persisted, and she developed pulmonary congestion. On diagnosis of severe babesiosis, we switched the medication to quinine and clindamycin, and red blood cell exchange was performed. As pulmonary congestion exacerbated, she was intubated due to respiratory failure (Fig. 2B). Doxycycline therapy was prescribed for possible coinfection with Borrelia or Anaplasma species.
PCR for B. microti was positive, confirming the diagnosis of babesiosis (Fig. 3). Also, the test for Borrelia burgdorferi was positive; IgG and IgM enzyme immunoassays titers were 1: 256 and 1:128, respectively. Both IgG and IgM Western blots were also positive, confirming co-infection with Lyme disease. The patient expired in hospital on day 31.
Polymerase Chain Reaction for Babesia species
For species identification, a nested PCR for B. microti was performed as described previously [17]. DNA was extracted from the whole blood of the patient using the QIAamp Blood Kit (Qiagen Co., Hilden, Germany). The first PCR was performed with the AccuPower PCR Premix (Bioneer Co., Daejeon, Korea), 2 μl of purified genomic DNA, 10 pmol each of the forward (Bab 1; 5′-CTT AGT ATA AGC TTT TAT ACA GC-3′) and reverse primers (Bab 4; 5′-ATA GGT CAG AAA CTT GAA TGA TAC A-3′), and the total volume was adjusted to 20 μl with distilled water. Thermal cycling conditions were as follows: denaturing at 94°C for 5 min; 35 cycles of 40 sec at 94°C, 40 sec at 55°C, and 40 sec at 72°C; and a final incubation at 72°C for 5 min. A second PCR was performed using the same buffer and DNA polymerase enzyme. The first PCR product (2 μl) was added and that different forward (Bab 2; 5′-GTT ATA GTT TAT TTG ATG TTC GTT T-3′) and reverse (Bab 3; 5′-AAG CCA TGC GAT TCG CTA AT-3′) primers were used. Theermal cycling conditions of the second PCR were as follows: denaturing at 94°C for 5 min; 35 cycles of 30 sec at 94°C, 30 sec at 55°C, and 40 sec at 72°C; and a final incubation at 72°C for 5 min. The PCR product was electrophoresed on a 1.5%-agarose gel. Approximately 240 bp (exactly 238 bp) PCR product representing B. microti DNA was visualized using ultraviolet transillumination after staining with ethidium bromide.
Numerous mechanisms underlying Babesia infection have been documented, including blood transfusion [18,19] and transplacental transmission [20,21]. However, infection with B. microti is most often observed following a tick bite in a person visiting or living in an area of endemicity. Although Babesia species are not endemic to Korea, 8 cases of infection have been reported: 1 endemic and 7 imported [5,7–11].
As the population of traveling abroad increases every year, both physicians and travelers need to be acquainted with not only endemic diseases of their provinces but also with those of other regions. Babesiosis is an increasingly imported disease in Korea [12].
The symptoms of babesiosis are easily mistaken for that of malaria. B. microti infection mimics malaria with symptoms of hemolytic anemia and a similar appearance of infected erythrocytes on blood smears. Moreover, malaria is endemic to the northern regions of South Korea. Therefore, malaria is easily assumed when patients in malaria-endemic regions present with high fever, malaise, and intra-erythrocyte parasites.
The patients we described here both resided in Incheon, a province where malaria is endemic. They were both initially mistaken as having malaria because of nonspecific febrile symptoms and intra-erythrocyte malaria-like protozoa on blood smears. However, negative results for the malaria antigen test and PCR and unresponsiveness to malaria treatment led to a suspicion of babesiosis. Minute history taking also aided the diagnosis. Both patients visited the northeastern part of the United States before the disease developed.
These 2 cases were also unique in that both patients presented unfamiliar complications of babesiosis. The patient of first case had splenic infarction, however, she did not have any hematologic or autoimmune disorders which may have caused embolic events. We suspect that she had splenic infarction as a complication of babesiosis. A few mechanisms underlying coagulopathy caused by babesiosis have been proposed, including microthrombus formation and local release of vasoactive factors by red blood cell lysis [22]. Additionally, in animal models, Babesia species-infected erythrocytes triggered an acute inflammatory response and activated the coagulation system, leading to increased erythrocyte adhesiveness to the capillaries [22].
