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Volume 52(5); October 2014

Original Articles

Degradation of the Transcription Factors NF-κB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
Kyeong Ah Kim, Arim Min, Young Ah Lee, Myeong Heon Shin
Korean J Parasitol 2014;52(5):459-469.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.459

Entamoeba histolytica is a tissue-invasive protozoan parasite causing dysentery in humans. During infection of colonic tissues, amoebic trophozoites are able to kill host cells via apoptosis or necrosis, both of which trigger IL-8-mediated acute inflammatory responses. However, the signaling pathways involved in host cell death induced by E. histolytica have not yet been fully defined. In this study, we examined whether calpain plays a role in the cleavage of pro-survival transcription factors during cell death of colonic epithelial cells, induced by live E. histolytica trophozoites. Incubation with amoebic trophozoites induced activation of m-calpain in a time- and dose-dependent manner. Moreover, incubation with amoebae resulted in marked degradation of STAT proteins (STAT3 and STAT5) and NF-κB (p65) in Caco-2 cells. However, IκB, an inhibitor of NF-κB, was not cleaved in Caco-2 cells following adherence of E. histolytica. Entamoeba-induced cleavage of STAT proteins and NF-κB was partially inhibited by pretreatment of cells with a cell-permeable calpain inhibitor, calpeptin. In contrast, E. histolytica did not induce cleavage of caspase-3 in Caco-2 cells. Furthermore, pretreatment of Caco-2 cells with a calpain inhibitor, calpeptin (but not the pan-caspase inhibitor, z-VAD-fmk) or m-calpain siRNA partially reduced Entamoeba-induced DNA fragmentation in Caco-2 cells. These results suggest that calpain plays an important role in E. histolytica-induced degradation of NF-κB and STATs in colonic epithelial cells, which ultimately accelerates cell death.

Citations

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    Yong Du, Shaoqiu Jiang, Lujia Feng, Jing Lu, Hui Peng, Xiyuan Zhou
    Scientific Reports.2025;[Epub]     CrossRef
  • CAPN5 attenuates cigarette smoke extract-induced apoptosis and inflammation in BEAS-2B cells
    Herui Li, Yiming Ma, Tiao Li, Zihang Zeng, Lijuan Luo, Xiangming Liu, Yi Li, Yan Chen
    Tobacco Induced Diseases.2024; 22(April): 1.     CrossRef
  • miR-146a-5p promotes epithelium regeneration against LPS-induced inflammatory injury via targeting TAB1/TAK1/NF-κB signaling pathway
    Xingping Chen, Weite Li, Ting Chen, Xiaohui Ren, Jiahao Zhu, Fangxin Hu, Junyi Luo, Lipeng Xing, Hao Zhou, Jiajie Sun, Qingyan Jiang, Yongliang Zhang, Qianyun Xi
    International Journal of Biological Macromolecules.2022; 221: 1031.     CrossRef
  • The NF-κB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites
    Attinder Chadha, Kris Chadee
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • Entamoeba histolytica activation of caspase-1 degrades cullin that attenuates NF-κB dependent signaling from macrophages
    Attinder Chadha, France Moreau, Shanshan Wang, Antoine Dufour, Kris Chadee, Dario S. Zamboni
    PLOS Pathogens.2021; 17(9): e1009936.     CrossRef
  • Entamoeba histolytica Up-Regulates MicroRNA-643 to Promote Apoptosis by Targeting XIAP in Human Epithelial Colon Cells
    Itzel López-Rosas, César López-Camarillo, Yarely M. Salinas-Vera, Olga N. Hernández-de la Cruz, Carlos Palma-Flores, Bibiana Chávez-Munguía, Osbaldo Resendis-Antonio, Nancy Guillen, Carlos Pérez-Plasencia, María Elizbeth Álvarez-Sánchez, Esther Ramírez-Mo
    Frontiers in Cellular and Infection Microbiology.2019;[Epub]     CrossRef
  • Gene Profile Expression Related to Type I Interferons in HT-29 Cells Exposed to Cryptosporidium parvum
    Seyede Manizhe Heidarnejadi, Abdollah Rafiei, Manoochehr Makvandi, Majid Pirestani, Jasem Saki, Ataallah Ghadiri
    Jundishapur Journal of Microbiology.2018;[Epub]     CrossRef
  • O-deGlcNAcylation is required for Entamoeba histolytica-induced HepG2 cell death
    Young Ah Lee, Arim Min, Myeong Heon Shin
    Microbial Pathogenesis.2018; 123: 285.     CrossRef
  • Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses
    Bruno M. Di Genova, Renata R. Tonelli
    Frontiers in Microbiology.2016;[Epub]     CrossRef
  • 11,208 View
  • 110 Download
  • 11 Web of Science
  • Crossref
Molecular Characterization of Various Trichomonad Species Isolated from Humans and Related Mammals in Indonesia
Mudyawati Kamaruddin, Masaharu Tokoro, Md. Moshiur Rahman, Shunsuke Arayama, Anggi P.N. Hidayati, Din Syafruddin, Puji B.S. Asih, Hisao Yoshikawa, Ei Kawahara
Korean J Parasitol 2014;52(5):471-478.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.471

Trichomonad species inhabit a variety of vertebrate hosts; however, their potential zoonotic transmission has not been clearly addressed, especially with regard to human infection. Twenty-one strains of trichomonads isolated from humans (5 isolates), pigs (6 isolates), rodents (6 isolates), a water buffalo (1 isolate), a cow (1 isolate), a goat (1 isolate), and a dog (1 isolate) were collected in Indonesia and molecularly characterized. The DNA sequences of the partial 18S small subunit ribosomal RNA (rRNA) gene or 5.8S rRNA gene locus with its flanking regions (internal transcribed spacer region, ITS1 and ITS2) were identified in various trichomonads; Simplicimonas sp., Hexamastix mitis, and Hypotrichomonas sp. from rodents, and Tetratrichomonas sp. and Trichomonas sp. from pigs. All of these species were not detected in humans, whereas Pentatrichomonas hominis was identified in humans, pigs, the dog, the water buffalo, the cow, and the goat. Even when using the high-resolution gene locus of the ITS regions, all P. hominis strains were genetically identical; thus zoonotic transmission between humans and these closely related mammals may be occurring in the area investigated. The detection of Simplicimonas sp. in rodents (Rattus exulans) and P. hominis in water buffalo in this study revealed newly recognized host adaptations and suggested the existence of remaining unrevealed ranges of hosts in the trichomonad species.

