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Aleksandro Schafer da Silva	2 Articles
In Vitro Trypanocidal Activity of Macela (Achyrocline satureioides) Extracts against Trypanosoma evansi Matheus D. Baldissera, Camila B. Oliveira, Carine E. P. Zimmermann, Aline A. Boligon, Margareth Linde Athayde, Leandro P. Bolzan, Rodrigo de A. Vaucher, Janio M. Santurio, Michele R. Sagrillo, Aleksandro Schafer da Silva, Silvia G. Monteiro Korean J Parasitol 2014;52(3):311-315. Published online June 26, 2014 DOI: https://doi.org/10.3347/kjp.2014.52.3.311 Abstract PDF The aim of this study was to verify the trypanocidal effectiveness of aqueous, methanolic, and ethanolic extracts of Achyrocline satureioides against Trypanosoma evansi in vitro. A. satureioides extracts, known as macela, were used on trypomastigotes at different concentrations (1, 5, 10, 50, 100, 500, and 1,000 ?g/ml) and exposure times (0, 1, 3, 6, and 9 hr). A dose-dependent effect was observed when the 3 extracts were tested. The concentrations of 1, 5, and 10 ?g/ml were not able to kill trypomastigotes until 3 hr after exposure, and the highest concentrations (500 and 1,000 ?g/ml) were able to kill all trypomastigotes after 1 hr. When the time of exposure was increased up to 9 hr, the concentrations at 50 and 100 ?g/ml were 100% effective to 3 extracts. The chemical analysis of the extracts revealed the presence of flavonoids, a trypanocidal compound already described. Based on the results, we can conclude that the A. satureioides extracts exhibit trypanocidal effects. Citations Citations to this article as recorded by Achyrocline satureioides infusion, popularly prepared and consumed, has an in vitro protective effect on human neural cells exposed to rotenone Ivana Beatrice Mânica da Cruz, Maria Eduarda Chelotti, Barbara Osmarin Turra, Nathália Cardoso de Afonso Bonotto, Débora Felipetto Pulcinelli, Ana Laura Kerkhoff Escher, Caroline Klein, Paola de Azevedo Mello, Gustavo Rossato Bitencourt, Fernanda Barbisan Journal of Ethnopharmacology.2024; 332: 118350. CrossRef Achyrocline satureioides review: From the pharmacochemical diversity to the technological development of products Sara Elis Bianchi, Gabriela de Carvalho Meirelles, Victorya Benes Raabe, Kellen Cristhinia Borges de Souza, Valquiria Linck Bassani Fitoterapia.2023; 168: 105537. CrossRef Acaricidal and anthelmintic action of ethanolic extract and essential oil of Achyrocline satureioides Rafaela Regina Fantatto, Ana Carolina de Souza Chagas, Yousmel Alemán Gainza, Flávio Augusto Sanches Politi, Leonardo Mendes de Souza Mesquita, Wagner Vilegas, Humberto Ribeiro Bizzo, Ílio Montanari Junior, Rosemeire Cristina Linhari Rodrigues Pietro Experimental Parasitology.2022; 236-237: 108252. CrossRef Trypanocidal Essential Oils: A Review Mayara Castro de Morais, Jucieudo Virgulino de Souza, Carlos da Silva Maia Bezerra Filho, Silvio Santana Dolabella, Damião Pergentino de Sousa Molecules.2020; 25(19): 4568. CrossRef Untargeted LC–MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase Lucas A. Chibli, Annylory L. Rosa, Maria Cristina Nonato, Fernando B. Da Costa Metabolomics.2019;[Epub] CrossRef Purification, structural elucidation, antioxidant capacity and neuroprotective potential of the main polyphenolic compounds contained in Achyrocline satureioides (Lam) D.C. (Compositae) Marcela Martínez-Busi, Florencia Arredondo, David González, Carolina Echeverry, Mauricio A. Vega-Teijido, Diego Carvalho, Alejandra Rodríguez-Haralambides, Felicia Rivera, Federico Dajas, Juan A. Abin-Carriquiry Bioorganic & Medicinal Chemistry.2019; 27(12): 2579. CrossRef Anticancer activity of flavonoids isolated from Achyrocline satureioides in gliomas cell lines Priscila Oliveira de Souza, Sara Elis Bianchi, Fabrício Figueiró, Luana Heimfarth, Karla Suzana Moresco, Rosângela Mayer Gonçalves, Juliana Bender Hoppe, Caroline Peres Klein, Christianne Gazzana Salbego, Daniel Pens Gelain, Valquíria Linck Bassani, Alfeu Toxicology in Vitro.2018; 51: 23. CrossRef Insight into trypanosomosis (Surra) of Indian livestock: Recent updates VEER SINGH, BISWA RANJAN MAHARANA The Indian Journal of Animal Sciences.2018; 88(10): 1101. CrossRef Achyrocline satureioides essential oil-loaded in nanocapsules reduces cytotoxic damage in liver of rats infected by Trypanosoma evansi Camila S. Ritter, Matheus D. Baldissera, Thirssa H. Grando, Carine F. Souza, Michele R. Sagrillo, Ana Paula T. da Silva, Rafael N. Moresco, Naiara