Parasites, Hosts and Diseases

"superoxide dismutase"

Original Articles

Oxidative Stress in the Heart of Rats Infected with Trypanosoma evansi: Matheus D. Baldissera, Carine de F. Souza, Cl?udia M. Bertoncheli, Karine L. da Silveira, Thirssa H. Grando, Bianca C. Z. Porto, Daniela B. R. Leal, Aleksandro S. Da Silva, Ricardo E. Mendes, Lenita M. Stefani, Silvia G. Monteiro; Korean J Parasitol 2016;54(3):247-252.
Published online June 30, 2016; DOI: https://doi.org/10.3347/kjp.2016.54.3.247

Abstract
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This study was conducted to investigate the occurrence of oxidative stress in the heart tissue of rats infected with Trypanosoma evansi. Rats were divided into 2 groups (A and B) with 12 animals each, and further subdivided into 4 subgroups (A1 and A2, 6 animals/each; and B1 and B2, 6 animals/each). Animals in the groups B1 and B2 were subcutaneously inoculated with T. evansi. Thiobarbituric acid reactive substances (TBARS), superoxide dismutase activity (SOD), glutathione S-transferase activity (GST), reduced glutathione activity (GSH), and non-protein thiols (NPSH) in the heart tissue were evaluated. At day 5 and 15 post-infection (PI), an increase in the TBARS levels and a decrease in the SOD activity (P<0.05) were observed. GSH and GST activities were decreased in infected animals at day 15 PI (P<0.05). Considering the proper functioning of the heart, it is possible that the changes in the activity of these enzymes involved in the oxidative stress may be related, at least in part, in the pathophysiology of rats infected with T. evansi.

Citations

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Novel insights into antioxidant status, gene expression, and immunohistochemistry in an animal model infected with camel-derived Trypanosoma evansi and Theileria annulata
Reem M. Ramadan, Alaa F. Bakr, Esraa Fouad, Faten F. Mohammed, Azza M. Abdel-Wahab, Sahar Z. Abdel-Maogood, Mohamed M. El-Bahy, Mai A. Salem
Parasites & Vectors.2024;[Epub] CrossRef
Molecular and phylogenetic analysis of a type K1 strain Trypanosoma evansi isolate from Nigerian cattle: An evaluation of the therapeutic effects of compounds from Brassica oleracea on the histopathology of infected wister rats
Kingsley Onyekachi Moh, Sodangi Abdulkarim Luka, Iliya Shehu Ndams, Idris Alao Lawal, Dahiru Sani, Sylvester Sunday Obeta, Gbenga Peter Oderinde, Emeka John Dingwoke, Fatima Amin Adamude, Abraham Ehinomhen Ubhenin, Saifullahi Umar
Biochemistry and Biophysics Reports.2023; 33: 101424. CrossRef
The disturbance of antioxidant/oxidant balance in fish experimentally infected by Aeromonas caviae: Relationship with disease pathophysiology
Matheus D. Baldissera, Carine F. Souza, Belisa Parmeggiani, Guilhian Leipnitz, Camila Marina Verdi, RobertoC.V. Santos, Lenita M. Stefani, Bernardo Baldisserotto
Microbial Pathogenesis.2018; 122: 53. CrossRef
Relationship between antioxidant defense in Acanthamoeba spp. infected lungs and host immunological status
N. Łanocha-Arendarczyk, I. Baranowska-Bosiacka, I. Gutowska, K. Kot, E. Metryka, D.I. Kosik-Bogacka
Experimental Parasitology.2018; 193: 58. CrossRef
Achyrocline satureioides essential oil loaded in nanocapsules ameliorate the antioxidant/oxidant status in heart of rats infected with Trypanosoma evansi
Carine F. Souza, Matheus D. Baldissera, Luciana F. Cossetin, Daiane F. Dalla Lana, Silvia G. Monteiro
Microbial Pathogenesis.2017; 105: 30. CrossRef

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Sequence Variation in Superoxide Dismutase Gene of Toxoplasma gondii among Various Isolates from Different Hosts and Geographical Regions: Shuai Wang, Aiping Cao, Xun Li, Qunli Zhao, Yuan Liu, Hua Cong, Shenyi He, Huaiyu Zhou; Korean J Parasitol 2015;53(3):253-258.
Published online June 30, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.3.253

Abstract
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Toxoplasma gondii, an obligate intracellular protozoan parasite of the phylum Apicomplexa, can infect all warm-blooded vertebrates, including humans, livestock, and marine mammals. The aim of this study was to investigate whether superoxide dismutase (SOD) of T. gondii can be used as a new marker for genetic study or a potential vaccine candidate. The partial genome region of the SOD gene was amplified and sequenced from 10 different T. gondii isolates from different parts of the world, and all the sequences were examined by PCR-RFLP, sequence analysis, and phylogenetic reconstruction. The results showed that partial SOD gene sequences ranged from 1,702 bp to 1,712 bp and A + T contents varied from 50.1% to 51.1% among all examined isolates. Sequence alignment analysis identified total 43 variable nucleotide positions, and these results showed that 97.5% sequence similarity of SOD gene among all examined isolates. Phylogenetic analysis revealed that these SOD sequences were not an effective molecular marker for differential identification of T. gondii strains. The research demonstrated existence of low sequence variation in the SOD gene among T. gondii strains of different genotypes from different hosts and geographical regions.

Citations

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Superoxide Dismutases in Immune Regulation and Infectious Diseases
Tong Liu, Jiajin Shang, Qijun Chen
Antioxidants.2025; 14(7): 809. CrossRef
Immunization with a DNA vaccine encoding Toxoplasma gondii Superoxide dismutase (TgSOD) induces partial immune protection against acute toxoplasmosis in BALB/c mice
Yuan Liu, Aiping Cao, Yawen Li, Xun Li, Hua Cong, Shenyi He, Huaiyu Zhou
BMC Infectious Diseases.2017;[Epub] CrossRef

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Brief Communication

Oxidative Stress in Vivax Malaria: Ramazan Bilgin, Mustafa S. Yalcin, Guzide Yucebilgic, Ismail S. Koltas, S?leyman Yazar; Korean J Parasitol 2012;50(4):375-377.
Published online November 26, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.4.375

Abstract
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Malaria is still a leading cause of morbidity and mortality. The increase in lipid peroxidation reported in malaria infection and antioxidant status may be a useful marker of oxidative stress during malaria infection. The aim of this study was to investigate the role of antioxidant enzymes against toxic reactive oxygen species in patients infected with Plasmodium vivax and healthy controls. Malondialdehyde levels, superoxide dismutase, and glutathione peroxidase activities were determined in 91 P. vivax patients and compared with 52 controls. Malondialdehyde levels, superoxide dismutase, and glutathione peroxidase activities were 8.07±2.29 nM/ml, 2.69±0.33 U/ml, and 49.6±3.2 U/g Hb in the patient group and 2.72±0.50 nM/ml, 3.71±0.47 U/ml, and 62.3±4.3 U/g Hb in the control group, respectively. Malondialdehyde levels were found statistically significant in patients with vivax malaria higher than in healthy controls (P<0.001). On the other hand, superoxide dismutase and glutathione peroxidase activities were found to be significantly lower in vivax malaria patients than in controls (P<0.05). There was an increase in oxidative stress in vivax malaria. The results suggested that antioxidant defense mechanisms may play an important role in the pathogenesis of P. vivax.

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