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Mejeong Lee	6 Articles
Development of resistance to reinfection by Clonorchis sinensis in rats Byung-Suk Chung, Hongman Zhang, Min-Ho Choi, Deogkyu Jeon, Shunyu Li, Mejeong Lee, Sung-Tae Hong Korean J Parasitol 2004;42(1):19-26. Published online March 20, 2004 DOI: https://doi.org/10.3347/kjp.2004.42.1.19 Abstract PDF We investigated the induction of resistance to Clonorchis sinensis infection by prior infection in rat and hamster models. Animals were challenged with C. sinensis metacercariae, then treated with praziquantel and reinfected. Worm recovery rate in reinfected animals was used to estimate resistance to reinfection. The determined resistance rates to reinfection in rats and hamsters were 97.7% and 10.3%, respectively. In rats, cure from the primary infection of C. sinensis increased resistant to reinfection, and the greatert the worm burden and the longer the duration of primary infection, the higher was the resistance rate. For primary infection doses of 10, 40 and 100 metacercariae per rat, the resistance rates were 87.4%, 93.8% and 98.4%, respectively. The resistance rates in rats after 2 or 8-week primary infection were 78.7% and 95.3%, respectively. All worms recovered from reinfected rats were immature. When cured rats were administered with methylprednisolone, resistance to reinfection became impaired. These findings indicate that rats develop a high degree of resistance to reinfection by C. sinensis after cure. The growths and maturations of reinfected worms were also impaired. Citations Citations to this article as recorded by Long Non-Coding RNA and mRNA Expression Analysis in Liver of Mice With Clonorchis sinensis Infection Su Han, Xue-Li Zhang, Xu Jiang, Xiang Li, Jian Ding, Li-Jiao Zuo, Shan-Shan Duan, Rui Chen, Bei-Bei Sun, Xin-Yi Hu, Yan-Nan Gao, Xiao-Li Zhang Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef Bacillus subtilis spore with surface display of paramyosin from Clonorchis sinensis potentializes a promising oral vaccine candidate Hengchang Sun, Zhipeng Lin, Lu Zhao, Tingjin Chen, Mei Shang, Hongye Jiang, Zeli Tang, Xinyi Zhou, Mengchen Shi, Lina Zhou, Pengli Ren, Honglin Qu, Jinsi Lin, Xuerong Li, Jin Xu, Yan Huang, Xinbing Yu Parasites & Vectors.2018;[Epub] CrossRef Local immune response to primary infection and re-infection by Clonorchis sinensis in FVB mice Eun-Min Kim, Hak Sun Yu, Yan Jin, Min-Ho Choi, Young Mee Bae, Sung-Tae Hong Parasitology International.2017; 66(4): 436. CrossRef Virus-like particles vaccine containing Clonorchis sinensis tegumental protein induces partial protection against Clonorchis sinensis infection Dong-Hun Lee, Ah-Ra Kim, Su-Hwa Lee, Fu-Shi Quan Parasites & Vectors.2017;[Epub] CrossRef Clonorchiasis Men-Bao Qian, Jürg Utzinger, Jennifer Keiser, Xiao-Nong Zhou The Lancet.2016; 387(10020): 800. CrossRef Systemic and local mucosal immune responses induced by orally delivered Bacillus subtilis spore expressing leucine aminopeptidase 2 of Clonorchis sinensis Hongling Qu, Yanquan Xu, Hengchang Sun, Jinsi Lin, Jinyun Yu, Zeli Tang, Jiqing Shen, Chi Liang, Shan Li, Wenjun Chen, Xuerong Li, Zhongdao Wu, Yan Huang, Xinbing Yu Parasitology Research.2014; 113(8): 3095. CrossRef Anti-inflammatory effect of prednisolone on the growth of human liver fluke in experimental opisthorchiasis Amornrat Juasook, Thidarut Boonmars, Sasithorn Kaewkes, Watcharin Loilome, Kulathida Veteewuthacharn, Zhiliang Wu, Puangrat Yongvanit