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Liver function in Clonorchis sinensis-infected rabbits
S J Hong,*1H C Woo,1M H Chung,1J H Ahn,1Y S Moon,2 and C H Choi2
1Department of Parasitology, College of Medicine, Gyeongsang National University, Chinju 660-280, Republic of Korea.
2Department of Internal Medicine, College of Medicine, Gyeongsang National University, Chinju 660-280, Republic of Korea.
Received July 28, 1994; Accepted August 05, 1994.
Abstract
Nine rabbits were fed with Clonorchis sinensis metacercariae (MC) and the blood samples chronologically obtained were analyzed biochemically. Rabbits infected by less than 100 flukes were grouped into Group I, and by 100-250 flukes into Group II. The serum level of alanine aminotransferase (ALT) was increased from 3 weeks after the infection of the metacercariae (AIM) and showed a peak at 8 weeks, and decreased from 12 weeks AIM. The serum level of aspartate aminotransferase (AST) was raised to 92.3 ± 65.4 U/L at 3 weeks AIM and stayed high until 8 weeks, then lowered thereafter. The serum level of γ-glutamyl transpeptidase (γ-GT) was increased rapidly to the highest value (18.9 ± 14.6 U/L) at 16 weeks AIM, and decreased to the control level after 20 weeks. The serum level of alkaline phosphatase (ALP) was headed down from the early infection to 52 weeks AIM. The serum cholesterol level was increased from 8 weeks and reached at a peak 16 weeks AIM, and decreased thereafter to the control level. It is suggested that serum ALT, AST, ALP and γ-GT tests be useful to diagnose the early infection of C. sinensis.
Tables
Table 1 Serum biochemical valuse from the Clonorchis sinensis-infected rabbits according to worm burden and period of infection
References
1.
Brocklehurst D, Wilde CE, Doar JW. The incidence and likely origins of serum particulate alkaline phosphatase and lipoprotein-X in liver disease. Clin Chim Acta 1978;88(3):509–515.
2.
Goldberg DM, Martin JV. Role of gamma-glutamyl transpeptidase activity in the diagnosis of hepatobiliary disease. Digestion 1975;12(4-6):232–246.
3.
Hagerstrand I. Acta Pathol Scand A 1975;83:519–526.
4.
Hatoff DE, Hardison WG. Bile acids modify alkaline phosphatase induction and bile secretion pressure after bile duct obstruction in the rat. Gastroenterology 1981;80(4):666–672.
5.
Iwata S. Jikken Shokaki Byogaku 1938;13:41–72.
6.
Kim MS, et al. Korea Univ Med J 1982;19:107–121.
8.
Kuwamura T. Shikoku Igaku Zasshi 1958;12:28–57.
9.
Lee SH, Shim TS, Lee SM, Chi JG. [Studies On Pathological Changes Of The Liver In Abino Rats Infected With Clonorchis Sinensis]. Korean J Parasitol 1978;16(2):148–155.
10.
Naftalin L, Child VJ, Morley DA, Smith DA. Observations on the site of origin of serum gamma-glutamyltranspeptidase. Clin Chim Acta 1969;26(2):297–300.
11.
Seo BS, Lee SH, Cho SY, Chai JY, Hong ST, Han IS, Sohn JS, Cho BH, Ahn SR, Lee SK, Chung SC, Kang KS, Shim HS, Hwang IS. An Epidemiologic Study On Clonorchiasis And Metagonimiasis In Riverside Areas In Korea. Korean J Parasitol 1981;19(2):137–150.
12.
Shaver WA, Bhatt H, Combes B. Low serum alkaline phosphatase activity in Wilson's disease. Hepatology 1986;6(5):859–863.
14.
Whitfield JB, Pounder RE, Neale G, Moss DW. Serum-glytamyl transpeptidase activity in liver disease. Gut 1972;13(9):702–708.
15.
Yamagata S, et al. Progress of Medical Parasitology in Japan 1964;1:663–721.
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