Parasites, Hosts and Diseases

"Mejeong Lee"

Original Articles

Development of resistance to reinfection by Clonorchis sinensis in rats: Byung-Suk Chung, Hongman Zhang, Min-Ho Choi, Deogkyu Jeon, Shunyu Li, Mejeong Lee, Sung-Tae Hong; Korean J Parasitol 2004;42(1):19-26.
Published online March 20, 2004; DOI: https://doi.org/10.3347/kjp.2004.42.1.19

Abstract
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We investigated the induction of resistance to Clonorchis sinensis infection by prior infection in rat and hamster models. Animals were challenged with C. sinensis metacercariae, then treated with praziquantel and reinfected. Worm recovery rate in reinfected animals was used to estimate resistance to reinfection. The determined resistance rates to reinfection in rats and hamsters were 97.7% and 10.3%, respectively. In rats, cure from the primary infection of C. sinensis increased resistant to reinfection, and the greatert the worm burden and the longer the duration of primary infection, the higher was the resistance rate. For primary infection doses of 10, 40 and 100 metacercariae per rat, the resistance rates were 87.4%, 93.8% and 98.4%, respectively. The resistance rates in rats after 2 or 8-week primary infection were 78.7% and 95.3%, respectively. All worms recovered from reinfected rats were immature. When cured rats were administered with methylprednisolone, resistance to reinfection became impaired. These findings indicate that rats develop a high degree of resistance to reinfection by C. sinensis after cure. The growths and maturations of reinfected worms were also impaired.

Citations

Citations to this article as recorded by

Long Non-Coding RNA and mRNA Expression Analysis in Liver of Mice With Clonorchis sinensis Infection
Su Han, Xue-Li Zhang, Xu Jiang, Xiang Li, Jian Ding, Li-Jiao Zuo, Shan-Shan Duan, Rui Chen, Bei-Bei Sun, Xin-Yi Hu, Yan-Nan Gao, Xiao-Li Zhang
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Bacillus subtilis spore with surface display of paramyosin from Clonorchis sinensis potentializes a promising oral vaccine candidate
Hengchang Sun, Zhipeng Lin, Lu Zhao, Tingjin Chen, Mei Shang, Hongye Jiang, Zeli Tang, Xinyi Zhou, Mengchen Shi, Lina Zhou, Pengli Ren, Honglin Qu, Jinsi Lin, Xuerong Li, Jin Xu, Yan Huang, Xinbing Yu
Parasites & Vectors.2018;[Epub] CrossRef
Local immune response to primary infection and re-infection by Clonorchis sinensis in FVB mice
Eun-Min Kim, Hak Sun Yu, Yan Jin, Min-Ho Choi, Young Mee Bae, Sung-Tae Hong
Parasitology International.2017; 66(4): 436. CrossRef
Virus-like particles vaccine containing Clonorchis sinensis tegumental protein induces partial protection against Clonorchis sinensis infection
Dong-Hun Lee, Ah-Ra Kim, Su-Hwa Lee, Fu-Shi Quan
Parasites & Vectors.2017;[Epub] CrossRef
Clonorchiasis
Men-Bao Qian, Jürg Utzinger, Jennifer Keiser, Xiao-Nong Zhou
The Lancet.2016; 387(10020): 800. CrossRef
Systemic and local mucosal immune responses induced by orally delivered Bacillus subtilis spore expressing leucine aminopeptidase 2 of Clonorchis sinensis
Hongling Qu, Yanquan Xu, Hengchang Sun, Jinsi Lin, Jinyun Yu, Zeli Tang, Jiqing Shen, Chi Liang, Shan Li, Wenjun Chen, Xuerong Li, Zhongdao Wu, Yan Huang, Xinbing Yu
Parasitology Research.2014; 113(8): 3095. CrossRef
Anti-inflammatory effect of prednisolone on the growth of human liver fluke in experimental opisthorchiasis
Amornrat Juasook, Thidarut Boonmars, Sasithorn Kaewkes, Watcharin Loilome, Kulathida Veteewuthacharn, Zhiliang Wu, Puangrat Yongvanit
Parasitology Research.2012; 110(6): 2271. CrossRef
Strain variation in the susceptibility and immune response to Clonorchis sinensis infection in mice
Md. Hafiz Uddin, Shunyu Li, Young Mee Bae, Min-Ho Choi, Sung-Tae Hong
Parasitology International.2012; 61(1): 118. CrossRef
Factors in the resistance of rats to re-infection and super-infection by Clonorchis sinensis
Hongman Zhang, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong
Parasitology Research.2008; 102(6): 1111. CrossRef
Changing Patterns of Serum and Bile Antibodies in Re-infected Rats with Clonorchis sinensis
Hongman Zhang, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong
The Korean Journal of Parasitology.2008; 46(1): 17. CrossRef
Susceptibility of experimental animals to reinfection with Clonorchis sinensis
Woon-Mok Sohn, Hongman Zhang, Min-Ho Choi, Sung-Tae Hong
The Korean Journal of Parasitology.2006; 44(2): 163. CrossRef
Bile duct changes in rats reinfected with Clonorchis sinensis
Dongil Choi, Sung-Tae Hong, Shunyu Li, Byung-Suk Chung, Jae Hoon Lim, Soon-Hyung Lee
The Korean Journal of Parasitology.2004; 42(1): 7. CrossRef

