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"Hyun Kim"

Case Report

Feline heartworm (Dirofilaria immitis) infection in stray cats in Ulsan, Korea
JiHyun Kim, MiRyeng Kim, SeungJin Lee, YoungMin Yun
Received August 31, 2025  Accepted November 11, 2025  Published online December 11, 2025  
DOI: https://doi.org/10.3347/PHD.25076    [Epub ahead of print]
Feline heartworm (Dirofilaria immitis) infection is an uncommon but clinically significant disease in Korea. A retrospective review of electronic medical records from a secondary referral animal hospital in Ulsan, Korea, identified 2 antigen-positive (1.5%) cases among 130 stray cats tested between 2019 and 2023, while no infections were detected in 298 client-owned cats. As antigen testing may yield false-negative results in cats with male-only infections, the true prevalence is likely underestimated. This report describes the clinical and echocardiographic findings of 2 infected stray cats. Case 1 involved successful long-term management of heartworm-associated respiratory disease, with the cat remaining healthy for 4 years following diagnosis. Case 2 demonstrated persistent evidence of adult heartworms and sudden death after an asymptomatic period of 1 year. Echocardiography in Case 2 revealed multiple hyperechoic double lines within the pulmonary arteries, consistent with intraluminal adult worms. These cases illustrate the diagnostic challenges and variable clinical outcomes of feline heartworm infection, emphasizing the need for increased awareness in Korea.
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Mini Review

Understanding the pathogenicity of Naegleria fowleri in association with N. fowleri antigen-1 (Nfa1)
Jong-Hyun Kim, Hae-Jin Sohn, Ho-Joon Shin, Stacy E. Walz, Suk-Yul Jung
Parasites Hosts Dis 2024;62(4):385-398.
Published online November 22, 2024
DOI: https://doi.org/10.3347/PHD.24025
Naegleria fowleri, a brain-eating amoeba, thrives in lakes and rivers with aquatic vegetation and causes primary amoebic meningoencephalitis (PAM) in humans. Most recently, it has become such a serious problem that N. fowleri was detected in tap water in Houston, USA. Several pathogenic factors are considered very important to destroy target cells in the brain. In particular, the food-cup where N. fowleri antigen-1 (Nfa1) is located, is strongly expressed in pseudopodia involved in the movement of N. fowleri, and is involved in phagocytosis by attaching to target cells. In this article, we reviewed the role of the Nfa1 protein and its associated pathogenicity. The nfa1 gene was cloned by cDNA library immunoscreening using infection serum and immune serum. Nfa1 protein is mainly distributed in pseudopodia important to movement and vacuoles. Moreover, heat shock protein 70, cathepsin-like proteare and Nf-actin are also associated with pseudopodia in which Nfa1 is localized. Interestingly, the amount of the nfa1 gene changed as N. fowleri trophozoites transformed into cysts. Polyclonal antiserum against Nfa1 showed a protective effect against cytotoxicity of approximately 19.7%. Nfa1-specific IgA antibodies prevent N. fowleri trophozoites from adhering to the nasal mucosa, delaying invasion. The nfa1-vaccinated mice showed significantly higher levels of Nfa1-specific antibody. The duration of anti-Nfa1 IgG in the vaccinated mice lasted 12 weeks, strongly suggesting that nfa1 is a significant pathogenic gene and that Nfa1 is a pathogenic protein. Several factors related to pseudopodia and locomotion have been linked to Nfa1. A clearer function of N. fowleri targeting nfa1 with other genes might enable target-based inhibition of N. fowleri pathogenicity.

Citations

Citations to this article as recorded by  Crossref logo
  • Computational exploration of natural inhibitors against toxin-associated proteins in Naegleria fowleri Karachi strain
    Rabia Faizan, Muhammad Naveed, Inmaculada Bellido Estevez, Nimra Hanif, Arooj Arshad, Tariq Aziz, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani
    Pathology - Research and Practice.2025; 274: 156184.     CrossRef
  • A review of the mechanism, diagnosis, and treatment of Naegleria fowleri infection
    Ling Dai, Xin-Ru Guo, Xu-Rui Chen, Ming-Hao Ma, Zi-Han Liu, Juan Lai, Jun Lu, Ming Feng, Xi-Xia Liu, Sheng-Hui Yang
    Frontiers in Microbiology.2025;[Epub]     CrossRef
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Original Article

Presence and diversity of free-living amoebae and their potential application as water quality indicators
Areum Choi, Ji Won Seong, Jeong Hyun Kim, Jun Young Lee, Hyun Jae Cho, Shin Ae Kang, Mi Kyung Park, Mi Jin Jeong, Seo Yeong Choi, Yu Jin Jeong, Hak Sun Yu
Parasites Hosts Dis 2024;62(2):180-192.
Published online May 27, 2024
DOI: https://doi.org/10.3347/PHD.24020
Free-living amoebae (FLA) are found in diverse environments, such as soils, rivers, and seas. Hence, they can be used as bioindicators to assess the water quality based solely on their presence. In this study, we determined the presence of FLA in river water by filtering water samples collected from various sites and culturing the resulting filtrates. FLA were detected in all the water samples with varying quality grades (Grades Ι-V). The significant increase in the size of the amoebae population with the deterioration in the water quality. Monoxenic cultures of the amoebae were performed, and genomic DNAs were isolated, among which 18S rDNAs were sequenced to identify the amoeba species. Of the 12 species identified, 10 belonged to the Acanthamoeba genus; of the remaining 2 species, one was identified as Vannella croatica and the other as a species of Vermamoeba. Acanthamoeba was detected in samples with Grades Ι to VI quality, whereas the Vermamoeba species was present only in Grade Ι water. V. croatica was found exclusively in water with Grade ΙΙ quality. Following morphological observations, genomic DNA was sequenced using 16S rDNA to determine whether the species of Acanthamoeba harbored endosymbionts. Most of the isolated Acanthamoeba contained endosymbionts, among which 4 species of endogenous bacteria were identified and examined using transmission electron microscopy. This study provides evidence that the distribution of amoebae other than Acanthamoeba may be associated with water quality. However, further confirmation will be required based on accurate water quality ratings and assessments using a more diverse range of FLA.

