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Volume 51(5); October 2013

Original Articles

Identification of Atg8 Isoform in Encysting Acanthamoeba
Eun-Kyung Moon, Yeonchul Hong, Dong-Il Chung, Hyun-Hee Kong
Korean J Parasitol 2013;51(5):497-502.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.497

Autophagy-related protein 8 (Atg8) is an essential component of autophagy formation and encystment of cyst-forming parasites, and some protozoa, such as, Acanthamoeba, Entamoeba, and Dictyostelium, have been reported to possess a type of Atg8. In this study, an isoform of Atg8 was identified and characterized in Acanthamoeba castellanii (AcAtg8b). AcAtg8b protein was found to encode 132 amino acids and to be longer than AcAtg8 protein, which encoded 117 amino acids. Real-time PCR analysis showed high expression levels of AcAtg8b and AcAtg8 during encystation. Fluorescence microscopy demonstrated that AcAtg8b is involved in the formation of the autophagosomal membrane. Chemically synthesized siRNA against AcAtg8b reduced the encystation efficiency of Acanthamoeba, confirming that AcAtg8b, like AcAtg8, is an essential component of cyst formation in Acanthamoeba. Our findings suggest that Acanthamoeba has doubled the number of Atg8 gene copies to ensure the successful encystation for survival when 1 copy is lost. These 2 types of Atg8 identified in Acanthamoeba provide important information regarding autophagy formation, encystation mechanism, and survival of primitive, cyst-forming protozoan parasites.

Citations

Citations to this article as recorded by  Crossref logo
  • Encystment and Excystment Processes in Acanthamoeba castellanii: An Emphasis on Cellulose Involvement
    Mathew Choaji, Ascel Samba-Louaka, Zineb Fechtali-Moute, Willy Aucher, Sébastien Pomel
    Pathogens.2025; 14(3): 268.     CrossRef
  • Efficacy of propolis extract and eye drop solutions to suppress encystation and excystation of Acanthamoeba triangularis WU19001-T4 genotype
    Suthinee Sangkanu, Abolghasem Siyadatpanah, Roghayeh Norouzi, Julalak Chuprom, Watcharapong Mitsuwan, Sirirat Surinkaew, Rachasak Boonhok, Alok K. Paul, Tooba Mahboob, Imran Sama-ae, Sonia M. R. Oliveira, Tajudeen O. Jimoh, Maria de Lourdes Pereira, Polra
    PeerJ.2024; 12: e16937.     CrossRef
  • Ac-HSP20 regulates autophagy and promotes the encystation of Acanthamoeba castellanii by inhibiting the PI3K/AKT/mTOR signaling pathway
    Siyao Guo, Di Liu, Xi Wan, Dingrui Guo, Meiyu Zheng, Wenyu Zheng, Xianmin Feng
    Parasites & Vectors.2024;[Epub]     CrossRef
  • Toxicity Evaluation of Potassium Sorbate In Vivo with Drosophila Melanogaster
    Xubo Zhang, Qian Zhang, Xiaoxuan Song, Wanchen Yang, Andi Cheng, Jianzhen Zhang, Wei Dong
    Insects.2024; 15(9): 703.     CrossRef
  • Biological characteristics and pathogenicity of Acanthamoeba
    Yuehua Wang, Linzhe Jiang, Yitong Zhao, Xiaohong Ju, Le Wang, Liang Jin, Ryan D. Fine, Mingguang Li
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • The roles of autophagy and mitophagy in corneal pathology: current knowledge and future perspectives
    Rajalakshmy Ayilam Ramachandran, Jose Marcos Sanches, Danielle M. Robertson
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Curcumin effect on Acanthamoeba triangularis encystation under nutrient starvation
    Rachasak Boonhok, Suthinee Sangkanu, Suganya Phumjan, Ramita Jongboonjua, Nawarat Sangnopparat, Pattamaporn Kwankaew, Aman Tedasen, Chooi Ling Lim, Maria de Lourdes Pereira, Mohammed Rahmatullah, Polrat Wilairatana, Christophe Wiart, Karma G. Dolma, Alok
    PeerJ.2022; 10: e13657.     CrossRef
  • Proteomic analysis of Atg8-dependent recruitment of phagosomal proteins in the enteric protozoan parasite Entamoeba histolytica
    Kumiko Nakada-Tsukui, Natsuki Watanabe, Kumiko Shibata, Ratna Wahyuni, Eri Miyamoto, Tomoyoshi Nozaki
    Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
  • Stimulation of Acanthamoeba castellanii excystment by enzyme treatment and consequences on trophozoite growth
    Zineb Fechtali-Moute, Philippe M. Loiseau, Sébastien Pomel
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Phragmites australis (Cav.) Trin. ex Steud. Extract Induces Apoptosis-like Programmed Cell Death in Acanthamoeba castellanii Trophozoites
    Hương-Giang Lê, Ji-Su Choi, Buyng-Su Hwang, Yong-Tae Jeong, Jung-Mi Kang, Tuấn-Cường Võ, Pyo-Yun Cho, Young-Kyung Lee, Won-Gi Yoo, Yeonchul Hong, Young-Taek Oh, Byoung-Kuk Na
    Plants.2022; 11(24): 3459.     CrossRef
  • Amoebicidal activity of Cassia angustifolia extract and its effect on Acanthamoeba triangularis autophagy-related gene expression at the transcriptional level
    Rachasak Boonhok, Suthinee Sangkanu, Roghayeh Norouzi, Abolghasem Siyadatpanah, Farzaneh Mirzaei, Watcharapong Mitsuwan, Nurdina Charong, Sueptrakool Wisessombat, Maria de Lourdes Pereira, Mohammed Rahmatullah, Polrat Wilairatana, Christophe Wiart, Hazel
    Parasitology.2021; 148(9): 1074.     CrossRef
  • Peganum harmala Extract Has Antiamoebic Activity to Acanthamoeba triangularis Trophozoites and Changes Expression of Autophagy-Related Genes
    Rachasak Boonhok, Suthinee Sangkanu, Julalak Chuprom, Mayuna Srisuphanunt, Roghayeh Norouzi, Abolghasem Siyadatpanah, Farzaneh Mirzaei, Watcharapong Mitsuwan, Sueptrakool Wisessombat, Maria de Lourdes Pereira, Mohammed Rahmatullah, Polrat Wilairatana, Chr
    Pathogens.2021; 10(7): 842.     CrossRef
  • Ubiquitin-Like Modifiers: Emerging Regulators of Protozoan Parasites
    Maryia Karpiyevich, Katerina Artavanis-Tsakonas
    Biomolecules.2020; 10(10): 1403.     CrossRef
  • Encystation: the most prevalent and underinvestigated differentiation pathway of eukaryotes
    Pauline Schaap, Christina Schilde
    Microbiology.2018; 164(5): 727.     CrossRef
  • Autophagy protein 12 plays an essential role in Acanthamoeba encystation
    So-Hee Kim, Eun-Kyung Moon, Yeonchul Hong, Dong-Il Chung, Hyun-Hee Kong
    Experimental Parasitology.2015; 159: 46.     CrossRef
  • Autophagy Inhibitors as a Potential Antiamoebic Treatment for Acanthamoeba Keratitis
    Eun-Kyung Moon, So-Hee Kim, Yeonchul Hong, Dong-Il Chung, Youn-Kyoung Goo, Hyun-Hee Kong
    Antimicrobial Agents and Chemotherapy.2015; 59(7): 4020.     CrossRef
  • 9,824 View
  • 99 Download
  • Crossref
A Rapid Diagnostic Test for Toxoplasmosis using Recombinant Antigenic N-terminal Half of SAG1 Linked with Intrinsically Unstructured Domain of GRA2 Protein
Kyoung Ju Song, Zhaoshou Yang, Chom-Kyu Chong, Jin-Soo Kim, Kyung Chan Lee, Tong-Soo Kim, Ho-Woo Nam
Korean J Parasitol 2013;51(5):503-510.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.503

Toxoplasma gondii is an apicomplexan parasite with a broad host range of most warm-blooded mammals including humans, of which one-thirds of the human population has been infected worldwide which can cause congenital defects, abortion, and neonatal complications. Here, we developed a rapid diagnostic test (RDT) for T. gondii infection. Antigenic N-terminal half of the major surface antigen (SAG1) was linked with intrinsically unstructured domain (IUD) of dense granule protein 2 (GRA2). The recombinant GST-GRA2-SAG1A protein was successfully expressed and purified as 51 kDa of molecular weight. Furthermore, antigenicity and solubility of the rGST-GRA2-SAG1A protein were significantly increased. The overall specificity and sensitivity of GST-GRA2-SAG1A loaded RDT (TgRDT) were estimated as 100% and 97.1% by comparing with ELISA result which uses T. gondii whole cell lysates as the antigen. The TgRDT tested with Uganda people sera for field trial and showed 31.9% of seroprevalence against T. gondii antibody. The TgRDT is proved to be a kit for rapid and easy to use with high accuracy, which would be a suitable serodiagnostic tool for toxoplasmosis.