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Specific and common antigens of Clonorchis sinensis and Opisthorchis viverrini (Opisthorchidae, Trematoda): Min-Ho Choi, Jin-Sook Ryu, Mejeong Lee, Shunyu Li, Byung-Suk Chung, Jong-Yil Chai, Paiboon Sithithaworn, Smarn Tesana, Sung-Tae Hong; Korean J Parasitol 2003;41(3):155-163.
Published online September 20, 2003; DOI: https://doi.org/10.3347/kjp.2003.41.3.155

Abstract
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The antigenic characterizations and serological reactions of human liver flukes, Clonorchis sinensis and Opisthorchis viverrini, were analyzed by immunoblot. The antigenic profiles of the crude extract of Clonorchis contained major proteins of 8, 26-28, 34-37, 43, and 70 kDa, and those of Opisthorchis 34-37, 43, 70, and 100 kDa. Of these, the 8, 26-28 and 34-37 kDa bands of Clonorchis and the 100 kDa of Opisthorchis were major components of each excretory-secretory antigen. The 8 and 26-28 kDa bands were specific to Clonorchis but the 100 kDa of Opisthorchis cross-reacted with the sera of clonorchiasis, and the 34-37, 70 and 100 kDa bands cross-reacted with sera of other helminthiases. The frequency and intensity of the immunoblot reactions were positively correlated with the intensity of the liver fluke infection.