The patient of second case was complicated by co-infection with Lyme disease. Ixodes ticks are known vectors in zoonosis and coinfection of tick-borne diseases such as Lyme disease, babesiosis, and human granulocytic anaplasmosis [14,23]. Particularly when patients do not improve clinically despite proper treatment, coinfection with other tick-borne diseases should be suspected. Babesiosis and Lyme disease are prevalent in overlapping regions of northeastern United States [14]. Moreover, epidemiologic studies have documented that approximately 2/3 of patients with babesiosis experience concurrent Lyme disease [23].
In Korea, several imported cases of babesiosis and severe coinfection with malaria have been reported [24,25]. However, this is the first report of co-infection of B. microti and Lyme disease detected in Korea.
The reason that co-infection of tick-borne diseases causes fatality is not well-known. One theory is that once the immune system is weakened by babesiosis, the patient becomes vulnerable to other tick-borne protozoa infections [2,13]. It is also possible that a patient may be asymptomatic after exposure to B. microti when the immune system remains intact. When the immune system is, however, weakened by other tick-borne diseases, the patient may develop severe symptoms due to a synergy of the newly introduced infection and chronic asymptomatic babesiosis.
Our findings suggest that to diagnose tick-associated diseases, an easier method to detect B. microti and anaplasmosis should be devised in Korea. Not only is suspicion of babesiosis and other co-infected diseases crucial, but prompt confirmation of diagnoses is important to treat patients appropriately.
In conclusion, we reported 2 unique cases of babesiosis. One patient was complicated by splenic infarction, and the other was coinfected with Lyme disease. Although not endemic, physicians and travelers should be acquainted with babesiosis and its complications. Since coinfection with other tick-borne diseases may aggravate the symptoms of babesiosis, easier and faster methods to detect Borrelia and Anaplasma species should be developed in Korea.
This work was supported by a research grant from Inha University Hospital.
Fig. 1
Peripheral blood smears. Erythrocytes containing multiple ring-like trophozoites, cross-maltase form, are observed. Giemsa stained. (A) ×1,000, (B) ×400.
kjp-56-6-609f1.jpg
Fig. 2
Photographs of abdominal CT and chest X-ray. (A) Complications of severe babesiosis were demonstrated as splenic infarction. (B) Pulmonary congestion. An arrow indicates splenic infarction.
kjp-56-6-609f2.jpg
Fig. 3
Agarose gel-electrophoreses of babesiosis PCR amplicons for the second case. (A) PCR amplicon using Babesia-universal primers Bab 5 and Bab 8 (1st). For the nested PCR, primersBab 6 and Bab 7 were used (2nd) (B). PCR amplification using B. microtispecific primer pair (Bab 1 and Bab 4) producing 250 bp (1st) amplicon. Primer pair (Bab 2 and Bab 3) used for the 2nd amplification (2nd). DW, negative control.
kjp-56-6-609f3.jpg
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Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea
Korean J Parasitol. 2018;56(6):609-613.   Published online December 31, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.6.609
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Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
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Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea
Korean J Parasitol. 2018;56(6):609-613.   Published online December 31, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.6.609
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Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea
Image Image Image
Fig. 1 Peripheral blood smears. Erythrocytes containing multiple ring-like trophozoites, cross-maltase form, are observed. Giemsa stained. (A) ×1,000, (B) ×400.
Fig. 2 Photographs of abdominal CT and chest X-ray. (A) Complications of severe babesiosis were demonstrated as splenic infarction. (B) Pulmonary congestion. An arrow indicates splenic infarction.
Fig. 3 Agarose gel-electrophoreses of babesiosis PCR amplicons for the second case. (A) PCR amplicon using Babesia-universal primers Bab 5 and Bab 8 (1st). For the nested PCR, primersBab 6 and Bab 7 were used (2nd) (B). PCR amplification using B. microtispecific primer pair (Bab 1 and Bab 4) producing 250 bp (1st) amplicon. Primer pair (Bab 2 and Bab 3) used for the 2nd amplification (2nd). DW, negative control.

Fig. 1

Fig. 2

Fig. 3

Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea
PHD : Parasites, Hosts and Diseases

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