Parasites, Hosts and Diseases

"protective"

Original Articles

The therapeutic potential of green synthesized zinc oxide nanoparticles in murine schistosomiasis: Asmaa M. El-kady, Majed H. Wakid, Khalil Mohamed, Abdullah Alhazmi, Wafa Abdullah Al-Megrin, Hayam Elshazly, Eman Sayed, Matthew W. Spears, Hatem A. Elshabrawy, Eman Fathy Fadel, Marawan Khodary, Somia Mohammed El Hassan; Received January 7, 2026 Accepted March 29, 2026 Published online June 25, 2026; DOI: https://doi.org/10.3347/PHD.26003 [Epub ahead of print]

Abstract
PDF

Schistosomiasis remains a major neglected tropical disease, affecting approximately 600 million individuals worldwide and accounting for nearly 500,000 deaths annually. The principal causative species—Schistosoma haematobium, S. mansoni, and S. japonicum—drive significant morbidity through hepatomegaly, splenomegaly, and progressive hepatic fibrosis. Praziquantel (PZQ) remains the cornerstone of treatment; however, its limited efficacy against immature worms and eggs, combined with concerns over emerging drug resistance, underscores the urgent need for novel therapeutic alternatives. This study investigated the anti-schistosomal potential of green-synthesized zinc oxide (ZnO) nanoparticles (NPs) in a murine model of S. mansoni infection, benchmarked against PZQ. ZnO NPs were fabricated using ginger extract via an eco-friendly green synthesis approach. Fifty male BALB/c mice were randomly assigned to five groups (n=10): normal control, infected untreated control, infected treated with PZQ alone, infected treated with ZnO NPs alone, and infected treated with a PZQ–ZnO NP combination. Parasitological, histopathological, and fibrosis assessments were subsequently performed. All treatment groups demonstrated significant reductions in worm burden and tissue egg counts relative to infected untreated controls. Histopathological examination of untreated infected mice revealed extensive chronic granulomatous inflammation, concentric perioval fibrosis, fibroblast proliferation, hepatocellular necrosis, hydropic degeneration, marked collagen deposition, and portal-to-portal fibrous bridging. Treated groups, by contrast, exhibited marked hepatic improvement characterized by reduced granuloma size, diminished fibrosis, and decreased collagen deposition. Collectively, these findings indicate that green-synthesized ZnO NPs possess promising anti-schistosomal and antifibrotic properties, warranting further investigation as a potential adjunct or alternative therapeutic strategy for schistosomiasis management.

334 View
11 Download

Vaccinia virus expressing MIC8 and AMA1 provides protection against Toxoplasma gondii ME49 infection: Hae-Ji Kang, Yan Jin, Zhao-Shou Yang, Md Atique Ahmed, Fu-Shi Quan; Parasites Hosts Dis 2025;63(4):340-348.
Published online November 19, 2025; DOI: https://doi.org/10.3347/PHD.25054

Abstract
PDF

Toxoplasma gondii is an intracellular protozoan parasite capable of causing chronic infection by forming persistent cysts in the brain. Despite its global burden, no approved vaccine exists. Virus-like particle vaccines expressing microneme protein 8 (MIC8) or apical membrane antigen 1 (AMA1) of T. gondii have previously shown efficacy. In this study, we generated recombinant vaccinia viruses (rVVs) expressing MIC8 and AMA1 and evaluated their efficacy against T. gondii ME49 infection. BALB/c mice were intramuscularly immunized with a combination of MIC8 and AMA1 rVVs and challenged orally with T. gondii ME49. Immunization with MIC8+AMA1 rVVs produced a significant increase in T. gondii-specific IgG. Splenocyte analysis revealed robust activation of CD4⁺ and CD8⁺ T cells, as well as expansion of memory B cells. The immunized group exhibited an 89.6% reduction in brain cyst count, with significantly improved survival compared to the control group. These findings demonstrate that combining the antigens MIC8 and AMA1 using a vaccinia virus platform can effectively promote both humoral and cellular immunity, supporting its potential as a vaccine strategy against T. gondii ME49.

