Parasites, Hosts and Diseases

"blood"

Original Article

Effects of histamine and antihistamine on the hard tick Haemaphysalis longicornis during blood sucking: Mohammad Saiful Islam, Abul Fatah Shah Muhammad Talha, Myung-Jo You; Parasites Hosts Dis 2023;61(2):172-182.
Published online May 23, 2023; DOI: https://doi.org/10.3347/PHD.22068

Abstract
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At the time of host attachment, ticks are very sensitive to histamine, but during rapid blood sucking they paradoxically require histamine. Using a rabbit model, we studied the effects of histamine and antihistamine during attachment and fast-feeding in different life stages of Haemaphysalis longicorns. We examined how they responded to histamine and antihistamine by analyzing the detachment rate, histology of feeding lesions, and post-feeding behavior. A significant difference (P<0.01) was found in the detachment rate between experimental and control treatments throughout the observation period. Ticks exhibited a higher detachment rate (30.1%) at 12 h after histamine application during attachment time and on antihistamine-treated skin (25.4%) at 96 h during fast-feeding. After feeding on histamine-treated rabbits, the fully engorged body weights of larvae and nymphs were 0.7±0.36 mg and 3.5±0.65 mg, respectively. An average increase in body weight of 0.6±0.05 mg and 3.2±0.30 mg was observed for larvae and nymphs compared to the respective control weights. Nymphs and adults engorged after antihistamine treatment had an average body weight of 1.3±0.54 mg and 54±0.81 mg, respectively. An average decrease in body weight was observed in antihistamine-treated H. longicornis compared with control nymphs (3.3±0.42 mg) and adults (174±1.78 mg). Skin biopsies were collected after treatment, and differential histopathological characteristics were found between the treatment and control groups. Tick-infested skin collected from rabbits in the antihistamine-treated group lacked erythrocytes in the feeding pool, indicating that antihistamine impaired tick fast-feeding stage.

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Comparative analysis of essential oil efficacy against the Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)
Mohammad Saiful Islam, Md. Samiul Haque, Myung-Jo You
Parasites, Hosts and Diseases.2024; 62(2): 217. CrossRef
Salp14 epitope-based mRNA vaccination induces early recognition of a tick bite
Yingjun Cui, Balasubramanian Cibichakravarthy, Xiaotian Tang, Mohamad G. Alameh, Garima Dwivedi, Drew Weissman, Erol Fikrig
Vaccine.2024; 42(24): 126304. CrossRef

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Case Report

Clinical Case of a Transfusion-Associated Canine Mycoplasma haemocanis Infection in the Republic of Korea: A Case Report: Jihu Kim, Donghwan Lee, Eunchae Yoon, Hyeona Bae, Daseul Chun, Jun-Gu Kang, Dong-In Jung, Do-Hyeon Yu; Korean J Parasitol 2020;58(5):565-569.
Published online October 22, 2020; DOI: https://doi.org/10.3347/kjp.2020.58.5.565

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This report describes the first clinical case of a transfusion-associated Mycoplasma haemocanis infection in a dog in Korea. A 6-year-old male Maltese underwent a red blood cell transfusion for idiopathic immune-mediated hemolytic anemia. Eighteen days after the blood transfusion, the recipient’s packed cell volume decreased and basophilic organisms were found on erythrocytes. A polymerase chain reaction and sequential analysis showed that both the donor dog and recipient dog had M. haemocanis. Six weeks after doxycycline administration, no organisms were detected and the recipient’s anemia had improved.

