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Case Report

Cerebral Paragonimiasis Presenting with Dementia

The Korean Journal of Parasitology 2022;60(5):353-355.
Published online: October 21, 2022

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*Corresponding author (hessemda@hanmail.net)
• Received: February 6, 2022   • Revised: August 29, 2022   • Accepted: August 29, 2022

© 2022, Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • We report a case of an 80-year-old Korean man with chronic cerebral paragonimiasis who presented with progressive memory impairment. He suffered from pulmonary paragonimiasis 60 years ago and has been experiencing epilepsy since the age of 45. He began experiencing memory and cognitive deterioration 3 years ago. He visited the neuropsychiatric department of our hospital to check his symptoms and health from a year ago. Contrast-enhanced brain magnetic resonance imaging study revealed calcifications and cystic lesions encompassing the right temporo-occipital region. Encephalomalatic changes were also observed in the right occipital and temporal areas. The anti-Paragonimus specific IgG antibodies in his serum showed a strong positive response. The neuropsychological test results showed a Global Deterioration Scale of 4 and a Clinical Dementia Rating Scale of 1. The chronic cerebral paragonimiasis lesions in the patient’s right temporo-occipital region might induce the dementic change.
Paragonimiasis occurs globally, but is one of the important enzootic helminthic diseases endemic to East and southeast Asian countries. The red-brown colored lung fluke infects humans and mammals, and thrives mainly in the host lung, forming granulomatous cysts. Paragonimus spp. infect the host for more than 20 years. It can sometimes ectopically migrate to any part of the body. Its most common extrapulmonary site is the subcutaneous tissue followed by abdominal cavity, liver, and brain. Cerebral paragonimiasis is one of the most important extrapulmonary forms with serious consequences and high mortality compared to the pulmonary form [14]. Paragonimiasis is diagnosed by the combination of sputum examination, serological tests, and imaging studies. In the case of cerebral paragonimiasis, brain magnetic resonance (MR) or computed tomography (CT) images help confirm various cystic and nodular space-occupying lesions. Most of cerebral cases are associated with chronic morbidity due to epilepsy, dementia and various neurologic sequelae [5]. Kim et al. [6] has also divided the various presentations of cerebral diseases into those with meningitis forms, mass lesions, dementia, epilepsy, etc.
There have been relatively few case reports of dementia associated with cerebral paragonimiasis, although it is known that dementic change may be an important aspect of the disease. Clinical features of cerebral paragonimiasis are comparable to those caused by neurocysticercosis, as manifested by several dementia cases [7,8]. We report a case of chronic cerebral paragonimiasis presenting with dementia to extend understanding of dementia related to cerebral paragonimiasis.
An 80-year-old Korean male reported memory and cognitive disorders without any disturbance in consciousness and alertness in his daily life for the last 3 years. He had not received any treatment, but was suspected of having had memory and cognitive deterioration in a dementia screening inspection at a public health center. He was transferred to the Psychiatry Department of our hospital. He was a retired farmer with a 6th-grade education. At age of 19, he visited a hospital with the chief complaints of aggravating headaches and was diagnosed with meningitis. His symptoms improved with drug therapy. One year later, he was drafted into the army. Three months later after he began his service in the seashore of Jeju Island, Korea, he was discharged due to fever, chills, abdominal pain and hemoptysis. Since then, he had experienced generalized tonic clonic (GTC) seizure once a month for 25 years. He took medicine for 3 months but voluntarily stopped. Epileptic seizures continued once a month until he visited our hospital. The results of his general physical and systemic examination were within normal ranges. There was no focal neurological deficit, and his cranial nerves were intact.