Citations

Citations to this article as recorded by

Protection Against Toxoplasma gondii Lethal ME49 Challenge Induced by Influenza Virus-like Particles Containing Dense Granule Protein 14
Jie Mao, Hae-Ji Kang, Gi-Deok Eom, Su In Heo, Hynnu Nam, Ji-Hyun Lee, Ki-Ho Park, Mi Suk Lee, Sung Soo Kim, Fu-Shi Quan
Pharmaceutics.2026; 18(1): 93. CrossRef
Self-assembled influenza a neuraminidase virus-like particle vaccination confers protection against influenza B virus
Gi-Deok Eom, Ki Back Chu, Keon-Woong Yoon, Jie Mao, Su in Heo, Hyeon-Woo Nam, Ji-Hyun Lee, Hae-Ji Kang, Ki-Ho Park, Zhao-Shou Yang, Manish Kumar Singh, Sung Soo Kim, Fu-Shi Quan
Nanomedicine.2026; 21(9): 1235. CrossRef
Toxoplasma gondii as a Direct Cause of Reproductive Dysfunction: Dual Threats to Male and Female Fertility
Farhab Farhab, Tariq Sohail, Al-Rasheed Al-Rasheed, Zohaib Saeed, Aftab Shaukat
Veterinary Sciences.2026; 13(5): 430. CrossRef
Dose- and time-dependent dissemination of viable Leishmania amazonensis following experimental footpad infection in mice
Gi-Deok Eom, Ki-Back Chu, Keon-Woong Yoon, Hyeon-Woo Nam, Jie Mao, Su In Heo, Ji-Hyun Lee, Manish Kumar Singh, Sung Soo Kim, Fu-Shi Quan
Acta Tropica.2026; 280: 108205. CrossRef

1,596 View
35 Download
5 Web of Science
Crossref

DNA Vaccines Encoding Toxoplasma gondii Cathepsin C 1 Induce Protection against Toxoplasmosis in Mice: Yali Han, Aihua Zhou, Gang Lu, Guanghui Zhao, Wenchao Sha, Lin Wang, Jingjing Guo, Jian Zhou, Huaiyu Zhou, Hua Cong, Shenyi He; Korean J Parasitol 2017;55(5):505-512.
Published online October 31, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.5.505

Abstract
PDF

Toxoplasma gondii cathepsin C proteases (TgCPC1, 2, and 3) are important for the growth and survival of T. gondii. In the present study, B-cell and T-cell epitopes of TgCPC1 were predicted using DNAstar and the Immune Epitope Database. A TgCPC1 DNA vaccine was constructed, and its ability to induce protective immune responses against toxoplasmosis in BALB/c mice was evaluated in the presence or absence of the adjuvant α-GalCer. As results, TgCPC1 DNA vaccine with or without adjuvant α-GalCer showed higher levels of IgG and IgG2a in the serum, as well as IL-2 and IFN-γ in the spleen compared to controls (PBS, pEGFP-C1, and α-Galcer). Upon challenge infection with tachyzoites of T. gondii (RH), pCPC1/α-Galcer immunized mice showed the longest survival among all the groups. Mice vaccinated with DNA vaccine without adjuvant (pCPC1) showed better protective immunity compared to other controls (PBS, pEGFP-C1, and α-Galcer). These results indicate that a DNA vaccine encoding TgCPC1 is a potential vaccine candidate against toxoplasmosis.

