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Original Article

Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand

The Korean Journal of Parasitology 2015;53(3):265-270.
Published online: June 30, 2015

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*Corresponding author (kesaratmu@yahoo.com)
• Received: December 19, 2014   • Revised: February 27, 2015   • Accepted: March 5, 2015

© 2015, Korean Society for Parasitology and Tropical Medicine

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  • Hemoglobinopathy and malaria are commonly found worldwide particularly in malaria endemic areas. Thalassemia, the alteration of globin chain synthesis, has been reported to confer resistance against malaria. The prevalence of thalassemia was investigated in 101 malaria patients with Plasmodium falciparum and Plasmodium vivax along the Thai-Myanmar border to examine protective effect of thalassemia against severe malaria. Hemoglobin typing was performed using low pressure liquid chromatography (LPLC) and α-thalassemia was confirmed by multiplex PCR. Five types of thalassemia were observed in malaria patients. The 2 major types of thalassemia were Hb E (18.8%) and α-thalassemia-2 (11.9%). There was no association between thalassemia hemoglobinopathy and malaria parasitemia, an indicator of malaria disease severity. Thalassemia had no significant association with P. vivax infection, but the parasitemia in patients with coexistence of P. vivax and thalassemia was about 2-3 times lower than those with coexistence of P. falciparum and thalassemia and malaria without thalassemia. Furthermore, the parasitemia of P. vivax in patients with coexistence of Hb E showed lower value than coexistence with other types of thalassemia and malaria without coexistence. Parasitemia, hemoglobin, and hematocrit values in patients with coexistence of thalassemia other than Hb E were significantly lower than those without coexistence of thalassemia. Furthermore, parasitemia with coexistence of Hb E were 2 times lower than those with coexistence of thalassemia other than Hb E. In conclusion, the results may, at least in part, support the protective effect of thalassemia on the development of hyperparasitemia and severe anemia in malaria patients.
Malaria is an ancient disease that causes death until present age. Resistance of malaria parasite to most of the available antimalarial drugs has been a major public health concern particularly in Southeast Asia. Plasmodium falciparum and Plasmodium vivax are the 2 predominant malarial species in this area [1]. Several host factors have been reported to contribute to malaria severity. These include innate immunity [2], hemoglobinopathies such as thalassemia [3], enzymopathies such as glucose-6-phosphate dehydrogenase (G6PD) deficiency [4], heme oxygenase (HO) polymorphism [5,6], and tumor necrosis factor-α promoter polymorphism (TNF-α) [7]. Among them, thalassemia has been reported to confer protection against malaria disease [3].
Thalassemia is a hemoglobin disorder caused by alteration in the synthesis of globin chain of hemoglobin. This hemoglobinopathy is classified into 2 forms according to the abnormality of globin chains, i.e., α-, and β-thalassemia. The α-thalassemia is a result of decrease in synthesis of 1 or 2 α-globin chain on chromosome 16p13.3 [8]. The deletion of α-globin gene results in alteration of the normal genotype (αα/αα) to the severe form, α-thalassemia-1 (--/αα, --/--), and the mild form, α-thalassemia-2 (-α/αα, -α/-α). Furthermore, α-globin chain is also inactivated by point mutation. Similarly to α-thalassemia, β-thalassemia is the disorder produced by decrease in synthesis of β-globin chain which located on chromosome 11 (11p15.5) [8]. The common abnormality of β-globin gene is usually resulted from mutation rather than deletion. Hemoglobin E (Hb E), the most common form of thalassemia in Southeast Asia [9], is caused by replacement of glutamic acid at codon 26 of β-globin chain with lysine [10].
Thalassemia is widely distributed around the world and is commonly observed in malaria-endemic areas [11]. The coexistence of thalassemia and malaria was reported to protect the infected host against malaria caused by P. falciparum [8,12-14]. Such association, however, was not demonstrated in P. vivax in a study from Papua New Guinea in children aged 3-21 months, although parasite density was significantly higher in α-thalassemia-2 [15]. To investigate the protective effect of thalassemia against malaria, the prevalence of thalassemia was investigated in patients infected with the 2 predominant malaria species, P. falciparum and P. vivax, in malaria endemic areas on the western and southern regions of Thailand.
Study subjects and sample collection