Citations

Citations to this article as recorded by  Crossref logo
  • Isolation of Acanthamoeba Species and Bacterial Symbiont Variability in Puna Salt Plains, Argentina
    Ronnie Mooney, Kiri Rodgers, Sandro Carnicelli, Matías E. Carnevale, Maria Eugenia Farias, Fiona L. Henriquez
    Environmental Microbiology Reports.2025;[Epub]     CrossRef
  • Identifying Promising Novel Compounds Against Free-Living Amoebae: A Systematic Review of In Vitro and In Vivo Studies
    Beni Jequicene Mussengue Chaúque, Thaisla Cristiane Borella da Silva, Luiza Bernardes Chagas, Letícia F. G. Kinape, Paula Eliete Rodrigues Bitencourt, Custódio José Gaspar, Alexandre Coelho Borges Cheinquer, Marilise Brittes Rott, Régis Adriel Zanette, Jo
    Parasitologia.2025; 5(4): 56.     CrossRef
  • The Microbial Trojan Horse and Antimicrobial Resistance: Acanthamoeba as an Environmental Reservoir for Multidrug Resistant Bacteria
    Ronnie Mooney, Erin Corbett, Elisa Giammarini, Kiri Rodgers, Carla Donet, Ernest Mui, Arhama T. A. Ansari, Ayush Ransingh, Pradnya S. Vernekar, Harleen K. Walia, Jyoti Sharma, John Connolly, Andrew Hursthouse, Suparna Mukherji, Soumyo Mukherji, Fiona L. H
    Environmental Microbiology.2025;[Epub]     CrossRef
  • Le monde fascinant des amibes libres, des protistes aux multiples facettes
    Aurélie Delumeau, Nina Allouch, Isaure Quétel, Virginie Nerrière, Isabel Marcelino
    médecine/sciences.2025; 41(10): 743.     CrossRef
  • 3,093 View
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  • 3 Web of Science
  • Crossref

Brief Communication

Elevated interleukin-10 levels in patients with ocular toxoplasmosis
Gee-Hyun Kim, Jae Hyuck Kwak, Young-Hoon Park
Parasites Hosts Dis 2023;61(3):310-316.
Published online August 21, 2023
DOI: https://doi.org/10.3347/PHD.22172
In elderly patients, ocular toxoplasmosis is one of the most common etiologies of uveitis, which should be differentially diagnosed from ocular lymphoma, another common pathology of uveitis in older adults. The high level of interleukin (IL)-10 and an IL-10/IL-6 ratio higher than 1 (>1.0) are helpful parameters to diagnose ocular lymphoma. In this study, we used aqueous humor samples to detect 4 cases of ocular toxoplasmosis in patients with high levels of IL-10 and an IL-10/IL-6 ratio higher than 1. Our results show that ocular toxoplasmosis may be associated with increased cytokine levels in aqueous humor.

Citations

Citations to this article as recorded by  Crossref logo
  • Toxoplasma gondii IST suppresses inflammatory and apoptotic responses by inhibiting STAT1-mediated signaling in IFN-γ/TNF-α-stimulated hepatocytes
    Seung-Hwan Seo, Ji-Eun Lee, Do-Won Ham, Eun-Hee Shin
    Parasites, Hosts and Diseases.2024; 62(1): 30.     CrossRef
  • Factors related to central nervous system involvement of primary vitreoretinal lymphoma
    Joo Young Kim, Jae Jung Kim, Rae Young Kim, Mirinae Kim, Young Gun Park, Young-Hoon Park
    Graefe's Archive for Clinical and Experimental Ophthalmology.2024; 262(8): 2421.     CrossRef
  • 7,942 View
  • 101 Download
  • 2 Web of Science
  • Crossref

Mini Review

Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia
Ik-Hwan Han, Jung-Hyun Kim, Jae-Sook Ryu
Parasites Hosts Dis 2023;61(1):2-14.
Published online February 22, 2023
DOI: https://doi.org/10.3347/PHD.22160
Trichomonas vaginalis is a flagellated protozoan that causes trichomoniasis, a common nonviral sexually transmitted infection. T. vaginalis infection is asymptomatic in most infected men but can lead to chronic infection. The inflammatory response to chronic T. vaginalis infection may contribute to prostatic diseases, such as prostatitis and benign prostatic hyperplasia (BPH); however, studies on the relationship between T. vaginalis infection and prostate diseases are scarce. In this review, we discuss evidence from our studies on the involvement of T. vaginalis in the pathogenesis of prostate diseases, such as prostatitis and BPH. Studies of prostatitis have demonstrated that the attachment of T. vaginalis trophozoite to prostate epithelial cells (PECs) induces inflammatory cytokine production and inflammatory cell migration, leading to prostatitis. T. vaginalis also causes pathological changes, such as inflammatory cell infiltration, acinar changes, interstitial fibrosis, and mast cell infiltration, in prostate tissues of infected rats. Thus, T. vaginalis is considered an infectious agent that triggers prostatitis. Meanwhile, studies of prostatic hyperplasia revealed that mast cells activated by T. vaginalis-infected prostate cells secreted inflammatory mediators, such as β-hexosaminidase and tryptase, which promoted proliferation of prostate stromal cell (PSC). Moreover, interleukin-6 produced by proliferating PSCs induced the multiplication of BPH-1 epithelial cells as a result of stromal–epithelial interaction, suggesting that the proliferation of T. vaginalis-infected prostate cells can be induced through crosstalk with mast cells. These collective findings suggest that T. vaginalis contributes to the progression of prostatitis and prostatic hyperplasia by creating an inflammatory microenvironment involving PECs and PSCs.

Citations

Citations to this article as recorded by  Crossref logo
  • Immunomodulatory roles of autophagic flux and IFIT in human ectocervical cells upon Trichomonas vaginalis infection
    Ching-Chun Liu, Lichieh Julie Chu, Yuan-Ming Yeh, Hsin-Chung Lin, Lih-Chyang Chen, Ching-Yun Huang, Shu-Fang Chiu, Fang-Wen Cheng, Wei-Ning Lin, Kuo-Yang Huang
    International Immunopharmacology.2025; 155: 114643.     CrossRef
  • Detection of trichomonads in induced sputum from asthma patients in Korea
    Myung-hee Yi, Myungjun Kim, Jun Ho Choi, Yoon Hee Cho, Hyun Kyung Oh, Jung-Won Park, Ju Yeong Kim
    Parasites, Hosts and Diseases.2025; 63(3): 254.     CrossRef
  • Interplay of obesity and parasitic infection: current evidence of immunogenesis, tumorigenesis and leptin receptor involvement
    Enas El Saftawy, Mansour Alghamdi, Basma Emad Aboulhoda
    Nutrition & Metabolism.2025;[Epub]     CrossRef
  • The Past, Present, and Future in the Diagnosis of a Neglected Sexually Transmitted Infection: Trichomoniasis
    Alexandra Ibáñez-Escribano, Juan José Nogal-Ruiz
    Pathogens.2024; 13(2): 126.     CrossRef
  • Evaluation of the clinical application value of cytokine expression profiles in the differential diagnosis of prostate cancer
    Rongfa Chen, Linna Liu, Hui Chen, Chao Xing, Tingting Zhang, Yilin Pang, Xunjun Yang
    Cancer Immunology, Immunotherapy.2024;[Epub]     CrossRef
  • CysLT receptor-mediated NOX2 activation is required for IL-8 production in HMC-1 cells induced by Trichomonas vaginalis-derived secretory products
    Young Ah Lee, Myeong Heon Shin
    Parasites, Hosts and Diseases.2024; 62(3): 270.     CrossRef
  • Dynamin 2-mediated endocytosis of BLT1 is required for IL-8 production in HMC-1 cells induced by Trichomonas vaginalis-derived secretory products
    Young Ah Lee, Myeong Heon Shin
    Parasites, Hosts and Diseases.2024; 62(3): 281.     CrossRef
  • 8,341 View
  • 283 Download
  • 8 Web of Science
  • Crossref