Citations

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Occurrence and molecular identification of haemotropic Mycoplasma species in grey wolves (Canis lupus) from southern Europe
Susana Remesar, David Cano-Terriza, Patrocinio Morrondo, Álvaro Oleaga, Barbara Moroni, Nuno Santos, Serena Robetto, Lisa Guardone, Pablo Díaz, Saúl Jiménez-Ruiz, Joana Ferreira-e-Silva, Moisés Gonzálvez, Ignacio García-Bocanegra
Veterinary Microbiology.2025; 302: 110390. CrossRef
Molecular Survey of Hemopathogens in Dogs, Including Blood Donors, from Central-Western Brazil
João Vitor dos Santos Alves da Silva, Lorena Freitas das Neves, Maria Eduarda Bolzan, Liliane Maria do Rosario Batista, Francisco Anilton Alves Araujo, Rosangela Zacarias Machado, Marcos Rogério André
Pathogens.2025; 14(11): 1180. CrossRef
Co-infection by multiple vector-borne agents in wild ring-tailed coatis (Nasua nasua) from Iguaçu National Park, southern Brazil
L. Perles, M. F. Moraes, M. Xavier da Silva, R. F. C. Vieira, R. Z. Machado, E. G. Lux Hoppe, M. R. André
Scientific Reports.2023;[Epub] CrossRef
Molecular Survey of Hemotropic Mycoplasma spp. and Bartonella spp. in Coatis (Nasua nasua) from Central-Western Brazil
Lívia Perles, Wanessa Teixeira Gomes Barreto, Filipe Martins Santos, Leidiane Lima Duarte, Gabriel Carvalho de Macedo, Darci Moraes Barros-Battesti, Heitor Miraglia Herrera, Rosangela Zacarias Machado, Marcos Rogério André
Pathogens.2023; 12(4): 538. CrossRef
Mycoplasmas as Host Pantropic and Specific Pathogens: Clinical Implications, Gene Transfer, Virulence Factors, and Future Perspectives
Ali Dawood, Samah Attia Algharib, Gang Zhao, Tingting Zhu, Mingpu Qi, Kong Delai, Zhiyu Hao, Marawan A. Marawan, Ihsanullah Shirani, Aizhen Guo
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef

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Original Articles

Survey of Rickettsia spp. and Orientia tsutsugamushi Pathogens Found in Animal Vectors (Ticks, Fleas, Chiggers) in Bangkaew District, Phatthalung Province, Thailand: Amornrat Sanprick, Thanapon Yooyen, Wuttikon Rodkvamtook; Korean J Parasitol 2019;57(2):167-173.
Published online April 30, 2019; DOI: https://doi.org/10.3347/kjp.2019.57.2.167

Abstract
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Rickettsial infections (Rickettsioses) are the causes of acute fever found in Thailand. It is classified as acute febrile illnesses transmitted by bloodsucking arthropod vectors (tick, flea, and chigger). This research investigated pathogens of scrub typhus in vectors from Bangkaew District, Phatthalung Province. A total of 303 pools of vector samples were ticks (Rhipicephalus sanguineus, R. microplus, and Haemaphysalis sp.), fleas (Ctenocephalides felis orientis, C. f. felis, and C. canis), and chiggers (Leptotrombidium deliense, Aschoschoengastia indica, Blankaartia acuscutellaris and Walchia disparunguis pingue) collected from reservoir hosts (dogs and rodents). The 17 and 56 kDa gene of Rickettsia causing scrub typhus were found in 29% of ticks and 98% of flea. DNA sequence analysis reveeled the detected strains were R. asembonensis and Rickettsia sp. cf1 and 5.The chiggers, 1%, were infected with Rickettsia strain TA763, a pathogen of scrub typhus.

