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Brief Communication

Differentially Expressed Gene Profile of Acanthamoeba castellanii Induced by an Endosymbiont Legionella pneumophila

Eun-Kyung Moon1orcid, So-Min Park2, Ki-Back Chu2, Fu-Shi Quan1,3, Hyun-Hee Kong4,*orcid
The Korean Journal of Parasitology 2021;59(1):67-76.
Published online: February 19, 2021

1Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea

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*Corresponding author (hhkong@dau.ac.kr)
• Received: October 14, 2020   • Revised: December 15, 2020   • Accepted: December 21, 2020

Copyright © 2021 by The Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Comparative analysis of differentially expressed genes in Acanthamoeba after ingestion of Legionella pneumophila and Escherichia coli
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    Experimental Parasitology.2022; 232: 108188.     CrossRef

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Differentially Expressed Gene Profile of Acanthamoeba castellanii Induced by an Endosymbiont Legionella pneumophila
Korean J Parasitol. 2021;59(1):67-75.   Published online February 19, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.1.67
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Differentially Expressed Gene Profile of Acanthamoeba castellanii Induced by an Endosymbiont Legionella pneumophila
Korean J Parasitol. 2021;59(1):67-75.   Published online February 19, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.1.67
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Differentially Expressed Gene Profile of Acanthamoeba castellanii Induced by an Endosymbiont Legionella pneumophila
Image Image Image
Fig. 1 An overview of significant changes in the gene expression profiles of A. castellanii. (A) Gene expressions under different experimental conditions displayed using a heat map. (B) The number of genes with significantly increased or decreased expression (more than 2 fold). (C) Venn diagram showing the number of overlapping genes differentially expressed among 3 experimental conditions. L+A(12 hr)/A; L. pneumohpila infected A. castellanii for 12 hr/A. castellanii, L+A(24 hr)/A; L. pneumohpila infected A. castellanii for 24 hr/A. castellanii, L+A(24 hr)/L+A(12 hr); L. pneumohpila infected A. castellanii for 24 hr/L. pneumohpila infected A. castellanii for 12 hr.
Fig. 2 Distribution of gene ontology (GO) functional classifications. GO analysis of downregulated (left-hand direction) and upregulated (right-hand direction) genes in A. castellanii infected with L. pneumophila after 12 hr.
Fig. 3 Distribution of gene ontology (GO) functional classifications. GO analysis of downregulated (left-hand direction) and upregulated (right-hand direction) genes in A. castellanii infected with L. pneumophila after 24 hr.

Fig. 1

Fig. 2

Fig. 3

Differentially Expressed Gene Profile of Acanthamoeba castellanii Induced by an Endosymbiont Legionella pneumophila