Original Article

Free-Living Amoeba Vermamoeba vermiformis Induces Allergic Airway Inflammation
Da-In Lee, Sung Hee Park, Shin-Ae Kang, Do Hyun Kim, Sun Hyun Kim, So Yeon Song, Sang Eun Lee, Hak Sun Yu
Korean J Parasitol 2022;60(4):229-239.
Published online August 24, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.4.229
The high percentage of Vermamoeba was found in tap water in Korea. This study investigated whether Vermamoeba induced allergic airway inflammation in mice. We selected 2 free-living amoebas (FLAs) isolated from tap water, which included Korean FLA 5 (KFA5; Vermamoeba vermiformis) and 21 (an homolog of Acanthamoeba lugdunensis KA/ E2). We axenically cultured KFA5 and KFA21. We applied approximately 1 × 106 to mice’s nasal passages 6 times and investigated their pathogenicity. The airway resistance value was significantly increased after KFA5 and KFA21 treatments. The eosinophil recruitment and goblet cell hyperplasia were concomitantly observed in bronchial alveolar lavage (BAL) fluid and lung tissue in mice infected with KFA5 and KFA21. These infections also activated the Th2-related interleukin 25, thymic stromal lymphopoietin, and thymus and activation-regulated chemokines gene expression in mouse lung epithelial cells. The CD4+ interleukin 4+ cell population was increased in the lung, and the secretion of Th2-, Th17-, and Th1-associated cytokines were upregulated during KFA5 and KFA21 infection in the spleen, lung-draining lymph nodes, and BAL fluid. The pathogenicity (allergenicity) of KFA5 and KFA21 might not have drastically changed during the long-term in vitro culture. Our results suggested that Vermamoeba could elicit allergic airway inflammation and may be an airway allergen.

Citations

Citations to this article as recorded by  Crossref logo
  • First report of biological contaminants in household water in the Philippines and long-term viability of Acanthamoeba species in one-year-old household water sediment
    Frederick R. Masangkay, Rafaella Maxine N. Almeda, Alianna Louise M. Abustan, Sarah Veronica F. Almendrala, Jan Camille B. Bathan, Jowey Shekainah C. Belandres, Maria Allana Angela M. Buenaventura, Lea May F. Cabansag, Gemina Bienne V. Caralian, Mikhaella
    Science of The Total Environment.2025; 989: 179818.     CrossRef
  • Presence and diversity of free-living amoebae and their potential application as water quality indicators
    Areum Choi, Ji Won Seong, Jeong Hyun Kim, Jun Young Lee, Hyun Jae Cho, Shin Ae Kang, Mi Kyung Park, Mi Jin Jeong, Seo Yeong Choi, Yu Jin Jeong, Hak Sun Yu
    Parasites, Hosts and Diseases.2024; 62(2): 180.     CrossRef
  • Global prevalence of free-living amoebae in solid matrices – A systematic review with meta-analysis
    Beni Jequicene Mussengue Chaúque, Thaisla Cristiane Borella da Silva, Denise Leal dos Santos, Guilherme Brittes Benitez, Leosvilda Gomes Henriques Chaúque, Antônio Domingues Benetti, Régis Adriel Zanette, Marilise Brittes Rott
    Acta Tropica.2023; 247: 107006.     CrossRef
  • 3,741 View
  • 180 Download
  • 2 Web of Science
  • Crossref

Brief Communication

Specific Detection of Acanthamoeba species using Polyclonal Peptide Antibody Targeting the Periplasmic Binding Protein of A. castellanii
Min-Jeong Kim, Fu-Shi Quan, Hyun-Hee Kong, Jong-Hyun Kim, Eun-Kyung Moon
Korean J Parasitol 2022;60(2):143-147.
Published online April 20, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.2.143
Acanthamoeba keratitis (AK) is a rare ocular disease, but it is a painful and sight-threatening infectious disease. Early diagnosis and adequate treatment are necessary to prevent serious complications. While AK is frequently diagnosis via several PCR assays or Acanthamoeba-specific antibodies, a more specific and effective diagnostic method is required. This study described the production of a polyclonal peptide antibody against the periplasmic binding protein (PBP) of A. castellanii and investigated its diagnostic potential. Western blot analysis showed that the PBP antibody specifically reacted with the cell lysates of A. castellanii. However, the PBP antibody did not interact with human corneal epithelial (HCE) cells and the other 3 major causative agents of keratitis. Immunocytochemistry (ICC) results revealed the specific detection of A. castellanii trophozoites and cysts by PBP antibodies when A. castellanii were co-cultured with HCE cells. PBP antibody specificity was further confirmed by co-culture of A. castellanii trophozoites with F. solani, S. aureus, and P. aeruginosa via ICC. The PBP antibody specifically reacted with the trophozoites and cysts of A. polyphaga, A. hatchetti, A. culbertsoni, A. royreba, and A. healyi, thus demonstrated its genus-specific nature. These results showed that the PBP polyclonal peptide antibody of A. castellanii could specifically detect several species of Acanthamoeba, contributing to the development of an effective antibody-based AK diagnostics.

Citations

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  • Evaluation of the potential for diagnosis of fungal keratitis using a Fusarium-specific antibody
    Hye-Jeong Jo, Min-Jeong Kim, Hae-Ahm Lee, Fu-Shi Quan, Hyun-Hee Kong, Eun-Kyung Moon
    Scientific Reports.2025;[Epub]     CrossRef
  • Detection of Fusarium solani using cutinase antibody and its application in diagnosing fungal keratitis in an animal model
    Hye-Jeong Jo, Min-Jeong Kim, Hae-Ahm Lee, Fu-Shi Quan, Hyun-Hee Kong, Eun-Kyung Moon, Olaf Kniemeyer
    PLOS One.2025; 20(8): e0330455.     CrossRef
  • A chorismate mutase-targeted, core-shell nanoassembly-activated SERS immunoassay platform for rapid non-invasive detection of Acanthamoeba infection
    Hyerin Lee, Min-Jeong Kim, Junkyu Chung, Wansun Kim, Hye-Jeong Jo, Tae Gi Kim, Jae-Ho Shin, Gi-Ja Lee, Fu-Shi Quan, Hyun-Hee Kong, Sang Woong Moon, Eun-Kyung Moon, Samjin Choi
    Nano Today.2024; 59: 102506.     CrossRef
  • Evaluating the Diagnostic Potential of Chorismate Mutase Poly-Clonal Peptide Antibody for the Acanthamoeba Keratitis in an Animal Model
    Min-Jeong Kim, Hye-Jeong Jo, Hae-Jin Sohn, Ho-Joon Shin, Fu-Shi Quan, Hyun-Hee Kong, Eun-Kyung Moon
    Pathogens.2023; 12(4): 526.     CrossRef
  • Detection of Acanthamoeba from Acanthamoeba Keratitis Mouse Model Using Acanthamoeba-Specific Antibodies
    Min-Jeong Kim, A-Jeong Ham, A-Young Park, Hae-Jin Sohn, Ho-Joon Shin, Fu-Shi Quan, Hyun-Hee Kong, Eun-Kyung Moon
    Microorganisms.2022; 10(9): 1711.     CrossRef
  • 3,770 View
  • 196 Download
  • 5 Web of Science
  • Crossref

