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Brief Communication

Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in the Republic of Korea

Jun-Gu Kang1orcid, Yoon-Kyoung Cho2, Young-Sun Jo2, Sun-Woo Han2, Jeong-Byoung Chae2, Jung-Eun Park3, Hyesung Jeong3, Weon-Hwa Jheong3, Joon-Seok Chae2,*orcid
The Korean Journal of Parasitology 2022;60(1):65-71.
Published online: February 23, 2022

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*Corresponding author (jschae@snu.ac.kr)
• Received: November 2, 2021   • Revised: December 12, 2021   • Accepted: January 19, 2022

© 2022, Korean Society for Parasitology and Tropical Medicine

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  • Severe fever with thrombocytopenia syndrome virus (SFTSV) is a zoonotic, tick-borne RNA virus of the genus Bandavirus (Family Phenuiviridae), mainly reported in China, Japan, and the Republic of Korea (Korea). For the purpose of this study, a total of 3,898 adult and nymphal ticks of species Haemaphysalis longicornis (94.2%), Haemaphysalis flava (5.0%), Ixodes nipponensis (0.8%), and 1 specimen of Ixodes ovatus, were collected from the Deogyusan National Park, Korea, between April 2016 and June 2018. A single-step reverse transcriptase–nested PCR was performed, targeting the S segment of the SFTSV RNA. Total infection rate (IR) of SFTSV in individual ticks was found to be 6.0%. Based on developmental stages, IR was 5.3% in adults and 6.0% in nymphs. The S segment sequences obtained from PCR were divided into 17 haplotypes. All haplotypes were phylogenetically clustered into clades B-2 and B-3, with 92.7% sequences in B-2 and 7.3% in B-3. These observations indicate that the Korean SFTSV strains were closer to the Japanese than the Chinese strains. Further epidemiological studies are necessary to better understand the characteristics of the Korean SFTSV and its transmission cycle in the ecosystem.
  • Key words: Haemaphysalis longicornis, severe fever with thrombocytopenia syndrome virus, tick, National Park, vegetation, Korea
Severe fever with thrombocytopenia syndrome (SFTS) is caused by Dabie bandavirus (formerly, SFTS virus, SFTSV), a tick-borne zoonotic virus belonging to the genus Bandavirus (Family Phenuiviride) [1]. SFTSV has mainly been reported in China, Japan, and the Republic of Korea (Korea) [2–4]. The main clinical symptoms of SFTS include high fever, thrombocytopenia, leukopenia, and increased liver enzymes [2]. In animals, several cases of SFTS-like illnesses have been reported in companion animals like dogs and cats, and in cheetahs [5–8]. Recently, a confirmed case of SFTS in human was reported in 2020 from Taiwan [9]. Moreover, molecular and serological detections of SFTSV in both humans and animals have been reported from Vietnam, Taiwan, Thailand, Pakistan, and Myanmar [10–14]. These reports indicate that SFTSV could be circulating in other southern Asian countries as well as in the endemic countries such as China, Japan, and Korea.
The origin of SFTSV and its transmission cycle have not yet been completely elucidated. Although incidences of human-to-human or animal-to-human transmission have occasionally been reported, tick bites are the main transmission route of SFTSV. Several studies suggest that the main vector of SFTSV could be Haemaphysalis longicornis, the most dominant hard-tick species in Korea [15–18]. SFTSV exhibits transstadial (from larva to nymph and/or adult) and transovarial transmission in H. longicornis [19]. In a previous study, we had reported the prevalence of SFTSV in ticks collected from 5 national parks in Korea [16]. However, that study was conducted for a short period, spanning from July to November 2015. Thus, an extended 3-year surveillance of hard ticks was undertaken in the Deogyusan National Park, Korea to monitor the SFTSV presence in the nature.
