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Parasit Host Dis > Volume 14(2):1976 > Article

Original Article
Korean J Parasitol. 1976 Dec;14(2):140-146. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1976.14.2.140
Copyright © 1976 by The Korean Society for Parasitology
Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis
Han-Jong Rim,Myung-Se Kim,Joung-Hwan Ha and Dong-Shik Chang
Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Seoul, Korea.

The new drug niclofolan (bayer 9015, Bilevon), 5,5'-dichloro-2,2'-dihydroxy-3, 3'-dinitrobiphenyl, has been used in the treatment of Paragonimus westermani in dogs and cats and P. iloktsuenensis in rats.

It was proved that administration of daily dose of 1.0 mg/kg body weight for 3 days or in 2 doses of 2.0 mg/kg body weight by alternate days were evidently effective for the infected dogs, cats and rats with the lung flukes, and toxic manifestations were not found.


Table 1
Results of treatment with niclofolan on 4 dogs experimentally infected with Paragonimus westermani

Table 2
Result of treatment with niclofolan on 5 cats experimentally infected with Paragonimus westermani

Table 3
Result of treatment with niclofolan on rats experimentally infected with Paragonimus westermani

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