Original Article

Proliferation of Mouse Prostate Cancer Cells Inflamed by Trichomonas vaginalis
Sang-Su Kim, Kyu-Shik Kim, Ik-Hwan Han, Yeseul Kim, Seong Sik Bang, Jung-Hyun Kim, Yong-Suk Kim, Soo-Yeon Choi, Jae-Sook Ryu
Korean J Parasitol 2021;59(6):547-556.
Published online December 22, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.6.547
Our
objective
was to investigate whether inflammatory microenvironment induced by Trichomonas vaginalis infection can stimulate proliferation of prostate cancer (PCa) cells in vitro and in vivo mouse experiments. The production of CXCL1 and CCL2 increased when cells of the mouse PCa cells (TRAMP-C2 cell line) were infected with live T. vaginalis. T. vaginalis-conditioned medium (TCM) prepared from co-culture of PCa cells and T. vaginalis increased PCa cells migration, proliferation and invasion. The cytokine receptors (CXCR2, CCR2, gp130) were expressed higher on the PCa cells treated with TCM. Pretreatment of PCa cells with antibodies to these cytokine receptors significantly reduced the proliferation, mobility and invasiveness of PCa cells, indicating that TCM has its effect through cytokine-cytokine receptor signaling. In C57BL/6 mice, the prostates injected with T. vaginalis mixed PCa cells were larger than those injected with PCa cells alone after 4 weeks. Expression of epithelial-mesenchymal transition markers and cyclin D1 in the prostate tissue injected with T. vaginalis mixed PCa cells increased than those of PCa cells alone. Collectively, it was suggested that inflammatory reactions by T. vaginalis-stimulated PCa cells increase the proliferation and invasion of PCa cells through cytokine-cytokine receptor signaling pathways.

Citations

Citations to this article as recorded by  Crossref logo
  • The role of proinflammatory cytokines and CXC chemokines (CXCL1–CXCL16) in the progression of prostate cancer: insights on their therapeutic management
    Amin Ullah, Wang Jiao, Bairong Shen
    Cellular & Molecular Biology Letters.2024;[Epub]     CrossRef
  • Trichomonas vaginalis excretory secretory proteins reduce semen quality and male fertility
    Zhenchao Zhang, Fakun Li, Yangyang Deng, Yuhua Li, Wanxin Sheng, Xiaowei Tian, Zhenke Yang, Shuai Wang, Lihua Guo, Lixia Hao, Xuefang Mei
    Acta Tropica.2023; 238: 106794.     CrossRef
  • Point-of-Care Diagnostic for Trichomonas vaginalis, the Most Prevalent, Non-Viral Sexually Transmitted Infection
    John F. Alderete, Hermes Chan
    Pathogens.2023; 12(1): 77.     CrossRef
  • Involvement of Macrophages in Proliferation of Prostate Cancer Cells Infected with Trichomonas vaginalis
    Kyu-Shik Kim, Hong-Sang Moon, Sang-Su Kim, Jae-Sook Ryu
    The Korean Journal of Parasitology.2021; 59(6): 557.     CrossRef
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  • 6 Web of Science
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Brief Communication

An Epidemiological Analysis of 28 Vivax Malaria Cases in Gimpo-si, Korea, 2020
Young Yil Bahk, Shin-Hyeong Cho, Kyoung-Nam Kim, Eun-Hee Shin, Byoung-Hak Jeon, Jeong-Hyun Kim, Sookkyung Park, Jeongran Kwon, Hyesu Kan, Miyoung Kim, Tong-Soo Kim
Korean J Parasitol 2021;59(5):507-512.
Published online October 22, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.5.507
Since 1993, vivax malaria has been recognized as a public health burden in Korea. Despite of pan-governmental malaria-control efforts and the dramatic reduction in the burden of this disease over the last 10 years, vivax malaria has not been well controlled and has remained continuously endemic. We focused interviewed and examined the charts of 28 confirmed vivax malaria patients given malarial therapy for whom daily records were kept from Gimpo-si, Gyeonggido of Korea. Various epidemiological characteristics of vivax malaria, including the incubation period, medication used, and recurrence, and an evaluation of the parasitic characteristics from the focused interviews of patients from this region are described here. Most of the participants indicated the 3 most common symptoms of malaria (headache, chills and fever). Of the 28 cases, 2 experienced a second attack and there were 17 and 11 cases with short- and long-term incubation periods, respectively, yielding a short-term to long-term ratio of 1.5. Based on the parasitemia stages, most of the participants were tested at 5 to 7 days (11 cases) and 7 to 15 days (11 cases) after initial wave of asexual parasites. In conclusion, public health authorities should consider developing management measures to decrease the time lag for diagnosis and drafting unified and robust guidelines for drug use for malaria and drawing up unified and robust guidelines on the use of medication for malaria. It also suggests that routine monitoring, surveillance, and precise medical surveys in high-risk vivax malaria endemic areas are pivotal to controlling this persistent public disease and finally eliminating it from Korea.

Citations

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  • Fine-Scale Spatial Prediction on the Risk of Plasmodium vivax Infection in the Republic of Korea
    Kyung-Duk Min, Yae Jee Baek, Kyungwon Hwang, Na-Ri Shin, So-dam Lee, Hyesu Kan, Joon-Sup Yeom
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Utilization of Glucose-6-Phosphate Dehydrogenase Test and the Prevalence of Enzyme Deficiency in Korea
    Rihwa Choi, Wonseo Park, Gayoung Chun, Sang Gon Lee, Eun Hee Lee
    Journal of Clinical Medicine.2023; 12(9): 3179.     CrossRef
  • Identification of breeding habitats and kdr mutations in Anopheles spp. in South Korea
    Hyelee Hong, Tae-Hui Eom, Thuy-Tien Thi Trinh, Bao Duong Tuan, Hyun Park, Seon-Ju Yeo
    Malaria Journal.2023;[Epub]     CrossRef
  • 5,498 View
  • 131 Download
  • 3 Web of Science
  • Crossref

Original Article

Expression of Chicken NK-Lysin and Its Role in Chicken Coccidiosis Induced by Eimeria necatrix
Woo Hyun Kim, Wongi Min, Kwang Il Park, Hyun S. Lillehoj, Cherry P. Fernandez-Colorado, Rochelle A. Flores, Paula Leona T. Cammayo, Binh Thanh Nguyen
Korean J Parasitol 2021;59(5):439-445.
Published online October 22, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.5.439
Coccidiosis in chickens is an intestinal parasitic disease caused by protozoan parasites named Eimeria spp. In some Eimeria infections, intestinal lymphocytes are known to highly express chicken NK-lysin (cNK-lysin), an antimicrobial peptide with anticoccidial activity. Therefore, this study aims to investigate the expression of cNK-lysin in E. necatrix-infected chickens and its role in E. necatrix infection. The expression of cNK-lysin transcript was significantly increased in E. necatrix sporozoites-treated lymphocytes. In E. necatrix infection, cNK-lysin transcript was induced in intestinal lymphocytes but not in the spleen. The recombinant cNK-lysin exhibited anticoccidial activity against E. necatrix sporozoites as well as immunomodulatory activity on macrophages by inducing proinflammatory cytokines. These results indicated that E. necatrix infection induces high local expression of cNK-lysin and the secreted cNK-lysin helps protect coccidiosis.