Citations

Citations to this article as recorded by

Cysteine cathepsin proteases in apicomplexan parasites
Antoine Mayté, Anne Silvestre, Florian Veillard, Sonia Lacroix-Lamandé, Gilles Lalmanach, Julie Tottey
Biological Chemistry.2026;[Epub] CrossRef
Modest Protective Immune Responses Induced by a DNA Vaccine Expressing IMP1 of Toxoplasma gondii in BALB/c Mice
Farid Alizadeh, Maryam Hataminejad, Hajar Yaghoobi, Hakim Azizi
Parasite Immunology.2025;[Epub] CrossRef
Insight into the current Toxoplasma gondii DNA vaccine: a review article
Xirui Zhang, Hao Yuan, Yasser S. Mahmmod, Zipeng Yang, Mengpo Zhao, Yining Song, Shengjun Luo, Xiu-Xiang Zhang, Zi-Guo Yuan
Expert Review of Vaccines.2023; 22(1): 66. CrossRef
iNKT cell agonists as vaccine adjuvants to combat infectious diseases
Ya-Qian Li, Cheng Yan, Rui Luo, Zheng Liu
Carbohydrate Research.2022; 513: 108527. CrossRef
Mining the Proteome of Toxoplasma Parasites Seeking Vaccine and Diagnostic Candidates
Sajad Rashidi, Javier Sánchez-Montejo, Reza Mansouri, Mohammad Ali-Hassanzadeh, Amir Savardashtaki, Mohammad Saleh Bahreini, Mohammadreza Karimazar, Raúl Manzano-Román, Paul Nguewa
Animals.2022; 12(9): 1098. CrossRef
A Novel Combined DNA Vaccine Encoding Toxoplasma gondii SAG1 and ROP18 Provokes Protective Immunity Against a Lethal Challenge in Mice
Lamei Wu, Huijian Yang, Jianglin Wang, Xiuwen Yu, Yanhong He, Shenxia Chen
Acta Parasitologica.2021; 66(4): 1387. CrossRef
Review of DNA Vaccine Approaches Against the Parasite Toxoplasma gondii
Rosalie C. Warner, Ryan C. Chapman, Brianna N. Davis, Paul H. Davis
Journal of Parasitology.2021;[Epub] CrossRef
Characterization of metalloproteases and serine proteases of Toxoplasma gondii tachyzoites and their effect on epithelial cells
Carlos J. Ramírez-Flores, Rosalba Cruz-Mirón, Rossana Arroyo, Mónica E. Mondragón-Castelán, Tais Nopal-Guerrero, Sirenia González-Pozos, Emmanuel Ríos-Castro, Ricardo Mondragón-Flores
Parasitology Research.2019; 118(1): 289. CrossRef
Antigenic Epitope Analysis and Efficacy Evaluation of GRA41 DNA Vaccine Against T. gondii Infection
Jian Zhou, Chenxi Li, Yingquan Luo, Lin Wang
Acta Parasitologica.2019; 64(3): 471. CrossRef
Cysteine proteases in protozoan parasites
Jair L. Siqueira-Neto, Anjan Debnath, Laura-Isobel McCall, Jean A. Bernatchez, Momar Ndao, Sharon L. Reed, Philip J. Rosenthal, Photini Sinnis
PLOS Neglected Tropical Diseases.2018; 12(8): e0006512. CrossRef
Immune Responses Induced by HSP60 DNA Vaccine against Toxoplasma gondii Infection in Kunming Mice
Zhong-Yuan Li, Jing Lu, Nian-Zhang Zhang, Jia Chen, Xing-Quan Zhu
The Korean Journal of Parasitology.2018; 56(3): 237. CrossRef
Evaluation of Protective Immune Response Induced by a DNA Vaccine Encoding GRA8 against Acute Toxoplasmosis in a Murine Model
Jia-Qi Chu, Shuai Huang, Wei Ye, Xuan-Yan Fan, Rui Huang, Shi-Cai Ye, Cai-Yuan Yu, Wei-Yun Wu, Yu Zhou, Wei Zhou, Young-Ha Lee, Juan-Hua Quan
The Korean Journal of Parasitology.2018; 56(4): 325. CrossRef

12,117 View
139 Download
13 Web of Science
Crossref

Isolation and Characterization of Vaccine Candidate Genes Including CSP and MSP1 in Plasmodium yoelii: Seon-Hee Kim, Young-An Bae, Ju-Young Seoh, Hyun-Jong Yang; Korean J Parasitol 2017;55(3):255-265.
Published online June 30, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.3.255

Malaria is an infectious disease affecting humans, which is transmitted by the bite of Anopheles mosquitoes harboring sporozoites of parasitic protozoans belonging to the genus Plasmodium. Despite past achievements to control the protozoan disease, malaria still remains a significant health threat up to now. In this study, we cloned and characterized the full-unit Plasmodium yoelii genes encoding merozoite surface protein 1 (MSP1), circumsporozoite protein (CSP), and Duffy-binding protein (DBP), each of which can be applied for investigations to obtain potent protective vaccines in the rodent malaria model, due to their specific expression patterns during the parasite life cycle. Recombinant fragments corresponding to the middle and C-terminal regions of PyMSP1 and PyCSP, respectively, displayed strong reactivity against P. yoelii-infected mice sera. Specific native antigens invoking strong humoral immune response during the primary and secondary infections of P. yoelii were also abundantly detected in experimental ICR mice. The low or negligible parasitemia observed in the secondary infected mice was likely to result from the neutralizing action of the protective antibodies. Identification of these antigenic proteins might provide the necessary information and means to characterize additional vaccine candidate antigens, selected solely on their ability to produce the protective antibodies.