Citations

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  • Development of an Immunochromatographic Test with Recombinant MIC2-MIC3 Fusion Protein for Serological Detection of Toxoplasma gondii
    Jianzhong Wang, Yi Zhao, Jicheng Qiu, Jing Liu, Rui Zhou, Xialin Ma, Xiaojie Wu, Xiaoguang Li, Wei Mao, Yiduo Liu, Heng Zhang
    Veterinary Sciences.2025; 12(6): 509.     CrossRef
  • Application of gold immunochromatographic assay strip combined with digital evaluation for early detection of Toxoplasma gondii infection in multiple species
    Jiyuan Fan, Hao Sun, Jiawen Fang, Yafan Gao, Haojie Ding, Bin Zheng, Qingming Kong, Xunhui Zhuo, Shaohong Lu
    Parasites & Vectors.2024;[Epub]     CrossRef
  • Single Cell Expression Systems for the Production of Recombinant Proteins for Immunodiagnosis and Immunoprophylaxis of Toxoplasmosis
    Karolina Sołowińska, Lucyna Holec-Gąsior
    Microorganisms.2024; 12(8): 1731.     CrossRef
  • Seroprevalence of Toxoplasma gondii infection among patients of a tertiary hospital in Guangzhou, Guangdong province, PR China
    Yu-bin Guan, Xiao-xiao Sun, Shao-lian Chen, Xiao-ting Zhu, Zhi-hua Zeng, Han-wei Lu, Hong-mei Feng, Yu Guo, Wen-gong Jiang, Kui Xiong, Xiao-rong Yang, Ho-Woo Nam, Zhao-shou Yang, Pan Li
    PLOS ONE.2023; 18(7): e0286430.     CrossRef
  • Past and present seroprevalence and disease burden estimates of Toxoplasma gondii infections in Germany: An appreciation of the role of serodiagnostics
    Frank Seeber
    International Journal of Medical Microbiology.2023; 313(6): 151592.     CrossRef
  • Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea
    Jeehi Jung, Jinyoung Lee, Yoon Kyung Chang, Seong Kyu Ahn, Seo Hye Park, Sung-Jong Hong, Jihoo Lee, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam, Tong-Soo Kim, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(1): 9.     CrossRef
  • Clusters of Toxoplasmosis in Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea
    Jihye Yu, Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(3): 251.     CrossRef
  • Serological and molecular rapid diagnostic tests for Toxoplasma infection in humans and animals
    Amjad Hayat Khan, Rahmah Noordin
    European Journal of Clinical Microbiology & Infectious Diseases.2020; 39(1): 19.     CrossRef
  • Clusters of Toxoplasmosis in Gyodong-Myeon and Samsan-Myeon, Ganghwa-Gun, Korea
    Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2020; 58(5): 493.     CrossRef
  • Identification of novel antigens for serum IgG diagnosis of human toxoplasmosis
    Juntao Luo, Jingyi Wan, Ziru Tang, Shuang Shen
    Experimental Parasitology.2019; 204: 107722.     CrossRef
  • Seroprevalence of Toxoplasmosis with ELISA and Rapid Diagnostic Test among Residents in Gyodong-do, Inchon city, Korea: A Four-Year Follow-up
    Yeong Hoon Kim, Ji hoo Lee, Seong kyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
    The Korean Journal of Parasitology.2017; 55(3): 247.     CrossRef
  • Development of direct assays for Toxoplasma gondii and its use in genomic DNA sample
    Lívia M. Alves, Vinícius R. Rodovalho, Ana C.H. Castro, Márcia A.R. Freitas, Caroline M. Mota, Tiago W.P. Mineo, José R. Mineo, João M. Madurro, Ana G. Brito-Madurro
    Journal of Pharmaceutical and Biomedical Analysis.2017; 145: 838.     CrossRef
  • Seroprevalence of Toxoplasmosis Detected by RDT in Residents near the DMZ (demilitarized zone) of Cheorwon-gun, Gangwon-do, Korea
    Yeong Hoon Kim, Jihoo Lee, Young-Eun Kim, Seongkyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
    The Korean Journal of Parasitology.2017; 55(4): 385.     CrossRef
  • Western Blot Detection of Human Anti-Chikungunya Virus Antibody with Recombinant Envelope 2 Protein
    Zhaoshou Yang, Jihoo Lee, Hye-Jin Ahn, Chom-Kyu Chong, Ronaldo F. Dias, Ho-Woo Nam
    The Korean Journal of Parasitology.2016; 54(2): 239.     CrossRef
  • Digested disorder, Quarterly intrinsic disorder digest (October-November-December, 2013)
    Shelly DeForte, Krishna D Reddy, Vladimir N Uversky
    Intrinsically Disordered Proteins.2015; 3(1): e984569.     CrossRef
  • Probability of Antibody Formation against Circumsporozoite Protein of Plasmodium vivax among Korean Malaria Patients
    Ho-Woo Nam, Kyoung Ju Song, Hye Jin Ahn, Zhaoshou Yang, Chom-Kyu Chong, Pyo Yun Cho, Seong Kyu Ahn, Tong-Soo Kim
    The Korean Journal of Parasitology.2014; 52(2): 143.     CrossRef
  • High Expression of Water-Soluble Recombinant Antigenic Domains ofToxoplasma gondii Secretory Organelles
    Zhaoshou Yang, Hye-Jin Ahn, Ho-Woo Nam
    The Korean Journal of Parasitology.2014; 52(4): 367.     CrossRef
  • 9,685 View
  • 106 Download
  • Crossref
Phylogenetic Analysis of Ruminant Theileria spp. from China Based on 28S Ribosomal RNA Gene
Huitian Gou, Guiquan Guan, Miling Ma, Aihong Liu, Zhijie Liu, Zongke Xu, Qiaoyun Ren, Youquan Li, Jifei Yang, Ze Chen, Hong Yin, Jianxun Luo
Korean J Parasitol 2013;51(5):511-517.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.511

Species identification using DNA sequences is the basis for DNA taxonomy. In this study, we sequenced the ribosomal large-subunit RNA gene sequences (3,037-3,061 bp) in length of 13 Chinese Theileria stocks that were infective to cattle and sheep. The complete 28S rRNA gene is relatively difficult to amplify and its conserved region is not important for phylogenetic study. Therefore, we selected the D2-D3 region from the complete 28S rRNA sequences for phylogenetic analysis. Our analyses of 28S rRNA gene sequences showed that the 28S rRNA was useful as a phylogenetic marker for analyzing the relationships among Theileria spp. in ruminants. In addition, the D2-D3 region was a short segment that could be used instead of the whole 28S rRNA sequence during the phylogenetic analysis of Theileria, and it may be an ideal DNA barcode.

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  • Differential detection of ovine Theileria species using loop-mediated isothermal amplification combined with nanoparticle-based lateral flow biosensor
    Haohan Zhu, Shuaiyang Zhao, Jin Luo, Muhammad Kashif Obaid, Shaohua Zhang, Peiqi Liu, Jianxun Luo, Hong Yin, Junlong Liu, Guiquan Guan
    Veterinary Parasitology.2025; 336: 110443.     CrossRef
  • An insight into misidentification of the small-subunit ribosomal RNA (18S rRNA) gene sequences of Theileria spp. as Theileria annulata
    Anil Kumar Nehra, Ansu Kumari, Aman Dev Moudgil, Sukhdeep Vohra
    BMC Veterinary Research.2022;[Epub]     CrossRef
  • DNA-based molecular identification of Urnula mediterranea (Ascomycota, Pezizales) collected in Central Serbia
    Dejan Arsenijević, Stefan Blagojević, Nevena Planojević, Aleksandra Nikezić, Dejan Vidanović, Nenad Milosavljević, Snežana Marković
    Kragujevac Journal of Science.2021; (43): 53.     CrossRef
  • Putative Internal Control Genes in Bovine Milk Small Extracellular Vesicles Suitable for Normalization in Quantitative Real Time-Polymerase Chain Reaction
    Md. Matiur Rahman, Shigeo Takashima, Yuji O. Kamatari, Yassien Badr, Kaori Shimizu, Ayaka Okada, Yasuo Inoshima
    Membranes.2021; 11(12): 933.     CrossRef
  • Clinical Pathology, Immunopathology and Advanced Vaccine Technology in Bovine Theileriosis: A Review
    Onyinyechukwu Ada Agina, Mohd Rosly Shaari, Nur Mahiza Md Isa, Mokrish Ajat, Mohd Zamri-Saad, Hazilawati Hamzah
    Pathogens.2020; 9(9): 697.     CrossRef
  • Transcriptome Comparison Reveals the Adaptive Evolution of Two Contrasting Ecotypes of Zn/Cd Hyperaccumulator Sedum alfredii Hance
    Qianying Yang, M. J. I. Shohag, Ying Feng, Zhenli He, Xiaoe Yang
    Frontiers in Plant Science.2017;[Epub]     CrossRef
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Breast-Feeding Protects Infantile Diarrhea Caused by Intestinal Protozoan Infections
Ekhlas Hamed Abdel-Hafeez, Usama Salah Belal, Manal Zaki Mohamed Abdellatif, Koji Naoi, Kazumi Norose
Korean J Parasitol 2013;51(5):519-524.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.519

This study investigated the effect of breast-feeding in protection against protozoan infection in infants with persistent diarrhea. Infants were classified into 2 groups; 161 breast-fed infants and the same number of non-breast-fed infants. Microscopic examinations of stool were done for detection of parasites and measuring the intensity of infection. Moreover, serum levels of IgE and TNF-α were measured by ELISA. Cryptosporidium spp., Entamoeba histolytica/Entamoeba dispar, Giardia lamblia, and Blastocystis sp. were demonstrated in infants with persistent diarrhea. The percentage of protozoan infections was significantly lower in breast-fed infants than that in the non-breast-fed infants. The levels of IgE and TNF-α were significantly lower in the breast-fed group than in the non-breast-fed group. There were significant positive associations between the serum levels of IgE and TNF-α and the intensity of parasite infection in the breast-fed group. It is suggested that breast-feeding has an attenuating effect on the rate and intensity of parasite infection.