Citations

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Acta Tropica.2024; 260: 107389. CrossRef
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Shin Moe Aoke, Amaya Watthanadirek, Napassorn Poolsawat, Nitipon Srionrod, Pornpiroon Nooroong, Sutthida Minsakorn, Sitthichok Lacharoje, Woraporn Sukhumavasi, Panat Anuracpreeda
Veterinary Parasitology.2022; 310: 109774. CrossRef
A first attempt at determining the antibody-specific pattern of Platynosomum fastosum crude antigen and identification of immunoreactive proteins for immunodiagnosis of feline platynosomiasis
Babi Kyi Soe, Poom Adisakwattana, Onrapak Reamtong, Panat Anuracpreeda, Woraporn Sukhumavasi
Veterinary World.2022; : 2029. CrossRef
Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia
Narong Khuntikeo, Attapol Titapun, Watcharin Loilome, Puangrat Yongvanit, Bandit Thinkhamrop, Nittaya Chamadol, Thidarat Boonmars, Teerachai Nethanomsak, Ross H. Andrews, Trevor N. Petney, Paiboon Sithithaworn
Frontiers in Medicine.2018;[Epub] CrossRef
Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War
George Psevdos, Florence M. Ford, Sung-Tae Hong
Infectious Diseases in Clinical Practice.2018; 26(4): 208. CrossRef
Comments on “Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War”
Theodore E. Nash, David Sullivan, Edward Mitre, Eric Garges, Victoria J. Davey, Gary Roselle, Stephen J. Davies, Peter D. Rumm
Infectious Diseases in Clinical Practice.2018; 26(4): 240. CrossRef
Responding to Letter “Comments on ‘Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War’” by Theodore E. Nash, David Sullivan, Edward Mitre, et al
George Psevdos, Florence M. Ford, Sung-Tae Hong
Infectious Diseases in Clinical Practice.2018; 26(4): 242. CrossRef
Characterization of immunogenic Clonorchis sinensis protein fractions by gel filtration chromatography
Duan Pham Ngoc, Yuji Arimatsu, Sasithorn Kaewkes, Banchob Sripa
Asian Pacific Journal of Tropical Disease.2015; 5(4): 284. CrossRef
Eosinophilia in Infectious Diseases
Elise M. O’Connell, Thomas B. Nutman
Immunology and Allergy Clinics of North America.2015; 35(3): 493. CrossRef
Predominance of IL-10 and TGF-β production from the mouse macrophage cell line, RAW264.7, in response to crude antigens from Clonorchis sinensis
Hae Joo Wi, Yan Jin, Min-Ho Choi, Sung-Tae Hong, Young Mee Bae
Cytokine.2012; 59(2): 237. CrossRef
The identification of antigenic proteins: 14-3-3 protein and propionyl-CoA carboxylase in Clonorchis sinensis
Myoung-Ro Lee, Yu-Jung Kim, Dae-Won Kim, Won Gi Yoo, Shin-Hyeong Cho, Kwang Yeon Hwang, Jung-Won Ju, Won-Ja Lee
Molecular and Biochemical Parasitology.2012; 182(1-2): 1. CrossRef
Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients
Ponlatham Chaiyarit, Paiboon Sithithaworn, Chanitra Thuwajit, Puangrat Yongvanit
Clinical Oral Investigations.2011; 15(4): 477. CrossRef
Clonorchis sinensis infection is positively associated with atopy in endemic area
M‐H Choi, Y‐S Chang, M. K. Lim, Y. M. Bae, S‐T Hong, J‐K Oh, E. H. Yun, M‐J Bae, H‐S Kwon, S‐M Lee, H‐W Park, K‐U Min, Y‐Y Kim, S‐H Cho
Clinical & Experimental Allergy.2011; 41(5): 697. CrossRef
Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory‐secretory products of Clonorchis sinensis adult worms
Jung‐Won Ju, Hyun‐Na Joo, Myoung‐Ro Lee, Shin‐Hyeong Cho, Hyeng‐Il Cheun, Jung‐Yeon Kim, Young‐Hee Lee, Kwang‐Jun Lee, Woon‐Mok Sohn, Dong‐Min Kim, Il‐Chul Kim, Byoung Chul Park, Tong‐Soo Kim
PROTEOMICS.2009; 9(11): 3066. CrossRef
Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory–secretory products of Clonorchis sinensis
Young Ju Kim, Min-Ho Choi, Sung-Tae Hong, Young Mee Bae
Parasitology Research.2009; 104(5): 1011. CrossRef
Serodiagnostic applicability of recombinant antigens of Clonorchis sinensis expressed by wheat germ cell-free protein synthesis system
Chenghua Shen, Jong-Ae Lee, Sonia Refaat Ahmed Allam, Young Mee Bae, Eun-Taek Han, Satoru Takeo, Takafumi Tsuboi, Sung-Tae Hong, Min-Ho Choi
Diagnostic Microbiology and Infectious Disease.2009; 64(3): 334. CrossRef
Proliferative effects of excretory/secretory products from Clonorchis sinensis on the human epithelial cell line HEK293 via regulation of the transcription factor E2F1
Young Ju Kim, Min-Ho Choi, Sung-Tae Hong, Young Mee Bae
Parasitology Research.2008; 102(3): 411. CrossRef
A Bile Based Study of Clonorchis sinensis Infections in Patients with Biliary Tract Diseases in Ulsan, Korea
Kwang Ro Joo, Sung-Jo Bang
Yonsei Medical Journal.2005; 46(6): 794. CrossRef
Organ-specific antigens of Clonorchis sinensis
Shunyu Li, Byung-Suk Chung, Min-Ho Choi, Sung-Tae Hong
The Korean Journal of Parasitology.2004; 42(4): 169. CrossRef
Evaluation of Clonorchis sinensis Recombinant 7-Kilodalton Antigen for Serodiagnosis of Clonorchiasis
Qin-Ping Zhao, Sung-Ung Moon, Hyeong-Woo Lee, Byoung-Kuk Na, Seung-Yull Cho, Yoon Kong, Ming-Sen Jiang, Ai-Hua Li, Tong-Soo Kim
Clinical and Vaccine Immunology.2004; 11(4): 814. CrossRef