Citations

Citations to this article as recorded by  Crossref logo
  • 18S rRNA gene metabarcoding for investigation of gastrointestinal parasite diversity in great cormorants
    Subin Lee, Badriah Alkathiri, Chang Hyeon Lee, Heon Woo Lee, Dong-Hyuk Jeong, Ju Yeong Kim, Seongjun Choe, Seung-Hun Lee
    Scientific Reports.2025;[Epub]     CrossRef
  • Spatial composition differences and diversity of gut eukaryotes in white-lipped deer in Xizang, China
    Yuangang Yang, Wei Luo, Peng Luo, Mingkun He, Feng Jiang, Jianli Xiong, Zhangqiang You
    Zoologia (Curitiba).2025;[Epub]     CrossRef
  • Development of a novel one-tube LAMP-CRISPR/Cas12b technique for detecting Pentatrichomonas hominis
    Qing-Xin Fan, Jin-Long Wang, Yao Liang, Yu-Xuan Wang, Han-Dan Xiao, Xing-Quan Zhu, Qing Liu
    Microchemical Journal.2025; 215: 114488.     CrossRef
  • Aspects of Genetic Diversity, Host Specificity and Public Health Significance of Single‐Celled Intestinal Parasites Commonly Observed in Humans and Mostly Referred to as ‘Non‐Pathogenic’
    Christen Rune Stensvold
    APMIS.2025;[Epub]     CrossRef
  • Prevalence of intestinal trichomonads in captive non-human primates in China
    Ping-Ping Ma, Yang Zou, Wen-Jie Mu, Yue-Yue Zhang, Ya-Qi Li, Zhong-Li Liu, Long Zhang, Li-Xian Chen, Guo-Hua Liu, Shuai Wang
    Parasite.2024; 31: 19.     CrossRef
  • Development of an LFD-RPA Assay for Rapid Detection of Pentatrichomonas hominis Infection in Dogs
    Yao Rong, Xichen Zhang, Xuejiao Chen, Jianhua Li, Pengtao Gong, Xiaocen Wang, Xin Li, Xu Zhang, Taotao Yue, Hongbo Zhang, Xiaofei Zhou, Nan Zhang
    Current Issues in Molecular Biology.2023; 45(11): 9252.     CrossRef
  • Prevalence and molecular characterization of Pentatrichomonas hominis in Siberian tigers (Panthera tigris altaica) in northeast China
    Hongbo ZHANG, Nan ZHANG, Pengtao GONG, Shuqin CHENG, Xiaocen WANG, Xin LI, Zhijun HOU, Chang LIU, Tianqi BI, Bobo WANG, Yidan CHENG, Jianhua LI, Xichen ZHANG
    Integrative Zoology.2022; 17(4): 543.     CrossRef
  • Pentatrichomonas hominis and other intestinal parasites in school-aged children: coproscopic survey
    Sarah Mohamed Abdo, Marwa Mohamed Ibrahim Ghallab, Nagwa Mohammed Elhawary, Heba Elhadad
    Journal of Parasitic Diseases.2022; 46(3): 896.     CrossRef
  • Occurrence and Genetic Diversity of the Zoonotic Enteric Protozoans and Enterocytozoon bieneusi in Père David’s Deer (Elaphurus davidianus) from Beijing, China
    Peiyang Zhang, Qingxun Zhang, Shuyi Han, Guohui Yuan, Jiade Bai, Hongxuan He
    Pathogens.2022; 11(11): 1223.     CrossRef
  • Molecular identification of Pentatrichomonas hominis in animals in central and western Thailand
    Aongart Mahittikorn, Ruenruetai Udonsom, Khuanchai Koompapong, Rachatawan Chiabchalard, Chantira Sutthikornchai, Preeyaporn Monatrakul Sreepian, Hirotake Mori, Supaluk Popruk
    BMC Veterinary Research.2021;[Epub]     CrossRef
  • Prevalence of Tetratrichomonas buttreyi and Pentatrichomonas hominis in yellow cattle, dairy cattle, and water buffalo in China
    Wen-Chao Li, Jia-min Huang, Zhui Fang, Qi Ren, Li Tang, Zhen-zhen Kan, Xin-chao Liu, You-fang Gu
    Parasitology Research.2020; 119(2): 637.     CrossRef
  • Protozoan genital invasions caused by the representatives of trichomonas and giardia
    Pavlo V. Fedorych, Gennadiy I. Mavrov, Tetiana V. Osinska, Yuliia V. Shcherbakova
    Wiadomości Lekarskie.2020; 73(2): 380.     CrossRef
  • Molecular prevalence of trichomonad species from pet shop puppies and kittens in Japan
    Naoyuki Itoh, Yuko Iijima, Isao Ogura, Natsumi Yonekura, Satoshi Kameshima, Yuya Kimura
    Revista Brasileira de Parasitologia Veterinária.2020;[Epub]     CrossRef
  • Three monophyletic clusters in Retortamonas species isolated from vertebrates
    Joko Hendarto, Tetsushi Mizuno, Anggi P.N. Hidayati, Ismail E. Rozi, Puji B.S. Asih, Din Syafruddin, Hisao Yoshikawa, Makoto Matsubayashi, Masaharu Tokoro
    Parasitology International.2019; 69: 93.     CrossRef
  • Possible pathogenicity of commensal Entamoeba hartmanni revealed by molecular screening of healthy school children in Indonesia
    Takahiro Matsumura, Joko Hendarto, Tetsushi Mizuno, Din Syafruddin, Hisao Yoshikawa, Makoto Matsubayashi, Taro Nishimura, Masaharu Tokoro
    Tropical Medicine and Health.2019;[Epub]     CrossRef
  • Use of nested PCR for the detection of trichomonads in bronchoalveolar lavage fluid
    Chao Lin, Furong Ying, Yanan Lai, Xiaolong Li, Xiangyang Xue, Tieli Zhou, Dongwei Hu
    BMC Infectious Diseases.2019;[Epub]     CrossRef
  • A survey of gastrointestinal parasites of goats in a goat market in Kathmandu, Nepal
    Tirth Raj Ghimire, Namita Bhattarai
    Journal of Parasitic Diseases.2019; 43(4): 686.     CrossRef
  • High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients
    Nan Zhang, Hongbo Zhang, Yanhui Yu, Pengtao Gong, Jianhua Li, Ziyi Li, Ting Li, Zhanjie Cong, Chunying Tian, Xiaofeng Liu, Xiuyan Yu, Xichen Zhang
    Parasites & Vectors.2019;[Epub]     CrossRef
  • Meta-taxonomic analysis of prokaryotic and eukaryotic gut flora in stool samples from visceral leishmaniasis cases and endemic controls in Bihar State India
    Rachael Lappan, Cajsa Classon, Shashi Kumar, Om Prakash Singh, Ricardo V. de Almeida, Jaya Chakravarty, Poonam Kumari, Sangeeta Kansal, Shyam Sundar, Jenefer M. Blackwell, Guy Caljon
    PLOS Neglected Tropical Diseases.2019; 13(9): e0007444.     CrossRef
  • Occurrence of Blastocystis sp. and Pentatrichomonas hominis in sheep and goats in China
    Wen Chao Li, Kai Wang, Youfang Gu
    Parasites & Vectors.2018;[Epub]     CrossRef
  • Simplicimonas- like DNA in vaginal swabs of cows and heifers cross-reacting in the real-time PCR for T. foetus
    Caroline F. Frey, Norbert Müller, Norbert Stäuber, Nelson Marreros, Larissa Hofmann, Brigitte Hentrich, Gaby Hirsbrunner
    Veterinary Parasitology.2017; 237: 30.     CrossRef
  • Report of the first clinical case of intestinal trichomoniasis caused by Tritrichomonas foetus in a cat with chronic diarrhoea in Brazil
    Aline S. Hora, Samantha I. Miyashiro, Fabiana C. Cassiano, Paulo E. Brandão, Archivaldo Reche-Junior, Hilda F. J. Pena
    BMC Veterinary Research.2017;[Epub]     CrossRef
  • Detection of Dientamoeba fragilis in animal faeces using species specific real time PCR assay
    Douglas Chan, Joel Barratt, Tamalee Roberts, Owen Phillips, Jan Šlapeta, Una Ryan, Deborah Marriott, John Harkness, John Ellis, Damien Stark
    Veterinary Parasitology.2016; 227: 42.     CrossRef
  • Human Blastocystis subtyping with subtype-specific primers developed from unique sequences of the SSU rRNA gene
    Hisao Yoshikawa, Ayana Iwamasa
    Parasitology International.2016; 65(6): 785.     CrossRef
  • Molecular and morphological diversity of the genus Hypotrichomonas (Parabasalia: Hypotrichomonadida), with descriptions of six new species
    Vít Céza, Tomáš Pánek, Pavla Smejkalová, Ivan Čepička
    European Journal of Protistology.2015; 51(2): 158.     CrossRef
  • 13,729 View
  • 153 Download
  • 22 Web of Science
  • Crossref
Prevalence of Cryptosporidium-Associated Diarrhea in a High Altitude-Community of Saudi Arabia Detected by Conventional and Molecular Methods
Yousry Hawash, Laila Sh. Dorgham, Ayman S. Al-Hazmi, Mohammed S. Al-Ghamdi
Korean J Parasitol 2014;52(5):479-485.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.479

Cryptosporidium diarrhea represents a relevant clinical problem in developing countries. In Al-Taif, a city of Saudi Arabia that lies at an altitude of an around 2 km above the sea level, Cryptosporidium infection seems to be undiagnosed in nearly all clinical laboratories. Furthermore, nothing was published regarding Cryptosporidium-associated diarrhea in this area. The
objective
s of this research were to (1) determine the Cryptosporidium prevalence among patients with diarrhea and (2) to estimate the performances of 3 different diagnostic methods. Total 180 diarrheal fecal samples, 1 sample per patient, were collected between January and August 2013. Samples were screened for Cryptosporidium with modified Zeihl Neelsen (ZN) microscopy, RIDA® Quick lateral flow (LF) immunotest, and a previously published PCR. The Cryptosporidium prevalence rate was 9.4% (17/180), 10% (18/180), and 11.6% (21/180) by microscopy, LF, and PCR test, respectively. Infection was significantly (P=0.004) predominant among children <5 years (22%) followed by children 5-9 years (11.1%). Although infection was higher in males than in females (16.2% males and 8.5% females), the difference was not statistically significant (P=0.11). Compared to PCR, the sensitivity of microscopy and the LF test were 80.9%, 85.7%, respectively. To conclude, high Cryptosporidium-associated diarrhea was found in this area especially in children ≤9 years. The PCR test showed the best performance followed by the LF test and ZN staining microscopy. The primary health care providers in Al-Taif need to be aware of and do testing for this protozoon, particularly for children seen with diarrhea.

Citations

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  • Intestinal Parasitic Infections Among Pediatric Patients in a Metropolitan City of Bangladesh With Emphasis on Cryptosporidiosis
    Nusrat Jahan Nipa, Nasima Aktar, Hasina M Hira, Farhana Akter, Dilshad Jahan, Salequl Islam, Ayukafangha Etando, Adnan Abdullah, Kona Chowdhury, Rahnuma Ahmad, Ahsanul Haq, Mainul Haque
    Cureus.2022;[Epub]     CrossRef
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    Shahira A. Ahmed, Panagiotis Karanis
    International Journal of Environmental Research and Public Health.2020; 17(18): 6824.     CrossRef
  • Foodborne intestinal protozoan infection and associated factors among patients with watery diarrhea in Northern Ethiopia; a cross-sectional study
    Birhane Berhe, Gessessew Bugssa, Sena Bayisa, Megbaru Alemu
    Journal of Health, Population and Nutrition.2018;[Epub]     CrossRef
  • Human cryptosporidiosis in Iran: a systematic review and meta-analysis
    Reza Berahmat, Adel Spotin, Ehsan Ahmadpour, Mahmoud Mahami-Oskouei, Azim Rezamand, Nayyereh Aminisani, Morteza Ghojazadeh, Roghayeh Ghoyounchi, Tahereh Mikaeili-Galeh
    Parasitology Research.2017; 116(4): 1111.     CrossRef
  • Cryptosporidium and Giardia Infections in Children
    Blandina T. Mmbaga, Eric R. Houpt
    Pediatric Clinics of North America.2017; 64(4): 837.     CrossRef
  • High Frequency of Enteric Protozoan, Viral, and Bacterial Potential Pathogens in Community-Acquired Acute Diarrheal Episodes: Evidence Based on Results of Luminex Gastrointestinal Pathogen Panel Assay
    Yousry A. Hawash, Khadiga A. Ismail, Mazen Almehmadi
    The Korean Journal of Parasitology.2017; 55(5): 513.     CrossRef
  • Assessment of microscopic and molecular tools for the diagnosis and follow-up of cryptosporidiosis in patients at risk
    Y. Le Govic, K. Guyot, G. Certad, A. Deschildre, R. Novo, C. Mary, B. Sendid, E. Viscogliosi, L. Favennec, E. Dei-Cas, E. Fréalle, E. Dutoit
    European Journal of Clinical Microbiology & Infectious Diseases.2016; 35(1): 137.     CrossRef
  • Genetic characterization of Cryptosporidium in animal and human isolates from Jordan
    Nawal Hijjawi, Rami Mukbel, Rongchang Yang, Una Ryan
    Veterinary Parasitology.2016; 228: 116.     CrossRef
  • 10,957 View
  • 110 Download
  • 13 Web of Science
  • Crossref
IgG Avidity Antibodies against Toxoplasma gondii in High Risk Females of Reproductive Age Group in India
Naushaba Siddiqui, Fatima Shujatullah, Haris M. Khan, Tamkin Rabbani, Parvez A. Khan
Korean J Parasitol 2014;52(5):487-491.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.487

Toxoplasma gondii is an obligate intracellular protozoan that is distributed worldwide. Recently, several tests for avidity of Toxoplasma IgG antibodies have been introduced to help discriminate between recently acquired and distant infections. The study was conducted in Jawaharlal Nehru Medical College and Hospital, India from February 2011 to September 2012. Serum specimens were subjected to Toxoplasma IgM ELISA and IgG avidity ELISA test. Out of 48 patients with abortions, 17 (35.4%) were positive for IgM ELISA, and 8 (16.6%) had low IgG avidity antibodies. Out of 48 patients with other obstetric problems, 23 (47.9%) were positive for IgM ELISA, and 17 (35.4%) had low IgG avidity antibodies. Combining both groups on avidity test, only 25 of 40 (62.5%) IgM-positive women had low-avidity IgG antibodies suggesting a recent T. gondii infection in these women. More importantly, 15 (37.5%) of the IgM-positive women had high-avidity antibodies suggesting that the infection was acquired before gestation The relation of IgM seropositivity with the following risk factors was not found to be statistically significant; contact with cats (0.13), non-vegetarian food habits (0.05), and low socio-economic status (0.49). While, for IgG avidity ELISA, only contact with cats (0.01) was significantly associated with seropositivity. All other risk factors have P-values of >0.05 (not significant). IgG avidity test when used in combination with IgM test was a valuable assay for diagnosis of ongoing or recently acquired T. gondii infection in India.