Citations

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  • Selected Protective Mechanisms of Human Milk Against Intestinal Protozoal Infections in Infants
    Joanna Wróblewska, Anna Długosz, Marcin Wróblewski, Jarosław Nuszkiewicz, Paweł Sutkowy, Alina Woźniak
    Current Issues in Molecular Biology.2025; 47(8): 674.     CrossRef
  • Giardia lamblia risk factors and burden in children with acute gastroenteritis in a Nicaraguan birth cohort
    Lester Gutiérrez, Nadja A. Vielot, Roberto Herrera, Yaoska Reyes, Christian Toval-Ruíz, Patricia Blandón, Rebecca J. Rubinstein, Javier Mora, Luther A. Bartelt, Filemón Bucardo, Sylvia Becker-Dreps, Samuel Vilchez, Sarman Singh
    PLOS Neglected Tropical Diseases.2024; 18(11): e0012230.     CrossRef
  • Tradeoffs in milk immunity affect infant infectious disease risk
    Katherine Wander, Masako Fujita, Siobhan M Mattison, Margaret Duris, Megan Gauck, Tessa Hopt, Katherine Lacy, Angela Foligno, Rebecca Ulloa, Connor Dodge, Frida Mowo, Ireen Kiwelu, Blandina T Mmbaga
    Evolution, Medicine, and Public Health.2022; 10(1): 295.     CrossRef
  • Intestinal Parasitic Infections Among Pediatric Patients in a Metropolitan City of Bangladesh With Emphasis on Cryptosporidiosis
    Nusrat Jahan Nipa, Nasima Aktar, Hasina M Hira, Farhana Akter, Dilshad Jahan, Salequl Islam, Ayukafangha Etando, Adnan Abdullah, Kona Chowdhury, Rahnuma Ahmad, Ahsanul Haq, Mainul Haque
    Cureus.2022;[Epub]     CrossRef
  • Association of genetic polymorphism at tumor necrosis factor-α gene promoter - 1031T/C and parasitic infections among children in Northern South Africa
    N.C. Davhana, A.K. ElBakri, P.O. Bessong, A. Samie
    Heliyon.2020; 6(10): e05129.     CrossRef
  • Antibodies, prophylaxis, transmission
    Pierre Lutgen
    Pharmacy & Pharmacology International Journal.2018;[Epub]     CrossRef
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    Hugo Aguilar-Diaz, Adrian Canizalez-Roman, Tomas Nepomuceno-Mejia, Francisco Gallardo-Vera, Yolanda Hornelas-Orozco, Kamran Nazmi, Jan G.M. Bolscher, Julio Cesar Carrero, Claudia Leon-Sicairos, Nidia Leon-Sicairos
    Biochemistry and Cell Biology.2017; 95(1): 82.     CrossRef
  • Cryptosporidium and Giardia in Africa: current and future challenges
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    Parasites & Vectors.2017;[Epub]     CrossRef
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    María A. Echevarría, María L. Eva
    Current Tropical Medicine Reports.2017; 4(3): 178.     CrossRef
  • Molecular Analysis of the Enteric Protozoa Associated with Acute Diarrhea in Hospitalized Children
    Sonia Boughattas, Jerzy M. Behnke, Khalid Al-Ansari, Aarti Sharma, Wafa Abu-Alainin, Asma Al-Thani, Marawan A. Abu-Madi
    Frontiers in Cellular and Infection Microbiology.2017;[Epub]     CrossRef
  • Killing of Cryptosporidium sporozoites by Lactoferrin
    Jose Luis Paredes, Hayley Sparks, A. Clinton White Jr., Griselle Martinez-Traverso, Theresa Ochoa, Alejandro Castellanos-González
    The American Journal of Tropical Medicine and Hygiene.2017; 97(3): 774.     CrossRef
  • Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin-25-Mediated Protection from Amebic Colitis
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    mBio.2017;[Epub]     CrossRef
  • Evolution of Socioeconomic Conditions and Its Relation to Spatial–Temporal Changes of Giardiasis and Helminthiasis in Amazonian Children
    B. M. Delfino, R. G. Campos, T. M. Pereira, S. A. S. Mantovani, H. Oliart-Guzmán, A. C. Martins, A. M. Braña, F. L. C. C. Branco, J. A. Filgueira-Júnior, A. P. Santos, T. S. Araújo, C. S. M. Oliveira, A. A. Ramalho, P. T. Muniz, C. T. Codeço, M. da Silva-
    EcoHealth.2016; 13(4): 743.     CrossRef
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    Alline R. Pacheco, Daniela Barile, Mark A. Underwood, David A. Mills
    Annual Review of Animal Biosciences.2015; 3(1): 419.     CrossRef
  • Exclusive breast feeding in early infancy reduces the risk of inpatient admission for diarrhea and suspected pneumonia in rural Vietnam: a prospective cohort study
    Sarah Hanieh, Tran T. Ha, Julie A. Simpson, Tran T. Thuy, Nguyen C. Khuong, Dang D. Thoang, Thach D. Tran, Tran Tuan, Jane Fisher, Beverley-Ann Biggs
    BMC Public Health.2015;[Epub]     CrossRef
  • Noninvasive intestinal amebiasis
    Gayatri V. Nair, Easwaran P. Variyam
    Current Opinion in Infectious Diseases.2014; 27(5): 465.     CrossRef
  • Breastfeeding and risk of parasitic infection-a review
    Prameela Kannan Kutty
    Asian Pacific Journal of Tropical Biomedicine.2014; 4(11): 847.     CrossRef
  • 13,616 View
  • 104 Download
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Comparison of Functional Gene Annotation of Toxascaris leonina and Toxocara canis using CLC Genomics Workbench
Ki Uk Kim, Sang Kyun Park, Shin Ae Kang, Mi Kyung Park, Min Kyoung Cho, Ho-jin Jung, Kyung-Yun Kim, Hak Sun Yu
Korean J Parasitol 2013;51(5):525-530.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.525

The ascarids, Toxocara canis and Toxascaris leonina, are probably the most common gastrointestinal helminths encountered in dogs. In order to understand biological differences of 2 ascarids, we analyzed gene expression profiles of female adults of T. canis and T. leonina using CLC Genomics Workbench, and the results were compared with those of free-living nematode Caenorhabditis elegans. A total of 2,880 and 7,949 ESTs were collected from T. leonina and T. canis, respectively. The length of ESTs ranged from 106 to 4,637 bp with an average insert size of 820 bp. Overall, our results showed that most functional gene annotations of 2 ascarids were quite similar to each other in 3 major categories, i.e., cellular component, biological process, and molecular function. Although some different transcript expression categories were found, the distance was short and it was not enough to explain their different lifestyles. However, we found distinguished transcript differences between ascarid parasites and free-living nematodes. Understanding evolutionary genetic changes might be helpful for studies of the lifestyle and evolution of parasites.

Citations

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  • CRISPR-Cas9 genome editing reveals that the Pgs gene of Fusarium circinatum is involved in pathogenicity, growth and sporulation
    Alida van Dijk, Andi M. Wilson, Bianke Marx, Bianca Hough, Benedicta Swalarsk-Parry, Lieschen De Vos, Michael J. Wingfield, Brenda D. Wingfield, Emma T. Steenkamp
    Fungal Genetics and Biology.2025; 177: 103970.     CrossRef
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    Jiayu Li, Yingying Fan, Na Li, Yaqiong Guo, Weijian Wang, Kangli Feng, Wei He, Falei Li, Jianbo Huang, Yanhua Xu, Lihua Xiao, Yaoyu Feng
    International Journal for Parasitology.2024; 54(7): 379.     CrossRef
  • Chromosome-level genome assembly of Cryptosporidium parvum by long-read sequencing of ten oocysts
    Yuancai Chen, Jianying Huang, Huikai Qin, Kaihui Zhang, Yin Fu, Junqiang Li, Rongjun Wang, Kai Chen, Jie Xiong, Wei Miao, Guangying Wang, Longxian Zhang
    Scientific Data.2024;[Epub]     CrossRef
  • High subtelomeric GC content in the genome of a zoonotic Cryptosporidium species
    Jiayu Li, Na Li, Dawn M. Roellig, Wentao Zhao, Yaqiong Guo, Yaoyu Feng, Lihua Xiao
    Microbial Genomics .2023;[Epub]     CrossRef
  • The Combination of Phages and Faecal Microbiota Transplantation Can Effectively Treat Mouse Colitis Caused by Salmonella enterica Serovar Typhimurium
    Xinwu Wang, Yating Xing, Yalu Ji, Hengyu Xi, Xiaohe Liu, Li Yang, Liancheng Lei, Wenyu Han, Jingmin Gu
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • Complete Plastome of Physalis angulata var. villosa, Gene Organization, Comparative Genomics and Phylogenetic Relationships among Solanaceae
    Xiaori Zhan, Zhenhao Zhang, Yong Zhang, Yadi Gao, Yanyun Jin, Chenjia Shen, Huizhong Wang, Shangguo Feng
    Genes.2022; 13(12): 2291.     CrossRef
  • Mitochondrial genes associated with pyrethroid resistance revealed by mitochondrial genome and transcriptome analyses in the malaria vector Anopheles sinensis (Diptera: Culicidae)
    Yi‐Ran Ding, Zhen‐Tian Yan, Feng‐Ling Si, Xu‐Dong Li, Qi‐Meng Mao, Sana Asghar, Bin Chen
    Pest Management Science.2020; 76(2): 769.     CrossRef
  • Environmental microbiology: Perspectives for legal and occupational medicine
    Saverio Giampaoli, Federica Alessandrini, Giovanni Vanni Frajese, Giovanni Guglielmi, Adriano Tagliabracci, Andrea Berti
    Legal Medicine.2018; 35: 34.     CrossRef
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Tetrathyridia of Mesocestoides lineatus in Chinese Snakes and Their Adults Recovered from Experimental Animals
Shin-Hyeong Cho, Tong-Soo Kim, Yoon Kong, Byoung-Kuk Na, Woon-Mok Sohn
Korean J Parasitol 2013;51(5):531-536.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.531

Morphological characteristics of Mesocestoides lineatus tetrathyridia collected from Chinese snakes and their adults recovered from experimental animals were studied. The tetrathyridia were detected mainly in the mesentery of 2 snake species, Agkistrodon saxatilis (25%) and Elaphe schrenckii (20%). They were 1.73 by 1.02 mm in average size and had an invaginated scolex with 4 suckers. Adult tapeworms were recovered from 2 hamsters and 1 dog, which were orally infected with 5-10 larvae each. Adults from hamsters were about 32 cm long and those from a dog were about 58 cm long. The scolex was 0.56 mm in average width with 4 suckers of 0.17 by 0.15 mm in average size. Mature proglottids measured 0.29 by 0.91 mm (av.). Ovaries and vitellaria bilobed and located in the posterior portion of proglottids. The cirrus sac was oval-shaped and located median. Testes were follicular, distributed in both lateral fields of proglottids, and 41-52 in number per proglottid. Gravid proglottids were 1.84 by 1.39 mm (av.) with a characteristic paruterine organ. Eggs were 35 by 27 ?m in average size with a hexacanth embryo. These morphological characteristics of adult worms were identical with those of M. lineatus reported previously. Therefore, it has been confirmed that the tetrathyridia detected in 2 species of Chinese snakes are the metacestodes of M. lineatus, and 2 snake species, A. saxatilis and E. schrenckii, play the role of intermediate hosts.