Citations

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  • Characterization of NK-lysin A, a potent antimicrobial peptide from the zebrafish Danio rerio
    Marius Ortjohann, Matthias Leippe
    Developmental & Comparative Immunology.2025; 162: 105266.     CrossRef
  • Exploring the interplay between Eimeria spp. infection and the host: understanding the dynamics of gut barrier function
    Pan Chen, Mujeeb Ur Rehman, Yanfeng He, Aoyun Li, Fuchun Jian, Longxian Zhang, Shucheng Huang
    Veterinary Quarterly.2025; 45(1): 1.     CrossRef
  • Development and immunological insights into recombinant/subunit vaccines against avian coccidiosis
    Shagufta Iqbal, Syed Tanveer, Idrees Mehraj Allaie, Yasmeena Jan, Shahana Tramboo, Nazima Maqbool
    Journal of Microbiological Methods.2025; 238: 107255.     CrossRef
  • Orally delivered Bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens
    Samiru S. Wickramasuriya, Inkyung Park, Youngsub Lee, Luciana M. Richer, Chris Przybyszewski, Cyril G. Gay, Jolieke G. van Oosterwijk, Hyun S. Lillehoj
    Poultry Science.2023; 102(5): 102590.     CrossRef
  • Research progress of the avian coccidiosis vaccine
    Haiming Cai, Nanshan Qi, Juan Li, Minna Lv, Xuhui Lin, Junjing Hu, Jianfei Zhang, Shenquan Liao, Mingfei Sun
    Veterinary Vaccine.2022; 1(1): 100002.     CrossRef
  • 5,024 View
  • 157 Download
  • 4 Web of Science
  • Crossref

Brief Communication

Anticoccidial Activity of Berberine against Eimeria-Infected Chickens
Binh Thanh Nguyen, Rochelle Alipio Flores, Paula Leona Taymen Cammayo, Suk Kim, Woo Hyun Kim, Wongi Min
Korean J Parasitol 2021;59(4):403-408.
Published online August 18, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.4.403
Avian coccidiosis has a major economic impact on the poultry industry, it is caused by 7 species of Eimeria, and has been primarily controlled using chemotherapeutic agents. Due to the emergence of drug-resistant strains, alternative control strategies are needed. We assessed anticoccidial effects of berberine-based diets in broiler chickens following oral infection with 5 Eimeria species (E. acervulina, E. maxima, E. tenella, E. mitis, and E. praecox). When 0.2% berberine, a concentration that does not affect weight gain, was added to the diet, the 4 groups infected with E. acervulina, E. tenella, E. mitis, or E. praecox showed significant reductions in fecal oocyst shedding (P<0.05) compared to their respective infected and untreated controls. In chickens treated 0.5% berberine instead of 0.2% and infected with E. maxima, fecal oocyst production was significantly reduced, but body weight deceased, indicating that berberine treatment was not useful for E. maxima infection. Taken together, these results illustrate the applicability of berberine for prophylactic use to control most Eimeria infections except E. maxima. Further studies on the mechanisms underlying the differences in anticoccidial susceptibility to berberine, particularly E. maxima, are remained.

Citations

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  • Evaluation of the Effectiveness of a Phytogenic Supplement (Alkaloids and Flavonoids) in the Control of Eimeria spp. in Experimentally Challenged Broiler Chickens
    Anne-Sophie Hascoët, Paulina Torres-Celpa, Roberto Riquelme-Neira, Héctor Hidalgo-Olate
    Animals.2025; 15(6): 847.     CrossRef
  • Improving The Sporulation of Eimeria tenella Oocysts Purified From Chicken Faeces
    Nurfazila Latif, Aravind Marcus, Paul Bura Thlama, Suhaili Mustafa, Muhamad Hakim Mohd Ali Hanafiah, Lirong Yu Abit, Sharifah Salmah Syed Hussain, Nor Azlina Abdul Aziz, Shu-San Loo, Kiew Lian Wan, Sarah A Altwaim, Juriah Kamaludeen
    Malaysian Applied Biology.2025; 54(1): 38.     CrossRef
  • Berberine Reveals Anticoccidial Activity by Influencing Immune Responses in Eimeria acervulina-Infected Chickens
    Binh T. Nguyen, Bujinlkham Altanzul, Rochelle A. Flores, Honghee Chang, Woo H. Kim, Suk Kim, Wongi Min
    Biomolecules.2025; 15(7): 985.     CrossRef
  • Vaccinations and Functional Feed Supplements as Alternatives to Coccidiostats for the Control of Coccidiosis in Raising Broiler Chickens
    Maciej Rosłoń, Edward Majewski, Monika Gębska, Anna Grontkowska, Michał Motrenko, Artur Żbikowski, Monika Michalczuk, Jakub Urban
    Animals.2025; 15(17): 2548.     CrossRef
  • Management and control of coccidiosis in poultry — A review
    Rafiq Ahmad, Yu-Hsiang Yu, Kuo-Feng Hua, Wei-Jung Chen, Daniel Zaborski, Andrzej Dybus, Felix Shih-Hsiang Hsiao, Yeong-Hsiang Cheng
    Animal Bioscience.2024; 37(1): 1.     CrossRef
  • Large-Scale Field Trials of an Eimeria Vaccine Induce Positive Effects on the Production Index of Broilers
    Binh T. Nguyen, Dongjean Yim, Rochelle A. Flores, Seung Yun Lee, Woo H. Kim, Seung-Hwan Jung, Sangkyu Kim, Wongi Min
    Vaccines.2024; 12(7): 800.     CrossRef
  • An insight into the potential of berberine in animal nutrition: Current knowledge and future perspectives
    Navid Ghavipanje, Mohammad Hasan Fathi Nasri, Einar Vargas‐Bello‐Pérez
    Journal of Animal Physiology and Animal Nutrition.2023; 107(3): 808.     CrossRef
  • Botanicals: A promising approach for controlling cecal coccidiosis in poultry
    Zohaib Saeed, Khalid A. Alkheraije
    Frontiers in Veterinary Science.2023;[Epub]     CrossRef
  • Pathological Role of Oxidative Stress in Aflatoxin-Induced Toxicity in Different Experimental Models and Protective Effect of Phytochemicals: A Review
    Martha Cebile Jobe, Doctor M. N. Mthiyane, Phiwayinkosi V. Dludla, Sithandiwe E. Mazibuko-Mbeje, Damian C. Onwudiwe, Mulunda Mwanza
    Molecules.2023; 28(14): 5369.     CrossRef
  • The Immunoprotective Effect of ROP27 Protein of Eimeria tenella
    Menggang Li, Xiaoling Lv, Mingxue Zheng, Yingyi Wei
    Animals.2023; 13(22): 3500.     CrossRef
  • Oral administration of Lactobacillus brevis 23017 combined with ellagic acid attenuates intestinal inflammatory injury caused by Eimeria infection by activating the Nrf2/HO-1 antioxidant pathway
    Xuelian Yang, Xinghui Pan, Zhipeng Jia, Bingrong Bai, Wenjing Zhi, Hang Chen, Chunli Ma, Dexing Ma
    Veterinary Research.2022;[Epub]     CrossRef
  • Epidemiological investigation and drug resistance of Eimeria species in Korean chicken farms
    Rochelle A. Flores, Binh T. Nguyen, Paula Leona T. Cammayo, Tuấn Cường Võ, Haung Naw, Suk Kim, Woo H. Kim, Byoung-Kuk Na, Wongi Min
    BMC Veterinary Research.2022;[Epub]     CrossRef
  • 6,499 View
  • 116 Download
  • 13 Web of Science
  • Crossref