Citations

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  • A meta-analysis and survey on the prevalence of Toxoplasma gondii infection in cats (Felis catus)
    Mohd Ubaid, Umra Fatima Zuberi, Syed Muhammad Sarosh Ghalib, Faizeaab Hashmi, Sana Aqeel
    The Journal of Basic and Applied Zoology.2025;[Epub]     CrossRef
  • Seroprevalence and associated behavioral factors of Toxoplasma gondii infection among pregnant women in Pokhara Valley, Nepal
    Mamata Thapa, Tulsi Ram Gompo, Tatsuki Sugi, Masahito Asada, Hiroaki Arima, Kishor Pandey
    Tropical Medicine and Health.2025;[Epub]     CrossRef
  • Relationship between the serum level, polymorphism and gene expression of IL-33 in samples of recurrent miscarriage Iraqi women infected with toxoplasmosis
    Sabreen Hadi Fadhil, Entsar Jabbar Saheb
    Experimental Parasitology.2024; 263-264: 108799.     CrossRef
  • Detection of persistent low IgG avidity–an interpretative problem in the diagnosis of acute toxoplasmosis
    Petr Kodym, Zuzana Kurzová, Dagmar Berenová, Marek Malý, Gheyath K. Nasrallah
    PLOS ONE.2023; 18(4): e0284499.     CrossRef
  • Diagnosis of Acute Toxoplasmosis in the First Trimester of Pregnancy by IgG Avidity
    Afshin Azimi, Mahdi Parsaei, Eissa Soleymani, Elham Mehranzadeh, Amir Hossein Maghsood
    Avicenna Journal of Clinical Medicine.2022; 29(1): 50.     CrossRef
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    Narges Kalantari, Tahmineh Gorgani-Firouzjaee, Zahra Moulana, Mohammad Chehrazi, Salman Ghaffari
    Microbial Pathogenesis.2021; 158: 105070.     CrossRef
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    Tooran Nayeri, Shahabeddin Sarvi, Mahmood Moosazadeh, Afsaneh Amouei, Zahra Hosseininejad, Ahmad Daryani, Maria Angeles Gómez-Morales
    PLOS Neglected Tropical Diseases.2020; 14(3): e0008103.     CrossRef
  • Analysis Concentration of <i>Toxoplasma gondii</i> on Anti-Toxoplasma IgG-IgM Antibody Levels, and the Outcomes of Pregnancy in Mice Balb/c
    Tigor Peniel Simanjuntak, Mochammad Hatta, Robert H. Sirait, Marni Br Karo, Lenny Irmawaty Sirait, Tetty Rina Aritonang, Syahrul Rauf, Ressy Dwiyanti
    Open Journal of Obstetrics and Gynecology.2017; 07(03): 281.     CrossRef
  • Seroprevalence of Toxoplasma gondii among pregnant women in Almadinah Almunawwarah KSA
    Naglaa F.A. Imam, Esra'a A.A. Azzam, Ahmed A. Attia
    Journal of Taibah University Medical Sciences.2016; 11(3): 255.     CrossRef
  • 9,252 View
  • 83 Download
  • 9 Web of Science
  • Crossref
A New IgG Immunoblot Kit for Diagnosis of Toxoplasmosis in Pregnant Women
Imen Khammari, Fatma Saghrouni, Sami Lakhal, Aida Bouratbine, Moncef Ben Said, Jalel Boukadida
Korean J Parasitol 2014;52(5):493-499.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.493

The determination of the accurate immune status of pregnant women is crucial in order to prevent congenital toxoplasmosis. Equivocal results with conventional serological techniques are not uncommon when IgG titers are close to the cut-off value of the test, so that a confirmatory technique is needed. For this purpose, we developed a homemade immunoblot (IB) using soluble extract of Toxoplasma gondii tachyzoites and assessed it by testing 154 positive, 100 negative, and 123 equivocal sera obtained from pregnant women. In order to select the more valuable bands in terms of sensitivity and specificity, we used the Youden Index (YI). The highest YIs were those given by the 32, 36, 98, 21, and 33 bands. The simultaneous presence on the same blot of at least 3 bands showed a much higher YI (0.964) and was adapted as the positivity criterion. The analysis of results showed that our homemade IB correlated well with the commercial LDBIO Toxo II IgG® kit recently recommended as a confirmatory test (96.7% of concordance).

Citations

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  • Systematic Review and Meta-Analysis of Congenital Toxoplasmosis Diagnosis: Advances and Challenges
    Priscila Silva Franco, Ana Carolina Morais Oliveira Scussel, Rafaela José Silva, Thadia Evelyn Araújo, Henrique Tomaz Gonzaga, Camila Ferreira Marcon, Joaquim Pedro Brito-de-Sousa, Angélica Lemos Debs Diniz, Marina Carvalho Paschoini, Bellisa Freitas Barb
    Journal of Tropical Medicine.2024; 2024: 1.     CrossRef
  • Trend in serological and molecular diagnostic methods for Toxoplasma gondii infection
    Min-ju Kim, Soeun J. Park, Hyunwoo Park
    European Journal of Medical Research.2024;[Epub]     CrossRef
  • Diagnostic Accuracy of LDBIO-Toxo II IgG and IgM Western Blot in Suspected Seroconversion in Pregnancy: A Multicentre Study
    Valeria Meroni, Francesca Genco, Luigia Scudeller, Marie-Pierre Brenier-Pinchart, Hélène Fricker-Hidalgo, Coralie L’Ollivier, Luc Paris, Hervé Pelloux
    Pathogens.2022; 11(6): 665.     CrossRef
  • Serological diagnosis of toxoplasmosis: evaluation of the commercial test recomLine Toxoplasma IgG immunoblot (Mikrogen) based on recombinant antigens
    Vincent Jean-Pierre, Julien Miozzo, Hélène Fricker-Hidalgo, Cécile Garnaud, Marie Gladys Robert, Hervé Pelloux, Marie-Pierre Brenier-Pinchart
    Parasite.2022; 29: 52.     CrossRef
  • A longitudinal study of Toxoplasma gondii seroconversion on four large Danish sow farms
    Abbey Olsen, Lis Alban, Matthew Denwood, Hans Houe, Tina Birk Jensen, Henrik Vedel Nielsen
    Veterinary Parasitology.2021; 295: 109460.     CrossRef
  • Performance of seven commercial automated assays for the detection of low levels of anti-Toxoplasma IgG in French immunocompromised patients
    Tiphaine Douet, Catherine Armengol, Elena Charpentier, Pamela Chauvin, Sophie Cassaing, Xavier Iriart, Antoine Berry, Judith Fillaux
    Parasite.2019; 26: 51.     CrossRef
  • Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays
    Bettie Voordouw, Barry Rockx, Thomas Jaenisch, Pieter Fraaij, Philippe Mayaud, Ann Vossen, Marion Koopmans
    Clinical Microbiology Reviews.2019;[Epub]     CrossRef
  • Semiquantitative Dot Blot with the GRA8 antigen to differentiate the stages of toxoplasmosis infection
    Juan Gabriel Costa, María Julia Vilariño
    Journal of Microbiological Methods.2018; 149: 9.     CrossRef
  • Knowledge and Practices of Toxoplasmosis among Clinical Laboratory Professionals: A Cross-Sectional Study in Durango, Mexico
    Cosme Alvarado-Esquivel, Luis Sánchez-Anguiano, Luis Berumen-Segovia, Jesús Hernández-Tinoco, Yazmin Rico-Almochantaf, Alfredo Cisneros-Camacho, Jorge Cisneros-Martínez
    International Journal of Environmental Research and Public Health.2017; 14(11): 1413.     CrossRef
  • Sensing parasites: Proteomic and advanced bio-detection alternatives
    Carlos Sánchez-Ovejero, Fernando Benito-Lopez, Paula Díez, Adriano Casulli, Mar Siles-Lucas, Manuel Fuentes, Raúl Manzano-Román
    Journal of Proteomics.2016; 136: 145.     CrossRef
  • The impact of lowering the cut-off value on the sensitivity of the Platelia Elisa IgG (Bio-Rad) test for toxoplasmosis diagnosis
    Oussama Mouri, Eric Kendjo, Feriel Touafek, Arnaud Fekkar, Ousmane Konte, Sebastien Imbert, Régis Courtin, Dominique Mazier, Luc Paris
    Parasite.2015; 22: 22.     CrossRef
  • 10,033 View
  • 117 Download
  • 12 Web of Science
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Evaluation of the Accuracy of the EasyTest™ Malaria Pf/Pan Ag, a Rapid Diagnostic Test, in Uganda
Chom-Kyu Chong, Pyo Yun Cho, Byoung-Kuk Na, Seong Kyu Ahn, Jin Su Kim, Jin-Soo Lee, Sung-Keun Lee, Eun-Taek Han, Hak-Yong Kim, Yun-Kyu Park, Seok Ho Cha, Tong-Soo Kim
Korean J Parasitol 2014;52(5):501-505.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.501

In recent years, rapid diagnostic tests (RDTs) have been widely used for malaria detection, primarily because of their simple operation, fast results, and straightforward interpretation. The Asan EasyTest™ Malaria Pf/Pan Ag is one of the most commonly used malaria RDTs in several countries, including Korea and India. In this study, we tested the diagnostic performance of this RDT in Uganda to evaluate its usefulness for field diagnosis of malaria in this country. Microscopic and PCR analyses, and the Asan EasyTest™ Malaria Pf/Pan Ag rapid diagnostic test, were performed on blood samples from 185 individuals with suspected malaria in several villages in Uganda. Compared to the microscopic analysis, the sensitivity of the RDT to detect malaria infection was 95.8% and 83.3% for Plasmodium falciparum and non-P. falciparum, respectively. Although the diagnostic sensitivity of the RDT decreased when parasitemia was ≤500 parasites/?l, it showed 96.8% sensitivity (98.4% for P. falciparum and 93.8% for non-P. falciparum) in blood samples with parasitemia ≥100 parasites/?l. The specificity of the RDT was 97.3% for P. falciparum and 97.3% for non-P. falciparum. These results collectively suggest that the accuracy of the Asan EasyTest™ Malaria Pf/Pan Ag makes it an effective point-of-care diagnostic tool for malaria in Uganda.