A total of 101 blood samples were collected from patients (12 Thais and 89 Burmeses) with mono-infection with P. falciparum (n=40), P. vivax (n=58), or mixed infection of P. falciparum and P. vivax (n=3). The study was conducted at malaria clinics in Tak (Mae Sot district: n=69) and Ranong (Kraburi district: n=32) provinces of Thailand during 2012 and 2013. The study protocol was approved by the Ethics Committee of Thammasat University (Certificate no. 040/2555). Giemsastained thin and thick blood smears were prepared and examined microscopically for the presence of malaria parasites. Parasites and white blood cells (WBCs) were counted on the thick film using a 100× oil-immersion objective, and the number of parasites was recorded when 200 WBCs were counted.
Detection of thalassemia
Hemoglobin analysis was screened using osmotic fragility test (OF test), and hemoglobin typing was performed using automated low pressure liquid chromatography (LPLC) (automated analyzer: Hb Gold, Drew Scientific Ltd., Cumbria, UK). The genomic DNA was extracted from peripheral blood using a QIAamp DNA extraction mini-kit (QIAGEN, Valencia, California, USA) according to the standard protocol. The common α-thalassemia including α-thalassemia-1 (SEA and THAI deletions), α-thalassemia-2 (3.7 and 4.2 kb deletions), Hb constant spring, and Hb Pakse mutations were analyzed by multiplex PCR methods.
Statistical analysis
Statistical analysis was performed using the SPSS statistical package (version 12.0 SPSS Inc., Chicago, Illinois, USA). Difference of qualitative and quantitative data between groups was analyzed using the chi-square test and ANOVA with Tukey analysis, respectively. Statistical significance level was set at α=0.05.
The prevalence of thalassemia in malaria patients
The typing of thalassemia was performed by determination of amount and type of Hb with Hb chromatogram, OF test, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH). Normal or non-clinically significant thalassemia was identified using negative OF test, HbA2 (<4%), MCV (≥80 fL), and MCH (≥27 pg). α-thalassemia-1 or 2 trait and homozygous α-thalassemia-2 were identified using positive OF test, HbA2 (<4%), MCV (≥80 fL), and MCH (≥27 pg). β-thalassemia trait was identified using the criteria similarly to that of α-thalassemia-1 or 2 trait, except that the cut-off HbA2 used was 4-8%. Hb E trait was identified using negative or positive OF test, Hb E (≤25%), MCV (<80 fL or normal), and MCH (<27 pg or normal); if the Hb E was less than 25%, it can be classified as Hb E trait with or without α-thalassemia. Homozygous Hb E with or without α-thalassemia was identified using positive OF test, Hb E (≥80%), Hb F (≤5%), MCV (<80 fL), and MCH (<27 pg).
The prevalence of thalassemia in 101 patients with malaria infection was 36.7%. Five types of thalassemia were observed, i.e., Hb E, β-thalassemia, α-thalassemia-2, Hb E/α-thalassemia-2, and β-thalassemia/α-thalassemia-2 (Table 1). The 2 major types were Hb E (18.8%) and α-thalassemia-2 (11.9%). The α-thalassemia-2 of all patients was a 3.7 kb deletion. The α-thalassemia-1 was not detected in any patient. The prevalence of Hb E vs α-thalassemia-2 thalassemia in Thai and Burmese patients were 2/12 (16.7%) vs 2/12 (16.7%) and 17/89 (19.1%) vs 15/89 (16.9%), respectively.
Relationship between malaria patients with and without coexistence of thalassemia
The malaria parasitemia in patients with and without coexistence of all 5 types of thalassemia were comparable (Table 2). No significant difference in parasitemia, hemoglobin, and hematocrit was observed between patients with malaria (both P. falciparum and P. vivax) with or without coexistence of thalassemia. However, the coexistence patients had 2 times lower parasitemia than malaria patients without coexistence. The prevalence of patients with and without coexistence of thalassemia in 2 endemic areas were 28 (40.6%) and 41 (59.1%) in western region and 9 (28.1%) and 23 (71.9%), respectively.
The P. falciparum-infected patients with coexistence of thalassemia showed 3 times lower parasitemia than P. falciparum-infected patients without coexistence (Table 2). High parasitemia was found in patient with coexistence of α-thalassemia-2. Whereas, P. vivax-infected patients with and without coexistence of thalassemia showed similar parasitemia. Furthermore, mixed infection of P. falciparum and P. vivax patients with coexistence of thalassemia represented closely 3 times lower parasitemia than mixed infection patients without coexistence. The results might suggest the protective effect of thalassemia on P. falciparum-infected patients but not on P. vivax-infected patients. Nevertheless, there was no significant difference in parasitemia, hemoglobin, and hematocirt between malaria (both P. falciparum and P. vivax) patients with or without coexistence of thalassemia.
The comparison of P. falciparum with coexistence of thalassemia and P. vivax with coexistence of thalassemia showed 3 times lower parasitemia in P. vivax patients. The coexistence of β-thalassemia was found only in P. falciparum infection whereas Hb E/α-thalassemia-2 was found only in P. vivax infection.