Parasitology Research.2012; 110(6): 2271. CrossRef Strain variation in the susceptibility and immune response to Clonorchis sinensis infection in mice Md. Hafiz Uddin, Shunyu Li, Young Mee Bae, Min-Ho Choi, Sung-Tae Hong Parasitology International.2012; 61(1): 118. CrossRef Factors in the resistance of rats to re-infection and super-infection by Clonorchis sinensis Hongman Zhang, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong Parasitology Research.2008; 102(6): 1111. CrossRef Changing Patterns of Serum and Bile Antibodies in Re-infected Rats with Clonorchis sinensis Hongman Zhang, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong The Korean Journal of Parasitology.2008; 46(1): 17. CrossRef Susceptibility of experimental animals to reinfection with Clonorchis sinensis Woon-Mok Sohn, Hongman Zhang, Min-Ho Choi, Sung-Tae Hong The Korean Journal of Parasitology.2006; 44(2): 163. CrossRef Bile duct changes in rats reinfected with Clonorchis sinensis Dongil Choi, Sung-Tae Hong, Shunyu Li, Byung-Suk Chung, Jae Hoon Lim, Soon-Hyung Lee The Korean Journal of Parasitology.2004; 42(1): 7. CrossRef 9,589 View 79 Download Crossref Specific and common antigens of Clonorchis sinensis and Opisthorchis viverrini (Opisthorchidae, Trematoda) Min-Ho Choi, Jin-Sook Ryu, Mejeong Lee, Shunyu Li, Byung-Suk Chung, Jong-Yil Chai, Paiboon Sithithaworn, Smarn Tesana, Sung-Tae Hong Korean J Parasitol 2003;41(3):155-163. Published online September 20, 2003 DOI: https://doi.org/10.3347/kjp.2003.41.3.155 Abstract PDF The antigenic characterizations and serological reactions of human liver flukes, Clonorchis sinensis and Opisthorchis viverrini, were analyzed by immunoblot. The antigenic profiles of the crude extract of Clonorchis contained major proteins of 8, 26-28, 34-37, 43, and 70 kDa, and those of Opisthorchis 34-37, 43, 70, and 100 kDa. Of these, the 8, 26-28 and 34-37 kDa bands of Clonorchis and the 100 kDa of Opisthorchis were major components of each excretory-secretory antigen. The 8 and 26-28 kDa bands were specific to Clonorchis but the 100 kDa of Opisthorchis cross-reacted with the sera of clonorchiasis, and the 34-37, 70 and 100 kDa bands cross-reacted with sera of other helminthiases. The frequency and intensity of the immunoblot reactions were positively correlated with the intensity of the liver fluke infection. Citations Citations to this article as recorded by Construction and validation of a novel multi-epitope in silico vaccine design against the paramyosin protein of Opisthorchis viverrini using immunoinformatics analyses Alok Kafle, Jan Clyden B. Tenorio, Roshan Kumar Mahato, Sahara Dhakal, Muhammad F. Heikal, Sutas Suttiprapa Acta Tropica.2024; 260: 107389. CrossRef Antigenic components, identification, and characterization of whole worm extract of Platynosomum illiciens Shin Moe Aoke, Amaya Watthanadirek, Napassorn Poolsawat, Nitipon Srionrod, Pornpiroon Nooroong, Sutthida Minsakorn, Sitthichok Lacharoje, Woraporn Sukhumavasi, Panat Anuracpreeda Veterinary Parasitology.2022; 310: 109774. CrossRef A first attempt at determining the antibody-specific pattern of Platynosomum fastosum crude antigen and identification of immunoreactive proteins for immunodiagnosis of feline platynosomiasis Babi Kyi Soe, Poom Adisakwattana, Onrapak Reamtong, Panat Anuracpreeda, Woraporn Sukhumavasi Veterinary World.2022; : 2029. CrossRef Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia Narong Khuntikeo, Attapol Titapun, Watcharin Loilome, Puangrat