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  • Asymptomatic malaria infection, associated factors and accuracy of diagnostic tests in a historically high transmission setting in Northern Uganda
    Bosco B. Agaba, Simon P. Rugera, Ruth Mpirirwe, Martha Atekat, Samuel Okubal, Khalid Masereka, Miseal Erionu, Bosco Adranya, Gertrude Nabirwa, Patrick B. Odong, Yasin Mukiibi, Isaac Ssewanyana, Susan Nabadda, Enoch Muwanguzi
    Malaria Journal.2022;[Epub]     CrossRef
  • Genetic diversity of Plasmodium vivax and Plasmodium falciparum lactate dehydrogenases in Myanmar isolates
    Jinyoung Lee, Tae Im Kim, Hương Giang Lê, Won Gi Yoo, Jung-Mi Kang, Seong-Kyu Ahn, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim, Byoung-Kuk Na
    Malaria Journal.2020;[Epub]     CrossRef
  • Limitations of rapid diagnostic tests in malaria surveys in areas with varied transmission intensity in Uganda 2017-2019: Implications for selection and use of HRP2 RDTs
    Agaba B. Bosco, Joaniter I. Nankabirwa, Adoke Yeka, Sam Nsobya, Karryn Gresty, Karen Anderson, Paul Mbaka, Christiane Prosser, David Smith, Jimmy Opigo, Rhoda Namubiru, Emmanuel Arinaitwe, John Kissa, Samuel Gonahasa, Sungho Won, Bora Lee, Chae Seung Lim,
    PLOS ONE.2020; 15(12): e0244457.     CrossRef
  • An Update on Malaria Rapid Diagnostic Tests
    Avinash N. Mukkala, Jason Kwan, Rachel Lau, David Harris, Dylan Kain, Andrea K. Boggild
    Current Infectious Disease Reports.2018;[Epub]     CrossRef
  • Comparative Assessment of Diagnostic Performances of Two Commercial Rapid Diagnostic Test Kits for Detection of Plasmodium spp. in Ugandan Patients with Malaria
    Young Yil Bahk, Seo Hye Park, Woojoo Lee, Kyoung Jin, Seong Kyu Ahn, Byoung-Kuk Na, Tong-Soo Kim
    The Korean Journal of Parasitology.2018; 56(5): 447.     CrossRef
  • An Evaluation of Active Case Detection in Malaria Control Program in Kiyuni Parish of Kyankwanzi District, Uganda
    Young Yil Bahk, Pyo Yun Cho, Seong Kyu Ahn, Woo-Joo Lee, Tong-Soo Kim
    The Korean Journal of Parasitology.2018; 56(6): 625.     CrossRef
  • Comparison of the diagnostic performance of microscopic examination with nested polymerase chain reaction for optimum malaria diagnosis in Upper Myanmar
    Jung-Mi Kang, Pyo-Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong-Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim, Byoung-Kuk Na
    Malaria Journal.2017;[Epub]     CrossRef
  • A Cluster Randomised Trial Introducing Rapid Diagnostic Tests into Registered Drug Shops in Uganda: Impact on Appropriate Treatment of Malaria
    Anthony K. Mbonye, Pascal Magnussen, Sham Lal, Kristian S. Hansen, Bonnie Cundill, Clare Chandler, Siân E. Clarke, Roly D Gosling
    PLOS ONE.2015; 10(7): e0129545.     CrossRef
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  • 111 Download
  • 10 Web of Science
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First Evaluation of an Outbreak of Bovine Babesiosis and Anaplasmosis in Southern Brazil Using Multiplex PCR
Mariana Feltrin Canever, Luisa Lemos Vieira, Carolina Reck, Luisa Richter, Luiz Claudio Miletti
Korean J Parasitol 2014;52(5):507-511.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.507

Outbreaks of tick-borne disease cases in Santa Catarina, Brazil are known, but the presence of the pathogen DNA has never been determined. In this study, the first survey of Anaplasma marginale, Babesia bigemina, and Babesia bovis DNA on blood samples of 33 cattle from an outbreak in Ponte Alta Municipality, Santa Catarina, Brazil, has been carried out. A multiplex PCR detected 54.5% of animals were co-infected with 2 or 3 parasites, while 24.2% were infected with only 1 species. The most prevalent agent was B. bigemina (63.6%) followed by A. marginale (60.6%). This is the first report of tick-borne disease pathogens obtained by DNA analysis in Southern Brazil.

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  • Prevalence and factors associated with Babesia bigemina infection in Crioula Lageana cattle breed
    Mariana da Silva Casa, Julio de Mattos Vettori, Ketriane Mota de Souza, Paulo Ricardo Benetti Todeschini, Luiz Cláudio Miletti, Carla Ivane Ganz Vogel, André Luís Ferreira Lima, Joandes Henrique Fonteque
    Revista Brasileira de Parasitologia Veterinária.2025;[Epub]     CrossRef
  • Revisão sistemática sobre diagnóstico molecular da tristeza parasitária bovina no Brasil: ocorrência e oportunidades futuras
    Natália Machado Rahal, Kauê Rodriguez Martins, Josiane de Oliveira Feijó, Marco Antonio Tonus Marinho, Marcio Nunes Corrêa
    Semina: Ciências Agrárias.2024; 45(3): 835.     CrossRef
  • Identification of Anaplasma marginale, Babesia bovis and Babesia bigemina resistance alleles in Crioulo Lageano cattle using PCR-SBT and BoLA-DRB3 gene sequencing
    Mariana da Silva Casa, Guillermo Giovambattista, Graziela Vieira Fonteque, Ellen Lara Miguel, Carla Ivane Ganz Vogel, Luiz Claudio Miletti, Shin-Nosuke Takeshima, Joandes Henrique Fonteque
    Frontiers in Veterinary Science.2023;[Epub]     CrossRef
  • Proportion and seasonality of blood parasites in animals in Mosul using the Veterinary Teaching Hospital Lab data
    Hussam M. S. Alimam, Dhiyaa A. Moosa, Eva A. Ajaj, Mohammad O. Dahl, Israa A. Al-Robaiee, Semaa F. Hasab Allah, Zahraa M. Al-Jumaa, Eman D. Hadi, Simon Clegg
    PLOS ONE.2022; 17(2): e0264121.     CrossRef
  • Prevalence of bovine Babesia spp., Anaplasma marginale, and their co-infections in Latin America: Systematic review-meta-analysis
    Gabriella Carvalho Mattos Ferreira, Maria Eugênia Andrighetto Canozzi, Vanessa Peripolli, Gabriely de Paula Moura, Javier Sánchez, Carlos Eduardo Nogueira Martins
    Ticks and Tick-borne Diseases.2022; 13(4): 101967.     CrossRef
  • Validation of a multiplex PCR assay to detect Babesia spp. and Anaplasma marginale in cattle in Uruguay in the absence of a gold standard test
    Pablo Parodi, Luis G. Corbellini, Vanessa B. Leotti, Rodolfo Rivero, Cecilia Miraballes, Franklin Riet-Correa, José M. Venzal, María T. Armúa-Fernández
    Journal of Veterinary Diagnostic Investigation.2021; 33(1): 73.     CrossRef
  • Low level of genetic diversity and high occurrence of vector-borne protozoa in water buffaloes in Thailand based on 18S ribosomal RNA and mitochondrial cytochrome b genes
    Anh H.L. Nguyen, Sonthaya Tiawsirisup, Morakot Kaewthamasorn
    Infection, Genetics and Evolution.2020; 82: 104304.     CrossRef
  • Molecular diagnosis and biochemical studies of tick-borne diseases (anaplasmosis and babesiosis) in Aberdeen Angus Cattle in New Valley, Egypt
    Nani Nasreldin, Rania M. Ewida, Hatem Hamdon, Yasser F. Elnaker
    Veterinary World.2020; 13(9): 1884.     CrossRef
  • Prevalence of Anaplasma marginale, Babesia bovis, and Babesia bigemina in cattle in the Campos de Lages region, Santa Catarina state, Brazil, estimated by multiplex-PCR
    Luisa Lemos Vieira, Mariana Feltrin Canever, Leonardo Leite Cardozo, Cristina Perito Cardoso, Marcos Edgar Herkenhoff, André Thaler Neto, Carla Ivane Ganz Vogel, Luiz Claudio Miletti
    Parasite Epidemiology and Control.2019; 6: e00114.     CrossRef
  • Molecular surveillance and phylogenetic traits of Babesia bigemina and Babesia bovis in cattle (Bos taurus) and water buffaloes (Bubalus bubalis) from Colombia
    Jeiczon Jaimes-Dueñez, Omar Triana-Chávez, Andrés Holguín-Rocha, Alberto Tobon-Castaño, Ana M. Mejía-Jaramillo
    Parasites & Vectors.2018;[Epub]     CrossRef
  • Phylogenetic relationship and genotypic variability in Anaplasma marginale strains causing anaplasmosis in India
    Neena George, Vasundhra Bhandari, Paresh Sharma
    Infection, Genetics and Evolution.2017; 48: 71.     CrossRef
  • Parasitological and molecular surveys reveal high rates of infection with vector-borne pathogens and clinical anemia signs associated with infection in cattle from two important livestock areas in Colombia
    Jeiczon Jaimes-Dueñez, Omar Triana-Chávez, Ana M. Mejía-Jaramillo
    Ticks and Tick-borne Diseases.2017; 8(2): 290.     CrossRef
  • High-resolution melting PCR assay, applicable for diagnostics and screening studies, allowing detection and differentiation of several Babesia spp. infecting humans and animals
    Wioletta Rozej-Bielicka, Aleksander Masny, Elzbieta Golab
    Parasitology Research.2017; 116(10): 2671.     CrossRef
  • First molecular survey and novel genetic variants’ identification of Anaplasma marginale, A. centrale and A. bovis in cattle from Tunisia
    Hanène Belkahia, Mourad Ben Said, Alberto Alberti, Khaoula Abdi, Zakia Issaoui, Dorra Hattab, Mohamed Gharbi, Lilia Messadi
    Infection, Genetics and Evolution.2015; 34: 361.     CrossRef
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Three Echinostome Species from Wild Birds in the Republic of Korea
Seongjun Choe, Dongmin Lee, Hansol Park, Mihyeon Oh, Hyeong-Kyu Jeon, Youngsun Lee, Ki-Jeong Na, Youngjun Kim, Hang Lee, Keeseon S. Eom
Korean J Parasitol 2014;52(5):513-520.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.513

Three echinostome species, i.e., Patagifer bilobus, Petasiger neocomense, and Saakotrema metatestis, are newly recorded in the trematode fauna of the Republic of Korea. They were recovered from 3 species of migratory birds (Platalea minor, Podiceps cristatus, and Egretta garzetta), which were donated by the Wildlife Center of Chungbuk (WCC) and the Conservation Genome Resource Bank for Korean Wildlife (CGRB). Only 1 P. bilobus specimen was recovered from the intestine of a black-faced spoonbill (P. minor), and characterized by the bilobed head crown with a deep dorsal incision and 54 collar spines. Twenty P. neocomense were recovered from the intestine of a great crested grebe (P. cristatus), and they had a well-developed head crown with 19 spines and 2 testes obliquely located at the posterior middle of the body. Total 70 S. metatestis were collected from the bursa of Fabricius of 1 little egret (E. garzetta). It is characterized by stout tegumental spines covered in the entire leaf-shaped body, posterior extension of the uterus, presence of the uroproct and a well-developed head crown with 12 pairs of collar spines on each side. By the present study, these 3 echinostome species are newly added to the trematode fauna in Korea.