The ticks in Deogyusan National Park were observed to appear in March and disappear by November throughout the study period. Specimens were collected using flags (0.5×1.5 sq. meters, white cotton) over a duration of 3 years (April 2016 to June 2018) (Fig. 1A). Through microscopic examinations, the collected specimens were classified into various species and developmental stages [20]. A total of 3,898 ticks were collected and classified into 4 species: H. longicornis (94.2%), H. flava (5.0%), Ixodes nipponensis (0.8%), and I. ovatus (negligible). Detailed sample descriptions are mentioned in Table 1. A lot of larvae were collected from September to October through the years, but were not included in this study (data not shown). The seasonal larval distribution was very similar to that reported by a previous study [18]. The larvae were not classified into species because of their miniscule sizes and morphological similarities at the genus level. Noticeably, the adult and nymphal tick populations surged in April and sustained on high until June or July (Table 2). Although not included in Table 1, larvae were found in July, August, and September of 2017, numbering 63 in July, 50 in August, and 413 in September; they were grouped into 53 pools.
Adult and nymphal ticks were placed singly in 2 ml round tubes and stored at −80°C until further analysis. Larval ticks were pooled (10 larvae/pool), mixed with sterile stainless steel beads in 250 μl tissue lysis buffer (iNtRON, Seongnam, Korea), and homogenized using TissueLyser II (Qiagen, Hilden, Germany) for 5 min at 30 Hz. The homogenized samples were centrifuged at 13,000 rpm for 10 min at room temperature and the supernatant was collected. Viral RNA was extracted from the supernatant using Viral DNA/RNA Extraction kit (iNtRON) according to the recommended protocol and stored at −80°C until use. To amplify the S segment of SFTSV RNA, 1-step reverse transcriptase (RT)–nested PCR was conducted using SFTSV-specific primer sets and One-step RT-PCR premix kit (SolGent, Daejeon, Korea), as previously described [16]. The first PCR primers were NP-2F (5′-CAT CAT TGT CTT TGC CCT GA-3′) and NP-2R (5′-AGA AGA CAG AGT TCA CAG CA-3′). The nested PCR primers were N2-F (5′-AAY AAG ATC GTC AAG GCA TCA-3′) and N2-R (5′-TAG TCT TGG TGA AGG CAT CTT-3′). RT reactions were performed with an initial step of 30 min at 45°C and 5 min at 94°C for denaturation. The PCR was run for 40 (first PCR) and 25 cycles (nested PCR) under the following conditions: 94°C for 20 sec, 52°C for 40 sec, 72°C for 30 sec, with a final extension step at 72°C for 5 min. For nested PCR, 1 μl of the first PCR products were used as template with HiPi PCR premix (Elpisbio, Daejeon, Korea). The amplicons were loaded on 1.2% agarose gel and observed under gel documentation system. The positive bands were purified using QIAquick Gel Extraction Kits (Qiagen). KH1 strain was used as a positive control [21]. The purified DNAs were sequenced using an automatic sequencer (3730 capillary DNA Analyzer; Applied Bio-systems, Foster City, California, USA). The sequences obtained were aligned by Clustal X (Ver 2.1) and analyzed using MEGA 7 [22,23]. A phylogenetic tree was constructed using the neighbor-joining method based on Tamura–Nei model. The data set was resampled 1,000 times to generate bootstrap values [23]. The sequences obtained from this study were deposited in GenBank under accession numbers (OL677550–OL677566).
SFTSV was detected in male, female, and nymphal ticks of H. longicornis and H. flava, but not in I. nipponensis and I. ovatus (Table 1). Infection rate (IR) in H. longicornis was 5.9% (1.9% in males, 6.4% in females, and 6.0% in nymphs) and that in H. flava was 7.7% (8.7% in males, 8.3% in females, and 7.6% in nymphs) (Table 1). Based on developmental stages, IR was observed to be 5.3% in the adults and 6.0% in the nymphs. Minimum field infection rate (MFIR; number of positive pools/number of tested ticks ×100) was 2.47% in the larvae. The year-wise IR was 8.0% (108/1,355) in 2016, 5.4% (46/855) in 2017, and 4.7% (79/1,688) in 2018. In spring (April–June), IR was slightly higher than the annual average every year (8.5% in 2016, 5.7% in 2017, and 4.8% in 2018).
Of the 233 SFTSV-positive ticks, 109 DNA samples were selected and sequenced from each developmental stage, collection date, and species. The sequences (346 bp long) were very similar to that of the S segment of SFTSV RNA and were sub-grouped into 17 haplotypes. Phylogenetic analysis revealed that all obtained haplotypes were clustered into 2 clades: B-2 and B-3 (Fig. 1B).
Of the 109 sequences obtained, 101 (92.7%) were clustered in clade B-2 and 8 (7.3%) were grouped in B-3 (Fig. 1B). However, no sequences were included in other clades such as A, B-1, D, and F. The major haplotype (DY173) comprised 68 sequences (62.4%) and was closely related to the Korean isolate Dog22, with 99.1% identity.
