Parasites, Hosts and Diseases

"Jin-Soo Lee"

Case Reports

Subcapsular Splenic Hemorrhage in Vivax Malaria: Jae Hyoung Im, Moon-Hyun Chung, Areum Durey, Jin-Soo Lee, Tong-Soo Kim, Hea Yoon Kwon, Ji Hyeon Baek; Korean J Parasitol 2019;57(4):405-409.
Published online August 31, 2019; DOI: https://doi.org/10.3347/kjp.2019.57.4.405

Abstract
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In malaria, splenic rupture is a serious complication potentially leading to death. Subcapsular hemorrhage of spleen is thought to be an impending sign of splenic rupture; however, the characteristics of subcapsular hemorrhage are not well known. We report 3 cases of subcapsular hemorrhage of the spleen in vivax malaria, with varying degrees of severity. Case 1 showed subcapsular hemorrhage without splenic rupture, was treated by antimalarial drug without any procedure. The healing process of the patient's spleen was monitored through 6 computed tomography follow-up examinations, over 118 days. Case 2 presented subcapsular hemorrhage with splenic rupture, treated only with an antimalarial drug. Case 3 showed subcapsular hemorrhage with splenic rupture and hypotension, treated using splenic artery embolization. They all recovered from subcapsular hemorrhage without any other complications. These 3 cases reveal the process of subcapsular hemorrhage leading to rupture and a potentially fatal outcome. The treatment plan of subcapsular hemorrhage should be determined carefully considering the vital signs, changes in hemoglobin, and bleeding tendency.

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Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea: Hea Yoon Kwon, Jae Hyoung Im, Yun-Kyu Park, Areum Durey, Jin-Soo Lee, Ji Hyeon Baek; Korean J Parasitol 2018;56(6):609-613.
Published online December 31, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.6.609

Abstract
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Babesiosis, caused by Babesia microti and B. divergens, is transmitted by Ixodid ticks. Symptoms of babesiosis vary from a mild flu-like illness to acute, severe, and sometimes fatal and fulminant disease. In Korea, 7 imported babesiosis cases and 1 endemic case have been reported. We report 2 cases of severe babesiosis initially mistaken as malaria. The first patient was complicated by shock and splenic infarction, the other co-infected with Lyme disease. As the population traveling abroad increases every year, physicians should be aware of babesiosis which mimics malaria, co-infection with other diseases, and its complications.