The results of the Consortium to Establish A Registry for Alzheimer’s Disease (CERAD-K; Korean version) test conducted when the subject visited the Psychiatry Department of our hospital were as follows: 7 marks for the Word Fluency Test (↓), 4 for the Boston Naming Test (↓↓), 14 for the Korean version of MMSE in the Korean version of CERAD Assessment Packet (MMSE-KC) (↓↓), 1 for the Word List Recall Test (↓↓), 5 for the Word List Recognition Test (↓↓), and 245 seconds for the Trail Making A (↓↓). The patient was assessed as suffering from dementia with 4 marks on the Global Deterioration Scale (GDS) and 1 on the Clinical Dementia Rating Scale (CDRS). He also had a mild depression with 15/30 marks on the Geriatric Depression Scale.
The neurological tests showed that the patient’s consciousness was clear. There were no findings of muscular anomalies. Motor and sensory functions were within normal range. However, the contrast-enhanced brain MRI revealed encephalomalacia in the right occipital and temporal lobes. Calcification and cystic lesions mainly in the right occipital lobe were also noticed (Fig. 1). As the patient was suspected of having paragonimiasis or cysticercosis, specific IgG antibody levels against Paragonimus westermani and Taenia solium metacestode were measured in his serum sample by enzyme-linked immunosorbent assay (ELISA). The ELISA results showed that the patient had anti-Paragonimus specific IgG antibody levels of 2.49 (positive criterion: 0.25), and those against anti-T. solium metacestode were 0.26 (positive criterion: 0.18). There was no abnormal in the chest X-ray images.
Our patient had a history of fever, chills, abdominal pain, and hemoptysis during 3 months of military service. He might be infected with paragonimiasis at that time. However, he could not receive adquate management because no effective agents for treating paragonimiasis had been developed until the early 1960s.
Previous studies have reported brain involvement of 2–27% of paragonimiasis patients and 30.3–60.4% of patients with extrapulmonary paragonimiasis cases [914]. Due to the space-occupying lesion in the brain, localizing neurologic signs might be observed. In this study, we expected to find some lesions in the lungs because anti-Paragonimus specific IgG antibody titers exceptionally high (2.49), but we found lesions only in the brain.
The most common symptoms of cerebral paragonimiasis include visual impairment, mental deterioration, headache, hemiplegia, nausea, and vomiting [1215]. Marty and Neafie reported that approximately 70% of cerebral paragonimiasis patients presented personality changes and a decline of cognitive function [16]. In some cases, however, these symptoms developed 30 years after the patient became infected [12]. In our case, the patient experienced GTC seizures once a month for 35 years since his first symptom appeared, which were accompanied by memory loss and cognitive declination. Considering the possibility of developing dementia in cerebral paragonimiasis patients [17,18], we surmise that our patient may have experienced cognitive deterioration due to cerebral paragonimiasis.
In general, Alzheimer’s disease dementia shows moderate to severe atrophy of medial temporal lobe. However, this patient did not show prominent brain atrophy compared to those with similar ages, suggesting that the etiology of the patient’s dementia symptom might be more related to chronic cerebral paragonimiasis. This case showed that cerebral paragonimiasis of the right temporo-occipital areas could induce the dementia.

The authors declare no conflict of interest related to this study.

Fig. 1
Horizontal (left) and coronal view (right) of brain MR image of an 80-year-old man who presented with dementia. Complicated cystic structures and calcifications (circles) are seen mainly in the right occipital lobe, with encephalomalasias in the right occipital and temporal lobes.
kjp-60-5-353f1.jpg

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Cerebral Paragonimiasis Presenting with Dementia
Korean J Parasitol. 2022;60(5):353-355.   Published online October 21, 2022
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Cerebral Paragonimiasis Presenting with Dementia
Korean J Parasitol. 2022;60(5):353-355.   Published online October 21, 2022
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Cerebral Paragonimiasis Presenting with Dementia
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Fig. 1 Horizontal (left) and coronal view (right) of brain MR image of an 80-year-old man who presented with dementia. Complicated cystic structures and calcifications (circles) are seen mainly in the right occipital lobe, with encephalomalasias in the right occipital and temporal lobes.
Cerebral Paragonimiasis Presenting with Dementia