Citations

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  • Gastrointestinal parasites of cats in the Middle East (2000−2023): A literature review
    Mahdi Soroushianfar, Soheil Sadr, Alireza Sazmand, Shiva Dianaty, Javad Khedri, Rolf Karl Schuster, Hassan Borji
    Parasitology International.2024; 102: 102919.     CrossRef
  • Wood mouse (Apodemus sylvaticus L.) as intermediate host for Mesocestoides canislagopodis (Rudolphi, 1810) (Krabbe 1865) in Iceland
    Damien Jouet, Aðalsteinn Örn Snæþórsson, Karl Skírnisson
    Parasitology Research.2023; 122(9): 2119.     CrossRef
  • Squamata reptiles as a potential source of helminth infections when preyed on by companion animals
    Mariaelisa Carbonara, Jairo Alfonso Mendoza-Roldan, Riccardo Paolo Lia, Giada Annoscia, Roberta Iatta, Antonio Varcasia, Giuseppe Conte, Giovanni Benelli, Domenico Otranto
    Parasites & Vectors.2023;[Epub]     CrossRef
  • Molecular identification of Taenia hydatigena and Mesocestoides species based on copro-DNA analysis of wild carnivores in Mongolia
    Gelegbalsan Ulziijargal, Chultemsuren Yeruult, Janchiv Khulan, Choijilsuren Gantsetseg, Toni Wandra, Hiroshi Yamasaki, Myadagsuren Narankhajid
    International Journal for Parasitology: Parasites and Wildlife.2020; 11: 72.     CrossRef
  • Morphological and Molecular Characterization of Post-Larval Pre-Tetrathyridia ofMesocestoidessp. (Cestoda: Cyclophyllidea) from Ground Skink,Scincella lateralis(SAURIA: SCINCIDAE), FROM SOUTHEASTERN OKLAHOMA
    Chris T. McAllister, Vasyl V. Tkach, David Bruce Conn
    Journal of Parasitology.2018; 104(3): 246.     CrossRef
  • ПЕРВЫЕ МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ДАННЫЕ ПО ТЕТРАТИРИДИЯМ РОДА MESOCESTOIDES ОТ КРАСНОЙ ПОЛЕВКИ ИЗ МАГАДАНСКОЙ ОБЛАСТИ, "Паразитология"
    Н. А. Поспехова, В.В. Переверзева, Н.Е. Докучаев
    Паразитология.2018; (5): 382.     CrossRef
  • Occurrence of Mesocestoides canislagopodis (Rudolphi, 1810) (Krabbe, 1865) in mammals and birds in Iceland and its molecular discrimination within the Mesocestoides species complex
    Karl Skirnisson, Damien Jouet, Hubert Ferté, Ólafur K. Nielsen
    Parasitology Research.2016; 115(7): 2597.     CrossRef
  • 12,254 View
  • 111 Download
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Histopathological Changes in Tissues of Bithynia siamensis goniomphalos Incubated in Crude Extracts of Camellia Seed and Mangosteen Pericarp
Ratchadawan Aukkanimart, Thidarut Boonmars, Somchai Pinlaor, Smarn Tesana, Surasit Aunpromma, Chantana Booyarat, Pranee Sriraj, Porntip Laummaunwai, Wiyada Punjaruk
Korean J Parasitol 2013;51(5):537-544.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.537

The present study was performed to observe histopathological changes in tissues of Bithynia siamensis goniomphalos (Gastropoda, Bithyniidae) incubated in crude extract solutions of camellia (Camellia oleifera) seed and mangosteen (Garcinia mangostana) pericarp, and furthermore to estimate the molluscicidal effects of 2 plant substances. Substantial numbers of bithyniid snails were incubated in various concentrations of 2 plant solution for 24 hr. As the positive control, snails incubated in various concentrations of niclosamide, a chemical molluscicide, were used. The histopathological findings were observed in sectioned snail specimens of each experimental and control groups. The results showed that both camellia and mangosteen extracts had molluscicidal effects at 24 hr with 50% lethal concentration (LC50) at concentrations of 0.003 and 0.002 g/ml, respectively, while niclosamide had LC50 at concentrations 0.599 ppm. B. siamensis goniomphalos snail tissues (foot, gill, and digestive system) showed disruption of columnar muscle fibers of the foot, reduction of the length and number of gill cilia, numerous mucous vacuoles, and irregularly shaped of epithelial cells. Irregular apical and calciferous cells, dilatation of the digestive gland tubule, and large hemolymphatic spaces, and irregular apical surfaces, detachment of cilia, and enlargement of lysosomal vacuoles of epidermis were also shown in all groups. By the present study, it is confirmed that 2 plants, camellia and mangosteen, are keeping some substance having molluscicidal effects, and histopathological findings obtained in this study will provide some clues in further studies on their action mechanisms to use them as natural molluscicides.

Citations

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  • Molluscicidal property of symbiotic bacteria associated with entomopathogenic nematodes against Indoplanorbis exustus and Radix rubiginosa, the intermediate hosts of trematode parasites
    Abdulhakam Dumidae, Chanatinart Homkeaw, Chanakan Subkrasae, Jiranun Ardpairin, Supawan Pansri, Raxsina Polseela, Ittipon Phoungpetchara, Tewarat Kumchantuek, Sarunporn Tandhavanan, Aunchalee Thanwisai, Apichat Vitta
    Parasite Epidemiology and Control.2024; 27: e00375.     CrossRef
  • Symbiotic bacteria associated with entomopathogenic nematodes showed molluscicidal activity against Biomphalaria glabrata, an intermediate host of Schistosoma mansoni
    Jiranun Ardpairin, Chanakan Subkrasae, Abdulhakam Dumidae, Supawan Pansri, Chanatinat Homkaew, Wipanee Meesil, Tewarat Kumchantuek, Ittipon Phoungpetchara, Adler R. Dillman, Coralie Pavesi, Helge B. Bode, Sarunporn Tandhavanant, Aunchalee Thanwisai, Apich
    Parasites & Vectors.2024;[Epub]     CrossRef
  • Biocontrol of snail-borne parasites with the glossiphoniid leech, Helobdella austinensis
    Naim Saglam, Diana S. Melissaratos, Daniel H. Shain
    Biology Letters.2023;[Epub]     CrossRef
  • Research progress and management strategies of fungal diseases in Camellia oleifera
    Xingzhou Chen, Yuan He, Zhikai Wang, Anqi Niu, Yi Xue, Diao Zhou, Guoying Zhou, Junang Liu
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Snail-borne parasitic diseases: an update on global epidemiological distribution, transmission interruption and control methods
    Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
    Infectious Diseases of Poverty.2018;[Epub]     CrossRef
  • Toxic effect of clove oil on the survival and histology of various tissues of pestiferous land snail Achatina fulica (Bowdich, 1822)
    Yadnya A. Parvate, Liji Thayil
    Journal of Experimental Biology and Agricultural Sciences.2017; 5(4): 492.     CrossRef
  • Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum
    Fan Yang, Erping Long, Juhua Wen, Lei Cao, Chengcheng Zhu, Huanxin Hu, Ying Ruan, Kamolnetr Okanurak, Huiling Hu, Xiaoxia Wei, Xiangyun Yang, Chaofan Wang, Limei Zhang, Xiaoying Wang, Pengyu Ji, Huanqin Zheng, Zhongdao Wu, Zhiyue Lv
    Parasites & Vectors.2014;[Epub]     CrossRef
  • 10,758 View
  • 138 Download
  • Crossref

Case Reports

An Autochthonous Case of Canine Visceral Leishmaniasis in Korea
Dong Ha Bhang, Ul Soo Choi, Hyun Jeong Kim, Kyoung-Oh Cho, Sung-Shik Shin, Hee-Jeong Youn, Cheol-Yong Hwang, Hwa-Young Youn
Korean J Parasitol 2013;51(5):545-549.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.545

A 12-year-old spayed female mixed-bred dog presented with nasal bleeding of 2 days duration and a skin nodule in the left flank. No abnormalities were found in coagulation profiles and blood pressure. Cytological evaluation of the nodule revealed numerous characteristic round organisms having a nucleus and a bar within macrophages and in the background, consistent with leishmaniasis. In vitro culture was unsuccessful but PCR of the nodular aspirate identified the organisms as Leishmania infantum, and the final diagnosis was canine leishmaniasis. No history of travel to endemic countries was noted. Because the dog had received a blood transfusion 2 years before the illness, serological screening tests were performed in all donor dogs of the commercial blood bank using the commercial Leishmania ELISA test kit, and there were no positive results. Additional 113 dogs with hyperglobulinemia from Seoul were also screened with the same kits but no positive results were obtained. To the best of the author's knowledge this is the first autochthonous case of canine leishmaniasis in Korea.

Citations

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  • Imported case of canine viscerocutaneous leishmaniasis in South Korea: clinical presentation and diagnostic approach in a Labrador Retriever
    Ki-Yeon Son, Gyeong-Gook Park, Joong-Hyun Song
    Journal of Veterinary Science.2025;[Epub]     CrossRef
  • Epidemiological Investigation of Asymptomatic Dogs with Leishmania Infection in Southwestern China Where Visceral Leishmaniasis is Intractable
    Gui-Hua Zhao, Kun Yin, Wei-Xia Zhong, Ting Xiao, Qing-Kuan Wei, Yong Cui, Gong-Zhen Liu, Chao Xu, Hong-Fa Wang
    The Korean Journal of Parasitology.2016; 54(6): 797.     CrossRef
  • Who Neglects Neglected Tropical Diseases? - Korean Perspective
    Min-Ho Choi, Jae-Ran Yu, Sung-Tae Hong
    Journal of Korean Medical Science.2015; 30(Suppl 2): S122.     CrossRef
  • 10,328 View
  • 100 Download
  • Crossref
A Case of Vivax Malaria Complicated by Adult Respiratory Distress Syndrome and Successful Management with Extracorporeal Membrane Oxygenation
Hyun-Jung Lee, Ji-Hyeon Baek, Myoung-Hun Chae, Hoyeon Joo, Jin-Soo Lee, Moon-Hyun Chung, Yun-Kyu Park, Joung-Teak Kim
Korean J Parasitol 2013;51(5):551-555.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.551

Complicated malaria is mainly caused by Plasmodium falciparum, but, increasingly, Plasmodium vivax is also being reported as a cause. Since the reemergence of indigenous vivax malaria in 1993, cases of severe malaria have been steadily reported in Korea. Herein, we report a case of vivax malaria complicated by adult respiratory distress syndrome (ARDS) that was successfully managed with extracorporeal membrane oxygenation (ECMO). A 59-year-old man presented at our hospital with fever and abdominal pain, which had persisted for 10 days. On admission, the patient had impaired consciousness, shock, hypoxia and haziness in both lungs, jaundice, thrombocytopenia and disseminated intravascular coagulation, metabolic acidosis, and acute kidney injury. A peripheral blood smear and a rapid diagnostic test verified P. vivax mono-infection. Ten hours after admission, hypoxia became more severe, despite providing maximal ventilatory support. The administration of antimalarial agents, ECMO, and continuous venovenous hemofiltration resulted in an improvement of his vital signs and laboratory findings. He was discharged from the hospital 7 weeks later, without any sequelae.