Yongvanit, Bandit Thinkhamrop, Nittaya Chamadol, Thidarat Boonmars, Teerachai Nethanomsak, Ross H. Andrews, Trevor N. Petney, Paiboon Sithithaworn Frontiers in Medicine.2018;[Epub] CrossRef Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War George Psevdos, Florence M. Ford, Sung-Tae Hong Infectious Diseases in Clinical Practice.2018; 26(4): 208. CrossRef Comments on “Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War” Theodore E. Nash, David Sullivan, Edward Mitre, Eric Garges, Victoria J. Davey, Gary Roselle, Stephen J. Davies, Peter D. Rumm Infectious Diseases in Clinical Practice.2018; 26(4): 240. CrossRef Responding to Letter “Comments on ‘Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War’” by Theodore E. Nash, David Sullivan, Edward Mitre, et al George Psevdos, Florence M. Ford, Sung-Tae Hong Infectious Diseases in Clinical Practice.2018; 26(4): 242. CrossRef Characterization of immunogenic Clonorchis sinensis protein fractions by gel filtration chromatography Duan Pham Ngoc, Yuji Arimatsu, Sasithorn Kaewkes, Banchob Sripa Asian Pacific Journal of Tropical Disease.2015; 5(4): 284. CrossRef Eosinophilia in Infectious Diseases Elise M. O’Connell, Thomas B. Nutman Immunology and Allergy Clinics of North America.2015; 35(3): 493. CrossRef Predominance of IL-10 and TGF-β production from the mouse macrophage cell line, RAW264.7, in response to crude antigens from Clonorchis sinensis Hae Joo Wi, Yan Jin, Min-Ho Choi, Sung-Tae Hong, Young Mee Bae Cytokine.2012; 59(2): 237. CrossRef The identification of antigenic proteins: 14-3-3 protein and propionyl-CoA carboxylase in Clonorchis sinensis Myoung-Ro Lee, Yu-Jung Kim, Dae-Won Kim, Won Gi Yoo, Shin-Hyeong Cho, Kwang Yeon Hwang, Jung-Won Ju, Won-Ja Lee Molecular and Biochemical Parasitology.2012; 182(1-2): 1. CrossRef Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients Ponlatham Chaiyarit, Paiboon Sithithaworn, Chanitra Thuwajit, Puangrat Yongvanit Clinical Oral Investigations.2011; 15(4): 477. CrossRef Clonorchis sinensis infection is positively associated with atopy in endemic area M‐H Choi, Y‐S Chang, M. K. Lim, Y. M. Bae, S‐T Hong, J‐K Oh, E. H. Yun, M‐J Bae, H‐S Kwon, S‐M Lee, H‐W Park, K‐U Min, Y‐Y Kim, S‐H Cho Clinical & Experimental Allergy.2011; 41(5): 697. CrossRef Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory‐secretory products of Clonorchis sinensis adult worms Jung‐Won Ju, Hyun‐Na Joo, Myoung‐Ro Lee, Shin‐Hyeong Cho, Hyeng‐Il Cheun, Jung‐Yeon Kim, Young‐Hee Lee, Kwang‐Jun Lee, Woon‐Mok Sohn, Dong‐Min Kim, Il‐Chul Kim, Byoung Chul Park, Tong‐Soo Kim PROTEOMICS.2009; 9(11): 3066. CrossRef Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory–secretory products of Clonorchis sinensis Young Ju Kim, Min-Ho Choi, Sung-Tae Hong, Young Mee Bae Parasitology Research.2009; 104(5): 1011. CrossRef Serodiagnostic applicability of recombinant antigens of Clonorchis sinensis expressed by wheat germ cell-free protein synthesis system Chenghua Shen, Jong-Ae Lee, Sonia Refaat Ahmed Allam, Young Mee Bae, Eun-Taek Han, Satoru Takeo, Takafumi Tsuboi, Sung-Tae Hong, Min-Ho Choi Diagnostic Microbiology and Infectious Disease.2009; 64(3): 334. CrossRef Proliferative effects of excretory/secretory products from Clonorchis sinensis on the human epithelial cell line HEK293 via regulation of the transcription factor E2F1 Young Ju Kim, Min-Ho Choi, Sung-Tae Hong, Young Mee Bae Parasitology Research.2008; 102(3): 411. CrossRef A Bile Based Study of Clonorchis