10,604 View
159 Download

Brief Communication

Gene Cloning, Expression and Immunogenicity of the Protective Antigen Subolesin in Dermacentor silvarum: Yonghong Hu, Hua Zeng, Jincheng Zhang, Duo Wang, Dongming Li, Tiantian Zhang, Shujie Yang, Jingze Liu; Korean J Parasitol 2014;52(1):93-97.
Published online February 19, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.1.93

Abstract
PDF

Subolesin (4D8), the ortholog of insect akirins, is a highly conserved protective antigen and thus has the potential for development of a broad-spectrum vaccine against ticks and mosquitoes. To date, no protective antigens have been characterized nor tested as candidate vaccines against Dermacentor silvarum bites and transmission of associated pathogens. In this study, we cloned the open reading frame (ORF) of D. silvarum 4D8 cDNA (Ds4D8), which consisted of 498 bp encoding 165 amino acid residues. The results of sequence alignments and phylogenetic analysis demonstrated that D. silvarum 4D8 (Ds4D8) is highly conserved showing more than 81% identity of amino acid sequences with those of other hard ticks. Additionally, Ds4D8 containing restriction sites was ligated into the pET-32(a+) expression vector and the recombinant plasmid was transformed into Escherichia coli rosetta. The recombinant Ds4D8 (rDs4D8) was induced by isopropyl β-D-thiogalactopyranoside (IPTG) and purified using Ni affinity chromatography. The SDS-PAGE results showed that the molecular weight of rDs4D8 was 40 kDa, which was consistent with the expected molecular mass considering 22 kDa histidine-tagged thioredoxin (TRX) protein from the expression vector. Western blot results showed that rabbit anti-D. silvarum serum recognized the expressed rDs4D8, suggesting an immune response against rDs4D8. These results provided the basis for developing a candidate vaccine against D. silvarum ticks and transmission of associated pathogens.

Citations

Citations to this article as recorded by

Subolesin gene structure and mRNA isoform diversity in South African R. microplus ticks: Relevance for understanding subolesin-based tick vaccines
Elsje Christine Rabie, Christine Maritz-Olivier
Ticks and Tick-borne Diseases.2025; 16(4): 102502. CrossRef
Transmission-Blocking Vaccines: Focus on Anti-Vector Vaccines against Tick-Borne Diseases
Girish Neelakanta, Hameeda Sultana
Archivum Immunologiae et Therapiae Experimentalis.2015; 63(3): 169. CrossRef
Screening and Identification of Antigenic Proteins from the Hard Tick <i>Dermacentor silvarum</i> (Acari: Ixodidae)
Tiantian Zhang, Xuejiao Cui, Jincheng Zhang, Hui Wang, Meng Wu, Hua Zeng, Yuanyuan Cao, Jingze Liu, Yonghong Hu
The Korean Journal of Parasitology.2015; 53(6): 789. CrossRef

10,129 View
95 Download
3 Web of Science
Crossref

Original Articles

Screening and Molecular Cloning of a Protective Antigen from the Midgut of Haemaphysalis longicornis: Yonghong Hu, Jincheng Zhang, Shujie Yang, Hui Wang, Hua Zeng, Tiantian Zhang, Jingze Liu; Korean J Parasitol 2013;51(3):327-334.
Published online June 30, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.3.327

Abstract
PDF

Vaccination is considered a promising alternative for controlling tick infestations. Haemaphysalis longicornis midgut proteins separated by SDS-PAGE and transferred to polyvinylidene difluoride (PVDF) membrane were screened for protective value against bites. The western blot demonstrated the immunogenicity of 92 kDa protein (P92). The analysis of the P92 amino acid sequence by LC-MS/MS indicated that it was a H. longicornis paramyosin (Hl-Pmy). The full lenghth cDNA of Hl-Pmy was obtained by rapid amplification of cDNA ends (RACE) which consisted of 2,783 bp with a 161 bp 3' untranslated region. Sequence alignment of tick paramyosin (Pmy) showed that Hl-Pmy shared a high level of conservation among ticks. Comparison with the protective epitope sequence of other invertebrate Pmy, it was calculated that the protective epitope of Hl-Pmy was a peptide (LEEAEGSSETVVEMNKKRDTE) named LEE, which was close to the N-terminal of Hl-Pmy protein. The secondary structure analysis suggested that LEE had non-helical segments within an α-helical structure. These results provide the basis for developing a vaccine against biting H. longicornis ticks.