Our 3-year field surveillance indicates that H. longicornis is a dominant tick species in the surveyed area of Deogyusan National Park. The species has also been previously reported as dominant in Ganghwa-do, Gyeonggi-do, Daejeon, Gyeongbuk, and 5 national parks [16–18,21,24]. Moreover, H. longicornis was observed to be the overwhelmingly dominant species in every season, month, and year in this study. This may be associated with the choice of grasslands as the sampling habitat. H. longicornis has a 3-host life cycle and 3 distinct developmental stages in one year [25]. Regarding the seasonal distribution of the H. longicornis developmental stages, the sequential dynamic changes in tick population peaks (adults, nymphs, and larvae) were observed in Korea by several studies, including the present study, and also in China [17,21,25]. The number of adults and nymphs decreased in July and larval population surged in August, indicating that oviposition period of H. longicornis might be pre-summer and could affect the second peak of nymphs observed in autumn [21,25]. Adults or nymphs perhaps hibernate under leaves or underground in the winter [26]. It was previously reported that nymphs and adults of H. longicornis could survive during winter and that nymph population was highest in spring in Korea [21,27].
Epidemiological studies about the prevalence of SFTSV in ticks have generally been conducted based on pooling method for reasons of convenience, economic benefit, and high sample size of ticks. In Korea, studies on SFTSV prevalence in pooled ticks from vegetation have reported an MFIR of 0–0.6% (0.5% in 8 provinces, 0.6% in Gyeongbuk province, and 0% in Ganghwa-do and Gyeonggi provinces) [17,18,28,29]. On the other hand, when analyses were made without using the pooling method, higher SFTSV prevalence in ticks was observed, with an IR of 3.6% [16]. In this study, an IR of 5.98% was observed, which is much higher than those reported in previous studies. These observations suggest that MFIR can not represent real IR in tick population and basing the sampling process on individual tick assay may be more suitable for the epidemiological studies on the prevalence of pathogens in ticks.
Although we only had data of one year (2017) on larval MFIR, the observed value of 2.5% was markedly higher than 0.3%, as reported in a previous study [16]. Recently, it has been reported that SFTSV was detected at all developmental stages including adults, nymphs, larvae, and eggs of H. longicornis ticks in Korea and China [16,29,30]. Moreover, the presence of SFTSV was also confirmed in several organs of H. longicornis larvae, nymphs, and adults [15]. These studies, including the present study, suggest that SFTSV could circulate in the wild by transovarial and transstadial transmissions.
Based on phylogenetic analysis, several previous studies have clustered the SFTSV strains, which can be broadly divided into 2 groups: the Chinese and the Korean/Japanese clades. In this study, phylogenetic analysis of SFTSV strains was performed and sequences were clustered as suggested by Yun et al. [31]. Clades A, D, and F included the Chinese strains while clade B consisted of the Korean/Japanese strains. Our results, based on partial sequences of SFTSV S segment, show that 92.7% of sequences were clustered in clade B-2 and 7.3% sequences were included in B-3 (Fig. 1B). Many Korean and Japanese isolates were mixed and included in clade B-2 clade but it included no Chinese strains [31]. In contrast, in clade B-3, many Chinese and Korean isolates were clustered with few Japanese strain. These observations indicate that the Korean SFTSV strains are more closely related to the Japanese than the Chinese strains (Fig. 1B). However, this study has some limitation such as using only partial S segment sequences of SFTSV, local collection site, etc. Therefore, for better understanding of the Korean SFTSV characteristics, continuous massive surveillance and evolutionary study for SFTSV are necessary.
To the best of our knowledge, this study has reported the highest IR of SFTSV till date. Annual SFTS cases show no declining trend and several patients with SFTS have succumbed to the disease in Korea. SFTSV-specific vaccines or drugs are not yet developed. It is, therefore, suggested that monitoring the spread of infection among the arthropod vectors, wild/domesticated/companion animals, and humans should be extended and intensified to minimize potential risks associated with SFTSV transmission in Korea.