Genes upregulated more than 10 fold in A. castellanii 12 hr pi

Gene symbol Fold change Annotation GO analysis
L+A(12)/A L+A(24)/A Product Category (Term)
ACA1_328910 1099.734 136.04 hypothetical protein MF (GO:0003677)
ACA1_183610 345.332 0.920 hypothetical protein -
ACA1_183700 173.774 0.462 S-adenosylmethionine-dependent methyltransferases -
ACA1_140050 116.896 15.154 hypothetical protein CC (GO:0016021)
ACA1_183570 87.745 0.232 GDPD-mannose-3′,5′-epimerase MF (GO:0003824)
ACA1_324870 66.918 38.929 hypothetical protein -
ACA1_300830 61.232 23.274 permeases of the major facilitator superfamily CC (GO:0016021)
ACA1_139940 51.100 7.577 hypothetical protein -
ACA1_183970 50.688 0.239 hypothetical protein CC (GO:0016021)
ACA1_264780 41.374 2.313 hypothetical protein -
ACA1_159010 36.741 11.383 NmrAlike family protein -
ACA1_098380 27.710 0.838 hypothetical protein -
ACA1_248200 25.965 3.365 phosphotransferase enzyme domain containing protein -
ACA1_183940 25.733 0.905 GTPase activating Rap/RanGAP domainlike 3, putative -
ACA1_096640 20.427 7.341 hypothetical protein -
ACA1_183760 17.942 0.999 lysine methyltransferase enzyme domain containing protein -
ACA1_376940 17.875 3.938 BNR/Aspbox repeat domain containing protein -
ACA1_183580 17.602 0.724 S-adenosylmethionine-dependent methyltransferases -
ACA1_270170 15.076 1.686 von Willebrand factor type A domain containing protein -
ACA1_158840 15.058 6.332 metal dependent phosphohydrolase -
ACA1_289630 14.765 11.367 hypothetical protein -
ACA1_381540 14.601 0.503 hypothetical protein -
ACA1_224160 14.371 6.761 Sec23/Sec24 beta-sandwich domain containing protein -
ACA1_175370 14.029 6.388 Erf4 domain containing protein CC (GO:0016021)
ACA1_140540 13.733 6.286 MORN repeatcontaining protein -
ACA1_184710 13.687 26.561 Phospholipid methyltransferase domain containing protein CC (GO:0016021)
ACA1_068540 13.266 5.034 Prokumamolisin, activation domain containing protein -
ACA1_217750 13.172 4.030 phosphoenolpyruvate carboxykinase (GTP), putative MF (GO:0016301)
ACA1_116700 13.149 9.620 hypothetical protein -
ACA1_279740 12.960 5.501 hydrogenase assembly factor, putative MF (GO:0051536)
ACA1_116690 12.553 5.917 hypothetical protein CC (GO:0016021)
ACA1_285180 12.470 58.313 DNA breaking-rejoining enzyme domain containing protein MF (GO:0003677)
ACA1_215790 12.170 8.113 copper/zinc superoxide dismutase -
ACA1_275740 12.097 4.360 glycerol-3-phosphate dehydrogenase (soluble) MF (GO:0051287)
ACA1_058320 12.094 4.914 GPR1/FUN34/yaaH family protein CC (GO:0016021)
ACA1_358270 11.433 7.344 pyridine nucleotidedisulfide oxidoreductase domain containing protein MF (GO:0016491)
ACA1_067720 11.300 8.046 hypothetical protein -
ACA1_153710 11.001 0.845 RFX_DNA_binding BP (GO:0006355)
ACA1_091110 10.950 0.842 hypothetical protein -
ACA1_256560 10.936 3.671 hypothetical protein -
ACA1_275730 10.900 2.743 phosphoglycerate mutase family domain containing protein -
ACA1_165640 10.762 1.971 hypothetical protein -
ACA1_060580 10.631 4.515 phosphatase -
ACA1_245710 10.555 7.545 hypothetical protein -
ACA1_325450 10.443 4.372 CBS domain containing protein -
ACA1_187310 10.274 6.715 heme NO binding domain containing protein -
ACA1_238590 10.109 3.454 CBS domain containing protein -