Original Article

Signaling Role of Adipocyte Leptin in Prostate Cell Proliferation Induced by Trichomonas vaginalis
Jung-Hyun Kim, Ik-Hwan Han, Su-Jin Shin, Sung-Yul Park, Hyo-Yeoung Chung, Jae-Sook Ryu
Korean J Parasitol 2021;59(3):235-249.
Published online June 21, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.3.235
Leptin is a type of adipokine mainly produced by adipocytes and reported to be overproduced in prostate cancer. However, it is not known whether it stimulates the proliferation of prostate cells. In this study, we investigated whether benign prostatic hyperplasia epithelial cells (BPH-1 cells) infected with Trichomonas vaginalis induced the proliferation of prostate cells via a leptin signaling pathway. To investigate the effect of crosstalk between adipocyte leptin and inflamed epithelial cell in proliferation of prostate cells, adipocytes 3T3-L1 cells were incubated in conditioned medium of BPH-1 cells infected with T. vaginalis (T. vaginalis-conditioned medium, TCM), and then the adipocyte-conditioned medium (ATCM) was identified to cause proliferation of prostate cells. BPH-1 cells incubated with live T. vaginalis released pro-inflammatory cytokines, and conditioned medium of these cells caused migration of adipocytes. When prostate stromal cells and BPH-1 cells were incubated with adipocyte conditioned medium containing leptin, their growth rates increased as did expression of the leptin receptor (known as OBR) and signaling molecules such as JAK2/STAT3, Notch and survivin. Moreover, blocking the OBR reduced this proliferation and the expression of leptin signaling molecules in response to ATCM. In conclusion, our findings show that inflamed BPH-1 cells infected with T. vaginalis induce the proliferation of prostate cells through leptin-OBR signaling. Therefore, it is likely that T. vaginalis contributes to prostate enlargement in BPH via adipocyte leptin released as a result of inflammation of the prostate.

Citations

Citations to this article as recorded by  Crossref logo
  • Interplay of obesity and parasitic infection: current evidence of immunogenesis, tumorigenesis and leptin receptor involvement
    Enas El Saftawy, Mansour Alghamdi, Basma Emad Aboulhoda
    Nutrition & Metabolism.2025;[Epub]     CrossRef
  • Intrinsic and extrinsic factors causing hyperplasia of the prostate
    Yuki Kyoda, Kosuke Shibamori, Tetsuya Shindo, Takeshi Maehana, Kohei Hashimoto, Ko Kobayashi, Toshiaki Tanaka, Fumimasa Fukuta, Naoya Masumori
    International Journal of Urology.2024; 31(7): 705.     CrossRef
  • Association between metabolic syndrome and benign prostatic hyperplasia: The underlying molecular connection
    Xun Fu, Yutao Wang, Yi Lu, Jiang Liu, Hongjun Li
    Life Sciences.2024; 358: 123192.     CrossRef
  • Point-of-Care Diagnostic for Trichomonas vaginalis, the Most Prevalent, Non-Viral Sexually Transmitted Infection
    John F. Alderete, Hermes Chan
    Pathogens.2023; 12(1): 77.     CrossRef
  • Trichomonas vaginalis excretory secretory proteins reduce semen quality and male fertility
    Zhenchao Zhang, Fakun Li, Yangyang Deng, Yuhua Li, Wanxin Sheng, Xiaowei Tian, Zhenke Yang, Shuai Wang, Lihua Guo, Lixia Hao, Xuefang Mei
    Acta Tropica.2023; 238: 106794.     CrossRef
  • The correlation between Trichomonas vaginalis infection and reproductive system cancer: a systematic review and meta-analysis
    Zhenchao Zhang, Dongxian Li, Yuhua Li, Rui Zhang, Xianghuan Xie, Yi Yao, Linfei Zhao, Xiaowei Tian, Zhenke Yang, Shuai Wang, Xuejing Yue, Xuefang Mei
    Infectious Agents and Cancer.2023;[Epub]     CrossRef
  • Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia
    Ik-Hwan Han, Jung-Hyun Kim, Jae-Sook Ryu
    Parasites, Hosts and Diseases.2023; 61(1): 2.     CrossRef
  • Proliferation of Mouse Prostate Cancer Cells Inflamed by Trichomonas vaginalis
    Sang-Su Kim, Kyu-Shik Kim, Ik-Hwan Han, Yeseul Kim, Seong Sik Bang, Jung-Hyun Kim, Yong-Suk Kim, Soo-Yeon Choi, Jae-Sook Ryu
    The Korean Journal of Parasitology.2021; 59(6): 547.     CrossRef
  • Involvement of Macrophages in Proliferation of Prostate Cancer Cells Infected with Trichomonas vaginalis
    Kyu-Shik Kim, Hong-Sang Moon, Sang-Su Kim, Jae-Sook Ryu
    The Korean Journal of Parasitology.2021; 59(6): 557.     CrossRef
  • 5,863 View
  • 93 Download
  • 9 Web of Science
  • Crossref

Brief Communication

Molecular Detection and Subtyping of Human Blastocystis and the Clinical Implications: Comparisons between Diarrheal and Non-diarrheal Groups in Korean Populations
Moon-Ju Kim, Eun Jeong Won, Soo Hyun Kim, Jong Hee Shin, Jong-Yil Chai
Korean J Parasitol 2020;58(3):321-326.
Published online June 26, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.3.321
Blastocystis has recently been recognized as the most common eukaryotic microbe of the human gut. We investigated the prevalence of Blastocystis and their subtypes in diarrheal and non-diarrheal groups and the associated clinical parameters. A total of 324 stool samples were obtained from 196 diarrheal and 128 non-diarrheal subjects. Blastocystis subtypes were determined by sequencing the small subunit ribosomal DNA (SSU rRNA) gene. Demographic, clinical and laboratory data were collected and analyzed by diarrhea and Blastocystis status. The overall rate of Blastocystis positivity was 9.0% (29/324) but was significantly higher in the non-diarrheal group (18.0% vs. 3.1%, P<0.0001). Of the 6 Blastocystis-positive diarrheal patients, 3 (50.0%), none (0.0%), 2 (33.3%), and 1 (16.7%) were infected with subtypes ST1, ST2, ST3, and multiple subtypes, respectively. Of the 23 Blastocystis-positive non-diarrheal patients, 4 (17.4%), 1 (4.3%), and 18 (78.3%) were infected with subtypes ST1, ST2, and ST3, respectively. Blastocystis was less common in the diarrheal than the non-diarrheal group (odds ratio, 0.144; 95% confidence interval, 0.057?0.365, P<0.001). Of the 3 subtypes, ST3 was more frequently observed in the non-diarrheal than diarrheal group (78.3% vs. 33.3%, P=0.0341). Collectively, Blastocystis was found in both the diarrheal and non-diarrheal groups and ST3 was the most common subtype in Korea.