sinensis Infections in Patients with Biliary Tract Diseases in Ulsan, Korea Kwang Ro Joo, Sung-Jo Bang Yonsei Medical Journal.2005; 46(6): 794. CrossRef Organ-specific antigens of Clonorchis sinensis Shunyu Li, Byung-Suk Chung, Min-Ho Choi, Sung-Tae Hong The Korean Journal of Parasitology.2004; 42(4): 169. CrossRef Evaluation of Clonorchis sinensis Recombinant 7-Kilodalton Antigen for Serodiagnosis of Clonorchiasis Qin-Ping Zhao, Sung-Ung Moon, Hyeong-Woo Lee, Byoung-Kuk Na, Seung-Yull Cho, Yoon Kong, Ming-Sen Jiang, Ai-Hua Li, Tong-Soo Kim Clinical and Vaccine Immunology.2004; 11(4): 814. CrossRef 9,641 View 108 Download Crossref Characterization of partially purified 8 kDa antigenic protein of Clonorchis sinensis Young-Bae Chung, Mejeong Lee, Hyun-Jong Yang, Byung-Suk Chung, Shun-Yu Lee, Min-Ho Choi, Sung-Tae Hong Korean J Parasitol 2002;40(2):83-88. Published online June 30, 2002 DOI: https://doi.org/10.3347/kjp.2002.40.2.83 Abstract PDF The 8 kDa antigenic protein of Clonorchis sinensis was partially purified by ammonium sulfate precipitation and subsequently by a column chromatographic steps. The purified protein was separated into 7 and 8 kDa protein bands through SDS-tricine gel electrophoresis, while the protein was found to migrate to a 8 kDa band in 7.5-15% SDS-PAGE. The molecular weight of the antigen was estimated to be 110 kDa by Superose 6 HR 10/30 gel filtration. The purified antigen strongly reacted with the human sera of clonorchiasis. The hyperimmune sera of BALB/c mice immunized against the 8 kDa protein were reacted with both the crude extract and the excretory-secretory product of adult worms, but not with the metacercarial extract. Immunohistochemical staining demonstrated that the protein was distributed to the tegument and subtegumental cells and also to the seminal receptacle. The present findings suggest that the 8 kDa protein is a partition of the multicomplex protein originating from various organs of adult C. sinensis, and that it is composed of several 7 and 8 kDa proteins. Citations Citations to this article as recorded by Partially Purified Gloriosa superba Peptides Inhibit Colon Cancer Cell Viability by Inducing Apoptosis Through p53 Upregulation Prapaphan Budchart, Ariya Khamwut, Chomdao Sinthuvanich, Sunanta Ratanapo, Yong Poovorawan, Nattanan Panjaworayan T-Thienprasert The American Journal of the Medical Sciences.2017; 354(4): 423. CrossRef Assessing the impact of meteorological factors on malaria patients in demilitarized zones in Republic of Korea Se-Min Hwang, Seok-Joon Yoon, Yoo-Mi Jung, Geun-Yong Kwon, Soo-Nam Jo, Eun-Jeong Jang, Myoung-Ok Kwon Infectious Diseases of Poverty.2016;[Epub] CrossRef Analysis of an expressed sequence tag library from Dicrocoelium dentriticum A.M. Martínez-Ibeas, M.J. Perteguer, C. González-Lanza, T. Gárate, M.Y. Manga-González Experimental Parasitology.2013; 135(2): 287. CrossRef Serodiagnostic applicability of recombinant antigens of Clonorchis sinensis expressed by wheat germ cell-free protein synthesis system Chenghua Shen, Jong-Ae Lee, Sonia Refaat Ahmed Allam, Young Mee Bae, Eun-Taek Han, Satoru Takeo, Takafumi Tsuboi, Sung-Tae Hong, Min-Ho Choi Diagnostic Microbiology and Infectious Disease.2009; 64(3): 334. CrossRef Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory‐secretory products of Clonorchis sinensis adult worms Jung‐Won Ju, Hyun‐Na Joo, Myoung‐Ro Lee, Shin‐Hyeong Cho, Hyeng‐Il Cheun, Jung‐Yeon Kim, Young‐Hee Lee, Kwang‐Jun Lee, Woon‐Mok