Citations

Citations to this article as recorded by

The current strategies and underlying mechanisms in the control of the vector tick, Haemaphysalis longicornis: Implications for future integrated management
Chuks F. Nwanade, Min Wang, Sisi Li, Zhijun Yu, Jingze Liu
Ticks and Tick-borne Diseases.2022; 13(2): 101905. CrossRef
Evaluation on two types of paramyosin vaccines for the control of Haemaphysalis longicornis infestations in rabbits
Pin-Xing Wu, Xue-Jiao Cui, Mi-Xue Cao, Li-Hong Lv, Hong-Meng Dong, Shu-Wen Xiao, Jing-Ze Liu, Yong-Hong Hu
Parasites & Vectors.2021;[Epub] CrossRef
Morphology and ultrastructure changes of Haemaphysalis longicornis Neumann (Acari: Ixodidae) female adult ticks at different developmental stages
Fang Wang, Duo Wang, Chao-Zhong Jiang, Na Liang, Yong-Hong Hu, Jing-Ze Liu
International Journal of Acarology.2017; 43(4): 308. CrossRef
Evaluation of immune protection induced by DNA vaccines from Haemaphysalis longicornis paramyosin in rabbits
Tian-Tian Zhang, Jin-Cheng Zhang, Xue-Jiao Cui, Jing-Jing Zheng, Ru Li, Fang Wang, Jing-Ze Liu, Yong-Hong Hu
Parasites & Vectors.2017;[Epub] CrossRef
Paramyosin of canine Onchocerca lupi: usefulness for the diagnosis of a neglected zoonotic disease
Bronwyn Campbell, Helder Cortes, Giada Annoscia, Alessio Giannelli, Antonio Parisi, Maria Stefania Latrofa, Filipe Dantas-Torres, Luís Cardoso, Domenico Otranto
Parasites & Vectors.2016;[Epub] CrossRef
Screening and Identification of Antigenic Proteins from the Hard Tick <i>Dermacentor silvarum</i> (Acari: Ixodidae)
Tiantian Zhang, Xuejiao Cui, Jincheng Zhang, Hui Wang, Meng Wu, Hua Zeng, Yuanyuan Cao, Jingze Liu, Yonghong Hu
The Korean Journal of Parasitology.2015; 53(6): 789. CrossRef

11,753 View
69 Download
Crossref

Lambs Infected with UV-Attenuated Sporocysts of Sarcocystis ovicanis Produced Abnormal Sarcocysts and Induced Protective Immunity against a Challenge Infection: Abdel-Azeem Abdel-Baki, Gamal Allam, Thabet Sakran, El-Mahy El-Malah; Korean J Parasitol 2009;47(2):131-138.
Published online May 27, 2009; DOI: https://doi.org/10.3347/kjp.2009.47.2.131

Abstract
PDF

The present study surveyed the prevalence of natural infection of the sheep esphagus muscle with sarcocysts of Sarcocystis ovicanis and examined induction of protective immunity using UV-attenuated sporocysts. The overall prevalence of natural infection of the sheep was 95%. Infectivity of the collected sarcocysts was confirmed by shedding of sporulated oocysts after feeding infected esophageal tissues to dogs. To induce protective immunity, lambs were immunized 3 times (once a week) with 1.5 × 10⁴ sporocysts exposed to UV-light for 30 min (UV-30 group) or 60 (UV-60 group) min and then challenged with 1.5 × 10⁴ normal sporocysts at the 3rd week post the 1st vaccination. These lambs showed high survival and less clinical signs of sarcocystosis than normal infected lambs. The attenuated sporocysts produced abnormal cysts; small in size and detached from the muscle fiber. These abnormalities were more obvious in UV-60 group than UV-30 group. Also, the IFN-γ level and lymphocyte percentage were increased while the total leukocyte count was decreased in the UV-60 group compared with other groups. The high level of IFN-γ may be an evidence for the induction of Th1 responses which may have protective effect against a challenge infection.