Citations

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Incidental amplification of Wolbachia sequences in fleas (Siphonaptera: Pulicidae) collected from pets in Thailand using 16S rDNA universal primers for hemoplasma detection
Kritsada Thongmeesee, Aung Aung, Duriyang Narapakdeesakul, Patchana Kamkong, Apinya Chatchaisuriya, Phichsita Satidsommon, Sarun Kerdrojwongkul, Sasikan Lilertlam, Sukritta Charoensiri, Sonthaya Tiawsirisup
Research in Veterinary Science.2026; 198: 105984. CrossRef
Molecular detection of Anaplasma phagocytophilum and Rickettsia monacensis in trombiculid mite pools collected from wild rodents in Korea: Implications for potential mite-borne transmission
Dong-Jae Yu, Dong-Min Kim, Choon-Mee Kim, Hyeon Je Song, Jeong-Chi Lee
Infection, Genetics and Evolution.2025; 133: 105789. CrossRef
Serological detection of Rickettsia spp. and evaluation of blood parameters in pet dogs and cats from Bangkok and neighboring provinces
Chanon Fa-ngoen, Gunn Kaewmongkol, Natnaree Inthong, Ampai Tanganuchitcharnchai, Mohammad Yazid Abdad, Jarunee Siengsanan-Lamont, Stuart D. Blacksell, Sarawan Kaewmongkol, Joshua Kamani
PLOS ONE.2024; 19(3): e0297373. CrossRef
Molecular detection of Orientia tsutsugamushi in ectoparasites & their small mammal hosts captured from scrub typhus endemic areas in Madurai district, India
R. Govindarajan, S. Gowri Sankar, M. Senthil Kumar, V. Rajamannar, R. Krishnamoorthi, A. Alwin Prem Anand, Ashwani Kumar, P. Philip Samuel
Indian Journal of Medical Research.2024; 159(2): 180. CrossRef
Not Only Leptotrombidium spp. an Annotated Checklist of Chigger Mites (Actinotrichida: Trombiculidae) Associated with Bacterial Pathogens
Hanna Moniuszko, Konrad Wojnarowski, Paulina Cholewińska
Pathogens.2022; 11(10): 1084. CrossRef
Current Arboviral Threats and Their Potential Vectors in Thailand
Chadchalerm Raksakoon, Rutcharin Potiwat
Pathogens.2021; 10(1): 80. CrossRef
Assessing scrub typhus and rickettsioses transmission risks in the Chiang Rai province of northern Thailand
Piyada Linsuwanon, Nutthanun Auysawasdi, Sirima Wongwairot, Surachai Leepitakrat, Wuttikon Rodkhamtook, Elizabeth Wanja, Taweesak Monkanna, Matthew Wegner, Silas Davidson, Yong Poovorawan, Betty Poole-Smith, Chawin Limsuwon, Patrick McCardle
Travel Medicine and Infectious Disease.2021; 42: 102086. CrossRef
Orientia tsutsugamushi dynamics in vectors and hosts: ecology and risk factors for foci of scrub typhus transmission in northern Thailand
Ivo Elliott, Neeranuch Thangnimitchok, Kittipong Chaisiri, Tri Wangrangsimakul, Piangnet Jaiboon, Nicholas P. J. Day, Daniel H. Paris, Paul N. Newton, Serge Morand
Parasites & Vectors.2021;[Epub] CrossRef

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The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity: Jiraporn Kuesap, Kesara Na-Bangchang; Korean J Parasitol 2018;56(2):167-173.
Published online April 30, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.2.167

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Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity such as blood group, hemoglobinopathy, and heme oxygenase-1 (HO-1) polymorphisms. This study was carried out to investigate association among ABO blood group, thalassemia types and HO-1 polymorphisms in malaria. The malarial blood samples were collected from patients along the Thai-Myanmar border. Determination of ABO blood group, thalassemia variants, and HO-1 polymorphisms were performed using agglutination test, low pressure liquid chromatography and polymerase chain reaction, respectively. Plasmodium vivax was the major infected malaria species in the study samples. Distribution of ABO blood type in the malaria-infected samples was similar to that in healthy subjects, of which blood type O being most prevalent. Association between blood group A and decreased risk of severe malaria was significant. Six thalassemia types (30%) were detected, i.e., hemoglobin E (HbE), β-thalassemia, α-thalassemia 1, α-thalassemia 2, HbE with α-thalassemia 2, and β-thalassemia with α-thalassemia 2. Malaria infected samples without thalassemia showed significantly higher risk to severe malaria. The prevalence of HO-1 polymorphisms, S/S, S/L and L/L were 25, 62, and 13%, respectively. Further study with larger sample size is required to confirm the impact of these 3 host genetic factors in malaria patients.