Citations

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  • Resolution of experimental malaria-associated acute respiratory distress syndrome is Alox12 independent and shows residual inflammation
    Fran Prenen, Bram De Pauw, Sofie Knoops, Emilie Pollenus, Hendrik Possemiers, Johan Van Weyenbergh, Philippe E. Van den Steen
    Malaria Journal.2025;[Epub]     CrossRef
  • Membrana de oxigenación extracorpórea (ECMO) como terapia puente a la cirugía en paciente con síndrome de distrés respiratorio agudo (SDRA) debido a la rotura de un quiste hidatídico pulmonar
    María Teresa Gómez-Hernández, Ernest J. Martínez, Marta G. Fuentes, Marta Paz, Israel Rodríguez, Nuria M. Novoa, Marcelo F. Jiménez
    Archivos de Bronconeumología.2021; 57(7): 503.     CrossRef
  • Extracorporeal membrane oxygenation (ECMO) as bridge therapy to surgery in a patient with acute respiratory distress syndrome (ARDS) due to rupture of a pulmonary hydatid cyst
    María Teresa Gómez-Hernández, Ernest J. Martínez, Marta G. Fuentes, Marta Paz, Israel Rodríguez, Nuria M. Novoa, Marcelo F. Jiménez
    Archivos de Bronconeumología (English Edition).2021; 57(7): 503.     CrossRef
  • Prevalence and risk factors related to poor outcome of patients with severe Plasmodium vivax infection: a systematic review, meta-analysis, and analysis of case reports
    Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni De Jesus Milanez, Frederick Ramirez Masangkay
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • The emergence of pathogenic TNF/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4
    Bruno Galvão-Filho, Júlia Teixeira de Castro, Maria Marta Figueiredo, Claudio Gonçalves Rosmaninho, Lis Ribeiro do Valle Antonelli, Ricardo Tostes Gazzinelli
    Mucosal Immunology.2019; 12(2): 312.     CrossRef
  • Monocyte-derived dendritic cells in malaria
    Isabella C Hirako, Patrícia A Assis, Bruno Galvão-Filho, Andrew D Luster, Lis RV Antonelli, Ricardo T Gazzinelli
    Current Opinion in Microbiology.2019; 52: 139.     CrossRef
  • Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?
    Marcelo L. M. Pereira, Claudio R. F. Marinho, Sabrina Epiphanio
    Frontiers in Cellular and Infection Microbiology.2018;[Epub]     CrossRef
  • Development of Visually Improved Loop Mediated Isothermal Amplification for the Diagnosis of Plasmodium vivax Malaria in a Tertiary Hospital in Chandigarh, North India
    Hargobinder Kaur, Rakesh Sehgal, Devendra Bansal, Ali A. Sultan, Ashish Bhalla, Sunit C. Singhi
    The American Journal of Tropical Medicine and Hygiene.2018; 98(5): 1374.     CrossRef
  • Severe Plasmodium vivax infection in Korea
    Jae Hyoung Im, Hea Yoon Kwon, JiHyeon Baek, Seong Wook Park, Areum Durey, Kyung Hee Lee, Moon-Hyun Chung, Jin-Soo Lee
    Malaria Journal.2017;[Epub]     CrossRef
  • Respiratory Complications of Plasmodium vivax Malaria: Systematic Review and Meta-Analysis
    Hernando del Portillo, Fernando Val, Wuelton Marcelo Monteiro, Quique Bassat, Kim Machado, Lisiane Barbosa, Jorge Luis Salinas, André Machado Siqueira, Marcus Vinícius Guimarães Lacerda, Maria Graças Costa Alecrim
    The American Journal of Tropical Medicine and Hygiene.2017; 97(3): 733.     CrossRef
  • Extracorporeal Membrane Oxygenation in Dengue, Malaria, and Acute Chagas Disease
    Leonardo A. Salazar, Cornelis M. Schreuder, Jhonathan A. Eslava, Adriana S. Murcia, Mario J. Forero, Mauricio A. Orozco-Levi, Luis E. Echeverría, Anton io Figueredo
    ASAIO Journal.2017; 63(6): e71.     CrossRef
  • Imported Plasmodium vivax malaria with severe thrombocytopaenia: can it be severe malaria or not?
    Spinello Antinori, Alberto Corona, Anna Lisa Ridolfo, Laura Galimberti, Davide Ricaboni, Laura Milazzo, Mario Corbellino
    Malaria Journal.2016;[Epub]     CrossRef
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A Case of Plasmodium ovale wallikeri Infection in a Chinese Worker Returning from West Africa
Yuchun Li, Guangze Wang, Dingwei Sun, Feng Meng, Shigan Lin, Ximin Hu, Shanqing Wang
Korean J Parasitol 2013;51(5):557-562.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.557

In contrast to the gradual reduction in the number of locally transmitted malaria cases in China, the number of imported malaria cases has been increasing since 2008. Here, we report a case of a 39-year-old Chinese man who acquired Plasmodium ovale wallikeri infection while staying in Ghana, West Africa for 6 months in 2012. Microscopic examinations of Giemsa-stained thin and thick blood smears indicated Plasmodium vivax infection. However, the results of rapid diagnostic tests, which were conducted 3 times, were not in agreement with P. vivax. To further check the diagnosis, standard PCR analysis of the small-subunit rRNA gene was conducted, based on which a phylogeny tree was constructed. The results of gene sequencing indicated that this malaria is a variant of P. ovale (P. ovale wallikeri). The infection in this patient was not a new infection, but a relapse of the infection from the one that he had contracted in West Africa.

Citations

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  • Geographical origin of Plasmodium vivax in the Hainan Island, China: insights from mitochondrial genome
    Yuchun Li, Xiaomin Huang, Ling Qing, Wen Zeng, Xiangjie Zeng, Feng Meng, GuangZe Wang, Yan Chen
    Malaria Journal.2023;[Epub]     CrossRef
  • An innovative three-layer strategy in response to a quartan malaria outbreak among forest goers in Hainan Island, China: a retrospective study
    Yuchun Li, Yingjuan Huang, Renqiang Chen, Weizhen Huang, Huanzhi Xu, Rongshen Ye, Shaoling Huang, Ji Zhen, Xiaodan Wen, Guoyi Wang, Yong Liu, Haishan Li, Zaichun Zheng, Jian Wang, Guoshen Wang, Chong Chen, Wen Zeng, Feng Meng, Xiaoming Huang, Guangze Wang
    Infectious Diseases of Poverty.2022;[Epub]     CrossRef
  • High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana
    Charles A. Brown, Prince J. Pappoe-Ashong, Nancy Duah, Anita Ghansah, Harry Asmah, Edwin Afari, Kwadwo A. Koram
    Malaria Journal.2021;[Epub]     CrossRef
  • A comparison of two PCR protocols for the differentiation of Plasmodium ovale species and implications for clinical management in travellers returning to Germany: a 10-year cross-sectional study
    Hagen Frickmann, Christine Wegner, Stefanie Ruben, Ulrike Loderstädt, Egbert Tannich
    Malaria Journal.2019;[Epub]     CrossRef
  • Indel-informed Bayesian analysis suggests cryptic population structure between Plasmodium knowlesi of humans and long-tailed macaques (Macaca fascicularis) in Malaysian Borneo
    JustinJ.S. Wilcox, Abigail Kerschner, Hope Hollocher
    Infection, Genetics and Evolution.2019; 75: 103994.     CrossRef
  • Detection of malaria with light microscopy and Nested polymerase chain reaction (Nested PCR) methods in peripheral blood expansions and investigation of the genetic diversity of Plasmodium species by 18S rRNA gene in Southeast of Iran
    Ahmad Taghdiri, Pooya Ghasemi Nejad Almani, Iraj Sharifi, Mohammad Ali Mohammadi, Samira Salari
    Microbial Pathogenesis.2019; 137: 103782.     CrossRef
  • WITHDRAWN: Indel-informed bayesian analysis suggests cryptic divisions between Plasmodium knowlesi of humans and long-tailed macaques (Macaca fascicularis) in Malaysian Borneo
    Justin J.S. Wilcox, Abigail Kerschner, Hope Hollocher
    Infection, Genetics and Evolution.2018;[Epub]     CrossRef
  • Diagnosis of an imported Plasmodium ovale wallikeri infection in Malaysia
    Jonathan Wee Kent Liew, Rohela Mahmud, Lian Huat Tan, Yee Ling Lau
    Malaria Journal.2016;[Epub]     CrossRef
  • Clinical implications of a gradual dormancy concept in malaria
    Joachim Richter, Gabriele Franken, Martha C. Holtfreter, Susanne Walter, Alfons Labisch, Heinz Mehlhorn
    Parasitology Research.2016; 115(6): 2139.     CrossRef
  • Genetic diversity of Plasmodium vivax population before elimination of malaria in Hainan Province, China
    Yu-Chun Li, Guang-Ze Wang, Feng Meng, Wen Zeng, Chang-hua He, Xi-Min Hu, Shan-Qing Wang
    Malaria Journal.2015;[Epub]     CrossRef
  • Molecular characterization of misidentified Plasmodium ovale imported cases in Singapore
    Jean-Marc Chavatte, Sarah Bee Hui Tan, Georges Snounou, Raymond Tzer Pin Valentine Lin
    Malaria Journal.2015;[Epub]     CrossRef
  • Characterization of Plasmodium ovale curtisi and P. ovale wallikeri in Western Kenya Utilizing a Novel Species-specific Real-time PCR Assay
    Robin H. Miller, Clifford O. Obuya, Elizabeth W. Wanja, Bernhards Ogutu, John Waitumbi, Shirley Luckhart, V. Ann Stewart, Alain Debrabant
    PLOS Neglected Tropical Diseases.2015; 9(1): e0003469.     CrossRef
  • 10,526 View
  • 109 Download
  • Crossref
Molecular Diagnosis of an Ocular Toxocariasis Patient in Vietnam
Nguyen Van De, Nguyen Vu Trung, Le Van Duyet, Jong-Yil Chai
Korean J Parasitol 2013;51(5):563-567.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.563

An ocular Toxocara canis infection is reported for the first time in Vietnam. A 34-year-old man residing in a village of Son La Province, North Vietnam, visited the National Eye Hospital (NEH) in August 2011. He felt a bulge-sticking pain in his left eye and loss of vision occurred over 3 months before visiting the hospital. The eye examination in the hospital showed damage of the left eye, red eye, retinal fibrosis, retinal detachment, inflammation of the eye tissues, retinal granulomas, and a parasitic cyst inside. A larva of Toxocara was collected with the cyst by a medical doctor by surgery. Comparison of 264 nucleotides of internal transcribed spacer 2 (ITS2) of ribosomal DNA was done between our Vietnamese Toxocara canis and other Toxocara geographical isolates, including Chinese T. canis, Japanese T. canis, Sri Lankan T. canis, and Iranian T. canis. The nucleotide homology was 97-99%, when our T. canis was compared with geographical isolates. Identification of a T. canis infection in the eye by a molecular method was performed for the first time in Vietnam.

