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Original Article

Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates

Weon-Gyu Kho1, Joon-Yong Chung1, Eun-Jeong Sim1, Dong-Wook Kim2, Woo-Chul Chung3
The Korean Journal of Parasitology 2001;39(2):143-150.
Published online: June 30, 2001

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Corresponding author (wgkho@ijnc.inje.ac.kr)
• Received: April 19, 2001   • Accepted: May 31, 2001

copyright © 2001 by The Korean Society for Parasitology

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Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates
Korean J Parasitol. 2001;39(2):143-150.   Published online June 30, 2001
DOI: https://doi.org/10.3347/kjp.2001.39.2.143
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Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates
Korean J Parasitol. 2001;39(2):143-150.   Published online June 30, 2001
DOI: https://doi.org/10.3347/kjp.2001.39.2.143
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Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates
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Fig. 1 Schematic representation of the PvDBP gene and its region. The relative position of primers for PCR (DL5, DS3, and PD3) and sequencing (DL5, PD3, and DL3) are indicated beneath the map. The structurally distinct regions of the PvDBP gene are shown above the diagram in Roman numbers (Adams et al., 1992): I, N terminus before amino cysteine-rich region; II, amino cysteine-rich region; III to V, hydrophilic regions; VI, carboxyl cysteine-rich region; VII, transmembrane domain region.
Fig. 2 The PCR products from the PvDBP gene of Korean isolates. The semi-nested PCR products were separated on a 0.8% agarose gel and stained with ethidium bromide. M, λDNA/EcoR I + Hind III marker (MBI fermantas); lanes 1-11, SK isolates 1-10.
Fig. 3 Alignment of deduced amino acid sequences of SK isolates comparing Sal-1, Belem, PNG (Papua New Guinea), COLV and COLT (Colombia) isolates in amino cysteine-rich region (region II, partial). The change between SK-1 and SK-2 genotype is showed by an arrow head (▼). The distinction of region II is showed above the amino acid sequence (Tsuboi et al., 1994).
Fig. 4 The nucleotide sequence comparisons for the region IV in PvDBP from South Korean isolates (SK-1 and SK-2), Papua New Guinea (PNG) isolates and Sal-1 allele (Tsuboi et al., 1994). Gaps indicated by dashes (---) are introduced into the sequence to optimize the alignment. Nucleotide sequence corresponding to oligonucleotides D4-AF1 and D4-BF3 were marked by underlined and arrowed, respectively.
Fig. 5 Analysis of PvDBP gene at the region IV by oligonucleotide hybridization. The PCR product (1 µg) transferred to nylon membrane and hybridized using the oligonucleotide primers. A. The PCR product separated on a 0.8% agarose gel. B. The transferred membrane was hybridized with the D4-BF3 oligonucleotide probe. C. The membrane was stripped and re-hybridized with the D4-AF1 probe.

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Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates
PHD : Parasites, Hosts and Diseases

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