Citations

Citations to this article as recorded by

Imported parasitic diseases in the Republic of Korea: status and issues
Jong-Yil Chai
Journal of the Korean Medical Association.2025; 68(1): 52. CrossRef
Splenic Infarction in Babesiosis: A Case Series
Kaetlyn Arant, Ty Agaisse, Athanasios Vassilopoulos, Sassine Ghanem, Michael Santos
Journal of Brown Hospital Medicine.2025;[Epub] CrossRef
Detection of US and Kobe‐type Babesia microti in ticks collected from small mammals of the Republic of Korea
Tae Yun Kim, Seong Yoon Kim, Jiye Seo, Hee IL Lee, Wook‐Gyo Lee, Hyunwoo Kim
Entomological Research.2024;[Epub] CrossRef
Current Status of Trypanosoma grosi and Babesia microti in Small Mammals in the Republic of Korea
Hyun Jung Kim, BoGyeong Han, Hee-Il Lee, Jung-Won Ju, Hyun-Il Shin
Animals.2024; 14(7): 989. CrossRef
Imported human babesiosis in the Republic of Korea, 2019: two case reports
Hyun Jung Kim, Min Jae Kim, Hyun-Il Shin, Jung-Won Ju, Hee-Il Lee
Parasites, Hosts and Diseases.2023; 61(1): 72. CrossRef
iSeq 100 for metagenomic pathogen screening in ticks
Ju Yeong Kim, Myung-hee Yi, Alghurabi Areej Sabri Mahdi, Tai-Soon Yong
Parasites & Vectors.2021;[Epub] CrossRef
Molecular evidence of zoonotic Babesia species, other than B. microti, in ixodid ticks collected from small mammals in the Republic of Korea
Tae Yun Kim, Seong Yoon Kim, Tae‐Kyu Kim, Hee IL Lee, Shin‐Hyeong Cho, Wook‐Gyo Lee, Hyunwoo Kim
Veterinary Medicine and Science.2021; 7(6): 2427. CrossRef
Interactions between Babesia microti merozoites and rat kidney cells in a short-term in vitro culture and animal model
Marta Albertyńska, Hubert Okła, Krzysztof Jasik, Danuta Urbańska-Jasik, Przemysław Pol
Scientific Reports.2021;[Epub] CrossRef
A Review of Zoonotic Babesiosis as an Emerging Public Health Threat in Asia
Sabir Hussain, Abrar Hussain, Muhammad Umair Aziz, Baolin Song, Jehan Zeb, David George, Jun Li, Olivier Sparagano
Pathogens.2021; 11(1): 23. CrossRef
Splenic Complications ofBabesia microtiInfection in Humans: A Systematic Review
Igor Dumic, Cristian Madrid, Libardo Rueda Prada, Charles W. Nordstrom, Pahnwat Tonya Taweesedt, Poornima Ramanan
Canadian Journal of Infectious Diseases and Medical Microbiology.2020; 2020: 1. CrossRef
A Practical Approach to the Diagnosis of Lyme Borreliosis: From Clinical Heterogeneity to Laboratory Methods
Giusto Trevisan, Serena Bonin, Maurizio Ruscio
Frontiers in Medicine.2020;[Epub] CrossRef

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Original Article

Evaluation of the Accuracy of the EasyTest™ Malaria Pf/Pan Ag, a Rapid Diagnostic Test, in Uganda: Chom-Kyu Chong, Pyo Yun Cho, Byoung-Kuk Na, Seong Kyu Ahn, Jin Su Kim, Jin-Soo Lee, Sung-Keun Lee, Eun-Taek Han, Hak-Yong Kim, Yun-Kyu Park, Seok Ho Cha, Tong-Soo Kim; Korean J Parasitol 2014;52(5):501-505.
Published online October 22, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.5.501

Abstract
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In recent years, rapid diagnostic tests (RDTs) have been widely used for malaria detection, primarily because of their simple operation, fast results, and straightforward interpretation. The Asan EasyTest™ Malaria Pf/Pan Ag is one of the most commonly used malaria RDTs in several countries, including Korea and India. In this study, we tested the diagnostic performance of this RDT in Uganda to evaluate its usefulness for field diagnosis of malaria in this country. Microscopic and PCR analyses, and the Asan EasyTest™ Malaria Pf/Pan Ag rapid diagnostic test, were performed on blood samples from 185 individuals with suspected malaria in several villages in Uganda. Compared to the microscopic analysis, the sensitivity of the RDT to detect malaria infection was 95.8% and 83.3% for Plasmodium falciparum and non-P. falciparum, respectively. Although the diagnostic sensitivity of the RDT decreased when parasitemia was ≤500 parasites/?l, it showed 96.8% sensitivity (98.4% for P. falciparum and 93.8% for non-P. falciparum) in blood samples with parasitemia ≥100 parasites/?l. The specificity of the RDT was 97.3% for P. falciparum and 97.3% for non-P. falciparum. These results collectively suggest that the accuracy of the Asan EasyTest™ Malaria Pf/Pan Ag makes it an effective point-of-care diagnostic tool for malaria in Uganda.

