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Parasit Host Dis > Volume 35(4):1997 > Article

Original Article
Korean J Parasitol. 1997 Dec;35(4):245-249. English.
Published online Dec 20, 1997.  http://dx.doi.org/10.3347/kjp.1997.35.4.245
Copyright © 1997 by The Korean Society for Parasitology
Effects of Cryptosporidium muris (strain MCR) infection on gastric mucosal mast cells in mice
J K Rhee,*C G Surl and H C Kim
Department of Parasitology, School of Veterinary Medicine, Chonbuk National University, Chonju 561-756, Korea.
Received October 04, 1997; Accepted November 17, 1997.


The responses of gastric mucosal mast cells (GMMCs) to infection with coccidian protozoa, Cryptosporidium muris, in mice were examined during primary and challenge infections. Each of three-week old ICR SPF mice was orally inoculated with a single dose of 2 × 106 oocysts of C. muris (strain MCR). After oocyst shedding ceased, the mice were orally challenged with a single dose of 2 × 106 oocysts of the same species. GMMCs reached a peak on days 20-30 postinoculation (PI) in number, and decreased thereafter. An increase on days 20-30 post-challenge-infection (PCI) was also observed. The mice showed, on the whole, normal profiles of oocyst shedding in droppings. The number of the cells of uninfected control mice remained constant. Judging from the above results, it is suggested that mastocytosis correlate with expulsion of C. muris in primary infection and the defense mechanism of challenge infection.


Fig. 1
Pattern of oocyst shedding in mice primarily inoculated with 2 × 106 oocysts of C. muris (strain MCR). (+) and (-) indicate that less than 103 oocysts were detected and oocysts were not detected, respectively.


Table 1
Fluctuations in numbers of gastric mucosal mast cells in mice infected with Cryptosporidium muris (strain MCR)

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