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    Nada A. Ibrahim, Ismail M. Shalaby, Mahi A. Ghobashy, Azza A. Taeleb, Elham A. Elkhawass
    Parasitology International.2025; 104: 102972.     CrossRef
  • The Nuclear Ribosomal Transcription Units of Two Echinostomes and Their Taxonomic Implications for the Family Echinostomatidae
    Yu Cao, Ye Li, Zhong-Yan Gao, Bo-Tao Jiang
    Biology.2025; 14(8): 1101.     CrossRef
  • First record of Patagifer bilobus (Rudolphi, 1819) Dietz, 1909 (Digenea: Echinostomatidae), with a morphological and molecular characterization from two threskiornithid species in Mexico
    Ana Lucia Sereno-Uribe, Marcelo Tonatiuh González-García, Mirza Patricia Ortega-Olivares, Alejandra López-Jiménez, Martín García-Varela, Leopoldo Andrade-Gómez
    Parasitology Research.2022; 121(7): 1921.     CrossRef
  • EXAMINATION OF HELMINTH PARASITES IN THE FECAL SAMPLES OF MAGPIES (Pica pica), JACKDAWS (Corvus monedula), AND ROOKS (Corvus frugilegus) IN THE VICINITIES OF VAN PROVINCE/TURKEY
    Ali Bilgin YILMAZ, Erkan AZİZOĞLU, Özdemir ADIZEL
    Commagene Journal of Biology.2020;[Epub]     CrossRef
  • Infections with Digenetic Trematode Metacercariae in Freshwater Fishes from Two Visiting Sites of Migratory Birds in Gyeongsangnam-do, Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na
    The Korean Journal of Parasitology.2019; 57(3): 273.     CrossRef
  • Infections of Two Isthmiophora Species (Digenea: Echinostomatidae) in Wild Mammals from Republic of Korea with Their Morphological Descriptions
    Seongjun Choe, Ki-Jeong Na, Youngjun Kim, Dong-Hyuk Jeong, Jeong-Jin Yang, Keeseon S. Eom
    The Korean Journal of Parasitology.2019; 57(6): 647.     CrossRef
  • Echinochasmus swabiensis n. sp. (Digenea: Echinostomatidae) from Black Kite (Milvus Migrans Migrans) in Swabi District, Pakistan
    S. Suleman, M. S. Khan, X. Q. Zhu, A. M. Dharejo, E. C. Uwalaka, M. Shah, O. A. Adediran
    Folia Veterinaria.2018; 62(2): 5.     CrossRef
  • New Definitive Hosts and Differential Body Indices of Isthmiophora hortensis (Digenea: Echinostomatidae)
    Woon-Mok Sohn, Byoung-Kuk Na, Sung-Shik Shin
    The Korean Journal of Parasitology.2017; 55(3): 287.     CrossRef
  • Echinostoma macrorchis (Digenea: Echinostomatidae): Metacercariae in Cipangopaludina chinensis malleata Snails and Adults from Experimental Rats in Korea
    Woon-Mok Sohn, Byoung-Kuk Na
    The Korean Journal of Parasitology.2017; 55(5): 541.     CrossRef
  • Two Echinostome Species, Pegosomum bubulcum and Nephrostomum ramosum (Digenea: Echinostomatidae), from an Eastern Cattle Egret, Bubulcus ibis coromandus, in Republic of Korea
    Seongjun Choe, Dongmin Lee, Hansol Park, Hyeong-Kyu Jeon, Youngsun Lee, Eunju Kim, Ki-Jeong Na, Keeseon S. Eom
    The Korean Journal of Parasitology.2016; 54(4): 485.     CrossRef
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  • 141 Download
  • 8 Web of Science
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Case Reports

Bronchopulmonary Infection of Lophomonas blattarum: A Case and Literature Review
Jian Xue, Ying-Li Li, Xue-Mei Yu, Dai-Kun Li, Ming-Fang Liu, Jing-Fu Qiu, Jian-Jiang Xue
Korean J Parasitol 2014;52(5):521-525.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.521

Human infections with Lophomonas blattarum are rare. However, the majority of the infections occurred in China, 94.4% (136 cases) of all cases in the world. This infection is difficult to differentiate from other pulmonary infections with similar symptoms. Here we reported a case of L. blattarum infection confirmed by bronchoalveolar lavage fluid smear on the microscopic observations. The patient was a 21-year-old female college student. The previous case which occurred in Chongqing was 20 years ago. We briefly reviewed on this infection reported in the world during the recent 20 years. The epidemiological characteristics, possible diagnostic basis, and treatment of this disease is discussed in order to provide a better understanding of recognition, diagnosis, and treatment of L. blattarum infection.

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  • Low occurrence of pulmonary lophomoniasis among cigarette smokers: An analysis of risk factors based on registry data
    Mahdi Fakhar, Zahra Hosseininejad, Ali Sharifpour, Fatemeh Z. Hosseini, Zakaria Zakariaei
    Lung India.2025; 42(2): 109.     CrossRef
  • Infecção broncopulmonar por Lophomonas blattarum: relato de caso com revisão de literatura
    Eduardo Fellipe Capini de Almeida Tavares, Caio Nicoli Passamani, Caio Azevedo Rezende, Maria das Graças Silva Mattede, Felipe Bertollo Ferreira, Ana Paula Hamer Sousa Clara, Haydêe F. Moreira Silva de Mendonça, Rodrigo Oliveira Neves, Alexandre Rodrigue
    Clinics Biopsychosocial.2025; 1(1): 09.     CrossRef
  • Development and Validation of In‐House Conventional and Multiplex PCR Methods for the Detection and Identification of Lophomonas spp.: An Innovative Approach
    Maryam Nakhaei, Mahdi Fakhar, Abouzar Bagheri, Hajar Ziaei Hezarjaribi, Saied Abediankenari, Ali Sharifpour, Maryam Ghasemi
    Journal of Clinical Laboratory Analysis.2025;[Epub]     CrossRef
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    Masoud Maboudi, Eissa Soleymani, Elham Sadat Banimostafavi, Shirafkan Kordi, Majidreza Adelani, Zakaria Zakariaei, Mahdi Fakhar
    Respirology Case Reports.2025;[Epub]     CrossRef
  • Misidentification of Lophomonas Blattarum: Methodological Flaws and Taxonomic Confusion in Molecular Diagnostics
    Nasrin Saberi Shahr-Babaki, Mitra Samareh Fekri, Majid Fasihi-Harandi, Behnam Dalfardi, Mohsen Shafiepour Marji
    Advanced Biomedical Research.2025;[Epub]     CrossRef
  • First Report of the Pulmonary Parasite Lophomonas blattarum in Ahvaz Province, Khuzestan: Case Report and Literature Review
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    Abhishek Mewara, Gillian H. Gile, Blaine Mathison, Huan Zhao, Bobbi Pritt, Richard S. Bradbury, Romney M. Humphries
    Journal of Clinical Microbiology.2024;[Epub]     CrossRef
  • Imaging patterns of Lophomonas blattarum infection in the respiratory tract: a registry-based analysis
    Amirmasoud Taheri, Mahdi Fakhar, Ali Sharifpour, Elhamsadat Banimostafavi, Sepideh SafaNavaei, Siavash Abedi, Hossein Mehravaran, Masoud Aliyali, Ahmad Shafahi, Asieh Delpzir
    BMC Infectious Diseases.2024;[Epub]     CrossRef
  • Severe lophomoniasis in a patient with diabetes and past history of COVID-19 in Central Iran: case report
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    Journal of International Medical Research.2024;[Epub]     CrossRef
  • Lophomoniasis broncopulmonar: a propósito de varios casos y revisión de la literatura
    Wesley Cardona Castro, Laura Victoria Valencia Zapata, Jorge Eduardo Ruiz Santacruz
    Acta Colombiana de Cuidado Intensivo.2024; 24(3): 302.     CrossRef
  • Pulmonary Infection of Lophomonas blattarum as a Co-infection with COVID-19 in Patients with Severe Pneumonia
    Azam Heidari, Samad Ghodrati, Ahmadreza Mobaien, Asghar Fazaeli
    Journal of Human Environment and Health Promotion.2024; 10(2): 79.     CrossRef
  • Geospatial Analysis and Molecular Epidemiologic Study of Emerging Pulmonary Lophomoniasis in Iran: A National Registry-Based Study
    Mohammad Amin Ghatee, Maryam Nakhaei, Ali Sharifpour, Mahdi Fakhar, Niloufar Mohamadi, Mostafa Soleymani, Siavash Abedi, Masoud Aliyali, Hossein Mehravaran, Eric Agola Lelo
    Journal of Parasitology Research.2023; 2023: 1.     CrossRef
  • Lophomoniasis Respiratory Infection in Two Immunocompetent Hosts: Two Case Reports
    Eder Donadoni Varela Macias, Juan Pablo Martinez Salazar, Juan Gonzalo Mesa Monsalve, Alejandro Díaz Díaz
    SN Comprehensive Clinical Medicine.2023;[Epub]     CrossRef
  • Lophomonas Infection in Patients with Respiratory Diseases in Southeastern Iran Using Wet Mount, Giemsa and Trichrome Staining
    Saeedeh Shamsaddini, Mitra Samareh Fekri, Mohsen Shafiepour, Hossein Kamyabi, Hossein Aghassi, Mehdi Borhani, Zahra Babaei, Majid Fasihi Harandi
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  • First Co-morbidity of Lophomonas blattarum and COVID-19 Infections: Confirmed Using Molecular Approach
    Maryam Nakhaei, Mahdi Fakhar, Ali Sharifpour, Elham Sadat Banimostafavi, Zakaria Zakariaei, Hossein Mehravaran, Reza Saberi, Sepideh Safanavaei, Siavash Abedi, Masoud Aliyali, Mostafa Soleimani
    Acta Parasitologica.2022; 67(1): 535.     CrossRef
  • Cavitary pulmonary lesions following emerging lophomoniasis: A novel perspective
    Amirmasoud Taheri, Mahdi Fakhar, Ali Sharifpour, Elham Sadat Banimostafavi
    Respirology Case Reports.2022;[Epub]     CrossRef
  • Molecular evidence of upper and lower respiratory infection due to Lophomonas in a post‐kidney transplantation patient
    Mahdi Fakhar, Sepideh Safanavaei, Maryam Nakhaei, Samira Esmaeili, Elham Sadat Banimostafavi, Fatemeh Spahbodi, Ali Sharifpour
    Clinical Case Reports.2022;[Epub]     CrossRef
  • First molecular approach to diagnose paediatric pulmonary lophomoniasis: A case series
    Amirmasoud Taheri, Mahdi Fakhar, Maryam Nakhaei, Elham Sadat Banimostafavi, Farzad Masiha, Javad Ghaffari, Soroush Sheydai, Mohammad Sadegh Rezaei, Ali Sharifpour
    Respirology Case Reports.2022;[Epub]     CrossRef
  • Global Status of Emerging Lophomonas Infection: A Systematic Review of Reported Cases (1993—2020)
    Maryam Nakhaei, Mahdi Fakhar, Ali Sharifpour, Hajar Ziaei Hezarjaribi, Elham Sadat Banimostafavi, Eisa Nazar, Vijay Kumar Srivastava
    Interdisciplinary Perspectives on Infectious Diseases.2022; 2022: 1.     CrossRef
  • Identificación de Lophomonas blattarum en secreción bronquial de un paciente con COVID-19. Reporte de un caso y revisión de la literatura
    Héctor Romeo Vásquez-Revilla, Eduardo Revilla-Rodríguez, Itzel Araís Millán-Villavicencio
    Medicina Crítica.2022; 36(3): 183.     CrossRef
  • Molecular Evidence of Emerged Pulmonary Lophomoniasis due to Lophomonas blattarum among Hospitalized Patients in Southwestern Iran: A National Registry-Based Study
    Kobra Mokhtarian, Simin Taghipour, Maryam Nakhaei, Amirmasoud Taheri, Ali Sharifpour, Mahdi Fakhar, Hajar Ziaei Hezarjaribi, Morteza Saki
    Interdisciplinary Perspectives on Infectious Diseases.2022; 2022: 1.     CrossRef
  • Fiberoptic Bronchoscopic Findings in Patients Suffering from Emerging Pulmonary Lophomoniasis: A First Registry-Based Clinical Study
    Masoud Aliyali, Amirmasoud Taheri, Mahdi Fakhar, Ali Sharifpour, Maryam Nakhaei, Siavash Abedi, Hossein Mehravaran, Sepideh Safanavaei, Payam Behzadi
    Interdisciplinary Perspectives on Infectious Diseases.2022; 2022: 1.     CrossRef
  • Lophomonas and Mycobacterium co-infection: the first molecular evidence to overcome potential diagnostic pitfalls
    Amirmasoud Taheri, Mahdi Fakhar, Ali Sharifpour, Maryam Nakhaei, Elham Sadat Banimostafavi
    Oxford Medical Case Reports.2022;[Epub]     CrossRef
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    Archana Keche, Shagufta Khatoon, Dibakar Sahu
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  • High Occurrence of Emerged Lophomonas Infection among Patients Suspected of Having Pulmonary Tuberculosis: In-House PCR-Based Evidence
    Hamed Kalani, Ayeneh Pangh, Maryam Nakhaei, Hajar Ziaei Hezarjaribi, Mahdi Fakhar, Ali Sharifpour, Elham Sadat Banimostafavi, Rabeeh Tabaripour, Meysam Sarshar
    Interdisciplinary Perspectives on Infectious Diseases.2022; 2022: 1.     CrossRef
  • Pulmonary Infection with Lophomonas blattarum
    Qin Ding, Kunling Shen
    The Indian Journal of Pediatrics.2021; 88(1): 23.     CrossRef
  • First report of Lophomonas spp. in German cockroaches (Blattella germanica) trapped in hospitals, northern Iran
    Seyyed Farzad Motevalli-Haghi, Atyeh Shemshadian, Maryam Nakhaei, Roghiyeh Faridnia, Omid Dehghan, Majid Malekzadeh Shafaroudi, Mehrasa Nejadi Kelarijani, Seyed Hassan Nikookar, Hamed Kalani, Mahdi Fakhar
    Journal of Parasitic Diseases.2021; 45(4): 937.     CrossRef
  • Morphological and Molecular Identification of Emerged Lophomonas blattarum Infection in Mazandaran Province, Northern Iran: First Registry-Based Study
    Mahdi Fakhar, Maryam Nakhaei, Ali Sharifpour, Sepideh Safanavaei, Sivash Abedi, Rabeeh Tabaripour, Masoud Aliyali, Mostafa Modanloo, Reza Saberi, Hamed Kalani, Elham Sadat Banimostafavi
    Acta Parasitologica.2021; 66(4): 1510.     CrossRef
  • A Bibliometric Analysis of Global Research on Lophomonas Spp. in Scopus (1933-2019)
    Masoud Keighobadi, Maryam Nakhaei, Ali Sharifpour, Ali Akbar Khasseh, Sepideh Safanavaei, Rabeeh Tabaripour, Masoud Aliyali, Siavash Abedi, Hossein Mehravaran, Elham Sadat Banimostafavi, Mahdi Fakhar
    Infectious Disorders - Drug Targets .2021; 21(2): 230.     CrossRef
  • Lophomonas sp. in the upper and lower respiratory tract of patients from a hospital in Lambayeque, Peru: clinical case studies
    Virgilio E. Failoc-Rojas, Sebastian Iglesias-Osores, Heber Silva-Díaz
    Respiratory Medicine Case Reports.2020; 31: 101142.     CrossRef
  • Authenticity of pulmonary Lophomonas blattarum infection: A case report
    Shuang-Shuang Meng, Zhi-Feng Dai, Hui-Chao Wang, Yu-Xia Li, Dan-Dan Wei, Rui-Lin Yang, Xu-Hong Lin
    World Journal of Clinical Cases.2019; 7(1): 95.     CrossRef
  • First Molecular Diagnosis of Lophomoniasis: the End of a Controversial Story
    Mahdi Fakhar, Maryam Nakhaei, Ali Sharifpour, Hamed Kalani, Elham Sadat Banimostafavi, Siavash Abedi, Sepideh Safanavaei, Masoud Aliyali
    Acta Parasitologica.2019; 64(2): 390.     CrossRef
  • Bronchopulmonary lophomoniasis: A rare cause of pneumonia in an immunosuppressed host
    Wathiqah Wahid, Nur Athirah Ahmad Fahmi, Ahmad Firdaus Mohd Salleh, ’Azlin Mohd Yasin
    Respiratory Medicine Case Reports.2019; 28: 100939.     CrossRef
  • Lophomoniasis pulmonar
    Gustavo Morales Muñoz, Yolanda Ceferino Contreras, Jaime Cadenas Caballero, Ana Gabriela Méndez Arias
    Medicina Crítica.2019; 33(3): 150.     CrossRef
  • Bronchopulmonary Disease Caused by Flagellated Protozoa Infection in 15 Chinese Children
    Jinrong Liu, Shaogang Li, Huimin Li, Yimu Fan, Haiming Yang, Hui Xu, Yuelin Shen, Shunying Zhao
    Pediatric Infectious Disease Journal.2017; 36(4): 392.     CrossRef
  • Lophomonas blattarum Infection or Just the Movement of Ciliated Epithelial Cells?
    Ran Li, Zhan-Cheng Gao
    Chinese Medical Journal.2016; 129(6): 739.     CrossRef
  • Lophomonas blattarum infection in immunocompetent patient
    Rahul Tyagi, Kavita Bala Anand, Kishore Teple, Rajkumar Singh Negi
    Lung India.2016; 33(6): 667.     CrossRef
  • 15,592 View
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  • 28 Web of Science
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The First Case of Capillaria hepatica Infection in a Nutria (Myocastor coypus) in Korea
Jae-Hak Park, Meliton N. Novilla, Juha Song, Kyung-Sul Kim, Seo-Na Chang, Ju-Hee Han, Byung Hee Lee, Do-Hun Lee, Hyun-Mac Kim, Young-Ha Kim, Hee-Jeong Youn, Jihyon Kil
Korean J Parasitol 2014;52(5):527-529.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.527

