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Original Article

Control of clonorchiasis by repeated treatments with praziquantel

Sung-Tae Hong1, Han-Jong Rim2, Duk-Young Min3, Xueming Li4, Jingxian Xu5, Zheng Feng6, Soon-Hyung Lee1
The Korean Journal of Parasitology 2001;39(4):285-292.
Published online: December 31, 2001

1Department of Parasitology and Institute of Endemic Diseases, Seoul National University College of Medicine and SNUMMC, Seoul 110-799, Korea.

2Korea Association of Health, Seoul 157-016, Korea.

3Department of Parasitology, College of Medicine Hanyang University, Seoul 133-791, Korea.

4Guangxi Institute of Parasitic Diseases Control, Nanning, Guangxi, China.

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Corresponding author (hst@snu.ac.kr)
• Received: November 5, 2001   • Accepted: November 27, 2001

Copyright © 2001 by The Korean Society for Parasitology

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Control of clonorchiasis by repeated treatments with praziquantel
Korean J Parasitol. 2001;39(4):285-292.   Published online December 31, 2001
DOI: https://doi.org/10.3347/kjp.2001.39.4.285
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Control of clonorchiasis by repeated treatments with praziquantel
Korean J Parasitol. 2001;39(4):285-292.   Published online December 31, 2001
DOI: https://doi.org/10.3347/kjp.2001.39.4.285
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Control of clonorchiasis by repeated treatments with praziquantel
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Fig. 1 Sites of the study; Buguchon, Guangxi province and Longxing, Liaoning province, People's Republic of China.

Fig. 1

Control of clonorchiasis by repeated treatments with praziquantel
Villages/Date No. of exam. No (%) of egg positive subjects
Csa) Al Tt Hw Total
Buguchon, Guangxi
 Oct. 98 100 69 21 22 6 82
(69.0) (21.0) (22.0) (6.0) (82.0)
 Jun. 99 101b) 38 38 16 1 64
(37.6) (37.6) (15.8) (1.0) (63.4)
 Nov. 99 181 31 24 18 4 58
(17.1) (13.3) (9.9) (2.2) (32.0)
Longxing, Liaoning
 Oct. 98 487b) 92 16 2 0 106
(18.9) (3.3) (0.4) (21.8)
 Sep. 99 139 17 0 0 0 17
(12.2) (12.2)
Villages/Date No. of subjects by EPG Grades
1-999 1000-4999 5000-9999 10000-19999 20000- Total
Buguchon, Guangxi
 Oct. ‘98 36 14 7 2 2 61
 Jun. ‘99 30 10 1 4 0 45
 Nov. ‘99 12 7 2 l 4 26
Longxing, Liaoning
 Oct, ‘98 27 11 3 1 3 45
 Sep. '99 18 0 0 0 0 18
Age group Sex No. of cases
 Positive rate (%)
Examineda) Positive
0-9 Male 24 6 25.0
Female 22 7 31.8
Total 46 13 28.3
10-19 Male 24 15 62.5
Female 21 10 47.6
Total 45 25 55.6
20-29 Male 26 22 84.6
Female 18 8 44.4
Total 44 30 68.2
30-39 Male 36 33 91.7
Female 30 17 56.7
Total 66 50 75.8
40-49 Male 25 24 96.0
Female 26 18 69.2
Total 51 42 82.3
50-59 Male 4 4 100.0
Female 8 6 75.0
Total 12 10 83.3
60-69 Male 12 11 91.7
Female 10 7 70.0
Total 22 18 81.8
70# Male 0 0 -
Female 2 0 0
Total 2 0 0
Total Male 151 115 76.2
Female 137 73 53.3
Total 288 188 65.3
Medication schemes Changes by examinations at
Pre-treatment 6-months post-treatment 12-months post-treatment
Egg positive rate (%)
 25 mg/kg x3, 6-months 69.0a) 37.6a) 17.1a)
 25 mg/kg x3, 6-monthsb) 66.7a) 41.0a) 15.4a)
 25 mg/kg x3, 12-months 18.9 - 12.2
Mean EPG counts (± S.D.)
 25 mg/kg x3, 6-months 2436 (± 4168) 2181 (± 4242) 5603 (± 9531)
 25 mg/kg x3, 6-monthsb) 2008 (± 4952)a) 1363 (± 3118)a) 512 (± 541)a)
 25 mg/kg x3, 12-months 4814 (± 5011)a) - 491 (± 523)a)
Cure rate (%)c)
 25 mg/kg x3. 6-months - 30.0a) 80.0a)
 25 mg/kg x3, 12-months - - 60.0
Egg reduction rate (%)c)
 25 mg/kg x3, 6-months - 36.6a) 95.4a)
 25 mg/kg x3, 12-months - - 95.9
Examined Results at the exam.
 No, of cases (%)
1st 2nd 3rd
39
3 times + + + 3 (7.7)
+ - - 11 (28.2)
+ - - 11 (28.2)
+ - + 1 (2.6)
- + + 1 (2.6)
- + - 1 (2.6)
- - + 1 (2.6)
- - - 10 (25.6)
77
2 times + + 14 (18.2)
+ - 26 (33.8)
- + 2 (2.6)
- - 35 (45.5)
101
once + 37 (36.6)
- 64 (63.4)
Table 1. Egg positive rate of Clonorchis sinensis and other intestinal helminths in Buguchon, Guangxi, and Longxing, Liaoning, China

Cs, Clonorchis sinensis; Al, Ascaris lumbricoides; Tt, Trichuris trichiura; Hw. hookworm.

All of egg positive cases of intestinal nematodes were treated with albendazole at a single dose of 400 mg.

• The decreasing tendency of Cs egg positive rate in Buguchon is statistically significant (p < 0.001 by Cochran-Mantel-Haenszel chi-square test) but that in Longxing insignificant (p = 0.068 by Cochran-Mantel-Haenszel chi-square test).

Table 2. Proportion of clonorchiasis subjects by EPG grades in Buguchon, Guangxi and Longxing, Liaoning

• Proportion of the subjects by EPG grades in sequential examinations is insignificant (p = 0.168 by Cochran-Mantel-Haenszel chi-square test) in Buguchon but significant (p = 0.012 by Cochran-Mantel-Haenszel chi-square test) in Longxing.

Table 3. Positive rate of clonorchiasis by age and sex among whole examined residents in Buguchon, Guangxi

The numbers of whole enrolled subjects during the 3 examinations, and egg positive cases at any examination.

• The positive rates significantly differ by age and gender (p < 0.001 by Cochran-Mantel-Haenszel chi-square test).

Table 4. Changes of egg positive rates and EPG counts of Clonorchis sinensis during repeated praziquantel treatments

The decrease of egg positive rate and EPG counts and the cure rate and egg reduction rate are statistically significant (p < 0.01).

Only the 39 cases who took all of three examinations and treatments are counted.

Qnly the egg positive cases at the initial examination are counted.

Table 5. Number of cases by results during the 3 examinations in Buguchon

Table 1.

Table 2.

Table 3.

Table 4.

Table 5.

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