Citations

Citations to this article as recorded by

Investigation into the potential of using UV-treated sporulated oocysts of Eimeria tenella as a local solution to immunization of chickens against caecal coccidiosis
Samir Djemai, Abdeslam Mekroud, Geoff Hide, Daoudi Khelifi, Inès Bellil
Journal of Parasitic Diseases.2023; 47(2): 238. CrossRef
Morphometric Study of Microscopic Cysts of Sarcocystis Sp. in Sheep Carcasses
As. Dahmani, M. Aissi, S. Zenia, K. Harhoura, R. Kadour, A. Saadi
Folia Veterinaria.2020; 64(3): 38. CrossRef
An update on sarcocystosis in one-humped camels (Camelus dromedarius)
Muhammad A. Saeed, Jane L. Vaughan, Abdul Jabbar
Parasitology.2018; 145(11): 1367. CrossRef
Immunoprotective responses against murine sarcocystosis by β - Irradiated sporocysts
Mahmoud Abdel-Latif, Thabet Sakran, Heba M. Abdel-Haleem, Mostafa F. Eissa, Shrouk E. Al-Sayed
Experimental Parasitology.2018; 191: 73. CrossRef

10,091 View
92 Download
Crossref

Protective effect of lectin from Synadenium carinatum on Leishmania amazonensis infection in BALB/c mice: Sandra R. Afonso-Cardoso, Fl?vio H. Rodrigues, M?rcio A.B. Gomes, Adriano G. Silva, Ademir Rocha, Aparecida H.B. Guimar?es, Ign?s Candeloro, S?lvio Favoreto, Marcelo S. Ferreira, Maria A. de Souza; Korean J Parasitol 2007;45(4):255-266.
Published online December 20, 2007; DOI: https://doi.org/10.3347/kjp.2007.45.4.255

Abstract
PDF

The protective effect of the Synadenium carinatum latex lectin (ScLL), and the possibility of using it as an adjuvant in murine model of vaccination against American cutaneous leishmaniasis, were evaluated. BALB/c mice were immunized with the lectin ScLL (10, 50, 100 ?g/animal) separately or in association with the soluble Leishmania amazonensis antigen (SLA). After a challenge infection with 10⁶ promastigotes, the injury progression was monitored weekly by measuring the footpad swelling for 10 weeks. ScLL appeared to be capable of conferring partial protection to the animals, being most evident when ScLL was used in concentrations of 50 and 100 ?g/animal. Also the parasite load in the interior of macrophages showed significant reduction (61.7%) when compared to the control group. With regard to the cellular response, ScLL 50 and 100 ?g/animal stimulated the delayed-type hypersensitivity (DTH) reaction significantly (P < 0.05) higher than SLA or SLA plus ScLL 10 weeks after the challenge infection. The detection of high levels of IgG2a and the expression of mRNA cytokines, such as IFN-γ, IL-12, and TNF-α (Th1 profiles), corroborated the protective role of this lectin against cutaneous leishmaniasis. This is the first report of the ScLL effect on leishmaniasis and shows a promising role for ScLL to be explored in other experimental models for treatment of leishmaniasis.