This study reports the first case of Capillaria hepatica infection in a nutria in Korea. Ten nutrias, captured near the Nakdong River, were submitted to our laboratory for necropsy. White-yellowish nodules were found in the liver of 1 of the nutrias at necropsy. Histologically, the lesions were granulomatous, and infiltrations of lipid-laden macrophages, eosinophils, and several multinucleated giant cells were observed. The lesions consisted of numerous eggs and necrotic hepatocytes. The eggs were lemon-shaped and had polar plugs at the ends of both long sides. The eggs were morphologically identified as those of C. hepatica. Worldwide, C. hepatica infection in nutrias is very rare. Nutrias are a kind of livestock, as well as wildlife; therefore, an epidemiological study for parasitic infections needs to be conducted.

Citations

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  • Histopathological evaluation of Capillaria hepatica (Bancroft, 1893) in Cricetomys gambianus (Waterhouse, 1840)
    Samson Eneojo Abalaka, Sunday Augustine Ejeh
    Journal of Parasitic Diseases.2025; 49(1): 186.     CrossRef
  • Intestinal parasites of Myocastor coypus (Rodentia, Myocastoridae) on animal farms in Eastern Ukraine
    N. V. Sumakova, A. P. Paliy, O. V. Pavlichenko, R. V. Petrov, B. S. Morozov, V. M. Plys, A. B. Mushynskyi
    Regulatory Mechanisms in Biosystems.2025; 16(3): e25117.     CrossRef
  • Population Genomic Insights Into Recent Nutria (Myocastor coypus) Invasion Dynamics
    Kristen D. Ahrens, Joshua M. Hallas, Antionette J. Piaggio, Kelly L. Carrothers, Valerie K. Cook, Michael R. Buchalski
    Evolutionary Applications.2025;[Epub]     CrossRef
  • Radio Tracking Reveals the Home Range and Activity Patterns of Nutria (Myocastor coypus) in the Macdo Wetland in South Korea
    Maniram Banjade, Pradeep Adhikari, Sun-Hee Hong, Do-Hun Lee
    Animals.2023; 13(10): 1716.     CrossRef
  • Climate change induced habitat expansion of nutria (Myocastor coypus) in South Korea
    Pradeep Adhikari, Baek-Jun Kim, Sun-Hee Hong, Do-Hun Lee
    Scientific Reports.2022;[Epub]     CrossRef
  • Updated checklist of helminths found in terrestrial mammals of Argentine Patagonia
    M.H. Fugassa
    Journal of Helminthology.2020;[Epub]     CrossRef
  • Zoonotic parasites carried by invasive alien species in China
    Guang-Li Zhu, Yi-Yang Tang, Yanin Limpanont, Zhong-Dao Wu, Jian Li, Zhi-Yue Lv
    Infectious Diseases of Poverty.2019;[Epub]     CrossRef
  • Complete mitochondrial genome of the invasive semi-aquatic mammal, nutria Myocastor coypus (Rodentia; Myocastoridae)
    Do-Hun Lee, Moo-Seung Lee, Young-Chae Kim, Il Ryong Kim, Hye Kwon Kim, Dae Gwin Jeong, Jung Ro Lee, Ji Hyung Kim
    Conservation Genetics Resources.2018; 10(4): 613.     CrossRef
  • RETROSPECTIVE ANALYSIS OF THE EPIDEMIOLOGIC LITERATURE, 1990–2015, ON WILDLIFE-ASSOCIATED DISEASES FROM THE REPUBLIC OF KOREA
    Jusun Hwang, Kyunglee Lee, Young-Jun Kim, Jonathan M. Sleeman, Hang Lee
    Journal of Wildlife Diseases.2017; 53(1): 5.     CrossRef
  • Histopathological Study of Hepatic Small Nodular Lesions on Slaughtered Cattle in Hokkaido
    Mutsuko SAKUI, Hiroshi OONO, Ayae OONISHI, Yuzaburo OKU
    Journal of the Japan Veterinary Medical Association.2016; 69(3): 147.     CrossRef
  • Histopathological findings in wild Nutrias (Myocastor coypus) with Capillaria hepatica infection
    Il-Hwa HONG, Sun-Young KANG, Jong-Hyun KIM, Seong-Hoon SEOK, Seong-Kyu LEE, Seong-Jin HONG, Seung-Yong LEE, Se-Jin PARK, Joo-Yeon KONG, Seong-Chan YEON
    Journal of Veterinary Medical Science.2016; 78(12): 1887.     CrossRef
  • 11,780 View
  • 96 Download
  • 10 Web of Science
  • Crossref
Strongyloides myopotami (Secernentea: Strongyloididae) from the Intestine of Feral Nutrias (Myocastor coypus) in Korea
Seongjun Choe, Dongmin Lee, Hansol Park, Mihyeon Oh, Hyeong-Kyu Jeon, Keeseon S. Eom
Korean J Parasitol 2014;52(5):531-535.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.531

Surveys on helminthic fauna of the nutria, Myocastor coypus, have seldom been performed in the Republic of Korea. In the present study, we describe Strongyloides myopotami (Secernentea: Strongyloididae) recovered from the small intestine of feral nutrias. Total 10 adult nutrias were captured in a wetland area in Gimhae-si (City), Gyeongsangnam-do (Province) in April 2013. They were transported to our laboratory, euthanized with ether, and necropsied. About 1,300 nematode specimens were recovered from 10 nutrias, and some of them were morphologically observed by light and scanning electron microscopies. They were 3.7-4.7 (4.0±0.36) mm in length, 0.03-0.04 (0.033) mm in width. The worm dimension and other morphological characters, including prominent lips of the vulva, blunted conical tail, straight type of the ovary, and 8-chambered stoma, were all consistent with S. myopotami. This nematode fauna is reported for the first time in Korea.