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Characterization of partially purified 8 kDa antigenic protein of Clonorchis sinensis: Young-Bae Chung, Mejeong Lee, Hyun-Jong Yang, Byung-Suk Chung, Shun-Yu Lee, Min-Ho Choi, Sung-Tae Hong; Korean J Parasitol 2002;40(2):83-88.
Published online June 30, 2002; DOI: https://doi.org/10.3347/kjp.2002.40.2.83

Abstract
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The 8 kDa antigenic protein of Clonorchis sinensis was partially purified by ammonium sulfate precipitation and subsequently by a column chromatographic steps. The purified protein was separated into 7 and 8 kDa protein bands through SDS-tricine gel electrophoresis, while the protein was found to migrate to a 8 kDa band in 7.5-15% SDS-PAGE. The molecular weight of the antigen was estimated to be 110 kDa by Superose 6 HR 10/30 gel filtration. The purified antigen strongly reacted with the human sera of clonorchiasis. The hyperimmune sera of BALB/c mice immunized against the 8 kDa protein were reacted with both the crude extract and the excretory-secretory product of adult worms, but not with the metacercarial extract. Immunohistochemical staining demonstrated that the protein was distributed to the tegument and subtegumental cells and also to the seminal receptacle. The present findings suggest that the 8 kDa protein is a partition of the multicomplex protein originating from various organs of adult C. sinensis, and that it is composed of several 7 and 8 kDa proteins.

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A.M. Martínez-Ibeas, M.J. Perteguer, C. González-Lanza, T. Gárate, M.Y. Manga-González
Experimental Parasitology.2013; 135(2): 287. CrossRef
Serodiagnostic applicability of recombinant antigens of Clonorchis sinensis expressed by wheat germ cell-free protein synthesis system
Chenghua Shen, Jong-Ae Lee, Sonia Refaat Ahmed Allam, Young Mee Bae, Eun-Taek Han, Satoru Takeo, Takafumi Tsuboi, Sung-Tae Hong, Min-Ho Choi
Diagnostic Microbiology and Infectious Disease.2009; 64(3): 334. CrossRef
Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory‐secretory products of Clonorchis sinensis adult worms
Jung‐Won Ju, Hyun‐Na Joo, Myoung‐Ro Lee, Shin‐Hyeong Cho, Hyeng‐Il Cheun, Jung‐Yeon Kim, Young‐Hee Lee, Kwang‐Jun Lee, Woon‐Mok Sohn, Dong‐Min Kim, Il‐Chul Kim, Byoung Chul Park, Tong‐Soo Kim
PROTEOMICS.2009; 9(11): 3066. CrossRef
Organ-specific antigens of Clonorchis sinensis
Shunyu Li, Byung-Suk Chung, Min-Ho Choi, Sung-Tae Hong
The Korean Journal of Parasitology.2004; 42(4): 169. CrossRef
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Hyun-Jong Yang, Young-Bae Chung
The Korean Journal of Parasitology.2004; 42(2): 81. CrossRef
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Kwangsig Kim, Hyun Jong Yang, Young-Bae Chung
The Korean Journal of Parasitology.2003; 41(2): 121. CrossRef
Excretory-secretory antigen is better than crude antigen for the serodiagnosis of clonorchiasis by ELISA
Min-Ho Choi, Il Chan Park, Shunyu Li, Sung-Tae Hong
The Korean Journal of Parasitology.2003; 41(1): 35. CrossRef
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Acta Materialia.2003; 51(6): 1775. CrossRef

