Abstract
Metagonimus yokogawai was found deeply invaded into the submucosa of the small intestine of mice (ICR) when they were immunosuppressed by prednisolone injection.
Experimental groups consisted of control, fluke infection (1,800 metacercariae per mouse), and fluke infection plus immunosuppression. In fluke infection group, many worms were found sectioned in the intervillous space of the jejunum and ileum at 6 hrs, 12 hrs, and 1 day after infection, and pathological changes characterized by villous atrophy and crypt hyperplasia were observed. After 3 days, only a few worms were found in intestinal sections, and after 7 days, the pathological changes became minimal. No worm was found penetrated beyond the mucosal layer. On the other hand, in immunosuppressed mice, numerous worms were found sectioned in the duodenum and jejunum, irrespective of the infection period up to 14 days. Pathological changes of the mucosa were minimal until 3 days after infection, but at 5 days marked destruction of the mucosal layer was observed. At this time many flukes were found invaded deeply into the submucosa facing the muscular layer. Despite continuous immunosuppression, the mucosal damage was gradually recovered at 7-21 days post-infection. The results showed that immunosuppression of ICR mice can induce, for a short period of time, severe mucosal damage, and allow deep invasion of M. yokogawai into the submucosa of the small intestine.
Citations
Citations to this article as recorded by
- Genetic and Morphologic Characterization of Diaschistorchis pandus (Digenea: Pronocephalidae) Trematodes Extracted from Hawksbill Turtles, Eretmochelys imbricata (Testudines: Cheloniidae), in Grenada, West Indies
Daniel M. Fitzpatrick, Monica A. Tetnowski, Thomas G. Rosser, Rhonda D. Pinckney, David P. Marancik, Brian P. Butler
Journal of Parasitology.2021;[Epub] CrossRef - Chronological analysis of the damages caused by the metacercariae of Centrocestus formosanus in the gills of Cyprinus carpio and lesions caused by the adult flukes in Ardeola ralloides: An experimental study
Bannak G.D. Sumuduni, Dona H.N. Munasinghe, Appudurai Arulkanthan
International Journal of Veterinary Science and Medicine.2018; 6(2): 165. CrossRef - Fishborne zoonotic heterophyid infections: An update
Jong-Yil Chai, Bong-Kwang Jung
Food and Waterborne Parasitology.2017; 8-9: 33. CrossRef - Experimental centrocestiasis: Worm burden, morphology and fecundity of Centrocestus formosanus (Trematoda: Heterophyidae) in dexamethasone immunosuppressed mice
Hudson Alves Pinto, Vitor Luís Tenório Mati, Alan Lane de Melo
Parasitology International.2015; 64(5): 236. CrossRef - Metagonimus yokogawai: metacercariae survey in fishes and its development to adult worms in various rodents
Ming-Hsien Li, Hai-I Huang, Pei-Lain Chen, Chiung-Hua Huang, Yu-Hsuan Chen, Hong-Kean Ooi
Parasitology Research.2013; 112(4): 1647. CrossRef - Infectivity and development of Metagonimus yokogawai in experimentally infected domestic ducks (Cairina moschata)
Ming-Hsien Li, Chien-Wei Liao, Yueh-Lun Lee, Hong-Kean Ooi, Wen-Yuan Du, Shen-Che Lu, Hai-I. Huang, Kua-Eyre Su, Chia-Kwung Fan
Veterinary Parasitology.2010; 168(1-2): 45. CrossRef - Foodborne Intestinal Flukes in Southeast Asia
Jong-Yil Chai, Eun-Hee Shin, Soon-Hyung Lee, Han-Jong Rim
The Korean Journal of Parasitology.2009; 47(Suppl): S69. CrossRef - Food-borne intestinal trematode infections in the Republic of Korea
Jong-Yil Chai, Soon-Hyung Lee
Parasitology International.2002; 51(2): 129. CrossRef - Stictodora lari (Digenea: Heterophyidae): The Discovery of the First Human Infections
J-Y. Chai, E-T. Han, Y-K. Park, S-M. Guk, J-H. Park, S-H. Lee
Journal of Parasitology.2002; 88(3): 627. CrossRef - A review of Gymnophalloides seoi (Digenea: Gymnophallidae) and human infections in the Republic of Korea
Soon-Hyung Lee, Jong-Yil Chai
The Korean Journal of Parasitology.2001; 39(2): 85. CrossRef - Intestinal histopathology and in situ postures of Gymnophalloides seoi in experimentally infected mice
Jong-Yil Chai, Hong-Soon Lee, Sung-Jong Hong, Jae Hyung Yoo, Sang-Mee Guk, Min Seo, Min-Ho Choi, Soon-Hyung Lee
The Korean Journal of Parasitology.2001; 39(1): 31. CrossRef