Citations

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Exploring the functional and immune landscape of E-β thalassemia patients through RNA sequencing of peripheral blood mononuclear cells
Nibedita Mitra, Prosanto Chowdhury, Anupam Basu
Heliyon.2025; 11(1): e41255. CrossRef
Prevalence and Association of Malaria With ABO Blood Groups in Bosaso City, Puntland, Somalia: A Cross‐Sectional Study
Yahye Isse Hassan, Mohamed Said Hassan
Health Science Reports.2025;[Epub] CrossRef
Malaria infection and its association with socio-demographics, long lasting insecticide nets usage and hematological parameters among adolescent patients in rural Southwestern Nigeria
Azeez Oyemomi IBRAHIM, Tosin Anthony Agbesanwa, Shuaib Kayode AREMU, Ibrahim Sebutu BELLO, Olayide Toyin ELEGBEDE, Olusegun Emmanuel GABRIEL-ALAYODE, Oluwaserimi Adewumi AJETUNMOBI, Kayode Rasaq ADEWOYE, Temitope Moronkeji OLANREWAJU, Ebenezer Kayode ARIY
PLOS ONE.2023; 18(7): e0287723. CrossRef
Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria
Suong T. Nguyen, Daniel Du, Daniel Wychrij, Matthew D. Cain, Qingping Wu, Robyn S. Klein, Ilaria Russo, Daniel E. Goldberg
Proceedings of the National Academy of Sciences.2023;[Epub] CrossRef
Genotyping of ABO and Duffy blood groups among malaria patients in Thailand
Phattharaphon Hongfongfa, Jiraporn Kuesap
Journal of Parasitic Diseases.2022; 46(1): 178. CrossRef
HMOX1 genetic polymorphisms and outcomes in infectious disease: A systematic review
Fergus W. Hamilton, Julia Somers, Ruth E. Mitchell, Peter Ghazal, Nicholas J. Timpson, Srinivas Mummidi
PLOS ONE.2022; 17(5): e0267399. CrossRef
The Clinical Utility of ABO and RHD Systems as Potential Indicators of Health Status, a Preliminary Study in Greek Population
Evgenia Lymperaki, Evangelia Stalika, George Tzavelas, Efthymia Tormpantoni, Diana Samara, Eleni Vagdatli, Ioannis Tsamesidis
Clinics and Practice.2022; 12(3): 406. CrossRef
Contribution of genetic factors to high rates of neonatal hyperbilirubinaemia on the Thailand-Myanmar border
Germana Bancone, Gornpan Gornsawun, Pimnara Peerawaranun, Penporn Penpitchaporn, Moo Kho Paw, Day Day Poe, December Win, Naw Cicelia, Mavuto Mukaka, Laypaw Archasuksan, Laurence Thielemans, Francois Nosten, Nicholas J. White, Rose McGready, Verena I. Carr
PLOS Global Public Health.2022; 2(6): e0000475. CrossRef
Malaria infection and its association with socio-demographics, preventive measures, and co-morbid ailments among adult febrile patients in rural Southwestern Nigeria: A cross-sectional study
Azeez Oyemomi Ibrahim, Ibrahim Sebutu Bello, Olabode Muftau Shabi, Adejumoke Oluwatosin Omonijo, Abayomi Ayodapo, Babatunde Adeola Afolabi
SAGE Open Medicine.2022;[Epub] CrossRef
HMOX1 STR polymorphism and malaria: an analysis of a large clinical dataset
Fergus Hamilton, Ruth Mitchell, Aubrey Cunnington, Peter Ghazal, Nicholas J. Timpson
Malaria Journal.2022;[Epub] CrossRef
Linkages between blood groups and malaria susceptibility
Minu Nain, Amit Sharma
Journal of Vector Borne Diseases.2022; 59(3): 193. CrossRef
AB Blood Group Confers Higher Risk for Primary Brain Tumors in Pediatrics
Abdulrahman Al Shudifat, Hala Al Suqi, Kutada Soub, Leen Al Nemrawi, Moa’tasem Abu Jaber, Mohammad Al Barbarawi, Nour Shewaikani, Yazan El Adwan, Assem Al Refaei
Risk Management and Healthcare Policy.2021; Volume 14: 4031. CrossRef
High susceptibility to severe malaria among patients with A blood group versus those with O blood group
Serge Tonen-Wolyec, Salomon Batina-Agasa
Tropical Parasitology.2021; 11(2): 97. CrossRef
Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia
Luiza Carvalho Mourão, Camila Maia Pantuzzo Medeiros, Gustavo Pereira Cardoso-Oliveira, Paula Magda da Silva Roma, Jamila da Silva Sultane Aboobacar, Beatriz Carolina Medeiros Rodrigues, Ubirajara Agero, Cor Jesus Fernandes Fontes, Érika Martins Braga
Microbes and Infection.2020; 22(8): 379. CrossRef
There will be blood
Sophia Häfner
Microbes and Infection.2020; 22(9): 385. CrossRef

