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Original Article

In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis

Joel Horacio Elizondo-Luevano1, Julia Verde-Star1, Azucena González-Horta1, Rocío Castro-Ríos2, Magda Elizabeth Hernández-García3,*, Abelardo Chávez-Montes1,*
The Korean Journal of Parasitology 2020;58(2):135-145.
Published online: April 30, 2020

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*Corresponding authors: (abelardo.chavezmn@uanl.edu.mx; magda.hernandez@imss.gob.mx)
• Received: October 9, 2019   • Revised: March 9, 2020   • Accepted: March 13, 2020

Copyright © 2020 by The Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis
Korean J Parasitol. 2020;58(2):135-145.   Published online April 30, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.2.135
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In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis
Korean J Parasitol. 2020;58(2):135-145.   Published online April 30, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.2.135
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In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis
Image Image Image Image
Fig. 1 HPLC-DAD chromatograms for AmexS (A), AmexL (B) crude extracts and berberine (C) solutions (15 mg/ml).
Fig. 2 Growth kinetics of Trichomonas vaginalis in TYI-S-33 medium. Each point is mean of 3 independent counts.
Fig. 3 Direct infusion-electrospray ionization-ion-trap MS2 full scan product. Ion mass spectra of [M]+ ions of (A) berberine (m/z 336) and (B) jatrorrhizine (m/z 338) obtained from the AmexL3 fraction.
Fig. 4 Hemolytic cytotoxicity of AmexS and AmexL extracts. The results in the columns are shown as the percentage of hemolysis. Values are shown as mean±SD. All assays were performed in triplicate.

Fig. 1

Fig. 2

Fig. 3

Fig. 4

In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis

Phytochemical analysis on crude extracts of Argemone mexicana stems and leaves

Chemical test AmexS AmexL
Unsaturates +++ +
Carbonyl groups − −
Coumarins − −
Sesquiterpene lactones − −
Quinones + ++
Triterpenes - sterols + +
Carboxyl group − −
Phenolic groups + ++
Saponins + +
Flavonoids + ++
Carbohydrates +++ +
Alkaloids +++ +++

The preliminary phytochemicals were analyzed in order to detect presence or absence of some important phyto-compounds. The results in the phytochemical tests are presented as negative - or presence +, high presence ++ and very high presence +++. The plant showed both presence and absence of various compounds.

Percentage of inhibition of Trichomonas vaginalis growth

Extract Concentration (μg/ml)
15.63 31.25 62.5 125 250 500 1,000
AmexS 14.7±1.2 25.3±1.2 38.7±0.4 64.4±0.6 83.4±2.0 97.4±0.1 100.0±0.0
AmexL 18.0±1.1 29.6±1.6 40.4±0.8 70.1±0.3 84.2±1.9 98.1±0.0 100.0±0.0

Evaluation of T. vaginalis viability in the presence of different extract concentrations. The values are shown as the mean of the percent inhibition±SD. Means followed by the same letter are not significantly different based on the Tukey test for multiple comparisons of means (P<0.05). All assays were performed in triplicate.

Mean half maximal inhibitory concentrations (IC50) against Trichomonas vaginalis determined by the Probit test

Treatment IC50 (μg/ml)
AmexS 70.8 (63.6–86.2)
AmexL 67.2 (61.9–74.7)
Berberine 40.7 (35.5–47.8)
Metronidazole 0.1 (0.1–0.2)

The values are shown as the mean±SD. Confidence interval 95%. Berberine: Main metabolite of A. mexicana. Metronidazole: Reference drug for the treatment of T. vaginalis. All assays were performed in triplicate.

Lethality percentage of fractions of the AmexS and AmexL extracts against Trichomonas vaginalis at 125 μg/ml

Fraction AmexS AmexL
1 ND 50.4±1.9
2 51.1±0.5 53.2±2.0
3 73.0±0.1 79.2±0.2
4 ND 55.2±0.3
5 ND ND

Data expressed as % lethality. ND: not determined because it did not reach 50% inhibition. The values are expressed as the mean±SD (P<0.05). All assays were performed in triplicate.

Table 1 Phytochemical analysis on crude extracts of Argemone mexicana stems and leaves

The preliminary phytochemicals were analyzed in order to detect presence or absence of some important phyto-compounds. The results in the phytochemical tests are presented as negative - or presence +, high presence ++ and very high presence +++. The plant showed both presence and absence of various compounds.

Table 2 Percentage of inhibition of Trichomonas vaginalis growth

Evaluation of T. vaginalis viability in the presence of different extract concentrations. The values are shown as the mean of the percent inhibition±SD. Means followed by the same letter are not significantly different based on the Tukey test for multiple comparisons of means (P<0.05). All assays were performed in triplicate.

Table 3 Mean half maximal inhibitory concentrations (IC50) against Trichomonas vaginalis determined by the Probit test

The values are shown as the mean±SD. Confidence interval 95%. Berberine: Main metabolite of A. mexicana. Metronidazole: Reference drug for the treatment of T. vaginalis. All assays were performed in triplicate.

Table 4 Lethality percentage of fractions of the AmexS and AmexL extracts against Trichomonas vaginalis at 125 μg/ml

Data expressed as % lethality. ND: not determined because it did not reach 50% inhibition. The values are expressed as the mean±SD (P<0.05). All assays were performed in triplicate.

Table 1

Table 2

Table 3

Table 4

PHD : Parasites, Hosts and Diseases

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