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Usefulness of IgG4 subclass antibodies for diagnosis of human clonorchiasis: Sung-Tae Hong, Mejeong Lee, Nak-Jin Sung, Sang Rock Cho, Jong-Yil Chai, Soon-Hyung Lee; Korean J Parasitol 1999;37(4):243-248.
Published online December 31, 1999; DOI: https://doi.org/10.3347/kjp.1999.37.4.243

Abstract
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The present study analyzed serum IgG subclass antibody reaction to major antigenic bands of Clonorchis sinensis to investigate improvement of its serodiagnosis. Of the four subclass antibodies, IgG1 and IgG2 antibodies were produced but not specific, IgG3 antibody was least produced, and IgG4 antibody was prominent and specific. The serum IgG antibody reaction to any of 43-50, 34-37, 26-28, and 8 kDa bands was found in 65.5% of 168 egg positive cases while IgG4 antibody reaction was found in 22.0% of them. The positive rates of IgG and IgG4 antibodies were directly correlated with the intensity of infection. All of the sera from heavily infected cases over EPG 5,000 showed positive reaction for specific IgG and IgG4 antibodies. The specific serum IgG4 antibody disappeared within 6 months after treatment. The bands of 35 kDa and 67 kDa cross-reacted with IgG antibodies but not with IgG4 antibodies in sera of other trematode infections. The present findings suggest that serum IgG4 antibody reaction to 8 kDa band is specific but not sensitive. Any method to increase its sensitivity is required for improved serodiagnosis.

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The identification of a Clonorchis sinensis gene encoding an antigenic egg protein
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Characterization of partially purified 8 kDa antigenic protein of Clonorchis sinensis
Young-Bae Chung, Mejeong Lee, Hyun-Jong Yang, Byung-Suk Chung, Shun-Yu Lee, Min-Ho Choi, Sung-Tae Hong
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Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits: Dongil Choi, Jae Hoon Lim, Seung Kwon Kim, Eung Yeop Kim, Mejeong Lee, Sung-Tae Hong; Korean J Parasitol 1999;37(2):77-83.
Published online June 30, 1999; DOI: https://doi.org/10.3347/kjp.1999.37.2.77

Abstract
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To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific.

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Control of clonorchiasis by repeated praziquantel treatment and low diagnostic efficacy of sonography: Sung-Tae Hong, Kisung Yoon, Mejeong Lee, Min Seo, Min-Ho Choi, Jung Suk Sim, Byung Ihn Choi, Chong Ku Yun, Soon-Hyung Lee; Korean J Parasitol 1998;36(4):249-254.
Published online December 20, 1998; DOI: https://doi.org/10.3347/kjp.1998.36.4.249

Abstract
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In Korea, Clonorchis sinensis infection is still highly prevalent because case detection in the field is difficult and the detected cases used to be incompletely cured due to treatment failure. The present study tried to control clonorchiasis in an endemic village by repeated treatments with praziquantel every 6 months and to evaluate sonography as a diagnostic measure. By stool examinations, the egg positive rate in the endemic village was 22.7%, but it decreased to 19.6% at 6 months, 15.1% at 12 months. 12.2% at 18 months, 6.3% at 24 months, 11.4% at 30 months, and 6.3% at 42 months after the beginning of repeated praziquantel administration. The sonography showed 61 (49.6%) positive cases of 123 screened residents: among egg-positives the sonography positive rate was 52.2% and among egg-negatives it was still 49%. The rate among cured cases was 64.3% after 6 months, 50.0% after 12 months, 50.0% after 18 months, and 66.7% after 24 months. In a non-endemic village, 64 residents were found egg-negative by fecal examination, but 20 (31.3%) of them were positive by sonography. The present findings indicate that control of clonorchiasis in an endemic village by repeated praziquantel treatment for 42 months is still insufficient and sonography is of little value for diagnosis of clonorchiasis.

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