Citations

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  • Toxocara cati Infection in Cats (Felis catus): A Systematic Review and Meta-Analysis
    Jorge Luis Bonilla-Aldana, Alba Cristina Espinosa-Nuñez, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales
    Animals.2024; 14(7): 1022.     CrossRef
  • An Integrated Coproscopic and Molecular Method Provides Insights into the Epidemiology of Zoonotic Intestinal Helminths of Dogs across Cambodia
    Patsy A. Zendejas-Heredia, Vito Colella, Lucas G. Huggins, Roland Schaper, Bettina Schunack, Rebecca J. Traub, Long-Xian Zhang
    Transboundary and Emerging Diseases.2023; 2023: 1.     CrossRef
  • An overview of human helminthioses in Vietnam: Their prevention, control and lessons learnt
    Hung Manh Nguyen, Dung Trung Do, Stephen E. Greiman, Ha Van Nguyen, Hien Van Hoang, Toan Quoc Phan, Phuc Pham-Duc, Henry Madsen
    Acta Tropica.2023; 238: 106753.     CrossRef
  • A delayed diagnosis of ocular toxocariasis presenting as total monocular retinal detachment in an immunocompetent 57-year-old male
    George W. Jowsey, Gavin X. McLeod
    IDCases.2023; 32: e01764.     CrossRef
  • Molecular and microscopic detection of natural and experimental infections of Toxocara vitulorum in bovine milk
    Amira Dewair, Mohamed Bessat, Jacopo Guccione
    PLOS ONE.2020; 15(5): e0233453.     CrossRef
  • Toxocariasis: a silent threat with a progressive public health impact
    Jia Chen, Quan Liu, Guo-Hua Liu, Wen-Bin Zheng, Sung-Jong Hong, Hiromu Sugiyama, Xing-Quan Zhu, Hany M. Elsheikha
    Infectious Diseases of Poverty.2018;[Epub]     CrossRef
  • Detection of Toxocara canis DNA in tissues of experimentally infected mice
    Micaele Quintana de Moura, Marcia Raquel Pegoraro de Macedo, Wesley Douglas da Silva Terto, Luciana Farias da Costa Avila, Fabio Pereira Leivas Leite, Carlos James Scaini, Natália Berne Pinto, Gabriela de Almeida Capella, Adriane Leites Strothmann, Marcos
    Acta Tropica.2018; 187: 51.     CrossRef
  • Dot enzyme-linked immunosorbent assay (ELISA) for the detection of Toxocara infection using a rat model
    Vachel Gay V. Paller, Cyrelle M. Besana, Isabel Kristine M. Valdez
    Journal of Parasitic Diseases.2017; 41(4): 933.     CrossRef
  • Levels of Toxocara infections in dogs and cats from urban Vietnam together with associated risk factors for transmission
    N. Thi Lan Anh, D. Thi Thu Thuy, D. Huu Hoan, N. Thi Hop, D. Trung Dung
    Journal of Helminthology.2016; 90(4): 508.     CrossRef
  • Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012
    Toan Nguyen, Fei Wen Cheong, Jonathan Wee Kent Liew, Yee Ling Lau
    Parasites & Vectors.2016;[Epub]     CrossRef
  • Field evaluation of a rapid diagnostic test to detect antibodies in human toxocariasis
    P.K.C. Lim, H. Yamasaki, J.W. Mak, S.F. Wong, C.W. Chong, I.K.S. Yap, S. Ambu, V. Kumarasamy
    Acta Tropica.2015; 148: 32.     CrossRef
  • 9,355 View
  • 94 Download
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A Case of Human Pulmonary Dirofilariasis in a 48-Year-Old Korean Man
Hyo Jae Kang, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Jong-Yil Chai, Jinwoo Lee
Korean J Parasitol 2013;51(5):569-572.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.569

Dirofilariasis is a rare disease in humans. We report here a case of a 48-year-old male who was diagnosed with pulmonary dirofilariasis in Korea. On chest radiographs, a coin lesion of 1 cm in diameter was shown. Although it looked like a benign inflammatory nodule, malignancy could not be excluded. So, the nodule was resected by video-assisted thoracic surgery. Pathologically, chronic granulomatous inflammation composed of coagulation necrosis with rim of fibrous tissues and granulations was seen. In the center of the necrotic nodules, a degenerating parasitic organism was found. The parasite had prominent internal cuticular ridges and thick cuticle, a well-developed muscle layer, an intestinal tube, and uterine tubules. The parasite was diagnosed as an immature female worm of Dirofilaria immitis. This is the second reported case of human pulmonary dirofilariasis in Korea.

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  • Human Pulmonary Dirofilariasis: A Review for the Clinicians
    Biplab K Saha, Alyssa Bonnier, Woon Hean Chong, Hau Chieng, Adam Austin, Kurt Hu, Boris Shkolnik
    The American Journal of the Medical Sciences.2022; 363(1): 11.     CrossRef
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    Biplab Saha, Woon Hean Chong, Hau Chieng, Amit Chopra
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    Devin Malik, Akshay Amaraneni, Sukhpreet Singh, Richard Roach
    IDCases.2016; 4: 43.     CrossRef
  • A 72-Year-Old Woman With Previous Pulmonary Metastasis and New Peripheral Nodule
    Giovanni Maria Comacchio, Chiara Giraudo, Nazarena Nannini, Alessandro Rebusso, Roberta Polverosi, Federico Rea, Fiorella Calabrese
    Chest.2015; 148(2): e42.     CrossRef
  • Investigation of Dirofilaria immitis infection in stray dogs from public animal shelters in Seoul
    Neung-Hee Kim, Jeong-Yeon Kwak, Hye-Ra Kim, Hyeong-Suk Park, Doo-Hwan Kim, Ju-Hyung Lee
    Korean Journal of Veterinary Service.2014; 37(3): 197.     CrossRef
  • Orbital Dirofilariasis
    Se Hyun Choi, Namju Kim, Jin Ho Paik, Jaeeun Cho, Jong-Yil Chai
    Korean Journal of Ophthalmology.2014; 28(6): 495.     CrossRef
  • 9,870 View
  • 91 Download
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Brief Communications
Detection of Acute Toxoplasmosis in Pigs Using Loop-Mediated Isothermal Amplification and Quantitative PCR
Yanhua Wang, Guangxiang Wang, Delin Zhang, Hong Yin, Meng Wang
Korean J Parasitol 2013;51(5):573-577.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.573

A loop-mediated isothermal amplification (LAMP) assay allows rapid diagnosis of Toxoplasma gondii infection. In the present study, the LAMP assay was evaluated using blood from both naturally and experimentally infected pigs. The sensitivity of the LAMP assay was compared with that of Q-PCR. Both assays detected T. gondii in the blood of experimentally infected pigs, with 100% agreement. In infected blood samples, the parasite was detected as early as 2 days post-infection and reached a peak in 3-5 days. In 216 field serum samples, the detection rates of LAMP and Q-PCR assays were 6.9% and 7.8%, respectively. This result indicates that the sensitivity of the LAMP assay was slightly lower than that of the Q-PCR assay. However, the LAMP may be an attractive diagnostic method in conditions where sophisticated and expensive equipment is unavailable. This assay could be a powerful supplement to current diagnostic methods.