Citations

Citations to this article as recorded by

Asymptomatic malaria infection, associated factors and accuracy of diagnostic tests in a historically high transmission setting in Northern Uganda
Bosco B. Agaba, Simon P. Rugera, Ruth Mpirirwe, Martha Atekat, Samuel Okubal, Khalid Masereka, Miseal Erionu, Bosco Adranya, Gertrude Nabirwa, Patrick B. Odong, Yasin Mukiibi, Isaac Ssewanyana, Susan Nabadda, Enoch Muwanguzi
Malaria Journal.2022;[Epub] CrossRef
Genetic diversity of Plasmodium vivax and Plasmodium falciparum lactate dehydrogenases in Myanmar isolates
Jinyoung Lee, Tae Im Kim, Hương Giang Lê, Won Gi Yoo, Jung-Mi Kang, Seong-Kyu Ahn, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim, Byoung-Kuk Na
Malaria Journal.2020;[Epub] CrossRef
Limitations of rapid diagnostic tests in malaria surveys in areas with varied transmission intensity in Uganda 2017-2019: Implications for selection and use of HRP2 RDTs
Agaba B. Bosco, Joaniter I. Nankabirwa, Adoke Yeka, Sam Nsobya, Karryn Gresty, Karen Anderson, Paul Mbaka, Christiane Prosser, David Smith, Jimmy Opigo, Rhoda Namubiru, Emmanuel Arinaitwe, John Kissa, Samuel Gonahasa, Sungho Won, Bora Lee, Chae Seung Lim,
PLOS ONE.2020; 15(12): e0244457. CrossRef
An Update on Malaria Rapid Diagnostic Tests
Avinash N. Mukkala, Jason Kwan, Rachel Lau, David Harris, Dylan Kain, Andrea K. Boggild
Current Infectious Disease Reports.2018;[Epub] CrossRef
Comparative Assessment of Diagnostic Performances of Two Commercial Rapid Diagnostic Test Kits for Detection of Plasmodium spp. in Ugandan Patients with Malaria
Young Yil Bahk, Seo Hye Park, Woojoo Lee, Kyoung Jin, Seong Kyu Ahn, Byoung-Kuk Na, Tong-Soo Kim
The Korean Journal of Parasitology.2018; 56(5): 447. CrossRef
An Evaluation of Active Case Detection in Malaria Control Program in Kiyuni Parish of Kyankwanzi District, Uganda
Young Yil Bahk, Pyo Yun Cho, Seong Kyu Ahn, Woo-Joo Lee, Tong-Soo Kim
The Korean Journal of Parasitology.2018; 56(6): 625. CrossRef
Comparison of the diagnostic performance of microscopic examination with nested polymerase chain reaction for optimum malaria diagnosis in Upper Myanmar
Jung-Mi Kang, Pyo-Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong-Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim, Byoung-Kuk Na
Malaria Journal.2017;[Epub] CrossRef
A Cluster Randomised Trial Introducing Rapid Diagnostic Tests into Registered Drug Shops in Uganda: Impact on Appropriate Treatment of Malaria
Anthony K. Mbonye, Pascal Magnussen, Sham Lal, Kristian S. Hansen, Bonnie Cundill, Clare Chandler, Siân E. Clarke, Roly D Gosling
PLOS ONE.2015; 10(7): e0129545. CrossRef

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Case Reports

A Case of Vivax Malaria Complicated by Adult Respiratory Distress Syndrome and Successful Management with Extracorporeal Membrane Oxygenation: Hyun-Jung Lee, Ji-Hyeon Baek, Myoung-Hun Chae, Hoyeon Joo, Jin-Soo Lee, Moon-Hyun Chung, Yun-Kyu Park, Joung-Teak Kim; Korean J Parasitol 2013;51(5):551-555.
Published online October 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.5.551