Genes downregulated more than 10 fold in A. castellanii 12 hr pi

Gene symbol Fold change Annotation GO analysis
L+A(12)/A L+A(24)/A Product Category (Term)
ACA1_113420 0.001 0.764 hypothetical protein -
ACA1_112520 0.001 0.493 Cysteine-rich 4 helical bundle widely conserved -
ACA1_111980 0.003 0.368 EF hand domain containing protein -
ACA1_112090 0.003 0.454 hypothetical protein -
ACA1_111740 0.007 0.190 hypothetical protein -
ACA1_112480 0.007 0.492 Fbox domain containing protein -
ACA1_376130 0.007 0.386 xylosyltransferase 1, putative -
ACA1_058410 0.009 0.019 hypothetical protein -
ACA1_147740 0.010 0.006 CBS domain containing protein -
ACA1_113310 0.013 0.765 hypothetical protein -
ACA1_166550 0.017 0.318 hypothetical protein -
ACA1_374390 0.018 0.924 hypothetical protein -
ACA1_101570 0.019 1.673 hypothetical protein -
ACA1_392590 0.020 0.401 hypothetical protein -
ACA1_060120 0.021 0.548 hypothetical protein -
ACA1_400130 0.021 0.021 hypothetical protein -
ACA1_307550 0.022 0.084 Fbox domain containing protein -
ACA1_230230 0.022 0.022 hypothetical protein -
ACA1_050390 0.024 2.233 3-oxoacyl-[acyl-carrier protein] reductase CC (GO: 0016021)
ACA1_112110 0.024 0.463 glycosyl transferase CC (GO: 0016021)
ACA1_112490 0.024 0.480 hypothetical protein -
ACA1_063680 0.026 0.072 Reverse transcriptase -
ACA1_390590 0.027 0.132 Hsp20/alpha crystallin superfamily protein -
ACA1_063960 0.029 0.078 hypothetical protein -
ACA1_112130 0.029 0.457 regulator of g protein signaling domain containing protein -
ACA1_111970 0.029 0.399 sulfiredoxin 1 -
ACA1_158820 0.029 0.646 hypothetical protein -
ACA1_064370 0.029 0.029 AT Hook plus PHD finger transcription factor family member (athp1), putative -
ACA1_064780 0.029 0.029 hypothetical protein -
ACA1_064790 0.029 0.029 hypothetical protein -
ACA1_340040 0.030 0.275 zinc finger, zz type domain containing protein -
ACA1_350050 0.030 0.298 hypothetical protein -
ACA1_112530 0.031 0.499 NLPC_P60 super family -
ACA1_112180 0.032 0.527 major facilitator subfamily transporter CC (GO: 0016021)
ACA1_112590 0.034 0.474 WH2 motif domain containing protein -
ACA1_050380 0.036 1.885 hypothetical protein -
ACA1_230220 0.037 0.025 hypothetical protein -
ACA1_199000 0.038 0.229 SnoaL-like domain containing protein -
ACA1_077210 0.040 0.376 hypothetical protein -
ACA1_173000 0.043 0.352 Predicted NAD/FAD-dependent oxidoreductase -
ACA1_326260 0.043 0.073 hypothetical protein -
ACA1_060740 0.045 0.310 hypothetical protein -
ACA1_270160 0.046 0.071 fascin subfamily protein -
ACA1_200180 0.048 0.428 hypothetical protein -
ACA1_383480 0.051 0.029 hypothetical protein -
ACA1_155760 0.052 0.145 phosphoribosyltransferase -
ACA1_207830 0.052 0.426 myotubularins and other putative membrane-associated proteins -
ACA1_133180 0.052 0.254 Ser/Thr phosphatase family superfamily protein -
ACA1_077290 0.053 0.638 5′nucleotidase CC (GO: 0016021)
ACA1_365080 0.053 0.367 hypothetical protein -
ACA1_383650 0.055 0.349 Human glyoxalase domain-containing protein 5 and similar proteins -
ACA1_048480 0.056 0.616 hypothetical protein -
ACA1_055330 0.059 0.292 N-terminal region of Chorein or VPS13 -
ACA1_346470 0.060 0.450 RUN domain containing protein -
ACA1_298420 0.062 0.056 hypothetical protein -
ACA1_197730 0.064 0.823 hypothetical protein -
ACA1_378930 0.064 0.329 hypothetical protein -
ACA1_214630 0.067 0.147 hypothetical protein CC (GO: 0016021)
ACA1_128200 0.068 0.051 CBS domain containing protein -
ACA1_052800 0.071 0.571 O-methyltransferase family 3 protein -
ACA1_112560 0.071 0.499 hypothetical protein -
ACA1_322750 0.072 0.552 Glycosyl hydrolases family 2, TIM barrel domain -
ACA1_383400 0.072 1.376 hypothetical protein CC (GO: 0016021)
ACA1_253630 0.073 0.947 hypothetical protein -
ACA1_391470 0.074 0.821 Hsp20/alpha crystallin superfamily protein -
ACA1_066110 0.074 0.05 SCP-like extracellular protein domain containing protein -
ACA1_131790 0.075 0.133 protein from patent family protein -
ACA1_111930 0.075 0.311 carbonsulfur lyase, putative BP (GO: 0008152)
ACA1_064380 0.077 0.052 hypothetical protein -
ACA1_064940 0.077 0.029 Fbox domain containing protein -
ACA1_323370 0.077 0.011 Hsp20/alpha crystallin superfamily protein -
ACA1_383750 0.078 0.236 Ubiquitinconjugating enzyme subfamily protein -
ACA1_006080 0.079 0.210 hypothetical protein CC (GO: 0016021)
ACA1_180590 0.082 0.546 TRRAP family protein -
ACA1_112980 0.083 0.755 protein kinase -
ACA1_077300 0.083 0.247 serine/threonine kinase CC (GO: 0016021)
ACA1_111880 0.084 0.225 Small acidic protein family -
ACA1_372720 0.084 0.148 obtusifoliol 14alphademethylase, putative CC (GO: 0016021)
ACA1_046720 0.086 0.076 Glycosyl hydrolase families -
ACA1_324050 0.088 0.646 Vacuolar sorting-associated protein 13 [Intracellular trafficking and secretion] -
ACA1_400540 0.088 0.076 sphingosine hydroxylase CC (GO: 0016021)
ACA1_290200 0.089 0.329 hypothetical protein -
ACA1_389110 0.09 1.016 hypothetical protein -
ACA1_112500 0.094 0.535 TBC domain containing protein -
ACA1_311650 0.095 0.096 hypothetical protein -
ACA1_112060 0.096 0.429 O-methyltransferase, putative -
ACA1_178260 0.097 0.118 cytochrome P450, putative MF (GO: 0005506)
ACA1_066960 0.098 1.036 hypothetical protein -
ACA1_046710 0.099 0.126 cytoplasmic protein, putative -
ACA1_112640 0.100 0.498 MBOAT family protein CC (GO: 0016021)
Table 1 Genes upregulated more than 10 fold in A. castellanii 12 hr pi
Table 2 Genes downregulated more than 10 fold in A. castellanii 12 hr pi

Table 1

Table 2

PHD : Parasites, Hosts and Diseases

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