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An Alternative Method for Extracting Plasmodium DNA from EDTA Whole Blood for Malaria Diagnosis: Krongkaew Seesui, Kanokwan Imtawil, Phimphakon Chanetmahun, Porntip Laummaunwai, Thidarut Boonmars; Korean J Parasitol 2018;56(1):25-32.
Published online February 28, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.1.25

Abstract
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Molecular techniques have been introduced for malaria diagnosis because they offer greater sensitivity and specificity than microscopic examinations. Therefore, DNA isolation methods have been developed for easy preparation and cost effectiveness. The present study described a simple protocol for Plasmodium DNA isolation from EDTA-whole blood. This study demonstrated that after heating infected blood samples with Tris?EDTA buffer and proteinase K solution, without isolation and purification steps, the supernatant can be used as a DNA template for amplification by PCR. The sensitivity of the extracted DNA of Plasmodium falciparum and Plasmodium vivax was separately analyzed by both PCR and semi-nested PCR (Sn-PCR). The results revealed that for PCR the limit of detection was 40 parasites/μl for P. falciparum and 35.2 parasites/μl for P. vivax, whereas for Sn-PCR the limit of detection was 1.6 parasites/μl for P. falciparum and 1.4 parasites/μl for P. vivax. This new method was then verified by DNA extraction of whole blood from 11 asymptomatic Myanmar migrant workers and analyzed by Sn-PCR. The results revealed that DNA can be extracted from all samples, and there were 2 positive samples for Plasmodium (P. falciparum and P. vivax). Therefore, the protocol can be an alternative method for DNA extraction in laboratories with limited resources and a lack of trained technicians for malaria diagnosis. In addition, this protocol can be applied for subclinical cases, and this will be helpful for epidemiology and control.

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Evaluation of A Simple DNA Extraction Method and Its Combination with Loop-Mediated Isothermal Amplification Assays for Rapid Plasmodium knowlesi Diagnosis
Meng-Yee Lai, Mohd Hafizi Abdul Hamid, Jenarun Jelip, Rose Nani Mudin, Yee-Ling Lau
Tropical Medicine and Infectious Disease.2023; 8(8): 389. CrossRef
Liquid Biopsy for Promising Non-invasive Diagnostic Biomarkers in Parasitic Infections
Eylem Akdur Ozturk, Ayse Caner
Acta Parasitologica.2022; 67(1): 1. CrossRef
Comparison of six methods for Loa loa genomic DNA extraction
Roland Dieki, Elsa-Rush Eyang-Assengone, Patrice Makouloutou-Nzassi, Félicien Bangueboussa, Edouard Nsi Emvo, Jean Paul Akue, Ricardo Santos
PLOS ONE.2022; 17(3): e0265582. CrossRef
Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum
Robin Schumann, Eileen Bischoff, Severina Klaus, Sophie Möhring, Julia Flock, Sandro Keller, Kim Remans, Markus Ganter, Marcel Deponte
Redox Biology.2021; 48: 102177. CrossRef

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Comparison of Placenta PCR and Maternal Serology of Aborted Women for Detection of Toxoplasma gondii in Ardabil, Iran: Somaie Matin, Gholamreza Shahbazi, Shervin Tabrizian Namin, Rouhallah Moradpour, Farideh Feizi, Hadi Piri-dogahe; Korean J Parasitol 2017;55(6):607-612.
Published online December 31, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.6.607