Citations

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  • Effect of antibiotic administration on Blastocystis persistence and gut microbiome–metabolome dynamics in an irritable bowel syndrome longitudinal case study
    Jamie M. Newton, William J.S. Edwards, Gary S. Thompson, Eleni Gentekaki, Anastasios D. Tsaousis
    Access Microbiology .2025;[Epub]     CrossRef
  • A Systematic Review about the Efficacy of Antiparasitic Agents in the Treatment of Blastocystis Species
    Özlem Ulusan Bağcı, Gülay Aral Akarsu
    Acta Parasitologica.2025;[Epub]     CrossRef
  • Molecular Prevalence of Blastocystis sp. from Patients with Diarrhea in the Republic of Korea
    Ji-Young Kwon, Jong-Hoon Choi, Hee-Il Lee, Jung-Won Ju, Myoung-Ro Lee
    Microorganisms.2024; 12(3): 523.     CrossRef
  • Subtype Distribution of Blastocystis spp. in Patients with Gastrointestinal Symptoms in Northern Spain
    Cristina Matovelle, Joaquín Quílez, María Teresa Tejedor, Antonio Beltrán, Patricia Chueca, Luis Vicente Monteagudo
    Microorganisms.2024; 12(6): 1084.     CrossRef
  • Systematic Review and Meta-Analysis: Epidemiology of Human Blastocystis spp. Infection in Malaysia
    Vinoth Kumarasamy, Arutchelvan Rajamanikam, Deepa Anbazhagan, Wahib Mohammed Atroosh, Meram Azzani, Vetriselvan Subramaniyan, Syamsa Rizal Abdullah
    Tropical Medicine and Infectious Disease.2023; 8(8): 415.     CrossRef
  • Prevalence of Blastocystis and Dientamoeba fragilis in diarrheal patients in Corum, Türkiye
    Ayşe Semra Gureser, Djursun Karasartova, Fakhiriddin Sarzhanov, Nezahat Kosar, Aysegul Taylan-Ozkan, Funda Dogruman-Al
    Parasitology Research.2023; 122(12): 2977.     CrossRef
  • First Report ofBlastocystisspp. Infection in Pet Birds in Henan Province, Central China
    Changwei Su, Xuefang Mei, Lai Wei, Fuqiang Zhang, Jiawen Wang, Yuan Chang, Mingyong Wang, Xiaowei Tian, Zhenchao Zhang, Xiangrui Li, Shuai Wang
    Vector-Borne and Zoonotic Diseases.2022; 22(7): 370.     CrossRef
  • Prevalence and Associated Factors of Blastocystis sp. Infection in Patients with Gastrointestinal Symptoms in Spain: A Case-Control Study
    Cristina Matovelle, María Teresa Tejedor, Luis Vicente Monteagudo, Antonio Beltrán, Joaquín Quílez
    Tropical Medicine and Infectious Disease.2022; 7(9): 226.     CrossRef
  • Prevalence and molecular subtyping of Blastocystis sp. in rabbits in Henan, Central China
    Changwei Su, Xuefang Mei, Xia Feng, Fuqiang Zhang, Pei Wang, Bo He, Fuyang Xu, Zishan Yang, Xiaowei Tian, Zhenchao Zhang, Xiangrui Li, Shuai Wang
    Folia Parasitologica.2022;[Epub]     CrossRef
  • Molecular identification and subtyping of Blastocystis sp. in hospital patients in Central China
    Junqiang Li, Haiju Dong, Md Robiul Karim, Xianli Yang, Liqin Chao, Shuai Liu, Hairong Song, Longxian Zhang
    European Journal of Protistology.2021; 79: 125796.     CrossRef
  • Genotypes of Blastocystis sp. among elderly health checkup people in South Korea with a questionnaire on risk factors
    Taehee Chang, Bong-Kwang Jung, Hyejoo Shin, Sooji Hong, Seungwan Ryoo, Jeonggyu Lee, Seihee Han, Sun Min Park, Min-Suk Rhee, Heejin Kimm, Sun Ha Jee, Jong-Yil Chai
    Parasitology Research.2021; 120(9): 3297.     CrossRef
  • The Coexistence of Blastocystis spp. in Humans, Animals and Environmental Sources from 2010–2021 in Asia
    Adedolapo Aminat Rauff-Adedotun, Farah Haziqah Meor Termizi, Nurshafarina Shaari, Ii Li Lee
    Biology.2021; 10(10): 990.     CrossRef
  • Metabolic Fluctuations in the Human Stool Obtained from Blastocystis Carriers and Non-Carriers
    Emma L. Betts, Jamie M. Newton, Gary S. Thompson, Fakhriddin Sarzhanov, Vasana Jinatham, Moon-Ju Kim, Siam Popluechai, Funda Dogruman-Al, Eun-Jeong Won, Eleni Gentekaki, Anastasios D. Tsaousis
    Metabolites.2021; 11(12): 883.     CrossRef
  • Gut Microbiome Profiles in Colonizations with the Enteric Protozoa Blastocystis in Korean Populations
    Moon-Ju Kim, Yu Jeong Lee, Tae-Jong Kim, Eun Jeong Won
    Microorganisms.2021; 10(1): 34.     CrossRef
  • Genetic Analysis of Zoonotic Gastrointestinal Protozoa and Microsporidia in Shelter Cats in South Korea
    Dongmi Kwak, Min-Goo Seo
    Pathogens.2020; 9(11): 894.     CrossRef
  • 5,658 View
  • 141 Download
  • 16 Web of Science
  • Crossref

Original Article

Polarization of M2 Macrophages by Interaction between Prostate Cancer Cells Treated with Trichomonas vaginalis and Adipocytes
Hyo-Yeoung Chung, Jung-Hyun Kim, Ik-Hwan Han, Jae-Sook Ryu
Korean J Parasitol 2020;58(3):217-227.
Published online June 26, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.3.217
Trichomonas vaginalis causes inflammation of the prostate and has been detected in tissues of prostate cancers (PCa), prostatitis and benign prostatic hyperplasia. Obesity is a risk factor for PCa and causes a chronic subclinical inflammation. This chronic inflammation further exacerbates adipose tissue inflammation as results of migration and activation of macrophages. Macrophages are the most abundant immune cells in the PCa microenvironment. M2 macrophages, known as Tumor-Associated Macrophages, are involved in increasing cancer malignancy. In this study, conditioned medium (TCM) of PCa cells infected with live trichomonads contained chemokines that stimulated migration of the mouse preadipocytes (3T3-L1 cells). Conditioned medium of adipocytes incubated with TCM (ATCM) contained Th2 cytokines (IL-4, IL-13). Macrophage migration was stimulated by ATCM. In macrophages treated with ATCM, expression of M2 markers increased, while M1 markers decreased. Therefore, it is suggested that ATCM induces polarization of M0 to M2 macrophages. In addition, conditioned medium from the macrophages incubated with ATCM stimulates the proliferation and invasiveness of PCa. Our findings suggest that interaction between inflamed PCa treated with T. vaginalis and adipocytes causes M2 macrophage polarization, so contributing to the progression of PCa.