Citations

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  • Morphological identification and phylogenetic analysis of Eimeria coypi and Eimeria fluviatilis (Apicomplexa: Eimeriidae) isolated from nutrias (Myocastor coypus [Rodentia]) in Japan
    Sora Ouchi, Ryosuke Koda, Yuzuru Ishizuka, Shigetoyo Ikemoto, Mutsuko Sakata, Susumu Iwaide, Tomoyuki Shibahara, Atsushi Hinenoya, Shigehiko Uni, Kazumi Sasai, Makoto Matsubayashi
    Systematic Parasitology.2025;[Epub]     CrossRef
  • Intestinal parasites of Myocastor coypus (Rodentia, Myocastoridae) on animal farms in Eastern Ukraine
    N. V. Sumakova, A. P. Paliy, O. V. Pavlichenko, R. V. Petrov, B. S. Morozov, V. M. Plys, A. B. Mushynskyi
    Regulatory Mechanisms in Biosystems.2025; 16(3): e25117.     CrossRef
  • Improved molecular identification of Strongyloides myopotami in nutrias using fecal samples
    Yuga MORI, Atsushi NAKA, Ryosuke KODA, Yuzuru ISHIZUKA, Atsushi HINENOYA, Tomoyuki SHIBAHARA, Kazumi SASAI, Makoto MATSUBAYASHI
    Journal of Veterinary Medical Science.2024; 86(3): 349.     CrossRef
  • An update on the distribution of the coypu, Myocastor coypus, in Asia and Africa through published literature, citizen-science and online platforms
    Luca Pedruzzi, Anna Schertler, Silvia Giuntini, Ivan Leggiero, Emiliano Mori
    Mammalian Biology.2022; 102(1): 109.     CrossRef
  • An annotated checklist of the eukaryotic parasites of humans, exclusive of fungi and algae
    Blaine A. Mathison, Sarah G. H. Sapp
    ZooKeys.2021; 1069: 1.     CrossRef
  • A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea
    Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong
    The Korean Journal of Parasitology.2018; 56(4): 375.     CrossRef
  • Histopathological findings in wild Nutrias (Myocastor coypus) with Capillaria hepatica infection
    Il-Hwa HONG, Sun-Young KANG, Jong-Hyun KIM, Seong-Hoon SEOK, Seong-Kyu LEE, Seong-Jin HONG, Seung-Yong LEE, Se-Jin PARK, Joo-Yeon KONG, Seong-Chan YEON
    Journal of Veterinary Medical Science.2016; 78(12): 1887.     CrossRef
  • 11,948 View
  • 143 Download
  • 9 Web of Science
  • Crossref
A Case of Ocular Toxocariasis Successfully Treated with Albendazole and Triamcinolon
San Seong, Daruchi Moon, Dong Kyu Lee, Hyung Eun Kim, Hyun Sup Oh, Soon Hyun Kim, Oh Woong Kwon, Yong Sung You
Korean J Parasitol 2014;52(5):537-540.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.537

We present a case of ocular toxocariasis treated successfully with oral albendazole in combination with steroids. A 26-year-old male visited the authors' clinic with the chief complaint of flying flies in his right eye. The fundus photograph showed a whitish epiretinal scar, and the fluorescein angiography revealed a hypofluorescein lesion of the scar and late leakage at the margin. An elevated retinal surface and posterior acoustic shadowing of the scar were observed in the optical coherence tomography, and Toxocara IgG was positive. The patient was diagnosed with toxocariasis, and the condition was treated with albendazole (400 mg twice a day) for a month and oral triamcinolone (16 mg for 2 weeks, once a day, and then 8 mg for 1 week, once a day) from day 13 of the albendazole treatment. The lesions decreased after the treatment. Based on this study, oral albendazole combined with steroids can be a simple and effective regimen for treating ocular toxocariasis.

Citations

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  • Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection
    Katrin Henke, Sotirios Ntovas, Eleni Xourgia, Aristomenis K. Exadaktylos, Jolanta Klukowska-Rötzler, Mairi Ziaka
    International Journal of Environmental Research and Public Health.2023; 20(21): 6972.     CrossRef
  • Toxocariasis ocular simulando un hamartoma retiniano. Reportefide un caso
    Luis R. Michel-Espinoza, Belina Arias-Cabello, Daniel Moreno-Páramo, M. Estela Arroyo-Yllanes
    Revista Mexicana de Oftalmología.2021; 95(6S): 285.     CrossRef
  • Treatment of larva migrans syndrome with long-term administration of albendazole
    Amy Hombu, Ayako Yoshida, Taisei Kikuchi, Eiji Nagayasu, Mika Kuroki, Haruhiko Maruyama
    Journal of Microbiology, Immunology and Infection.2019; 52(1): 100.     CrossRef
  • Ocular toxocariasis in a pediatric patient undergoing a bone marrow transplantation
    Blanca Molina, Marta González-Vicent, Isabel Valls, Miguel Ángel Díaz
    Enfermedades Infecciosas y Microbiología Clínica.2019; 37(9): 617.     CrossRef
  • Ocular toxocariasis: a neglected parasitic disease in Egypt
    Nagwa Mostafa El-Sayed, Nagham Gamal Masoud
    Bulletin of the National Research Centre.2019;[Epub]     CrossRef
  • Ocular toxocariasis in a pediatric patient undergoing a bone marrow transplantation
    Blanca Molina, Marta González-Vicent, Isabel Valls, Miguel Ángel Díaz
    Enfermedades infecciosas y microbiologia clinica (English ed.).2019; 37(9): 618.     CrossRef
  • Toxocariasis: critical analysis of serology in patients attending a public referral center for ophthalmology in Brazil
    Guita Rubinsky-Elefant, Joyce H. Yamamoto, Carlos E. Hirata, Luiz E. Prestes-Carneiro
    Japanese Journal of Ophthalmology.2018; 62(1): 77.     CrossRef
  • 13,215 View
  • 124 Download
  • 5 Web of Science
  • Crossref
Eosinophilic Pleuritis due to Sparganum: A Case Report
Youngmin Oh, Jeong-Tae Kim, Mi-Kyeong Kim, You-Jin Chang, Keeseon Eom, Jung-Gi Park, Ki-Man Lee, Kang-Hyeon Choe, Jin-Young An
Korean J Parasitol 2014;52(5):541-543.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.541

Sparganosis is a rare parasitic disease caused by migrating plerocercoid tapeworm larva of the genus Spirometra. Infection in humans is mainly caused by the ingestion of raw or inadequately cooked flesh of infected frogs, snakes, and chickens. Here, we report a rare case of a 45-year-old man who was admitted to our hospital with left lower chest pain. The chest radiograph and computed tomography (CT) scan revealed localized pleural effusion in the left lower lobe; further, peripheral blood eosinophilia and eosinophilic pleural effusion were present. Percutaneous catheter drainage was performed, which revealed long worm-shaped material that was identified as a sparganum by DNA sequencing. The patient showed clinical improvement after drainage of the sparganum. This study demonstrates the importance of considering parasitic diseases in the differential diagnosis of eosinophilic pleural effusion.

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  • Pleural effusion caused by Trichinella spiralis infection: two case reports
    Zhen-zhen Pan, Miao-juan Zhu, Yu-qiong Rong, Jiong Yang
    BMC Infectious Diseases.2023;[Epub]     CrossRef
  • Epidemiology, Diagnosis, and Prevention of Sparganosis in Asia
    Wei Liu, Tengfang Gong, Shuyu Chen, Quan Liu, Haoying Zhou, Junlin He, Yong Wu, Fen Li, Yisong Liu
    Animals.2022; 12(12): 1578.     CrossRef
  • Incidence, aetiology and clinical features of eosinophilic pleural effusion: a retrospective study
    Minfang Li, Yunxiang Zeng, Yaqing Li, Dan Jia, Sheng Chen, Jinlin Wang
    BMC Pulmonary Medicine.2021;[Epub]     CrossRef
  • Recurrent eosinophilic pleuritis caused by sparganum infection
    Liangjie Fang, Yuehong Wang, Qiqi Gao, Bing Yan, Jianying Zhou
    Medicine.2020; 99(22): e20226.     CrossRef
  • Retrospective study of pleural parasitic infestations: a practical diagnostic approach
    Jinlin Wang, Weizhan Luo, Panxiao Shen, Jianxing He, Yunxiang Zeng
    BMC Infectious Diseases.2019;[Epub]     CrossRef
  • Eosinophilia in Pleural Effusions: a Speculative Negative Predictor for Malignancy
    Fang-Yeh Chu, Ching-Biau Liou, Jen-Tang Sun, Chia-Hao Bei, Tse-Hsuan Liou, N-Chi Tan, Yun-Chieh Yu, Chih-Chun Chang, Tzung-Hai Yen, Ming-Jang Su
    Asian Pacific Journal of Cancer Prevention.2016; 17(3): 1411.     CrossRef
  • Clinical Features of Pulmonary Sparganosis
    Ning Li, Yi Xiang, Yun Feng, Min Li, Bei Li Gao, Qing Yun Li
    The American Journal of the Medical Sciences.2015; 350(6): 436.     CrossRef
  • 9,482 View
  • 83 Download
  • 6 Web of Science
  • Crossref
Scrotal Sparganosis Mimicking Scrotal Teratoma in an Infant: A Case Report and Literature Review
Yi-Ming Zhao, Hao-Chuan Zhang, Zhong-Rong Li, Hai-Yan Zhang
Korean J Parasitol 2014;52(5):545-549.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.545

Sparganosis is an infection with a parasitic tapeworm larva that occurs by eating infected foods or drinking contaminated water. The larvae can migrate to a tissue or muscle in the chest, abdominal wall, extremities, eyes, brain, urinary tract, pleura, pericardium, spinal canal, or scrotum. Herein, we report a 5-month old infant with scrotal sparganosis who was initially suspected to have a scrotal inflammatory mass with a history of applying raw frog meat into the umbilicus. Preoperative ultrasound examinations and computed tomography (CT) scanning misdiagnosed the mass as a scrotal teratoma. The scrotal mass was surgically removed, and the histopathology proved it to be scrotal sparganosis. This case displays the youngest patient ever reported with scrotal sparganosis, and the first description of CT characteristics of scrotal sparganosis. A detailed medical history is necessary for patients with scrotal masses suspected of sparganosis. In addition, ultrasound and CT examinations are helpful to rule out other causes of a scrotal mass.