Abstract
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Primary maternal infection with toxoplasmosis during pregnancy is frequently associated with transplacental transmission of the parasite to the fetus. This study was conducted to test the utility of PCR assay to detect recent infections with Toxoplasma in aborted women at various gestational ages who referred to Obstetrics and Gynecology Department of Alavi Hospital in Ardabil during 2014 and 2016. Two hundred women with a history of single or repeated abortion were investigated in this study. Blood samples were tested for specific anti-Toxoplasma IgM and IgG antibodies by ELISA. According to the results, 53.5% of the women under study were positive for anti-Toxoplasma antibodies: 4.0% of them had IgM, 43.0% had IgG, and 6.5% had both IgM and IgG. Subsequently, Nested-PCR analysis was used to detect T. gondii DNA in the placenta of subjects. In 10.5% of the women, the results were positive for 529 bp element of T. gondii. Among them, 5 (23.8%) cases were IgM positive, 1 (4.8%) case was IgG positive, and 11 (52.4%) were both IgM and IgG positive. In 4 (19.0%) patients, none of the antibodies were found to be positive. In total, 16 patients had positive results in both ELISA and PCR methods, and 174 cases had negative results for new infection. The findings of this study revealed that T. gondii might be one of the significant factors leading to abortion, and that the analysis of placenta can be important in order to achieve increased detection sensitivity.