S. Guarda, Aleksandro S. da Silva, Lenita M. Stefani, Silvia G. Monteiro Microbial Pathogenesis.2017; 103: 149. CrossRef Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi Guilherme M. Do Carmo, Matheus D. Baldissera, Rodrigo A. Vaucher, Virginia Cielo Rech, Camila B. Oliveira, Michele Rorato Sagrillo, Aline A. Boligon, Margareth L. Athayde, Marta P. Alves, Raqueli T. França, Sonia T.A. Lopes, Claiton I. Schwertz, Ricardo E Experimental Parasitology.2015; 149: 39. CrossRef 9,526 View 125 Download 10 Web of Science Crossref Influence of Toxoplasma gondii Acute Infection on Cholinesterase Activities of Wistar Rats Alexandre Alberto Tonin, Aleksandro Schafer da Silva, Maria Luiza Thorstenberg, L?via Gelain Castilhos, Raqueli Teresinha Fran?a, Daniela Bitencourt Rosa Leal, Marta Maria Medeiros Frescura Duarte, Fernanda Silveira Flores Vogel, Mario Luiz de La Rue, Sonia Terezinha dos Anjos Lopes Korean J Parasitol 2013;51(4):421-426. Published online August 30, 2013 DOI: https://doi.org/10.3347/kjp.2013.51.4.421 Abstract PDF Several studies have shown the mechanisms and importance of immune responses against Toxoplasma gondii infection and the notable role of cholinesterases in inflammatory reactions. However, the association between those factors has not yet been investigated. Therefore, the aim of this study was to evaluate the acetylcholinesterase (AChE) activity in blood and lymphocytes and the activity of butyrylcholinesterase (BChE) in serum of rats experimentally infected with T. gondii during the acute phase of infection. For that, an in vivo study was performed with evaluations of AChE and BChE activities on days 5 and 10 post-infection (PI). The activity of AChE in blood was increased on day 5 PI, while in lymphocytes its activity was enhanced on days 5 and 10 PI (P<0.05). No significant difference was observed between groups regarding to the activity of BChE in serum. A positive (P<0.01) correlation was observed between AChE activity and number of lymphocytes. The role of AChE as an inflammatory marker is well known in different pathologies; thus, our results lead to the hypothesis that AChE has an important role in modulation of early immune responses against T. gondii infection. Citations Citations to this article as recorded by A meta-analysis of changes in cholinesterase activity among experimental animals infected with Toxoplasma gondii F. K. Mohammad, S. H. Eassa, R. G. Abdullah BULGARIAN JOURNAL OF VETERINARY MEDICINE.2025; 28(2): 195. CrossRef Variation in Gene Expression Across Infection Status and Elevation in a Hawaiian Honeycreeper Loren Cassin‐Sackett, Katherine M. McClure, Taylor E. Callicrate, Eben H. Paxton, Robert C. Fleischer Ecology and Evolution.2025;[Epub] CrossRef Plasma Cholinesterase Activity in Patients With Rheumatoid Arthritis and Toxoplasmosis Rabie G Abdullah, Souzan H Eassa, Fouad K Mohammad Cureus.2023;[Epub] CrossRef Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders Tooran Nayeri, Shahabeddin Sarvi, Ahmad Daryani Metabolic Brain Disease.2022; 37(1): 123. CrossRef Toxoplasma gondii: A possible etiologic agent for Alzheimer's disease Tooran Nayeri, Shahabeddin Sarvi, Mehdi Sharif, Ahmad Daryani Heliyon.2021; 7(6): e07151. CrossRef Diagnostic significance of C-reactive protein and hematological parameters in acute toxoplasmosis Vanessa Sandri, Itamar Luís Gonçalves, Gustavo Machado das Neves, Marisa Lucia Romani Paraboni Journal of Parasitic Diseases.2020; 44(4): 785. CrossRef STUDY ON THE PREVALENCE AND HEMATOLOGICAL ALTERATIONS IN TOXOPLASMA GONDII INFECTED CAPTIVE PHEASANT SPECIES OF BAHAWALPUR ZOO, PAKISTAN M.H. Lashari, M Bibi, U Farooq, F Afzal, A Ali, M Safdar, M.S. Akhtar, A.A. Farooq, S Masood, M Ayaz, M.I. Khan The Journal of Animal and Plant Sciences.2020; 31(2): 625. CrossRef Is There a Cholinergic Survival Incentive for Neurotropic Parasites in the Brain? Abdul Mannan Baig ACS Chemical Neuroscience.2017; 8(12): 2574. CrossRef Sulfamethoxazole-trimethoprim associated with resveratrol for the treatment of toxoplasmosis in mice: Influence on the activity of enzymes involved in brain neurotransmission Nathieli B. Bottari, Matheus D. Baldissera, Alexandre A. Tonin, Virginia C. Rech, Vivian S.K. Nishihira, Gustavo R. Thomé, Maria Rosa C. Schetinger, Vera M. Morsch, Giovana Camillo, Fernanda F. Vogel, Camila Tochetto, Rafael Fighera, Gustavo Machado, Leni Microbial Pathogenesis.2015; 79: 17. CrossRef 9,112 View 70 Download Crossref