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Doo-Hee Yun	4 Articles
Experimental Murine Fascioliasis Derives Early Immune Suppression with Increased Levels of TGF-β and IL-4 Joon-Yong Chung, Young-An Bae, Doo-Hee Yun, Hyun-Jong Yang, Yoon Kong Korean J Parasitol 2012;50(4):301-308. Published online November 26, 2012 DOI: https://doi.org/10.3347/kjp.2012.50.4.301 Abstract PDF In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19⁺ B cells was observed as early as week 1 post-infection while CD4⁺/CD8⁺ T cells were down-regulated. Accumulation of Mac1⁺ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes significantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection. Citations Citations to this article as recorded by Evaluation of Th1/Th2, regulatory cytokines and transcriptional factor FoxP3 in sheep immunized with a partially protective and non-protective vaccine and challenged with Fasciola hepatica María Teresa Ruiz-Campillo, Isabel Lourdes Pacheco, Nieves Abril, María José Bautista, Álvaro Martínez-Moreno, Francisco Javier Martínez-Moreno, Leandro Buffoni, José Pérez, Verónica Molina-Hernández, Rafael Zafra Veterinary Research.2024;[Epub] CrossRef Fascioliasis: Image Findings, Diagnosis, and Treatment Jae Seung Lee Clinical Ultrasound.2024; 9(1): 18. CrossRef Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development Luis Miguel Flores-Velázquez, María Teresa Ruiz-Campillo, Guillem Herrera-Torres, Álvaro Martínez-Moreno, Francisco Javier Martínez-Moreno, Rafael Zafra, Leandro Buffoni, Pablo José Rufino-Moya, Verónica Molina-Hernández, José Pérez Frontiers in Veterinary Science.2023;[Epub] CrossRef The immunosuppression effects of deforolimus (ridaforolimus, AP23573) on allograft organ transplantation Lumin Wang, Yanping Li, Dawei Yang, Jiazhao Fu, Bin Zhao, Yaguang Li, Yanrong Ye, Zhongquan Qi Clinical and Translational Discovery.2023;[Epub] CrossRef Immunization of Goats with Recombinant Protein 14-3-3 Isoform 2(rHcftt-2) Induced Moderate Protection against Haemonchus contortus Challenge Yongqian Bu, Caiwen Jia, Xiaowei Tian, Kalibixiati Aimulajiang, Muhammad Ali Memon, Ruofeng Yan, Xiaokai Song, Lixin Xu, Xiangrui Li Pathogens.2020; 9(1): 46. CrossRef Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica María Teresa Ruiz-Campillo, Verónica Molina-Hernández, María José Bautista, Isabel L. Pacheco, Rafael Zafra, Leandro Buffoni, Francisco Javier Martínez-Moreno, Alvaro Martínez-Moreno, José Pérez Veterinary Research.2020;[Epub] CrossRef Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola Maria João Gouveia, Maria Y. Pakharukova, Gabriel Rinaldi, Viatcheslav A. Mordvinov, Paul J. Brindley, Fátima Gärtner, Nuno Vale, Martin Michaelis Experimental Results.2020;[Epub] CrossRef Fasciola and fasciolosis in ruminants in Europe: Identifying research needs N. J. Beesley, C. Caminade, J. Charlier, R. J. Flynn, J. E. Hodgkinson, A. Martinez-Moreno, M. Martinez-Valladares, J. Perez, L. Rinaldi, D. J. L. Williams Transboundary and Emerging Diseases.2018; 65: 199. CrossRef Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection Isabel L. Pacheco, Nieves Abril, Rafael Zafra, Verónica Molina-Hernández, Noelia Morales-Prieto, María J. Bautista, María T. Ruiz-Campillo, Raúl Pérez-Caballero, Alvaro Martínez-Moreno, José Pérez Veterinary Research.2018;[Epub] CrossRef Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review Claudia Machicado, Jorge D. Machicado, Vicente Maco, Angelica Terashima, Luis A. Marcos, Hector H Garcia PLOS Neglected Tropical Diseases.2016; 10(9): e0004962. CrossRef 8,914 View 68 Download Crossref Differential expression of the 27 kDa cathepsin L-like cysteine protease in developmental stages of Spirometra erinacei Yoon Kong, Doo-Hee Yun, Seung-Yull Cho, Woon-Mok Sohn, Young-Bae Chung, Shin-Yong Kang Korean J Parasitol 2000;38(3):195-199. Published online September 30, 2000 DOI: https://doi.org/10.3347/kjp.2000.38.3.195 Abstract PDF The 27 kDa cathepsin L-like cysteine protease of Spirometra erinacei plerocercoid is known to play an important function in tissue penetration, nutrient uptake and immune modulation in human sparganosis. In the present study, the expression of this enzyme was examined at different developmental stages of S. erinacei including immature egg, coracidium, plerocercoid in tadpole and rat, and adult. Proteolytic activity against