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  • First report of molecular detection and phylogenetic analysis of Toxoplasma Gondii in soil, water and vegetables from Chandigarh city, India
    Divya Rattan, Priya Datta, Devyani Sharma, Chandra Kanta Bhusal, Rakesh Sehgal
    Scientific Reports.2025;[Epub]     CrossRef
  • Detection of chronic toxoplasmosis in the brain of mice using loop-mediated isothermal amplification (LAMP) and conventional PCR
    Mona K. Hegazy, Nora E. Saleh, Wafaa A. Aboukamar
    Experimental Parasitology.2023; 251: 108556.     CrossRef
  • Immune system roles in pathogenesis, prognosis, control, and treatment of Toxoplasma gondii infection
    Mohammad Mahdi Jafari, Zahra Azimzadeh Tabrizi, Mohammad Saaid Dayer, Nazanin Atieh Kazemi-Sefat, Mahshid Mohtashamifard, Rahimeh Mohseni, Atefeh Bagheri, Saeed Bahadory, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar
    International Immunopharmacology.2023; 124: 110872.     CrossRef
  • Clinical validation of visual LAMP and qLAMP assays for the rapid detection of Toxoplasma gondii
    Zhi Cao, Ke Zhang, Dehua Yin, Qiaoya Zhang, Ying Yu, Jianxin Wen, Hongbo Ni
    Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
  • RAA-Cas12a-Tg: A Nucleic Acid Detection System for Toxoplasma gondii Based on CRISPR-Cas12a Combined with Recombinase-Aided Amplification (RAA)
    Qiao-Ni Ma, Meng Wang, Lai-Bao Zheng, Zi-Qin Lin, Muhammad Ehsan, Xing-Xing Xiao, Xing-Quan Zhu
    Microorganisms.2021; 9(8): 1644.     CrossRef
  • Loop mediated isothermal amplification (LAMP) of Toxoplasma DNA from dried blood spots
    Mona K. Hegazy, Soha I. Awad, Nora E. Saleh, Mamdouh M. Hegazy
    Experimental Parasitology.2020; 211: 107869.     CrossRef
  • Advances in serological, imaging techniques and molecular diagnosis of Toxoplasma gondii infection
    Ali Rostami, Panagiotis Karanis, Shirzad Fallahi
    Infection.2018; 46(3): 303.     CrossRef
  • Molecular detection and phylogenetic analyses ofToxoplasma gondiifrom naturally infected sheep in Northern and Central Tunisia
    Mariem Rouatbi, Yosra Amdouni, Safa Amairia, Mohamed R. Rjeibi, Said Sammoudi, Mourad Rekik, Mohamed Gharbi
    Veterinary Medicine and Science.2017; 3(1): 22.     CrossRef
  • Comparison of PCR assays targeting the multi-copy targets B1 gene and 529 bp repetitive element for detection of Toxoplasma gondii in swine muscle
    Fabrizia Veronesi, Azzurra Santoro, Giovanni Luigi Milardi, Manuela Diaferia, Raffaella Branciari, Dino Miraglia, Attilia Cioffi, Simona Gabrielli, David Ranucci
    Food Microbiology.2017; 63: 213.     CrossRef
  • Molecular detection of Toxoplasma gondii in house sparrow (Passer domesticus) by LAMP and PCR methods in Tehran, Iran
    Amir Abdoli, Abdolhossein Dalimi, Haleh Soltanghoraee, Fatemeh Ghaffarifar
    Journal of Parasitic Diseases.2016; 40(4): 1317.     CrossRef
  • Development and application of loop-mediated isothermal amplification assays based on ITS-1 for rapid detection of Toxoplasma gondii in pork
    Xunhui Zhuo, Bin Huang, Jiaqing Luo, Haijie Yu, Baolong Yan, Yi Yang, Aifang Du
    Veterinary Parasitology.2015; 208(3-4): 246.     CrossRef
  • Diagnosis of toxoplasmosis and typing of Toxoplasma gondii
    Quan Liu, Ze-Dong Wang, Si-Yang Huang, Xing-Quan Zhu
    Parasites & Vectors.2015;[Epub]     CrossRef
  • Loop-Mediated Isothermal Amplification for Rapid and Semiquantitative Detection of Loa loa Infection
    Papa M. Drame, Doran L. Fink, Joseph Kamgno, Jesica A. Herrick, Thomas B. Nutman, M. J. Loeffelholz
    Journal of Clinical Microbiology.2014; 52(6): 2071.     CrossRef
  • 7,577 View
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Seroprevalence of Toxoplasma gondii Infection in Police Dogs in Shenyang, Northeastern China
Cheng-Wu Liu, Na Yang, Jian-Bin He, Ming-Yang Mu, Min Yang, Ning Sun, Hong-Kui Li
Korean J Parasitol 2013;51(5):579-581.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.579

In recent years, worldwide surveys of Toxoplasma gondii infection in dogs have been reported. However, only limited surveys of T. gondii infection in police dogs have been available, including China. In the present study, we report the seroprevalence of T. gondii in police dogs in Shenyang, northeastern China. Sera from 291 police dogs were examined for T. gondii antibodies with the modified agglutination test (MAT), and 30.9% animals were tested seropositive. The results of the present study indicated a relatively high prevalence of T. gondii infection in police dogs in Shenyang, China.

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  • First Sero-Molecular Diagnosis of Toxoplasma gondii and Toxocara spp. Infections in the Police Dogs and Their Trainers in Iran
    Ali Asghari, Shirin Jalili, Nader Azadi
    Acta Parasitologica.2024; 69(3): 1724.     CrossRef
  • Investigation of Toxoplasma gondii Infection in Yunnan Semi-fine Wool Sheep (Ovis aries) and wild Rodents in Yunnan, China
    Zhao Li, Wen-Jie Cheng, Cai-Qin Deng, Meng-Ling Deng, Hai-Bo Peng, Xing-Quan Zhu, Feng-Cai Zou
    Acta Parasitologica.2024; 69(3): 1592.     CrossRef
  • Screening of Toxoplasmosis in Owned and Stray Dogs of District Faisalabad, Pakistan through Latex Agglutination and Indirect ELISA
    Hamidullah, Muhammad Saqib, Muhammad Sohail Sajid, Sabir Hussain, Hafiz Muhammad Rizwan, Khurram Ashfaq, Sadia Ghazanfer, Asif Ali Butt, Mahvish Maqbool, Sibtain Ahmad, Olivier Andre Sparagano
    Pathogens.2022; 11(11): 1307.     CrossRef
  • Toxoplasma gondii infections in dogs: 2009-2020
    Jitender P. Dubey, Fernando H.A. Murata, Camila K. Cerqueira-Cézar, Oliver C.H. Kwok, Yurong Yang, Chunlei Su
    Veterinary Parasitology.2020; 287: 109223.     CrossRef
  • Seroprevalence and Risk Factors of Toxoplasma gondii Infection in Farmed Raccoon Dogs (Nyctereutes procyonoides) in China
    Wen-Bin Zheng, Wei Cong, Junling Hou, Jian-Gang Ma, Xiao-Xuan Zhang, Xing-Quan Zhu, Qing-Feng Meng, Dong-Hui Zhou
    Vector-Borne and Zoonotic Diseases.2017; 17(3): 209.     CrossRef
  • Seroprevalence and risk factors of Toxoplasma gondii infection in stray dogs in northern China
    Xiao-Xuan Zhang, Ya-Nan Cai, Chun-Feng Wang, Jing Jiang, Ying-Tian Xu, Gui-Lian Yang, Quan Zhao
    Parasitology Research.2015; 114(12): 4725.     CrossRef
  • Low prevalence of Neospora caninum and Toxoplasma gondii antibodies in dogs in Jilin, Henan and Anhui Provinces of the People’s Republic of China
    Yurong Yang, Qiongfang Zhang, Yangguang Kong, Yuqing Ying, Oliver Hung Chun Kwok, Hongde Liang, Jitender Prakash Dubey
    BMC Veterinary Research.2014;[Epub]     CrossRef
  • Prevalence of Toxoplasma gondii antibodies in stray and owned dogs of Grenada, West Indies
    Ravindra N. Sharma, Gabriel Ordas, Keshaw Tiwari, Alfred Chikweto, Muhammad Iqbal Bhaiyat, Claude De Allie, Tara Paterson
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    Asian Pacific Journal of Tropical Biomedicine.2014; 4(9): 725.     CrossRef
  • 9,715 View
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Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice
Shin Ae Kang, Mi-Kyung Park, Min Kyoung Cho, Hak Sun Yu
Korean J Parasitol 2013;51(5):583-588.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.583

To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and measured T-helper (Th) cell-related serial cytokine production after infection. At day 5 post infection (PI), most larvae were detected from the lungs, spleen, intestine, and muscle. Expression of thymic stromal lymphopoietin (TSLP) and CCL11 (eotaxin) showed a significant increase in most infected organs, except the intestine. However, expression of the CXCL1 (Gro-α) gene was most highly enhanced in the intestine at day 14 PI. Th1-related cytokine secretion of splenocytes showed increases at day 28 PI, and the level showed a decrease at day 42 PI. Th2-related cytokine secretion of splenocytes also showed an increase after infection; in particular, IL-5 level showed a significant increase at day 14 PI, and the level showed a decrease at day 28 PI. However, levels of Th17-related cytokines, IL-6 and IL-17A, showed gradual increases until day 42 PI. In conclusion, Th1, Th2, and Th17-related cytokine production might be important in immune responses against T. leonina VLM in experimental mice.

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  • Histopathological lesions caused by experimental Toxocara canis and Toxascaris leonina infections in farm mink (Neovison vison)
    Maciej Klockiewicz, Małgorzata Sobczak-Filipiak, Tadeusz Jakubowski, Ewa Długosz
    Journal of Veterinary Research.2019; 63(2): 205.     CrossRef
  • Experimental infection with T. canis and T. leonina in farm mink (Neovison vison)
    Maciej Klockiewicz, Tadeusz Jakubowski, Małgorzata Sobczak-Filipiak, Justyna Bartosik, Ewa Długosz
    Journal of Veterinary Research.2019; 63(2): 197.     CrossRef
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STAT6 Expression and IL-13 Production in Association with Goblet Cell Hyperplasia and Worm Expulsion of Gymnophalloides seoi from C57BL/6 Mice
Jin-Joo Lee, Donghee Kim, Kyoung-Ho Pyo, Min-Ki Kim, Hyo-Jin Kim, Jong-Yil Chai, Eun-Hee Shin
Korean J Parasitol 2013;51(5):589-594.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.589

In intestinal helminth infections, Th2 immune respones are generally associated with mucin secretion for worm expulsion from the host intestine. In particular, IL-4 and IL-13 are the important cytokines related with intestinal mucus production via STAT6 signalling in nematode infections. However, this perspective has never been studied in Gymnophalloides seoi infection. The present study aimed to observe the STAT6 signalling and cytokine responses in C57BL/6 mice, a mouse strain resistant to infection with this trematode. The results showed that worm expulsion occurred actively during days 1-2 post-infection (PI), when goblet cells began to proliferate in the small intestine. The STAT6 gene expression in the mouse spleen became remarkable from day 2 PI. Moreover, G. seoi infection induced a significant increase of IL-13 from day 4 PI in the spleen of infected mice. Our results suggested that goblet cell hyperplasia and worm expulsion in G. seoi-infected mice should be induced by STAT6 signalling, in which IL-13 may be involved as a dominant triggering cytokine.