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Igor Falco Arruda, Patricia Riddell Millar, Fernanda da Silva Lopes, Caroline Martins da Costa, Mario Felipe Alvarez Balaro, Lucas Almeida Zangirolami, Raissa Cristina Ferreira Ramos, Thamires Francisco Bonifácio, Julia Araujo Panza Ribeiro, Maria Regina
Veterinary Research Communications.2025;[Epub] CrossRef
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Forouzan Rahmani, Shabnam Hasani, Masoumeh Sadat Mousavi, Leila Kianfard
Journal of Kermanshah University of Medical Sciences.2025;[Epub] CrossRef
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Narges Arbabi, Nima Firouzeh, Seyed Ghader Azizi, Ahmad Mehravaran, Soudabeh Etemadi, Reza Shafiei, Hadi Mirahmadi
Tropical Diseases, Travel Medicine and Vaccines.2025;[Epub] CrossRef
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Amal Farahat Allam, Amel Youssef Shehab, Nashwa Abdelaleem Ahmed, Amel Gaber Elshereedy, Hoda Fahmy Farag, Sarah Mohamed Abdo, Heba Said Ibrahim
Experimental Parasitology.2025; 279: 109065. CrossRef
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Raissa Cristina Ferreira Ramos, Alynne da Silva Barbosa, Ana Luisa Quintella do Couto Aleixo, Igor Falco Arruda, Maria Regina Reis Amendoeira, Khaled Abd EL-Hamid Abd EL-Razik
PLOS ONE.2024; 19(2): e0298393. CrossRef
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Naglaa Fathi Abd El-Latif, Aziza Ibrahim Salem, Nadia Aly Sadek, Sally A. M. Salah, Doaa Gaber Shalaby, Heba Elhadad
Journal of Parasitic Diseases.2023; 47(4): 778. CrossRef
Infectious and environmental placental insults: from underlying biological pathways to diagnostics and treatments
Samuel Chenge, Harrison Ngure, Bernard N Kanoi, Amanda N Sferruzzi-Perri, Francis M Kobia
Pathogens and Disease.2023;[Epub] CrossRef
Prevalence and risk factors of Toxoplasma gondii infection among women with miscarriage and their aborted fetuses in the northwest of Iran
Shiva Zeinali, Shahram Khademvatan, Rasool Jafari, Shabnam Vazifekhah, Elham Yousefi, Tahereh Behroozi-Lak, Bibi Razieh Hosseini Farash
PLOS ONE.2023; 18(10): e0283493. CrossRef
Toksoplazma serolojisi pozitif gebelerde intrauterin toksoplazmoz riskinin değerlendirilmesi
Ümit GÖRKEM, Cagdaş KOCAMAN, Djursun KARASARTOVA, Deniz TAŞKIRAN, Ayşe GÜRESER, Cahit BABÜR, Nezahat KOŞAR, Ayşegül TAYLAN ÖZKAN
Avrasya Sağlık Bilimleri Dergisi.2022; 5(3): 54. CrossRef
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Christen Rune Stensvold, Lone Storgaard, Lisa Leth Maroun, Jørgen Anders Lindholm Kurtzhals, Henrik Vedel Nielsen
Parasite Epidemiology and Control.2022; 19: e00279. CrossRef
Detection and genetic characterisation of Toxoplasma gondii circulating in free-range chickens, pigs and seropositive pregnant women in Benue state, Nigeria
Ifeoma N. Nzelu, Jacob K. P. Kwaga, Junaidu Kabir, Idris A. Lawal, Christy Beazley, Laura Evans, Damer P. Blake, Arnau Casanovas-Massana
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Toxoplasma gondii infection and spontaneous abortion: A systematic review and meta-analysis
Narges Kalantari, Tahmineh Gorgani-Firouzjaee, Zahra Moulana, Mohammad Chehrazi, Salman Ghaffari
Microbial Pathogenesis.2021; 158: 105070. CrossRef
Genetic characterization of Toxoplasma gondii isolates from human spontaneous aborted fetuses in Jahrom, southern Iran
Salar Maani, Hassan Rezanezhad, Kavous Solhjoo, Mohsen Kalantari, Saiedeh Erfanian
Microbial Pathogenesis.2021; 161: 105217. CrossRef
Detection of Acute and Chronic Toxoplasma gondii Infection among Women with History of Abortion in the Southwest of Iran
Jasem Saki, Maryam Zamanpour, Mahin Najafian, Niloofar Mohammadpour, Masoud Foroutan, José F. Silveira
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The global seroprevalence of anti-Toxoplasma gondii antibodies in women who had spontaneous abortion: A systematic review and meta-analysis
Tooran Nayeri, Shahabeddin Sarvi, Mahmood Moosazadeh, Afsaneh Amouei, Zahra Hosseininejad, Ahmad Daryani, Maria Angeles Gómez-Morales
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Maria Tânia Silva Oliveira, Caline Novais Teixeira Oliveira, Lucas Miranda Marques, Cláudio Lima Souza, Márcio Vasconcelos Oliveira
Revista Brasileira de Saúde Materno Infantil.2020; 20(2): 361. CrossRef
Molecular genotyping and serological evaluation of Toxoplasma gondii in mothers and their spontaneous aborted fetuses in Southwest of Iran
Nasir Arefkhah, Bahman Pourabbas, Qasem Asgari, Abdolali Moshfe, Fataneh Mikaeili, Gordafarin Nikbakht, Bahador Sarkari
Comparative Immunology, Microbiology and Infectious Diseases.2019; 66: 101342. CrossRef
Evaluation of Toxoplasma gondii B1 gene in Placental Tissues of Pregnant Women with Acute Toxoplasmosis
Khosro Sardarian, Amir Hossein Maghsood, Marzieh Farimani, Mehrdad Hajiloii, Massoud Saidijam, Mahsa Rezaeepoor, Hanie Mahaki, Alireza Zamani
Advanced Biomedical Research.2018;[Epub] CrossRef

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Brief Communication

Serological and Molecular Detection of Toxoplasma gondii and Babesia microti in the Blood of Rescued Wild Animals in Gangwon-do (Province), Korea: Sung-Hee Hong, Hee-Jong Kim, Young-Il Jeong, Shin-Hyeong Cho, Won-Ja Lee, Jong-Tak Kim, Sang-Eun Lee; Korean J Parasitol 2017;55(2):207-212.
Published online April 30, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.2.207