carboxybenzoyl-phenylalanyl-arginyl-7-amino-4-methylcoumarin was detected in the extracts of coracidia and plerocercoid while no activity was observed in those of immature egg and adult. The specific activity in coracidial extracts was lower than that in the plerocercoid. Reverse transcription-polymerase chain reaction and Northern blot analysis demonstrated that the gene was expressed in the coracidium and plerocercoid but not in immature egg and adult. These results suggest that the 27 kDa cysteine protease is only expressed in the stages involving active migration of the parasite in the host tissue. Citations Citations to this article as recorded by Surgical treatment of a patient with live intracranial sparganosis for 17 years Jialing Hu, Kaili Liao, Xiaojin Feng, Danling Jiang, Hailin Liu, Qingcui Zheng, Hai Qiu, Fuzhou Hua, Guohai Xu, Chunhua Xu BMC Infectious Diseases.2022;[Epub] CrossRef Follow-up study of high-dose praziquantel therapy for cerebral sparganosis Peng Zhang, Yang Zou, Feng-Xia Yu, Zheng Wang, Han Lv, Xue-Huan Liu, He-Yu Ding, Ting-Ting Zhang, Peng-Fei Zhao, Hong-Xia Yin, Zheng-Han Yang, Zhen-Chang Wang, Siddhartha Mahanty PLOS Neglected Tropical Diseases.2019; 13(1): e0007018. CrossRef A cysteine protease from Spirometra erinaceieuropaei plerocercoid is a critical factor for host tissue invasion and migration Daigo Tsubokawa, Takeshi Hatta, Hiroki Maeda, Fusako Mikami, Yukinobu Goso, Takeshi Nakamura, M. Abdul Alim, Naotoshi Tsuji Acta Tropica.2017; 167: 99. CrossRef Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis Li Na Liu, Zhong Quan Wang, Xi Zhang, Peng Jiang, Xin Qi, Ruo Dan Liu, Zi Fang Zhang, Jing Cui, Xiao-Nong Zhou PLOS Neglected Tropical Diseases.2015; 9(6): e0003807. CrossRef Diagnosis and stereotactic aspiration treatment of cerebral sparganosis: summary of 11 cases Lei Deng, Pengju Xiong, Suokai Qian Journal of Neurosurgery.2011; 114(5): 1421. CrossRef Identification of host immune regulation candidate genes of Toxascaris leonina by expression sequenced tags (ESTs) analysis Min Kyoung Cho, Keun Hee Lee, Sun Joo Lee, Se Won Kang, Mee Sun Ock, Yeon Chul Hong, Yong Seok Lee, Hak Sun Yu Veterinary Parasitology.2009; 164(2-4): 242. CrossRef Comparison of carbohydrate moieties of sparganum proteins of the snake, mouse and those of adult worm Hyun Jong Yang The Korean Journal of Parasitology.2003; 41(2): 135. CrossRef 9,050 View 81 Download Crossref The 10 kDa protein of Taenia solium metacestodes shows genus specific antigenicity Seung-Kyu Park, Doo-Hee Yun, Joon-Yong Chung, Yoon Kong, Seung-Yull Cho Korean J Parasitol 2000;38(3):191-194. Published online September 30, 2000 DOI: https://doi.org/10.3347/kjp.2000.38.3.191 Abstract PDF Genus specific antigenicity of the 10 kDa protein in cyst fluid (CF) of Taenia solium metacestodes was demonstrated by comparative immunoblot analysis. When CFs from taeniid metacestodes of T. saginata, T. solium, T. taeniaeformis and T. crassiceps were probed with specific monoclonal antibody (mAb) raised against 150 kDa protein of T. solium metacestodes, specific antibody reactions were observed in 7 and 10 kDa proteins of T. solium and in 7/8 kDa of T. saginata, T. taeniaeformis and T. crassiceps. The mAb did not react with any protein in hydatid fluid of Echinococcus granulosus and E. multilocularis. This result revealed that the 10 kDa peptide of T. solium metacestodes and its equivalent proteins of different Taenia metacestodes are genus specific antigens that are shared among different Taenia species. Citations Citations to this article as recorded by Echinococcus granulosus antigen B: A Hydrophobic Ligand Binding Protein at the host–parasite interface Valeria Silva-Álvarez, Ana Maite Folle, Ana Lía Ramos, Fernando Zamarreño, Marcelo D. Costabel, Eduardo García-Zepeda, Gustavo Salinas, Betina Córsico, Ana María Ferreira Prostaglandins, Leukotrienes and Essential Fatty Acids.2015; 93: 17. CrossRef Development of the S3Pvac Vaccine Against MurineTaenia crassicepsCysticercosis: A Historical Review Edda Sciutto, Gladis Fragoso, Marisela Hernández, Gabriela Rosas, José J. Martínez, Agnès Fleury, Jacquelynne Cervantes, Aline Aluja, Carlos Larralde Journal of Parasitology.2013; 99(4): 693. CrossRef 8,330 View 70 Download Crossref Persisting antibody reaction in paragonimiasis after praziquantel treatment is elicited mainly by egg antigens