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Brief Communication

Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations

Purva Gupta1, Veena Pande2, Aparup Das1, Vineeta Singh1
The Korean Journal of Parasitology 2014;52(5):557-564.
Published online: October 22, 2014

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Corresponding author (vineetas_2000@yahoo.com)
• Received: January 16, 2014   • Revised: April 1, 2014   • Accepted: May 20, 2014

© 2014, Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
Korean J Parasitol. 2014;52(5):557-564.   Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.557
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Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
Korean J Parasitol. 2014;52(5):557-564.   Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.557
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Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
Image Image Image
Fig. 1 Map of India showing regions where blood samples of malaria patients were collected. The number of P. falciparum (Pf) and P. vivax (Pv) samples collected from each region are shown in the map.
Fig. 2 Phylogenetic tree for vir 1/9. The evolutionary history was inferred using the Minimum Evolution method. The optimal tree with the sum of branch length=0.53931989 is shown.
Fig. 3 (A) Vir 27 neighbor joining unrooted tree. The phylogenetic tree is based on pairwise Nei genetic distance. The optimal tree with the sum of branch length=0.01525000 is shown. (B) Vir 12 neighbor joining unrooted tree. The phylogenetic tree is based on pairwise Nei genetic distance. The optimal tree with the sum of branch length=0.08350000 is shown. (C) Vir 21 neighbor joining unrooted tree. The phylogenetic tree is based on pairwise Nei genetic distance. The optimal tree with the sum of branch length=0.05150000 is shown. (D) Vir 1/9 neighbor joining unrooted tree. The phylogenetic tree is based on pairwise Nei genetic distance. The optimal tree with the sum of branch length=0.02750000 is shown.

Fig. 1

Fig. 2

Fig. 3

Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
Vir genes Sequence length No. of SNPs (S) No. of haplotypes Haplotype diversity Nucleotide diversity
Tests of neutrality
π Θw Tajima’s D Vir 27 1,255 bp 18 15 0.845 0.00265 0.00301 -0.36015 Vir 4 1,314 bp 2 3 0.711 0.00068 0.00054 0.83017 Vir 12 686 bp 120 17 0.962 0.06401 0.0458 1.47617 Vir 21 970 bp 179 13 0.925 0.05557 0.0469 0.70136 Vir 1/9 258 bp 78 9 0.855 0.1128 0.08805 1.07093 Average 79.4 11.4 0.8596 0.047142 0.03686 0.743696 Region Vir genes Sequence length No. of segregating sites (S) No. of haplotypes Haplotype diversity Nucleotide diversity
Tests of neutrality
π Θw Tajima’s D Mangalore Vir 27 1,255 bp 13 6 0.833 0.00283 0.00381 -1.22450 Vir 12 686 bp 101 5 1.000 0.07201 0.07697 -0.48969 Delhi Vir 27 1,255 bp 5 5 1.000 0.00191 0.00191 0.00000 Vir 12 686 bp 91 4 0.900 0.07172 0.06647 0.59975 Vir 1/9 258 bp 75 6 0.929 0.12915 0.12407 0.22226 Goa Vir 27 1,255 bp 3 4 0.583 0.00053 0.00088 -1.51297 Vir 12 686 bp 65 5 1.000 0.05015 0.04828 0.29278 Vir 21 970 bp 176 7 0.917 0.06446 0.06904 -0.34406 Vir 1/9 258 bp 52 3 0.700 0.10349 0.09860 0.37405 Rourkela Vir 27 1,255 bp 12 8 0.956 0.00397 0.00338 0.78364 Vir 12 686 bp 82 3 0.833 0.06487 0.06759 -0.42015 Vir 21 970 bp 117 4 0.900 0.05515 0.05839 -0.42177
Table 1. Genewise summary statistics for the 5 vir genes
Table 2. Population wise summary statistics for the 5 vir genes analyzed

Table 1.

Table 2.

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