To evaluate the feasibility of irradiation as a control measure for metagonimiasis, the metacercariae of Metagonimus yokogawai were irradiated with gamma ray, either after isolation from the sweetfish (Plecoglossus altivelis) or in situ of the fish, and their survival and development in rats were observed at 7 days post-infection. The radiation dose varied from 5 to 100 Gy for the metacercaria-irradiation group and from 5 to 500 Gy for fish-irradiation group. The results showed that the worm recovery rate from the irradiation groups decreased as the radiation dose was increased. Higher doses of radiation were required for the fish-irradiation group to obtain the same results as the metacercaria-irradiation group. The LD50 of the metacercaria-irradiation group was 4.5 Gy, whereas that of the fish- irradiation group 6.2 Gy. A few number of worms which survived until 7 days in rats were severely retarded especially in the growth of their reproductive organs, i.e., complete or partial failure in the development of testes and formation of uterine eggs. The present study revealed that irradiation of sweetfish by 200 Gy is effective to control infectivity as well as development of M. yokogawai metacercaria in rats.
Citations
Citations to this article as recorded by
Fishborne zoonotic heterophyid infections: An update Jong-Yil Chai, Bong-Kwang Jung Food and Waterborne Parasitology.2017; 8-9: 33. CrossRef
Immunization and challenge shown by hamsters infected withOpisthorchis viverrinifollowing exposure to gamma-irradiated metacercariae of this carcinogenic liver fluke A. Papatpremsiri, P. Junpue, A. Loukas, P.J. Brindley, J.M. Bethony, B. Sripa, T. Laha Journal of Helminthology.2016; 90(1): 39. CrossRef
The effects of radioactive pollution on the dynamics of infectious diseases in wildlife N.J. Morley Journal of Environmental Radioactivity.2012; 106: 81. CrossRef
Comparison of Resistance to γ-Irradiation betweenCryptosporidium parvumandCryptosporidium murisUsing In Vivo Infection Sejoung Yoon, Jae-Ran Yu The Korean Journal of Parasitology.2011; 49(4): 423. CrossRef
Rejoining of gamma-ray-induced DNA damage in Cryptosporidium parvum measured by the comet assay Soo-Ung Lee, Mikyo Joung, Taekyoung Nam, Woo-Yoon Park, Jae-Ran Yu Experimental Parasitology.2010; 125(3): 230. CrossRef
Quantitative Evaluation of Infectivity Change of Cryptosporidium parvum after Gamma Irradiation Soo-Ung Lee, Mikyo Joung, Taekyoung Nam, Woo-Yoon Park, Jae-Ran Yu The Korean Journal of Parasitology.2009; 47(1): 7. CrossRef
Foodborne Intestinal Flukes in Southeast Asia Jong-Yil Chai, Eun-Hee Shin, Soon-Hyung Lee, Han-Jong Rim The Korean Journal of Parasitology.2009; 47(Suppl): S69. CrossRef
Radioresistance of Anisakis simplex Third-Stage Larvae and the Possible Role of Superoxide Dismutase M. Seo, B-M. Kho, S-M. Guk, S-H. Lee, J-Y. Chai Journal of Parasitology.2006; 92(2): 416. CrossRef
Fish-borne parasitic zoonoses: Status and issues Jong-Yil Chai, K. Darwin Murrell, Alan J. Lymbery International Journal for Parasitology.2005; 35(11-12): 1233. CrossRef
Effects of gamma-irradiation on the infectivity and chromosome aberration of Clonorchis sinensis Gab-Man Park, Tai-Soon Yong The Korean Journal of Parasitology.2003; 41(1): 41. CrossRef
The Effect of γ-Irradiation on the Viability of Cryptosporidium parvum J. R. Yu, W. Y. Park Journal of Parasitology.2003; 89(3): 639. CrossRef
Food-borne intestinal trematode infections in the Republic of Korea Jong-Yil Chai, Soon-Hyung Lee Parasitology International.2002; 51(2): 129. CrossRef
Effects of gamma-irradiation on the survival and development of Gymnophalloides seoi in C3H mice J Y Chai, M S Han, M Seo, S H Lee The Korean Journal of Parasitology.1996; 34(1): 21. CrossRef