Relationship between Hb E thalassemia and malaria parasitemia, hemoglobin, and hematocrit
The malaria patients with coexistence of Hb E showed more prevalence than other types of thalassemia; therefore, parasitemia, hemoglobin, and hematocrit were compared. Parasitemia of malaria in patients with coexistence of Hb E showed lower than those with coexistence with other types of thalassemia and malaria without coexistence, 2 and 3 times, respectively (Table 3). Parasitemia, hemoglobin, and hematocrit values in patients with coexistence of thalassemia other than Hb E were significantly lower than those without coexistence of thalassemia (parasitemia: P=0.048; hemoglobin: P=0.021; hematocrit: P=0.018). There was no significant relationship for such values in malaria patients with Hb E thalassemia.
Tak province in the western region and Ranong province in the southern region are the 2 top 10 provinces of Thailand with malaria incidence in 2013. Most of the patients included in the study were Burmese, and the prevalence rate of P. vivax infection was found to be higher than P. falciparum infection with the ratio 1.5:1. The overall prevalence rate of thalassemia hemoglobinopathy in this group of populations was 36.7%. The most prevalent type Hb E (18.8%) is a common abnormal hemoglobin form of thalassemia which is distributed in Mediterranean, East Asia, India subcontinent, and Southeast Asia [16]. Hb E carriers in Thai (10-60%) and Burmese (11.4-60%) populations have been reported to vary markedly depending on the areas of investigation [17]. Results of the present study showed that Hb E is the most predominant form of thalassemia with prevalence rates of 2/12 (16.7%) and 17/89 (19.1%) in Thai and Burmese malaria patients, respectively. This was consistent with that previously observed in other Southeast Asian countries such as Laos and Cambodia [9]. The most severe form α-thalassemia-1, is found in Southeast Asia and China. In Thailand, the prevalence of this thalassemia type varies from 2.5 to 10% in each area of the country [9]. In addition, α-thalassemia-2 is also distributed in several malaria endemic countries including Nepal, India, and Papua New Guinea [18]. The common types are those with deletion of 3.7 and 4.2 kb. In Southeast Asia, the most common types of α-thalassemia-1 and α-thalassemia-2 are --SEA and -α3.7, respectively. The frequency of -α3.7 in Thai population in northeast area of the country was reported as 17.5% [19].
The association between malaria disease severity and various red cell disorders were investigated in various studies [20-22]. Most studies were performed in patients with P. falciparum infection to explore the protective effect of red cell disorders on malaria. These red cell disorders included disorders related to merozoite invasion protection, parasite growth within the red blood cell, and the ability to eliminate malaria from red blood cells [23]. Study on the relationship between red cell disorders and the incidence of malaria in Myanmar suggested protection of thalassemic red cells against severe falciparum malaria [21]. The mean parasitemia in α- or β-thalassaemia trait patients was significantly lower than patients with normal hemoglobin or heterozygous HbE. In a study in Thailand, HbA2 and Hb E levels were shown not to be enhanced by P. falciparum infection. This suggests that Hb E disorder might be due to the natural selection of malaria [24]. Furthermore, it was shown that the Hb E trait red blood cells were resistant to invasion by P. falciparum, with unidentified membrane abnormality [25].
In this study, hemoglobin and hematocrit of patients with thalassemia other than Hb E were found to be significantly lower than those with normal red cells. However, no such relationship was found with those carrying Hb E. Results may at least in part support the assumption that thalassemic red cells may protect patients from further development to severe malaria as a result of hyperparasitemia. Interestingly, it is of note for the coexistence of malaria with only α-thalassemia-2 but not α-thalassemia-1, the commonly found thalassemia type in Southeast Asia. It is possible that α-thalassemia-1 protects host red cells from malaria infection in this population. Definite conclusion on this issue should be further explored with inclusion of a larger sample in the analysis.
In conclusion, a trend of decreasing parasitemia was found in malaria patients with coexistence of thalassemia. The results may, at least in part, support the protective effect of thalassemia on the development of hyperparasitemia and severe anemia in malaria patients. Nevertheless, definite conclusion on such relationship including the underlying mechanisms needs to be confirmed in a larger study.