Sohn, Dong‐Min Kim, Il‐Chul Kim, Byoung Chul Park, Tong‐Soo Kim PROTEOMICS.2009; 9(11): 3066. CrossRef Organ-specific antigens of Clonorchis sinensis Shunyu Li, Byung-Suk Chung, Min-Ho Choi, Sung-Tae Hong The Korean Journal of Parasitology.2004; 42(4): 169. CrossRef Immunolocalization of the 150 kDa protein in cyst fluid of Taenia solium metacestodes Hyun-Jong Yang, Young-Bae Chung The Korean Journal of Parasitology.2004; 42(2): 81. CrossRef Usefulness of 8 kDa protein of Fasciola hepatica in diagnosis of fascioliasis Kwangsig Kim, Hyun Jong Yang, Young-Bae Chung The Korean Journal of Parasitology.2003; 41(2): 121. CrossRef Excretory-secretory antigen is better than crude antigen for the serodiagnosis of clonorchiasis by ELISA Min-Ho Choi, Il Chan Park, Shunyu Li, Sung-Tae Hong The Korean Journal of Parasitology.2003; 41(1): 35. CrossRef Simulation of stored energy and orientation gradients in cold-rolled interstitial free steels S.-H. Choi Acta Materialia.2003; 51(6): 1775. CrossRef 8,441 View 72 Download Crossref Usefulness of IgG4 subclass antibodies for diagnosis of human clonorchiasis Sung-Tae Hong, Mejeong Lee, Nak-Jin Sung, Sang Rock Cho, Jong-Yil Chai, Soon-Hyung Lee Korean J Parasitol 1999;37(4):243-248. Published online December 31, 1999 DOI: https://doi.org/10.3347/kjp.1999.37.4.243 Abstract PDF The present study analyzed serum IgG subclass antibody reaction to major antigenic bands of Clonorchis sinensis to investigate improvement of its serodiagnosis. Of the four subclass antibodies, IgG1 and IgG2 antibodies were produced but not specific, IgG3 antibody was least produced, and IgG4 antibody was prominent and specific. The serum IgG antibody reaction to any of 43-50, 34-37, 26-28, and 8 kDa bands was found in 65.5% of 168 egg positive cases while IgG4 antibody reaction was found in 22.0% of them. The positive rates of IgG and IgG4 antibodies were directly correlated with the intensity of infection. All of the sera from heavily infected cases over EPG 5,000 showed positive reaction for specific IgG and IgG4 antibodies. The specific serum IgG4 antibody disappeared within 6 months after treatment. The bands of 35 kDa and 67 kDa cross-reacted with IgG antibodies but not with IgG4 antibodies in sera of other trematode infections. The present findings suggest that serum IgG4 antibody reaction to 8 kDa band is specific but not sensitive. Any method to increase its sensitivity is required for improved serodiagnosis. Citations Citations to this article as recorded by Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report Pengyan Yin, Miaohui Duan, Lingyao Deng, Tianli Li, Xuan Huang, Raohong Fang, Hailong Li, Binliang Bai Journal of International Medical Research.2025;[Epub] CrossRef Imported Familial Pulmonary and Cerebral Paragonimiasis in Korea: Cases and Literature Review from a Clinical Grand Round Conference Ji Young Lee, Jee Yeon Baek, Haesung Yoon, Mi-Jung Lee, Hoon-Chul Kang, Se Hee Kim, Joon Soo Lee, Ji-Man Kang, Jong Gyun Ahn Infection & Chemotherapy.2025; 57(4): 462. CrossRef An Innovative Test for the Rapid Detection of Specific IgG Antibodies in Human Whole-Blood for the Diagnosis of Opisthorchis viverrini Infection Lakkhana Sadaow, Rutchanee Rodpai, Penchom Janwan, Patcharaporn Boonroumkaew, Oranuch Sanpool, Tongjit Thanchomnang, Hiroshi Yamasaki, Wannaporn Ittiprasert, Victoria H. Mann, Paul J. Brindley, Wanchai Maleewong, Pewpan M. Intapan Tropical Medicine and Infectious Disease.2022; 7(10): 308. CrossRef