Seung-Yull Cho, Yoon Kong, Doo-Hee Yun, Shin-Yong Kang, Lee-Soo Kim, Young-Bae Chung, Hyun-Jong Yang Korean J Parasitol 2000;38(2):75-84. Published online June 30, 2000 DOI: https://doi.org/10.3347/kjp.2000.38.2.75 Abstract PDF Antibody responses in serum and cerebrospinal fluid (CSF) samples from patients with active and chronic paragonimiasis and in sera from patients on whom follow-up studies were done after praziquantel treatment were analyzed using antigens of Paragonimus westermani prepared from eggs, metacercariae, juveniles of 4- and 7-week old, adult worms and recombinant protein of 28 kDa cruzipain-like cysteine protease (rPw28CCP). The patient sera/CSFs of active and chronic paragonimiasis revealed strong antibody reactions against the crude extracts of 4- and 7-week old juveniles as well as against those from egg and adult. rPw28CCP also showed specific reaction to the sera with active paragonimiasis. After the treatment, levels of specific antibodies in the sera gradually decreased to negative range in most patients. In some cases with persisting high antibody levels, however, the reactions at 27 kDa egg protein were sustained throughout the observation period of 34 months. The reactions at 35 and 32 kDa in adult extract and rPw28CCP disappeared rapidly after the treatment. Persistent antibody reactions even after successful treatment are provoked by continuous antigenic challenge from eggs which were not resolved by treatment. Citations Citations to this article as recorded by Cerebral paragonimiasis: Clinicoradiological features and serodiagnosis using recombinant yolk ferritin Jeong-Geun Kim, Chun-Seob Ahn, Insug Kang, Jong-Wook Shin, Hae-Bong Jeong, Yukifumi Nawa, Yoon Kong, Chukwunonso Nzelu PLOS Neglected Tropical Diseases.2022; 16(3): e0010240. CrossRef Paragonimiasis presenting as an acute hemorrhagic stroke Neha Paranjape, Victor Nunez, Demetrius Dicks IDCases.2021; 26: e01287. CrossRef Lineage-specific expansion and loss of tyrosinase genes across platyhelminths and their induction profiles in the carcinogenic oriental liver fluke, Clonorchis sinensis SEON-HEE KIM, YOUNG-AN BAE Parasitology.2017; 144(10): 1316. CrossRef Parallel ELISAs using crude soluble antigen and excretory-secretory antigen for improved serodiagnosis of amoebic liver abscess Weng-Kin Wong, Phiaw-Chong Foo, Alfonso Olivos-Garcia, Rahmah Noordin, Zeehaida Mohamed, Nurulhasanah Othman, Ling-Ling Few, Boon-Huat Lim Acta Tropica.2017; 172: 208. CrossRef Cerebral Paragonimiasis Presenting with Sudden Death Gary W. Procop, Annie Cowell, Sharon L. Reed, Deirdre E. Amaro, Marion J. Tuohy, Jacquelyn Morhaime The American Journal of Tropical Medicine and Hygiene.2016; 95(6): 1424. CrossRef Molecular and biochemical characterization ofParagonimus westermanityrosinase Y.-A. BAE, S.-H. KIM, C.-S. AHN, J.-G. KIM, Y. KONG Parasitology.2015; 142(6): 807. CrossRef Expression pattern and substrate specificity of Clonorchis sinensis tyrosinases Young-An Bae, Guo-Bin Cai, Seon-Hee Kim, Woon-Mok Sohn, Yoon Kong International Journal for Parasitology.2013; 43(11): 891. CrossRef A Case of Incidentally Diagnosed Adrenal Paragonimiasis Shin-Ae Park, Seung-Hwan Lee, Seung-Hyun Ko, Jun-Gi Kim, Soo-Youn Park, Jin-Young Yoo, Ho-Woo Nam, Yu-Bae Ahn Endocrinology and Metabolism.2011; 26(1): 97. CrossRef Paragonimus westermani: Identification and characterization of the fasciclin I domain-containing protein Su-Min Song, Jong-Won Shin, Jefferson V. de Guzman, Jin Kim, Hak-Sun Yu, Bijay Kumar Jha, Hyun-Hee Kong, Yeonchul Hong, Dong-Il Chung Experimental Parasitology.2010; 125(2): 76. CrossRef Molecular cloning and characterization of a major egg antigen in Paragonimus westermani and its use in ELISA for the immunodiagnosis of paragonimiasis Jae Sik Lee, Jongweon Lee, Sun Hyun Kim, Tai-Soon Yong Parasitology Research.2007; 100(4): 677. CrossRef Differential expression of Paragonimus westermani eggshell proteins during the developmental stages Young-An Bae, Seon-Hee Kim, Guo-Bin Cai, Eung-Goo Lee, Tong-Soo Kim, Takeshi Agatsuma, Yoon Kong International Journal for Parasitology.2007; 37(3-4): 295. CrossRef Excretory-secretory antigen is better than crude antigen for the serodiagnosis of clonorchiasis by ELISA Min-Ho Choi, Il Chan Park, Shunyu Li, Sung-Tae Hong The Korean Journal of Parasitology.2003; 41(1): 35. CrossRef 9,508 View 71 Download Crossref