We have no conflict of interest related to this work.

The study was supported by Thammasat University Research Fund under the TU Research Scholar, Contract No. 57/2555.
Table 1.
Prevalence of thalassemia in patients with malaria in the western (Tak province) and southern (Ranong province) regions of Thailand
Table 1.
Western region
Southern region
Summation (%)
P. falciparum P. vivax Mixed Total P. falciparum P. vivax Mixed Total
Malaria with thalassemia
 Hb Ea 3 9 2 14 5 0 0 5 19 (18.8)
 β-thalassemia 1 0 0 1 0 0 0 0 1 (1.0)
 α-thalassemia 2a 3 6 0 9 2 1 0 3 12 (11.9)
 Hb E/α-thalassemia 2 0 1 0 1 0 0 0 0 1 (1.0)
 β-thal/α-thalassemia 2 1 2 0 3 1 0 0 1 4 (4.0)
Malaria alone 18 23 0 41 6 16 1 23 64 (63.4)
Total 26 41 2 69 14 17 1 32 101 (100)

Data are presented as numbers (%).

aIncluding individuals with heterozygous and homozygous.

Table 2.
Malaria parasitemia in patients with or without thalassemia
Table 2.
Number of patients Parasitemia (parasite/μl)
Total P. falciparum P. vivax Mixed infection
Coexistence of malaria with thalassemia 37 15,981 (7,247-81,661) 24,697 (2,500-151,086) 8,525 (280-42,988) 17,080 (11,439-22,720)
 Hb E 19 17,563 (4,444-72,158) 4,888 (865-12,075) 17,080 (11,439-22,720)
 β-thalassemia 1 2,500 - -
 α-thalassemia 2 12 42,545 (9,703-151,086) 12,256 (280-42,988) -
 Hb E/α-thalassemia 2 1 - 14,720 (14,720) -
 β/α-thalassemia 2 4 19,711 (17,631-21,790) 8,738 (4,667-12,808) -
Malaria alone 64 37,207 (7,200-24,761) 83,496 (355-1,427,200) 8,386 (50-74,667) 50,320

Data are presented as mean (95% CI) values.