High prevalence of opisthorchiasis in rural populations from Khammouane Province, central Lao PDR: serological screening using total IgG- and IgG4-based ELISA Weeraya Phupiewkham, Rutchanee Rodpai, Somchith Inthavongsack, Sakhone Laymanivong, Tongjit Thanchomnang, Lakkhana Sadaow, Patcharaporn Boonroumkaew, Oranuch Sanpool, Penchom Janwan, Pewpan M Intapan, Wanchai Maleewong Transactions of The Royal Society of Tropical Medicine and Hygiene.2021; 115(12): 1403. CrossRef Comparative assessment of immunochromatographic test kits using somatic antigens from adult Opisthorchis viverrini and IgG and IgG4 conjugates for serodiagnosis of human opisthorchiasis Weeraya Phupiewkham, Lakkhana Sadaow, Oranuch Sanpool, Rutchanee Rodpai, Hiroshi Yamasaki, Wannaporn Ittiprasert, Victoria H. Mann, Paul J. Brindley, Wanchai Maleewong, Pewpan M. Intapan Parasitology Research.2021; 120(8): 2839. CrossRef Development of an Immunochromatographic Point-of-Care Test for Serodiagnosis of Opisthorchiasis and Clonorchiasis Lakkhana Sadaow, Oranuch Sanpool, Rutchanee Rodpai, Hiroshi Yamasaki, Wannaporn Ittiprasert, Victoria H. Mann, Paul J. Brindley, Wanchai Maleewong, Pewpan M. Intapan The American Journal of Tropical Medicine and Hygiene.2019; 101(5): 1156. CrossRef The serological diagnosis of human clonorchiasis by time-resolved fluoroimmunoassay based on GST2-specific IgG4 detection Jin Xu, Lexun Wang, Chuanhuan Deng, Xuchu Hu, Ran Li, Tingjin Chen, Dan Ning, Yingsong Wu, Yan Huang, Xuerong Li, Zhongdao Wu, Xinbing Yu, Yonglong Li Parasitology Research.2014; 113(1): 149. CrossRef 41.5-kDa Cathepsin L protease from Clonorchis sinensis: expression, characterization, and serological reactivity of one excretory–secretory antigen Yanwen Li, Yan Huang, Xuchu Hu, Xiaoquan Liu, Changling Ma, Junhong Zhao, Zhongdao Wu, Jin Xu, Xinbing Yu Parasitology Research.2012; 111(2): 673. CrossRef Evaluation and Characterization of Fasciola hepatica Tegument Protein Extract for Serodiagnosis of Human Fascioliasis Adelaida Morales, Ana M. Espino Clinical and Vaccine Immunology.2012; 19(11): 1870. CrossRef Serodiagnostic applicability of recombinant antigens of Clonorchis sinensis expressed by wheat germ cell-free protein synthesis system Chenghua Shen, Jong-Ae Lee, Sonia Refaat Ahmed Allam, Young Mee Bae, Eun-Taek Han, Satoru Takeo, Takafumi Tsuboi, Sung-Tae Hong, Min-Ho Choi Diagnostic Microbiology and Infectious Disease.2009; 64(3): 334. CrossRef The identification of a Clonorchis sinensis gene encoding an antigenic egg protein Mejeong Lee, Young-Bae Chung, Suk-Keun Lee, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong Parasitology Research.2005; 95(3): 224. CrossRef Evaluation of Immunoglobulin G Subclass Antibodies against RecombinantFasciola giganticaCathepsin L1 in an Enzyme-Linked Immunosorbent Assay for Serodiagnosis of Human Fasciolosis Chaisiri Wongkham, Chairat Tantrawatpan, Pewpan M. Intapan, Wanchai Maleewong, Sopit Wongkham, Kunio Nakashima Clinical and Vaccine Immunology.2005; 12(10): 1152. CrossRef Excretory-secretory antigen is better than crude antigen for the serodiagnosis of clonorchiasis by ELISA Min-Ho Choi, Il Chan Park, Shunyu Li, Sung-Tae Hong The Korean Journal of Parasitology.2003; 41(1): 35. CrossRef Immunology and molecular biology of Opisthorchis viverrini infection S. Wongratanacheewin, R.W. Sermswan, S. Sirisinha Acta Tropica.2003; 88(3): 195. CrossRef Specific and common antigens of Clonorchis sinensis and Opisthorchis viverrini (Opisthorchidae, Trematoda) Min-Ho Choi, Jin-Sook Ryu, Mejeong Lee, Shunyu Li, Byung-Suk Chung, Jong-Yil Chai, Paiboon Sithithaworn, Smarn Tesana, Sung-Tae Hong The Korean Journal of Parasitology.2003; 41(3): 155. CrossRef Characterization of partially purified 8 kDa antigenic protein of Clonorchis sinensis Young-Bae Chung, Mejeong Lee, Hyun-Jong Yang, Byung-Suk Chung, Shun-Yu Lee, Min-Ho Choi, Sung-Tae Hong The Korean Journal of Parasitology.2002; 40(2): 83. CrossRef Antigenic profile and localization of Clonorchis sinensis proteins in the course of infection Sung-Jong Hong, Tae Yun Kim, Kye-Yong Song, Woon-Mok Sohn, Shin-Yong Kang The Korean Journal of Parasitology.2001; 39(4): 307. CrossRef Cystatin Capture Enzyme-Linked Immunosorbent Assay for Serodiagnosis of Human Clonorchiasis and Profile of Captured Antigenic Protein ofClonorchis sinensis Tae Yun Kim, Shin-Yong Kang, Sun Hyo Park, Kom Sukontason, Kabkaew Sukontason, Sung-Jong Hong Clinical Diagnostic Laboratory Immunology.2001; 8(6): 1076. CrossRef Partial characterization of a 17 kDa protein of Clonorchis sinensis Young-Bae Chung, Byung-Suk Chung, Min-Ho Choi, Jong-Yil Chai, Sung-Tae Hong The Korean Journal of Parasitology.2000; 38(2): 95. CrossRef 9,460 View 68 Download Crossref Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits Dongil Choi, Jae Hoon Lim, Seung Kwon Kim, Eung Yeop Kim, Mejeong Lee, Sung-Tae Hong Korean J Parasitol 1999;37(2):77-83. Published online June 30, 1999 DOI: https://doi.org/10.3347/kjp.1999.37.2.77 Abstract PDF To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific. Citations Citations to this article as recorded by Clonorchis sinensis and Cholangiocarcinoma Eun-Min Kim, Sung-Tae Hong Journal of Korean Medical Science.2025;[Epub] CrossRef Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced T1 mapping to evaluate liver damage caused by Clonorchis sinensis Yanhan Xiang, Ningqin Li, Zhongyang Zhou, Jing Fang, Jinyuan Liao Radiology of Infectious Diseases.2021; 8(3): 108. CrossRef Changes in Sonographic Findings after Treatment of Patients with Clonorchiasis in a Heavy Endemic Area Dongil Choi, Yong Hwan Jeon, Geun-Chan Lee, Min-Ho Choi, Sung-Tae Hong The Korean Journal of Parasitology.2009; 47(1): 19. CrossRef Gallstones and Clonorchis sinensis infection: A hospital‐based case–control study in Korea Dongil Choi, Jae Hoon Lim, Kyu Taek Lee, Jong Kyun Lee, Seong Ho Choi, Jin Seok Heo, Dong Wook Choi, Kee‐Taek Jang, Nam Yong Lee, Seonwoo Kim, Sung‐Tae Hong Journal of Gastroenterology and Hepatology.2008;[Epub] CrossRef Imaging diagnosis of clonorchiasis Dongil Choi, Sung-Tae Hong The Korean Journal of Parasitology.2007; 45(2): 77. CrossRef Cholangiocarcinoma and Clonorchis sinensis infection: A case–control study in Korea Dongil Choi, Jae Hoon Lim, Kyu Taek Lee, Jong Kyun Lee, Seong Ho Choi, Jin Seok Heo, Kee-Taek Jang, Nam Yong Lee, Seonwoo Kim, Sung-Tae Hong Journal of Hepatology.2006; 44(6): 1066. CrossRef Sonographic findings of active Clonorchis sinensis infection Dongil Choi, Sung‐Tae Hong, Jae Hoon Lim, Seung‐Yull Cho, Han‐Jong Rim, Zhuo Ji, Ren Yuan, Shuyu Wang Journal of Clinical Ultrasound.2004; 32(1): 17. CrossRef Bile duct changes in rats reinfected with Clonorchis sinensis Dongil Choi, Sung-Tae Hong, Shunyu Li, Byung-Suk Chung, Jae Hoon Lim, Soon-Hyung Lee The Korean Journal of Parasitology.2004; 42(1): 7. CrossRef Clonorchiasis and Cholangiocarcinoma: Etiologic Relationship and Imaging Diagnosis Byung Ihn Choi, Joon Koo