Abstract
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Complicated malaria is mainly caused by Plasmodium falciparum, but, increasingly, Plasmodium vivax is also being reported as a cause. Since the reemergence of indigenous vivax malaria in 1993, cases of severe malaria have been steadily reported in Korea. Herein, we report a case of vivax malaria complicated by adult respiratory distress syndrome (ARDS) that was successfully managed with extracorporeal membrane oxygenation (ECMO). A 59-year-old man presented at our hospital with fever and abdominal pain, which had persisted for 10 days. On admission, the patient had impaired consciousness, shock, hypoxia and haziness in both lungs, jaundice, thrombocytopenia and disseminated intravascular coagulation, metabolic acidosis, and acute kidney injury. A peripheral blood smear and a rapid diagnostic test verified P. vivax mono-infection. Ten hours after admission, hypoxia became more severe, despite providing maximal ventilatory support. The administration of antimalarial agents, ECMO, and continuous venovenous hemofiltration resulted in an improvement of his vital signs and laboratory findings. He was discharged from the hospital 7 weeks later, without any sequelae.

Citations

Citations to this article as recorded by

Resolution of experimental malaria-associated acute respiratory distress syndrome is Alox12 independent and shows residual inflammation
Fran Prenen, Bram De Pauw, Sofie Knoops, Emilie Pollenus, Hendrik Possemiers, Johan Van Weyenbergh, Philippe E. Van den Steen
Malaria Journal.2025;[Epub] CrossRef
Membrana de oxigenación extracorpórea (ECMO) como terapia puente a la cirugía en paciente con síndrome de distrés respiratorio agudo (SDRA) debido a la rotura de un quiste hidatídico pulmonar
María Teresa Gómez-Hernández, Ernest J. Martínez, Marta G. Fuentes, Marta Paz, Israel Rodríguez, Nuria M. Novoa, Marcelo F. Jiménez
Archivos de Bronconeumología.2021; 57(7): 503. CrossRef
Extracorporeal membrane oxygenation (ECMO) as bridge therapy to surgery in a patient with acute respiratory distress syndrome (ARDS) due to rupture of a pulmonary hydatid cyst
María Teresa Gómez-Hernández, Ernest J. Martínez, Marta G. Fuentes, Marta Paz, Israel Rodríguez, Nuria M. Novoa, Marcelo F. Jiménez
Archivos de Bronconeumología (English Edition).2021; 57(7): 503. CrossRef
Prevalence and risk factors related to poor outcome of patients with severe Plasmodium vivax infection: a systematic review, meta-analysis, and analysis of case reports
Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni De Jesus Milanez, Frederick Ramirez Masangkay
BMC Infectious Diseases.2020;[Epub] CrossRef
The emergence of pathogenic TNF/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4
Bruno Galvão-Filho, Júlia Teixeira de Castro, Maria Marta Figueiredo, Claudio Gonçalves Rosmaninho, Lis Ribeiro do Valle Antonelli, Ricardo Tostes Gazzinelli
Mucosal Immunology.2019; 12(2): 312. CrossRef
Monocyte-derived dendritic cells in malaria
Isabella C Hirako, Patrícia A Assis, Bruno Galvão-Filho, Andrew D Luster, Lis RV Antonelli, Ricardo T Gazzinelli
Current Opinion in Microbiology.2019; 52: 139. CrossRef
Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?
Marcelo L. M. Pereira, Claudio R. F. Marinho, Sabrina Epiphanio
Frontiers in Cellular and Infection Microbiology.2018;[Epub] CrossRef
Development of Visually Improved Loop Mediated Isothermal Amplification for the Diagnosis of Plasmodium vivax Malaria in a Tertiary Hospital in Chandigarh, North India
Hargobinder Kaur, Rakesh Sehgal, Devendra Bansal, Ali A. Sultan, Ashish Bhalla, Sunit C. Singhi
The American Journal of Tropical Medicine and Hygiene.2018; 98(5): 1374. CrossRef
Severe Plasmodium vivax infection in Korea
Jae Hyoung Im, Hea Yoon Kwon, JiHyeon Baek, Seong Wook Park, Areum Durey, Kyung Hee Lee, Moon-Hyun Chung, Jin-Soo Lee
Malaria Journal.2017;[Epub] CrossRef
Respiratory Complications of Plasmodium vivax Malaria: Systematic Review and Meta-Analysis
Hernando del Portillo, Fernando Val, Wuelton Marcelo Monteiro, Quique Bassat, Kim Machado, Lisiane Barbosa, Jorge Luis Salinas, André Machado Siqueira, Marcus Vinícius Guimarães Lacerda, Maria Graças Costa Alecrim
The American Journal of Tropical Medicine and Hygiene.2017; 97(3): 733. CrossRef
Extracorporeal Membrane Oxygenation in Dengue, Malaria, and Acute Chagas Disease
Leonardo A. Salazar, Cornelis M. Schreuder, Jhonathan A. Eslava, Adriana S. Murcia, Mario J. Forero, Mauricio A. Orozco-Levi, Luis E. Echeverría, Anton io Figueredo
ASAIO Journal.2017; 63(6): e71. CrossRef
Imported Plasmodium vivax malaria with severe thrombocytopaenia: can it be severe malaria or not?
Spinello Antinori, Alberto Corona, Anna Lisa Ridolfo, Laura Galimberti, Davide Ricaboni, Laura Milazzo, Mario Corbellino
Malaria Journal.2016;[Epub] CrossRef