Table 3.
Malaria parasitemia, hemoglobin, and hematocrit in patients with hemoglobin E thalassemia, other types of thalassemia, and those without thalassemia
Table 3.
Number of patients Parasitemia (parasite/μl) Hb (g/dl) Hct (%)
Coexistence of malaria with Hb E 19 11,508 (4,227-27,243) 11.63 (9.69-13.56) 35.53 (29.50-41.56)
Coexistence of malaria with other types of thalassemia 18 20,702a (13,366-54,770) 10.52b (7.72-13.32) 32.39c (24.17-40.61)
Malaria alone 64 37,207 (14,0758-215,173) 12.25 (9.87-14.63) 37.28 (30.12-44.44)

Data are presented as mean (95% CI) values.

Hb, hemoglobin; Hct, hematocrit.

aStatistically significant difference with patients without thalassemia (P=0.048)

bStatistically significant difference with patients without thalassemia (P=0.021)

cStatistically significant difference with patients without thalassemia (P=0.018)

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Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand
Korean J Parasitol. 2015;53(3):265-270.   Published online June 30, 2015
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Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand
Korean J Parasitol. 2015;53(3):265-270.   Published online June 30, 2015
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Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand
Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand
Western region
Southern region
Summation (%)
P. falciparum P. vivax Mixed Total P. falciparum P. vivax Mixed Total
Malaria with thalassemia
 Hb Ea 3 9 2 14 5 0 0 5 19 (18.8)
 β-thalassemia 1 0 0 1 0 0 0 0 1 (1.0)
 α-thalassemia 2a 3 6 0 9 2 1 0 3 12 (11.9)
 Hb E/α-thalassemia 2 0 1 0 1 0 0 0 0 1 (1.0)
 β-thal/α-thalassemia 2 1 2 0 3 1 0 0 1 4 (4.0)
Malaria alone 18 23 0 41 6 16 1 23 64 (63.4)
Total 26 41 2 69 14 17 1 32 101 (100)
Number of patients Parasitemia (parasite/μl)
Total P. falciparum P. vivax Mixed infection
Coexistence of malaria with thalassemia 37 15,981 (7,247-81,661) 24,697 (2,500-151,086) 8,525 (280-42,988) 17,080 (11,439-22,720)
 Hb E 19 17,563 (4,444-72,158) 4,888 (865-12,075) 17,080 (11,439-22,720)
 β-thalassemia 1 2,500 - -
 α-thalassemia 2 12 42,545 (9,703-151,086) 12,256 (280-42,988) -
 Hb E/α-thalassemia 2 1 - 14,720 (14,720) -
 β/α-thalassemia 2 4 19,711 (17,631-21,790) 8,738 (4,667-12,808) -
Malaria alone 64 37,207 (7,200-24,761) 83,496 (355-1,427,200) 8,386 (50-74,667) 50,320
Number of patients Parasitemia (parasite/μl) Hb (g/dl) Hct (%)
Coexistence of malaria with Hb E 19 11,508 (4,227-27,243) 11.63 (9.69-13.56) 35.53 (29.50-41.56)
Coexistence of malaria with other types of thalassemia 18 20,702a (13,366-54,770) 10.52b (7.72-13.32) 32.39c (24.17-40.61)
Malaria alone 64 37,207 (14,0758-215,173) 12.25 (9.87-14.63) 37.28 (30.12-44.44)
Table 1. Prevalence of thalassemia in patients with malaria in the western (Tak province) and southern (Ranong province) regions of Thailand

Data are presented as numbers (%).

Including individuals with heterozygous and homozygous.

Table 2. Malaria parasitemia in patients with or without thalassemia

Data are presented as mean (95% CI) values.

Table 3. Malaria parasitemia, hemoglobin, and hematocrit in patients with hemoglobin E thalassemia, other types of thalassemia, and those without thalassemia

Data are presented as mean (95% CI) values.

Hb, hemoglobin; Hct, hematocrit.

Statistically significant difference with patients without thalassemia (P=0.048)

Statistically significant difference with patients without thalassemia (P=0.021)

Statistically significant difference with patients without thalassemia (P=0.018)