Citations

Citations to this article as recorded by

Review on macrophage polarization during visceral leishmaniasis and impact of glycoprotein
Nayanika Datta, Sajal Dasmahapatra, Madhusri Pramanik, Santanu Kar Mahapatra
Glycoconjugate Journal.2026;[Epub] CrossRef
Partial characterization of purified glycoprotein from nutshell of Arachis hypogea L. towards macrophage activation and leishmaniacidal activity
Sujatha Srinivasan, Mamilla R. Charan Raja, Amrita Kar, Aishwarya Ramasamy, Adithyan Jayaraman, Vellingiri Vadivel, Santanu Kar Mahapatra
Glycoconjugate Journal.2023; 40(1): 1. CrossRef
Microgramma vacciniifolia Frond Lectin: In Vitro Anti-leishmanial Activity and Immunomodulatory Effects Against Internalized Amastigote Forms of Leishmania amazonensis
Lethícia Maria de Souza Aguiar, Michel Muálem de Moraes Alves, Enoque Pereira Costa Sobrinho Júnior, Patrícia Maria Guedes Paiva, Fernando Aécio de Amorim Carvalho, Lidiane Pereira de Albuquerque, Leydianne Leite de Siqueira Patriota, Thiago Henrique Napo
Acta Parasitologica.2023; 68(4): 869. CrossRef
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus
Arbind Kumar, Aashish Sharma, Narendra Vijay Tirpude, Yogendra Padwad, Vipin Hallan, Sanjay Kumar
Pharmacological Reports.2022; 74(6): 1238. CrossRef
Ovicidal and toxicological effect of hydroalcoholic extracts of Euphorbia milli var splendens, Synadenium carinatum Boiss and Tagetes minuta L. against Ancylostoma spp.: In vitro study
Matheus Diniz Gonçalves Coêlho, Lucas Tobias Rodrigues Maciel, Thaís de Fátima Kieko Ozaki, Maria Eduarda Godoi Silva, Lilian Saito Ormachea Bozo, Yumi Ando Consoli, Fernanda Bueno Sant’Anna Pereira-Maciel, Gokithi Akisue, Francine Alves da Silva-Coêlho
Journal of Parasitic Diseases.2021; 45(1): 252. CrossRef
Edwardsiella piscicida Type III Secretion System Effector EseK Inhibits Mitogen-Activated Protein Kinase Phosphorylation and Promotes Bacterial Colonization in Zebrafish Larvae
Huifang Cao, Fajun Han, Jinchao Tan, Mingyu Hou, Yuanxing Zhang, Dahai Yang, Qin Liu, Shelley M. Payne
Infection and Immunity.2018;[Epub] CrossRef
Plant lectins ConBr and CFL modulate expression toll-like receptors, pro-inflammatory cytokines and reduce the bacterial burden in macrophages infected with Salmonella enterica serovar Typhimurium
JEC Batista, MT Ralph, RV Vaz, PFC Souza, AB Silva, DCO Nascimento, LT Souza, MV Ramos, P Mastroeni, JV Lima-Filho
Phytomedicine.2017; 25: 52. CrossRef
Targeting the Immune System with Plant Lectins to Combat Microbial Infections
Jannyson J. B. Jandú, Roberval N. Moraes Neto, Adrielle Zagmignan, Eduardo M. de Sousa, Maria C. A. Brelaz-de-Castro, Maria T. dos Santos Correia, Luís C. N. da Silva
Frontiers in Pharmacology.2017;[Epub] CrossRef
Lectins from Synadenium carinatum (ScLL) and Artocarpus heterophyllus (ArtinM) Are Able to Induce Beneficial Immunomodulatory Effects in a Murine Model for Treatment of Toxoplasma gondii Infection
Eliézer L. P. Ramos, Silas S. Santana, Murilo V. Silva, Fernanda M. Santiago, Tiago W. P. Mineo, José R. Mineo
Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef
Porifera Lectins: Diversity, Physiological Roles and Biotechnological Potential
Johan Gardères, Marie-Lise Bourguet-Kondracki, Bojan Hamer, Renato Batel, Heinz Schröder, Werner Müller
Marine Drugs.2015; 13(8): 5059. CrossRef
Adjuvant and immunostimulatory effects of a D-galactose-binding lectin from Synadenium carinatum latex (ScLL) in the mouse model of vaccination against neosporosis
Mariana R D Cardoso, Caroline M Mota, Dâmaso P Ribeiro, Pablo G Noleto, William B F Andrade, Maria A Souza, Neide M Silva, Tiago W P Mineo, José R Mineo, Deise A O Silva
Veterinary Research.2012;[Epub] CrossRef
Effect of the Synadenium carinatum latex lectin (ScLL) on Leishmania (Leishmania) amazonensis infection in murine macrophages
Sandra R. Afonso-Cardoso, Claudio Vieira Silva, Marcelo S. Ferreira, Maria A. Souza
Experimental Parasitology.2011; 128(1): 61. CrossRef
A lactose specific lectin from the sponge Cinachyrella apion: Purification, characterization, N-terminal sequences alignment and agglutinating activity on Leishmania promastigotes
Danielle S. Medeiros, Thales L. Medeiros, Jannison K.C. Ribeiro, Norberto K.V. Monteiro, Ludovico Migliolo, Adriana F. Uchoa, Ilka Maria Vasconcelos, Adeliana S. Oliveira, Maurício. P. de Sales, Elizeu A. Santos
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology.2010; 155(3): 211. CrossRef
Mechanism of Trypanosoma cruzi death induced by Cratylia mollis seed lectin
M. P. Fernandes, N. M. Inada, M. R. Chiaratti, F. F. B. Araújo, F. V. Meirelles, M. T. S. Correia, L. C. B. B. Coelho, M. J. M. Alves, F. R. Gadelha, A. E. Vercesi
Journal of Bioenergetics and Biomembranes.2010; 42(1): 69. CrossRef
Angiogenic activity of Synadenium umbellatum Pax latex
PR. Melo-Reis, LS. Andrade, CB. Silva, LMM. Araújo, MS. Pereira, F. Mrue, L. Chen-Chen
Brazilian Journal of Biology.2010; 70(1): 189. CrossRef