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Original Article

Ameliorative Effect of Bone Marrow-Derived Stem Cells on Injured Liver of Mice Infected with Schistosoma mansoni

Magda M. El-Mahdi1, Wafaa A. Mansour2, Olfat Hammam2, Noha A. Mehana1, Taghreed M. Hussein1
The Korean Journal of Parasitology 2014;52(2):151-162.
Published online: April 18, 2014

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Corresponding author (magda_elmahdi@hotmail.com)
• Received: May 5, 2013   • Revised: July 30, 2013   • Accepted: August 21, 2013

© 2014, Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ameliorative Effect of Bone Marrow-Derived Stem Cells on Injured Liver of Mice Infected with Schistosoma mansoni
Korean J Parasitol. 2014;52(2):151-162.   Published online April 18, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.2.151
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Ameliorative Effect of Bone Marrow-Derived Stem Cells on Injured Liver of Mice Infected with Schistosoma mansoni
Korean J Parasitol. 2014;52(2):151-162.   Published online April 18, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.2.151
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Ameliorative Effect of Bone Marrow-Derived Stem Cells on Injured Liver of Mice Infected with Schistosoma mansoni
Image Image Image Image Image Image Image Image Image Image Image Image Image Image Image Image Image Image Image
Fig. 1 UV transilluminated agarose gel of PCR products of sry gene. Lane 1, PCR marker; lane 2, normal group; lane 3, infected group; lane 4, BMSCs treated group; lane 5, BMSCs-HGF treated group.
Fig. 2 Effect of BMSCs and BMSCs-HGF treatments on mean hepatic granuloma diameter in infected and treated groups. MGD, mean granuloma diameter.
Fig. 3 Effect of BMSCs and BMSCs-HGF treatment on mean hepatic granuloma count in infected and treated groups.
Fig. 4 Effect of BMSCs and BMSCs-HGF on serum albumin level of Schistosoma mansoni-infected mice in different studied groups.
Fig. 5 Effect of BMSCs and BMSCs-HGF on serum ALT, AST, and ALP levels of Schistosoma mansoni-infected mice in different studied groups.
Fig. 6 Liver tissue section of normal uninfected negative control mice (Sirius Red, ×200).
Fig. 7 Liver tissue section of infected control mice at week 12 PI showing a large fibrocellular granuloma surrounded by pink-red dense collagen bundles (Sirius Red, ×200).
Fig. 8, 9 Liver tissue sections of BMSCs and BMSCs-HGF recipient female mice at the 1st month post treatment showing a medium fibrocellular granuloma with red-stained concentric collagen bundles (Sirius Red, ×200).
Fig. 10 Liver tissue section of infected control mice at week 16 PI showing a medium fibrocellular granuloma surrounded by red-stained concentric collagen bundles (Sirius Red, ×200).
Fig. 11, 12 Liver tissue sections of BMSCs and BMSCs-HGF recipient female mice at the 2nd month post treatment showing a small fibrocellular granuloma surrounded the parasite's ovum with scattered concentric red-stained collagen bundles (Sirius Red, ×200).
Fig. 13 Liver tissue section of infected control mice at week 20 PI showing a characteristic large fibrocellular granuloma surrounded the parasite's ovum with dense red-stained collagen bundles (Sirius Red, ×200).
Fig. 14, 15 Liver tissue sections of BMSCs and BMSCs-HGF recipient female mice at the 3rd month post treatment showing a diminished fibrocellular granuloma surrounded the parasit's ovum with scattered concentric red-stained collagen bundles (Sirius Red, ×200).
Fig. 16 Immunostain for OV-6 antibody (DAB, ×200) in a liver section of normal uninfected negative control mice showing negative expression for OV-6 monoclonal antibody.
Fig. 17 Immunostain for OV-6 antibody (DAB, ×200) in a liver section of infected control mice at week 12 PI showing negative expression of OV-6 monoclonal antibody in hepatocytes and granuloma cells.
Fig. 18, 19 Immunostain for OV-6 antibody (DAB, ×200) in liver sections of BMSCs and BMSCs-HGF recipient female mice at the 1st month post treatment showing markedly mild expression of OV-6 monoclonal antibody (as cytoplasmic brown colour) in hepatocytes like cells and granuloma cells.
Fig. 20 Immunostain for OV-6 antibody (DAB, ×200) in a liver section of infected control mice at week 16 PI showing negative expression of OV-6 monoclonal antibody in hepatocytes and granuloma cells.
Fig. 21, 22 Immunostain for OV-6 antibody (DAB, ×200) in liver sections of BMSCs and BMSCs-HGF recipient female mice at the 2nd month post treatment showing marked and mild expression of OV-6 monoclonal antibody (as cytoplasmic brown colour) in hepatocytes like cells and granuloma cells.
Fig. 23 Immunostain for OV-6 antibody (DAB, ×200) in a liver section of infected control mice at week 20 PI showing negative expression of OV-6 in hepatocytes and granuloma cells.
Fig. 24, 25 Immunostain for OV-6 antibody (DAB, ×200) in liver sections of BMSCs and BMSCs-HGF recipient female mice at the 3rd month post treatment showing marked and mild expression of OV-6 monoclonal antibody (as cytoplasmic brown colour) in hepatocytes like cells and granuloma cells.