Citations

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  • Low prevalence of spargana infection in farmed frogs in the Yangtze River Delta of China
    Xiaoli Zhang, Rongsheng Mi, Yehua Zhang, Shijie Zhang, Tao Sun, Haiyan Jia, Yan Huang, Haiyan Gong, Xiangan Han, Zhaoguo Chen
    Infection, Genetics and Evolution.2020; 85: 104466.     CrossRef
  • Sparganosis as an accidental human parasitic disease
    Jolanta Czyżewska, Joanna Matowicka-Karna
    Diagnostyka Laboratoryjna.2018; 54(3): 167.     CrossRef
  • Seroprevalence of Sparganosis in Rural Communities of Northern Tanzania
    Nicholas Kavana, Parthasarathy Sonaimuthu, Christopher Kasanga, Ayub Kassuku, Hesham M. Al-Mekhlafi, Mun Yik Fong, Mohammad Behram Khan, Rohela Mahmud, Yee Ling Lau
    The American Journal of Tropical Medicine and Hygiene.2016; 95(4): 874.     CrossRef
  • 9,974 View
  • 90 Download
  • 2 Web of Science
  • Crossref
Brief Communications
Prevalence of Trichomonas vaginalis by PCR in Men Attending a Primary Care Urology Clinic in South Korea
Jun-Hyeok Seo, Hye-Won Yang, So-Young Joo, Su-Min Song, Yu-Ran Lee, Jae-Sook Ryu, Eun Sang Yoo, Won Kee Lee, Hyun-Hee Kong, Sang-Eun Lee, Won-Ja Lee, Youn-Kyoung Goo, Dong-Il Chung, Yeonchul Hong
Korean J Parasitol 2014;52(5):551-555.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.551

Trichomonas vaginalis, a causative agent of trichomoniasis, may trigger symptomatic or asymptomatic nongonococcal urethritis and chronic prostatitis in men. Despite the availability of highly sensitive diagnostic tests, such as nucleic acid amplification tests, including PCR, few prospective studies present data on male T. vaginalis infection in South Korea. In the present study, the prevalence of T. vaginalis and associated clinical conditions were evaluated in 201 male patients from a primary care urology clinic in South Korea. The prevalence of T. vaginalis infection in our cohort was 4% (8/201) by PCR. T. vaginalis infection was common in men older than 40 years (median age, 52 years). Among the 8 Trichomonas-positive patients, 87.5% (7/8) had prostatic diseases, such as prostatitis and benign prostatic hyperplasia, and 25.0% (2/8) and 12.5% (1/8) were coinfected with Chlamydia trachomatis and Mycoplasma genitalium, respectively. Our results suggest that T. vaginalis infection is not rare in men attending primary care urology clinics in South Korea, especially in those older than 40 years, in whom it may explain the presence of prostatic disease. The possibility of T. vaginalis infection should be routinely considered in older male patients with prostatic diseases in South Korea.

Citations

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  • Trichomoniasis in Men: A Neglected Factor in Male Infertility?
    Seyed Ali Hosseini, Mohammad Matini, Maryam Bahmanzadeh, Reza Aslani, Faeze Foroughi-Parvar
    Acta Parasitologica.2025;[Epub]     CrossRef
  • Systematic review and meta-analysis of the global prevalence and infection risk factors of Trichomonas vaginalis
    Wenjie Tian, Yuhua Li, Yani Zhang, Yiming Zhang, Yiran Qin, Yalin Han, Dongxian Li, Shuai Wang, Zhenke Yang, Xiaowei Tian, Xuefang Mei, Zhenchao Zhang
    Parasite.2025; 32: 56.     CrossRef
  • Prevalence of trichomoniasis infection among adults in Nigerian community settings
    K. Chukwuemeka Obetta, Innocent Okonkwo Ogbonna, Dorida Nneka Oyigbo, Oliver Onyemaechi Ugwu, Kenneth Okonkwo Ugwu, Beatrice N. Onah, Chinasa Maryrose Ugwunnadi, Joseph O. Acha, Ngozi Uzoamaka Chuke, Ogechi Nkemjika, Onyinyechi Elizabeth Okoye
    Medicine.2023; 102(37): e34585.     CrossRef
  • Prevalence and Genotype of Trichomonas vaginalis among Men in Xinxiang City, Henan Province, China
    Zhenchao Zhang, Yuhui Sang, Pucheng Wu, Yujia Shang, Lesong Li, Yujuan Duan, Linfei Zhao, Minghui Gao, Lihua Guo, Xiaowei Tian, Zhenke Yang, Shuai Wang, Lixia Hao, Xuefang Mei, Jianbing Mu
    Journal of Tropical Medicine.2023; 2023: 1.     CrossRef
  • Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia
    Ik-Hwan Han, Jung-Hyun Kim, Jae-Sook Ryu
    Parasites, Hosts and Diseases.2023; 61(1): 2.     CrossRef
  • Urogenital Trichomonas vaginalis infection in males: a case report and retrospective analysis of a 10‐year period in a tertiary hospital
    Miguel Alpalhão, Luís Marques‐Lito, Paulo Filipe, João Borges‐Costa
    International Journal of Dermatology.2022;[Epub]     CrossRef
  • Seroprevalence and risk factors of Trichomonas vaginalis among couples in Al-Hamza city-Iraq.
    Musafer H. Al-Ardi
    Al-Kufa University Journal for Biology.2021; 13(1): 26.     CrossRef
  • Comparison of Seropositivity to Trichomonas vaginalis between Men with Prostatic Tumor and Normal Men
    Jung-Hyun Kim, Hong-Sang Moon, Kyu-Shik Kim, Hwan-Sik Hwang, Jae-Sook Ryu, Sung-Yul Park
    The Korean Journal of Parasitology.2019; 57(1): 21.     CrossRef
  • Comparison of Two PCR Assays for Trichomonas vaginalis
    Chang-Suk Noh, Sang-Su Kim, Sung-Yul Park, Hong-Sang Moon, Yeonchul Hong, Jae-Sook Ryu
    The Korean Journal of Parasitology.2019; 57(1): 27.     CrossRef
  • Status of common parasitic diseases in Korea in 2019
    Sun Huh
    Journal of the Korean Medical Association.2019; 62(8): 437.     CrossRef
  • Prevalence of Trichomonas vaginalis in Women Visiting 2 Obstetrics and Gynecology Clinics in Daegu, South Korea
    Youn-Kyoung Goo, Won-Sik Shin, Hye-Won Yang, So-Young Joo, Su-Min Song, Jae-Sook Ryu, Won-Myung Lee, Hyun-Hee Kong, Won-Ki Lee, Sang-Eun Lee, Won-Ja Lee, Dong-Il Chung, Yeonchul Hong
    The Korean Journal of Parasitology.2016; 54(1): 75.     CrossRef
  • Prostatic Disease Associated withTrichomonas vaginalis
    Jae-Sook Ryu
    The Korean Journal of Urogenital Tract Infection and Inflammation.2014; 9(2): 61.     CrossRef
  • 11,538 View
  • 127 Download
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Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
Purva Gupta, Veena Pande, Aparup Das, Vineeta Singh
Korean J Parasitol 2014;52(5):557-564.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.557

The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies.

Citations

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  • Genomic dynamics of clinical Plasmodium vivax: comparative genomic hybridization in severe malaria cases
    Sampreeti Tahbildar, Pon Arunachalam Boopathi, Sanjay Kumar Kochar, Dhanpat Kumar Kochar, Mohamed Aiyaz, Raja C. Mugasimangalam, Sudha N. Rao, Ashis Das
    Frontiers in Malaria.2025;[Epub]     CrossRef
  • Population genetic analysis of Plasmodium vivax vir genes in Pakistan
    Sylvatrie-Danne Dinzouna-Boutamba, Zin Moon, Sanghyun Lee, Sahib Gul Afridi, Hương Giang Lê, Yeonchul Hong, Byoung-Kuk Na, Youn-Kyoung Goo
    Parasites, Hosts and Diseases.2024; 62(3): 313.     CrossRef
  • Misidentification of Plasmodium Species by Cross-Reacting Primers and Cerebral Malaria Caused by Plasmodium vivax
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Ixodid Tick Infestation in Cattle and Wild Animals in Maswa and Iringa, Tanzania
You Shine Kwak, Tae Yun Kim, Sung-Hyun Nam, In-Yong Lee, Hyung-Pyo Kim, Simon Mduma, Julius Keyyu, Robert Fyumagwa, Tai-Soon Yong
Korean J Parasitol 2014;52(5):565-568.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.565

Ticks and tick-borne diseases are important in human and livestock health worldwide. In November 2012, ixodid ticks were collected and identified morphologically from cattle and wild animals in the Maswa district and Iringa urban, Tanzania. Amblyomma gemma, A. lepidum, and A. variegatum were identified from Maswa cattle, and A. variegatum was the predominant species. A. marmoreum, Hyalomma impeltatum, and Rhipicephalus pulchellus were identified from Iringa cattle in addition to the above 3 Amblyomma species, and A. gemma was the most abundant species. Total 4 Amblyomma and 6 Rhipicephalus species were identified from wild animals of the 2 areas. A. lepidum was predominant in Maswa buffaloes, whereas A. gemma was predominant in Iringa buffaloes. Overall, A. variegatum in cattle was predominant in the Maswa district and A. gemma was predominant in Iringa, Tanzania.

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  • Prevalence of Tick-Borne Pathogens from Ticks Collected from Cattle and Wild Animals in Tanzania in 2012
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  • Abundance and distribution of Ixodid tick species infesting cattle reared under traditional farming systems in Tanzania
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V-shaped Pits in Regions of Ancient Baekje Kingdom Paleoparasitologically Confirmed as Likely Human-Waste Reservoirs
Dong Hoon Shin, Sang-Yuck Shim, Myeung Ju Kim, Chang Seok Oh, Mi-Hyun Lee, Suk Bae Jung, Geon Il Lee, Jong-Yil Chai, Min Seo
Korean J Parasitol 2014;52(5):569-573.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.569

In a paleo-parasitological analysis of soil samples obtained from V-shaped pits dating to the ancient Baekje period in Korean history, we discovered Ascaris lumbricoides, Trichuris trichiura, and Clonorchis sinensis eggs. In light of the samples' seriously contaminated state, the V-shaped pits might have served as toilets, cesspits, or dung heaps. For a long period of time, researchers scouring archaeological sites in Korea have had difficulties locating such structures. In this context then, the present report is unique because similar kind of the ancient ruins must become an ideal resource for successful sampling in our forthcoming paleoparasitological studies.

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    The Korean Journal of Parasitology.2017; 55(3): 357.     CrossRef
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