Citations

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  • Immune Regulation of Goblet Cell and Mucus Functions in Health and Disease
    Jenny K. Gustafsson, Gunnar C. Hansson
    Annual Review of Immunology .2025; 43(1): 169.     CrossRef
  • The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis
    Franziska Bayer, Olga Dremova, My Phung Khuu, Könül Mammadova, Giulia Pontarollo, Klytaimnistra Kiouptsi, Natalia Soshnikova, Helen Louise May-Simera, Kristina Endres, Christoph Reinhardt
    Nutrients.2021; 13(7): 2198.     CrossRef
  • Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
    Songwei Yang, Min Yu
    Journal of Inflammation Research.2021; Volume 14: 3171.     CrossRef
  • The relationship between intestinal goblet cells and the immune response
    Mingming Zhang, Chenchen Wu
    Bioscience Reports.2020;[Epub]     CrossRef
  • Developmental expression of STATs, nuclear factor-κB and inflammatory genes in the jejunum of piglets during weaning
    Hongbo Yi, Denghu Jiang, Lin Zhang, Haitao Xiong, Feifei Han, Yizhen Wang
    International Immunopharmacology.2016; 36: 199.     CrossRef
  • Increased Intestinal Epithelial Cell Turnover and Intestinal Motility in Gymnophalloides seoi-Infected C57BL/6 Mice
    Sang Hyub Lee, Bong-Kwang Jung, Jae-Hwan Park, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2014; 52(3): 273.     CrossRef
  • 8,961 View
  • 88 Download
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Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai
Korean J Parasitol 2013;51(5):595-597.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.595

In December 2011, we reported an autochthonous case of Echinococcus multilocularis infection in a 42-year-old woman in Korea. The diagnosis was based on histopathological findings of the surgically resected liver cyst. In the present study, we evaluated the serological and molecular characteristics of this Korean E. multilocularis case. The patient's serum strongly reacted with affinity-purified native Em18 and recombinant Em18 antigens (specific for E. multilocularis) but negative for recombinant antigen B8/1 (reactive for Echinococcus granulosus). In immunoaffinity chromatography, the serum also strongly reacted with E. multilocularis and only weakly positive for E. granulosus. We determined the whole nucleotide sequence of cox1 (1,608 bp) using the paraffin-embedded cystic tissue which was compared with E. multilocularis isolates from China, Japan, Kazakhstan, Austria, France, and Slovakia. The Korean case showed 99.8-99.9% similarity with isolates from Asia (the highest similarity with an isolate from Sichuan, China), whereas the similarity with European isolates ranged from 99.5 to 99.6%.

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  • Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
    Sven Baumann, Rong Shi, Wenya Liu, Haihua Bao, Julian Schmidberger, Wolfgang Kratzer, Weixia Li, Thomas F. E. Barth, Sven Baumann, Johannes Bloehdorn, Iris Fischer, Tilmann Graeter, Natalja Graf, Beate Gruener, Doris Henne-Bruns, Andreas Hillenbrand, Tanj
    Infection.2019; 47(5): 703.     CrossRef
  • Lasiopodomys fuscus as an important intermediate host for Echinococcus multilocularis: isolation and phylogenetic identification of the parasite
    Qi-Gang Cai, Xiu-Min Han, Yong-Hai Yang, Xue-Yong Zhang, Li-Qing Ma, Panagiotis Karanis, Yong-Hao Hu
    Infectious Diseases of Poverty.2018;[Epub]     CrossRef
  • Assessment of the global pattern of genetic diversity in Echinococcus multilocularis inferred by mitochondrial DNA sequences
    Adel Spotin, Belgees Boufana, Ehsan Ahmadpour, Adriano Casulli, Mahmoud Mahami-Oskouei, Soheila Rouhani, Amirreza Javadi-Mamaghani, Firooz Shahrivar, Paria Khoshakhlagh
    Veterinary Parasitology.2018; 262: 30.     CrossRef
  • The echinococcoses in Asia: The present situation
    Akira Ito, Christine M. Budke
    Acta Tropica.2017; 176: 11.     CrossRef
  • 8,868 View
  • 98 Download
  • Crossref
Human Neurocysticercosis Case and an Endemic Focus of Taenia solium in Lao PDR
Hyeong-Kyu Jeon, Tai-Soon Yong, Woon-Mok Sohn, Jong-Yil Chai, Duk-Young Min, Han-Jong Rim, Bounnaloth Insisiengmay, Keeseon S. Eom
Korean J Parasitol 2013;51(5):599-602.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.599

A male patient with neurocysticercosis was identified in Montai Village, Xay District, Oudomxay Province, Lao PDR in February 2004. He had a history of diagnosis for neurocysticercosis by a CT scan in Thailand after an onset of epileptic seizure in 1993. A pig in the same district was found to contain Taenia solium metacestodes (=cysticerci); the slaughtered pig body contained more than 2,000 cysticerci. In addition to morphological identification, molecular identification was also performed on the cysticerci by DNA sequencing analysis of the mitochondrial cox1 gene; they were confirmed as T. solium metacestodes. The patient is regarded as an indigenous case of neurocysticercosis infected in an endemic focus of T. solium taeniasis/cysticercosis in Oudomxay Province, Lao PDR.

Citations

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  • The challenges of detecting Taenia solium and neurocysticercosis in low and middle‐income countries: A scoping review of Lao People's Democratic Republic
    Andrew Larkins, Sarah Keatley, Bounnaloth Insisiengmay, Rattanaxay Phetsouvanh, Mieghan Bruce, Amanda Ash
    Tropical Medicine & International Health.2023; 28(5): 344.     CrossRef
  • A Spatial Autocorrelation Method for Taenia solium Risk Mapping: The Case of Lao PDR
    Andrew Larkins, Mieghan Bruce, Amanda Ash
    Tropical Medicine and Infectious Disease.2023; 8(4): 221.     CrossRef
  • Risk mapping for Taenia solium: Applying multicriteria decision analysis in Lao PDR
    Andrew Larkins, Mieghan Bruce, Rattanxay Phetsouvanh, Amanda Ash
    Tropical Medicine & International Health.2023; 28(9): 736.     CrossRef
  • Taeniasis and cysticercosis in Asia: A review with emphasis on molecular approaches and local lifestyles
    Akira Ito, Tiaoying Li, Toni Wandra, Paron Dekumyoy, Tetsuya Yanagida, Munehiro Okamoto, Christine M Budke
    Acta Tropica.2019; 198: 105075.     CrossRef
  • Improved methods to capture the total societal benefits of zoonotic disease control: Demonstrating the cost-effectiveness of an integrated control programme for Taenia solium, soil transmitted helminths and classical swine fever in northern Lao PDR
    Walter O. Okello, Anna L. Okello, Phouth Inthavong, Tassilo Tiemann, Ammaly Phengsivalouk, Brecht Devleesschauwer, Alexandra Shaw, John Allen, Agnes Fleury
    PLOS Neglected Tropical Diseases.2018; 12(9): e0006782.     CrossRef
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    Hai-Wei Wu, Akira Ito, Lin Ai, Xiao-Nong Zhou, Luz P. Acosta, Arve Lee Willingham III
    Acta Tropica.2017; 165: 121.     CrossRef
  • Needs of exploring the burden of recent onset seizures due to neurocysticercosis and challenges in southeast Asia focusing on scenario in Malaysia
    Priyadarshi S. Sahu, Yvonne A.L. Lim, Rohela Mahmud, Sushela D. Somanath, Chong T. Tan, C.P. Ramachandran
    Asian Pacific Journal of Tropical Medicine.2017; 10(4): 332.     CrossRef
  • Neurocysticercosis: A case study of a Mongolian traveler who visited China and India with an updated review in Asia
    Anu Davaasuren, Abmed Davaajav, Baigalmaa Ukhnaa, Altantsetseg Purvee, Saraa Unurkhaan, Amartuvshin Luvsan, Jenae E. Logan, Akira Ito
    Travel Medicine and Infectious Disease.2017; 20: 31.     CrossRef
  • A Case of Cerebral Cysticercosis in Thailand
    Samasuk Thammachantha, Ratana Kunnatiranont, Pongwat Polpong
    The Korean Journal of Parasitology.2016; 54(6): 793.     CrossRef
  • Cultural drivers and health-seeking behaviours that impact on the transmission of pig-associated zoonoses in Lao People’s Democratic Republic
    Stephanie Burniston, Anna L Okello, Boualam Khamlome, Phouth Inthavong, Jeffrey Gilbert, Stuart D Blacksell, John Allen, Susan C Welburn
    Infectious Diseases of Poverty.2015;[Epub]     CrossRef
  • Prevalence of Endemic Pig-Associated Zoonoses in Southeast Asia: A Review of Findings from the Lao People's Democratic Republic
    Anna L. Okello, Stephanie Burniston, James V. Conlan, Phouth Inthavong, Boualam Khamlome, Susan C. Welburn, Jeffrey Gilbert, John Allen, Stuart D. Blacksell
    The American Journal of Tropical Medicine and Hygiene.2015; 92(5): 1059.     CrossRef
  • 9,756 View
  • 125 Download
  • Crossref
Intestinal Parasites among Wild Rodents in Northern Gangwon-do, Korea
Young-Il Lee, Hee-Jang Pyeon, Min Seo
Korean J Parasitol 2013;51(5):603-606.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.603

To determine geographical patterns of natural parasite infections among wild rodents, a total of 46 wild rodents from 3 different localities in northern Gangwon-do (Province), Korea were examined for intestinal parasite infections. Along with nematodes such as hookworms and Syphacia spp., Plagiorchis muris (2 specimens) (Trematoda) were collected from striped field mice, Apodemus agrarius. In a Korean wood mouse, Apodemus peninsulae, the overall nematode infections were similar to A. agrarius, but an adult worm of Echinostoma hortense (Trematoda) was collected. In addition, 2 species of cestodes, i.e., Hymenolepis nana and Hymenolepis diminuta, were collected from A. agrarius. Through this survey, A. agrarius and A. peninsule were confirmed as the natural definite hosts for zoonotic intestinal helminths, i.e., P. muris, E. hortense, H. nana, and H. diminuta, in northern Gangwon-do, Korea. Considering increased leisure activities around these areas, seasonal and further comprehensive surveys on wild rodents seem to be needed to prevent zoonotic parasite infections.

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    Biologia.2022; 78(1): 119.     CrossRef
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    Soo Lim Kim, Jun Ho Choi, Myung-hee Yi, Seogwon Lee, Myungjun Kim, Singeun Oh, In-Yong Lee, Bo-Young Jeon, Tai-Soon Yong, Ju Yeong Kim
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    Tropical Natural History.2022; 22: 119.     CrossRef
  • The fauna and perspective of rodentia ectoparasites in Iran relying on their roles within public health and veterinary characteristics
    Mousa khosravani
    Journal of Parasitic Diseases.2018; 42(1): 1.     CrossRef
  • Infections of Intestinal Helminth at Two Species of Field Mice, Apodemus agrarius and A. Peninsulae, in Gangwondo and Chungcheongnam-do, Korea
    Jae-Hyung Lee, Shuang Gong, Yung Chul Park, Hyun-Ju Kim, In-Wook Choi, Young-Ha Lee
    The Korean Journal of Parasitology.2018; 56(3): 301.     CrossRef
  • Study of Internal Parasites of Rodents in Ahvaz, South-West of Iran
    Mahmoud Rahdar, Elham-Al- Sadat Roointan, Babak Vazirianzadeh, Alireza Alborzi
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