Abstract
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Infections of Toxoplasma gondii and Babesia microti are reported in many wild animals worldwide, but information on their incidence and molecular detection in Korean wild fields is limited. In this study, the prevalence of T. gondii and B. microti infection in blood samples of 5 animal species (37 Chinese water deer, 23 raccoon dogs, 6 roe deer, 1 wild boar, and 3 Eurasian badgers) was examined during 2008-2009 in Gangwon-do (Province), the Republic of Korea (=Korea) by using serological and molecular tests. The overall seropositivity of T. gondii was 8.6% (6/70); 10.8% in Chinese water deer, 4.3% in raccoon dogs, and 16.7% in roe deer. PCR revealed only 1 case of T. gondii infection in Chinese water deer, and phylogenic analysis showed that the positive isolate was practically identical to the highly pathogenetic strain type I. In B. microti PCR, the positive rate was 5.7% (4/70), including 2 Chinese water deer and 2 Eurasian badgers. Phylogenetic analysis results of 18S rRNA and the β-tubulin gene showed that all positive isolates were US-type B. microti. To our knowledge, this is the first report of B. microti detected in Chinese water deer and Eurasian badger from Korea. These results indicate a potentially high prevalence of T. gondii and B. microti in wild animals of Gangwon-do, Korea. Furthermore, Chinese water deer might act as a reservoir for parasite infections of domestic animals.

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Detection of US and Kobe‐type Babesia microti in ticks collected from small mammals of the Republic of Korea
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Original Articles

Molecular Identification of Haemadipsa rjukjuana (Hirudiniformes: Haemadipsidae) in Gageo Island, Korea: Sohyun Won, Bae Keun Park, Baek Jun Kim, Hye Won Kim, Jun Gu Kang, Tae Seo Park, Hong Yul Seo, Ye Eun, Ki Gyoung Kim, Joon Seok Chae; Korean J Parasitol 2014;52(2):169-175.
Published online April 18, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.2.169

Abstract
PDF

There are 60 species of blood-feeding land leeches, 50 species belonging to the family Haemadipsidae and 10 species belonging to the family Xerobdellidae. Despite recent papers on the land leeches, their taxonomic identification is not fully understood, especially at a species level. In Korea, there have been no historical records of the terrestrial leeches, but recently an unrecorded blood-feeding land leech was discovered at Gageo-do (Island), Korea. Molecular analysis was used to identify the species of 29 leeches collected from Mt. Dock-Sil in Gageo-do. Conventional PCR was conducted using nuclear 18S rRNA and mitochondrial cytochrome c oxidase subunit 1 (CO1) genetic marker. The 18S rRNA sequences revealed that the leeches share 99.9% identity with Haemadipsa rjukjuana (inhabiting Taiwan), and the CO1 sequences revealed that the leeches are very close to H. rjukjuana (inhabiting Taiwan). The CO1 sequences were separated into 2 categories, 1 with 94.6% and the other with 94.3% similarity to the H. rjukjuana L00115A (inhabiting Taiwan). This new finding of the land leech is the first record in Korea. In addition, the north range of the distribution of the blood-feeding leech (Hirudiniformes: Haemadipisidae) should be reconsidered including Korea.

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Animal Cells and Systems.2024; 28(1): 272. CrossRef
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Partial cross-resistance between Strongyloides venezuelensis and Nippostrongylus brasiliensis in rats: Byeong-Kirl Baek, M. Khyrul Islam, Jin-Ho Kim, John-Wha Lee, Jin Hur; Korean J Parasitol 1999;37(2):101-107.
Published online June 30, 1999; DOI: https://doi.org/10.3347/kjp.1999.37.2.101

Abstract
PDF

Rats were immunized through an initial infection with 1,000 filariform larvae (L₃) of Nippostrongylus brasiliensis and after complete expulsion of worms they were challenged with 1,000 L₃ of Strongyloides venezuelensis to investigate whether cross-resistance developed against a heterologous parasite. Nippostrongylus brasiliensis-immunized rats developed a partial cross-resistance against S. venezuelensis migrating larvae (MSL₃) in the lungs and adult worms in the small intestine. The population of MSL₃ in the lungs were significantly lower (P<0.05) in immunized rats (22.0 ± 7.4) compared with controls (105.0 ± 27.6). The populations of adult worms, egg output and fecundity were initially decreased but from day 14 post-challenge they did not show any significant difference between immunized and control rats. However, the length of worm in immunized rat was revealed as retardation. Peripheral blood eosinophilia was significantly decreased (P<0.05) on day 7 post-challenge and then gradually increased, which peaked on day 42 post-challenge when most of the worms were expelled. These results suggest that peripheral blood eosinophilia is strongly involved in the worm establishment and expulsion mechanisms.

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