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Ameliorative Effect of Bone Marrow-Derived Stem Cells on Injured Liver of Mice Infected with Schistosoma mansoni
Months post reat ment Animal groups No. of granuloma Mean±SE % Reduction Granuloma diameter (pm) Mean±SE PR 1st group Normal - - - - Infected 22.8±0.7a - 281.2±12.7a - BMSCs 19.0±2.7a 16.7 205.6±8.6b 26.9 BMSCs-HGF 17.4±1.8a 23.7 204.3±7.4b 27.4 2nd group Normal - - - - Infected 19.8±0.7a - 273.0±12.5a - BMSCs 12.4±1.4b 37.4 162.5±7.6b 40.5 BMSCs-HGF 11.6±0.51b 41.4 160.5±7.3b 41.2 3rd group Normal - - - - Infected 16.6±3.2a - 260.7±16.5a - BMSCs 5.6±0.8b 66.3 100.6±4.9b 61.4 BMSCs-HGF 5.4±0.8b 67.5 108.5±10.9b 58.4 Months post treatment Animal groups ALT (GOT); U/L AST (GPT); U/L Alkaline phosphatase; IU/L (ALP) Albumin; g/100 ml 1st month Normal 46.7±0.5c 45.4±1.6b 65.5±2.1c 3.3±0.14a Infected 62.5±2.3a 72.8±2.9a 178.1±3.5a 2.8b BMSCs 56.4±1.8b 69.7±1.9a 161.3±6.7b 2.8±0.1b BMSCs-HGF 56.2±2.3b 69.5±2.2a 161.6±5.9b 2.8±0.3b 2nd month Normal 46.7±0.5b 45.4±1.6c 66.7±2.4c 3.3±0.1a Infected 65.6±2.8a 67.3±1.4a 128.7±5.3a 2.6±0.1b BMSCs 50.6±1.1b 57.5±1.9b 100.9±4.6b 3.0±0.1a BMSCs-HGF 50.3±0.5b 57.3±1.5b 100.8±3.8b 3.0±0.1a 3rd month Normal 46.7±0.5b 45.4±1.6b 65.6±1.7b 3.3±0.1a Infected 69.3±2.2a 63.8±2.1a 110.6±4.9a 2.2±0.1b BMSCs 49.3±0.9b 49.9±1.4b 56.9±2.1bc 3.1±0.1a BMSCs-HGF 49.2±1.1b 49.8±1.2b 55.8±2.4c 3.1±0.1a
Table 1. Effect of treatment with BMSCs and BMSCs-HGF on mean hepatic granuloma diameter and number of mice

Data are expressed as the mean±SE (standard error).

a,bThe values in the same row with different superscripts are significantly different (P<0.05).

Table 2. Effect of treatment with BMSCs and BMSCs-HGF on the serum concentration of liver albumin and activities of ALT, AST, and ALP of mice

Data are expressed as the mean±SE (standar error).

ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase.

a,b,cThe values in the same row with different superscripts are significantly different (P<0.05).

Table 1.

Table 2.

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