The authors declare that they have no conflicts of interest in the publication of this paper.

This work was supported by a grant of the National Institute of Environmental Research (NIER-2017-353), Korea.
Fig. 1
(A) Map of the tick collection site, Deogyusan National Park, Korea. (B) Phylogenetic tree for SFTSV based on S segment sequences. Bold letters indicate the SFTSV sequences obtained from the ticks in this study. n=number of sequences. A scale bar shows nucleotide substitutions per position.
kjp-60-1-65f1.jpg
Table 1
Prevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) in different developmental stages of ticks collected from Deogyusan National Park, Korea
Table 1
Tick species Developmental stage No. of tested ticks No. of SFTSV-positive ticks Infection rate (%)
Haemaphysalis longicornis Male 54 1 1.9
Female 173 11 6.4
Nymph 3,444 206 6.0
Subtotal 3,671 218 5.9
Haemaphysalis flava Male 23 2 8.7
Female 12 1 8.3
Nymph 159 12 7.6
Subtotal 194 15 7.7
Ixodes nipponensis Male 16 0 0.0
Female 5 0 0.0
Nymph 11 0 0.0
Subtotal 32 0 0.0
Ixodes ovatus Male 1 0 0.0
Total 3,898 233 6.0
Table 2
Seasonal prevalence of severe fever with thrombocytopenia syndrome virus in the adult and nymphal ticks collected from Deogyusan National Park, Korea, 20162-018
Table 2
Developmental stages Items 2016 2017 2018 Total
Apr May Jun Jul Aug Sep Oct Nov Apr May Jun Jul Aug Sep Oct Nov Mar Apr May Jun
Adult No. of tested ticks 8 39 89 34 3 2 2 11 2 5 8 31 0 13 3 8 11 1 4 10 284
Infection rate (%) 0 7.7 7.9 0 33.3 0 0 9.1 0 0 0 3.2 0 15.4 0 0 0 0 0 0 5.3
Nymph No. of tested ticks 260 462 291 69 24 2 51 8 191 44 256 180 54 33 13 14 58 686 514 404 3,614
Infection rate (%) 4.6 9.1 11.7 0 8.3 0 11.8 0 12 2.3 2 3.9 1.9 18.2 0 0 1.7 9.9 1.8 0.3 6.0
Total No. of tested ticks 268 501 380 103 27 4 53 19 193 49 264 211 54 46 16 22 69 687 518 414 3,898
Infection rate (%) 4.5 9 10.8 0 11.1 0 11.3 5.3 11.9 2 1.9 3.8 1.9 17.4 0 0 1.5 9.9 1.7 0.2 6.0
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Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in the Republic of Korea
Korean J Parasitol. 2022;60(1):65-71.   Published online February 23, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.1.65
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Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in the Republic of Korea
Korean J Parasitol. 2022;60(1):65-71.   Published online February 23, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.1.65
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Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in the Republic of Korea
Image
Fig. 1 (A) Map of the tick collection site, Deogyusan National Park, Korea. (B) Phylogenetic tree for SFTSV based on S segment sequences. Bold letters indicate the SFTSV sequences obtained from the ticks in this study. n=number of sequences. A scale bar shows nucleotide substitutions per position.

Fig. 1

Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in the Republic of Korea

Prevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) in different developmental stages of ticks collected from Deogyusan National Park, Korea

Tick species Developmental stage No. of tested ticks No. of SFTSV-positive ticks Infection rate (%)
Haemaphysalis longicornis Male 54 1 1.9
Female 173 11 6.4
Nymph 3,444 206 6.0
Subtotal 3,671 218 5.9
Haemaphysalis flava Male 23 2 8.7
Female 12 1 8.3
Nymph 159 12 7.6
Subtotal 194 15 7.7
Ixodes nipponensis Male 16 0 0.0
Female 5 0 0.0
Nymph 11 0 0.0
Subtotal 32 0 0.0
Ixodes ovatus Male 1 0 0.0
Total 3,898 233 6.0

Seasonal prevalence of severe fever with thrombocytopenia syndrome virus in the adult and nymphal ticks collected from Deogyusan National Park, Korea, 20162-018

Developmental stages Items 2016 2017 2018 Total
Apr May Jun Jul Aug Sep Oct Nov Apr May Jun Jul Aug Sep Oct Nov Mar Apr May Jun
Adult No. of tested ticks 8 39 89 34 3 2 2 11 2 5 8 31 0 13 3 8 11 1 4 10 284
Infection rate (%) 0 7.7 7.9 0 33.3 0 0 9.1 0 0 0 3.2 0 15.4 0 0 0 0 0 0 5.3
Nymph No. of tested ticks 260 462 291 69 24 2 51 8 191 44 256 180 54 33 13 14 58 686 514 404 3,614
Infection rate (%) 4.6 9.1 11.7 0 8.3 0 11.8 0 12 2.3 2 3.9 1.9 18.2 0 0 1.7 9.9 1.8 0.3 6.0
Total No. of tested ticks 268 501 380 103 27 4 53 19 193 49 264 211 54 46 16 22 69 687 518 414 3,898
Infection rate (%) 4.5 9 10.8 0 11.1 0 11.3 5.3 11.9 2 1.9 3.8 1.9 17.4 0 0 1.5 9.9 1.7 0.2 6.0
Table 1 Prevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) in different developmental stages of ticks collected from Deogyusan National Park, Korea
Table 2 Seasonal prevalence of severe fever with thrombocytopenia syndrome virus in the adult and nymphal ticks collected from Deogyusan National Park, Korea, 20162-018

Table 1

Table 2

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