Han, Sung Tae Hong, Kyoung Ho Lee Clinical Microbiology Reviews.2004; 17(3): 540. CrossRef Experimental Clonorchiasis in Dogs: CT Findings before and after Treatment Kyoung Ho Lee, Sung Tae Hong, Joon Koo Han, Chang Jin Yoon, Sun Lee, Se Hyung Kim, Byung Ihn Choi Radiology.2003; 228(1): 131. CrossRef 8,858 View 62 Download Crossref Control of clonorchiasis by repeated praziquantel treatment and low diagnostic efficacy of sonography Sung-Tae Hong, Kisung Yoon, Mejeong Lee, Min Seo, Min-Ho Choi, Jung Suk Sim, Byung Ihn Choi, Chong Ku Yun, Soon-Hyung Lee Korean J Parasitol 1998;36(4):249-254. Published online December 20, 1998 DOI: https://doi.org/10.3347/kjp.1998.36.4.249 Abstract PDF In Korea, Clonorchis sinensis infection is still highly prevalent because case detection in the field is difficult and the detected cases used to be incompletely cured due to treatment failure. The present study tried to control clonorchiasis in an endemic village by repeated treatments with praziquantel every 6 months and to evaluate sonography as a diagnostic measure. By stool examinations, the egg positive rate in the endemic village was 22.7%, but it decreased to 19.6% at 6 months, 15.1% at 12 months. 12.2% at 18 months, 6.3% at 24 months, 11.4% at 30 months, and 6.3% at 42 months after the beginning of repeated praziquantel administration. The sonography showed 61 (49.6%) positive cases of 123 screened residents: among egg-positives the sonography positive rate was 52.2% and among egg-negatives it was still 49%. The rate among cured cases was 64.3% after 6 months, 50.0% after 12 months, 50.0% after 18 months, and 66.7% after 24 months. In a non-endemic village, 64 residents were found egg-negative by fecal examination, but 20 (31.3%) of them were positive by sonography. The present findings indicate that control of clonorchiasis in an endemic village by repeated praziquantel treatment for 42 months is still insufficient and sonography is of little value for diagnosis of clonorchiasis. 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CrossRef Therapeutic evaluation of sustained-releasing praziquantel (SRP) for clonorchiasis: Phase 1 and 2 clinical studies Min-Ho Choi, Byung-Chan Chang, Seung-Jin Lee, In-Jin Jang, Sang-Goo Shin, Weon-Gyu Kho, Jin-Ho Chun, Sung-Tae Hong The Korean Journal of Parasitology.2006; 44(4): 361. CrossRef Bile duct changes in rats reinfected with Clonorchis sinensis Dongil Choi, Sung-Tae Hong, Shunyu Li, Byung-Suk Chung, Jae Hoon Lim, Soon-Hyung Lee The Korean Journal of Parasitology.2004; 42(1): 7. CrossRef Sonographic findings of active Clonorchis sinensis infection Dongil Choi, Sung‐Tae Hong, Jae Hoon Lim, Seung‐Yull Cho, Han‐Jong Rim, Zhuo Ji, Ren Yuan, Shuyu Wang Journal of Clinical Ultrasound.2004; 32(1): 17. CrossRef Clonorchiasis and Cholangiocarcinoma: Etiologic Relationship and Imaging Diagnosis Byung Ihn Choi, Joon Koo Han, Sung Tae Hong, Kyoung Ho Lee Clinical Microbiology Reviews.2004; 17(3): 540. 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CrossRef Control of clonorchiasis by repeated treatments with praziquantel Sung-Tae Hong, Han-Jong Rim, Duk-Young Min, Xueming Li, Jingxian Xu, Zheng Feng, Soon-Hyung Lee The Korean Journal of Parasitology.2001; 39(4): 285. CrossRef Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits Dongil Choi, Jae Hoon Lim, Seung Kwon Kim, Eung Yeop Kim, Mejeong Lee, Sung-Tae Hong The Korean Journal of Parasitology.1999; 37(2): 77. CrossRef 9,359 View 61 Download Crossref