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A case of symptomatic splenic infarction in vivax malaria: Areum Kim, Yun-Kyu Park, Jin-Soo Lee, Moon-Hyun Chung, Eun Sil Kim; Korean J Parasitol 2007;45(1):55-58.
Published online March 20, 2007; DOI: https://doi.org/10.3347/kjp.2007.45.1.55

Abstract
PDF

Splenic infarction is a rare complication in malaria cases, and is caused primarily by Plasmodium falciparum. Recently in South Korea, only P. vivax has prevailed since 1993. Although the probability that symptomatic splenic infarction may occur in vivax malaria cases is considered relatively high, there have never been any case reports describing the occurrence of symptomatic splenic infarction in cases of vivax malaria. A 34-year-old man presented with fever that had persisted for 5 days. P. vivax infection was verified using a peripheral blood smear, and chloroquine was utilized to treat the fever successfully. Six days later, the patient developed pain in the left upper abdomen, which was diagnosed as splenic infarction by computed tomography.

Citations

Citations to this article as recorded by

Splenic Infarction in Plasmodium vivax Infection in South Korea
Jae Hyoung Im, Moon-Hyun Chung, Areum Durey, Hea Yoon Kwon, Jin-Soo Lee, Man-Jong Lee, Ji Hyeon Baek
The American Journal of Tropical Medicine and Hygiene.2019; 101(4): 803. CrossRef
Severe Plasmodium vivax infection in Korea
Jae Hyoung Im, Hea Yoon Kwon, JiHyeon Baek, Seong Wook Park, Areum Durey, Kyung Hee Lee, Moon-Hyun Chung, Jin-Soo Lee
Malaria Journal.2017;[Epub] CrossRef
Acute necrotizing hemorrhagic pancreatitis in falciparum malaria
JOSÉ FELIPE REOYO PASCUAL
Revista Española de Enfermedades Digestivas.2015;[Epub] CrossRef
Imaging of the spleen in malaria
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Splenic infarction and malaria
Francesca F. Norman, Jorge Rojas-Marcos, José-Manuel Hermida-Donate, Begoña Monge-Maillo, Jose Antonio Perez-Molina, Rogelio López-Vélez
Transactions of The Royal Society of Tropical Medicine and Hygiene.2014; 108(8): 455. CrossRef
Plasmodium vivaxmalaria complicated by splenic infarct
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Paediatrics and International Child Health.2014; 34(1): 63. CrossRef
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The American Journal of Tropical Medicine and Hygiene.2014; 91(6): 1094. CrossRef
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J. Kevin Baird
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Two Cases of Vivax Malaria Accompanied by Splenic Complications (such as splenic rupture and splenic infarction)
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Acute pancreatitis and subdural haematoma in a patient with severe falciparum malaria: Case report and review of literature
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