Citations

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  • Interplay of obesity and parasitic infection: current evidence of immunogenesis, tumorigenesis and leptin receptor involvement
    Enas El Saftawy, Mansour Alghamdi, Basma Emad Aboulhoda
    Nutrition & Metabolism.2025;[Epub]     CrossRef
  • Adipocyte–Tumor Interactions in the Bone Marrow Niche: Implications for Metastasis and Therapy
    Alhomam Dabaliz, Mohammad Nawar Al Hakawati, Najmuddeen Alrashdan, Sarah Alrashdan, Mohamad Bakir, Khalid S. Mohammad
    International Journal of Molecular Sciences.2025; 26(19): 9781.     CrossRef
  • Extracellular Vesicles Derived from Three-Dimensional-Cultured Human Umbilical Cord Blood Mesenchymal Stem Cells Prevent Inflammation and Dedifferentiation in Pancreatic Islets
    Eunwon Lee, Seungyeon Ha, Gyuri Kim, Jae Hyeon Kim, Sang-Man Jin, Patricia Murray
    Stem Cells International.2023; 2023: 1.     CrossRef
  • The correlation between Trichomonas vaginalis infection and reproductive system cancer: a systematic review and meta-analysis
    Zhenchao Zhang, Dongxian Li, Yuhua Li, Rui Zhang, Xianghuan Xie, Yi Yao, Linfei Zhao, Xiaowei Tian, Zhenke Yang, Shuai Wang, Xuejing Yue, Xuefang Mei
    Infectious Agents and Cancer.2023;[Epub]     CrossRef
  • The Roles of Tumor-Associated Macrophages in Prostate Cancer
    Chenglin Han, Yuxuan Deng, Wenchao Xu, Zhuo Liu, Tao Wang, Shaogang Wang, Jihong Liu, Xiaming Liu, Eshan Khan
    Journal of Oncology.2022; 2022: 1.     CrossRef
  • Sevoflurane activates the IL-6/HO-1 pathway to promote macrophage M2 polarization and prostate cancer lung metastasis
    Fang Yu, Tao Bai
    International Immunopharmacology.2022; 113: 109380.     CrossRef
  • Signaling Role of Adipocyte Leptin in Prostate Cell Proliferation Induced by Trichomonas vaginalis
    Jung-Hyun Kim, Ik-Hwan Han, Su-Jin Shin, Sung-Yul Park, Hyo-Yeoung Chung, Jae-Sook Ryu
    The Korean Journal of Parasitology.2021; 59(3): 235.     CrossRef
  • Proliferation of Mouse Prostate Cancer Cells Inflamed by Trichomonas vaginalis
    Sang-Su Kim, Kyu-Shik Kim, Ik-Hwan Han, Yeseul Kim, Seong Sik Bang, Jung-Hyun Kim, Yong-Suk Kim, Soo-Yeon Choi, Jae-Sook Ryu
    The Korean Journal of Parasitology.2021; 59(6): 547.     CrossRef
  • Involvement of Macrophages in Proliferation of Prostate Cancer Cells Infected with Trichomonas vaginalis
    Kyu-Shik Kim, Hong-Sang Moon, Sang-Su Kim, Jae-Sook Ryu
    The Korean Journal of Parasitology.2021; 59(6): 557.     CrossRef
  • Is Trichomonas vaginalis a Risk Factor for Prostate Cancer? A Systematic Review and Meta-analysis
    Gianpaolo Perletti, Vittorio Magri, Louise Beckers-Perletti, Alberto Trinchieri, Konstantinos Stamatiou
    Hellenic Urology.2021; 33(1): 12.     CrossRef
  • 8,866 View
  • 192 Download
  • 10 Web of Science
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Brief Communications

Four Taeniasis saginata Cases Diagnosed at a University Hospital in Korea
Eun Jeong Won, Ju Hyeon Shin, Yu Jeong Lee, Moon-Ju Kim, Seung Ji Kang, Sook In Jung, Soo Hyun Kim, Jong Hee Shin, Jong-Yil Chai, Sung-Shik Shin
Korean J Parasitol 2019;57(3):313-318.
Published online June 30, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.3.313
In recent years, the taeniasis has been rarely reported in the Republic of Korea (Korea). But in this study, we intend to report 4 taeniasis cases caused by Taenia saginata during a 5-month period (February to June 2018) at a unversity hospital in Gwangju, Korea. Worm samples (proglottids) discharged from all cases were identified by phenotypic and molecular diagnostics. Mitochondrial cytochrome c oxidase subunit I sequences showed 99.4-99.9% identity with T. saginata but, differed by 4% from T. asiatica and by 7% from T. multiceps, respectively. We found that tapeworms in 2 cases (Cases 2 and 3) yielded exactly the same sequences between them, which differed from those in Cases 1 and 4, suggesting intra-species variation in tapeworms. These taeniasis cases by T. saginata infection in this study, which occurred within a limited time period and region, suggest the possibility of a mini-outbreak. This study highlights the need for further epidemiological investigation of potentially overlooked cases of T. saginata infection in Korea.

Citations

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  • The prevalence and molecular detection of bovine cysticercosis and its impact on slaughtered cattle in Egypt
    Khaled Mohamed El-Dakhly, Shaimaa Ahmed Hany, Waleed M. Arafa, Omima Ramadan Abdel-Fatah, Nasser Sayed Abdel-Atty, El-Shaymaa El-Nahass
    Journal of Parasitic Diseases.2023; 47(3): 527.     CrossRef
  • 6,280 View
  • 130 Download
  • Crossref
Production of Inflammatory Cytokines and Nitric Oxide by Human Mast Cells Incubated with Toxoplasma gondii Lysate
Eun-Ah Park, Ik-Hwan Han, Jung-Hyun Kim, Soon-Jung Park, Jae-Sook Ryu, Myoung-Hee Ahn
Korean J Parasitol 2019;57(2):201-206.
Published online April 30, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.2.201
The roles of mast cells in allergic diseases and helminth infections are well known. However, the roles of mast cells in T. gondii infection is poorly understood. This study was focused on the production of pro-inflammatory cytokines (TNF-α, IL-4), chemokines (CXCL8, MCP-1) and nitric oxide (NO) by mast cells in response to soluble lysate of T. gondii tachyzoites. Production of CXCL8 (IL-8), MCP-1, TNF-α and IL-4 were measured by RT-PCR and ELISA. Western blot were used for detection of CXCR-1 and CXCR2. Our results showed that T. gondii lysates triggered mast cells to release CXCL8, MCP-1, TNF-α, IL-4 and to produce NO. This suggests that mast cells play an important role in inflammatory responses to T. gondii.

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    Carolina Salomão Lopes, Ricardo José Victal Carvalho, Tamires Lopes da Silva, Heber Leão Silva Barros, Lucas Vasconcelos Soares Costa, Danielly Christine Adriani Maia Mota, Bellisa Freitas Barbosa, Luan Souza Vieira, Talyene Marques de Araújo, Alírio Rese
    Pathogens.2025; 14(4): 330.     CrossRef
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    Ashley Catchpole, Brinley N. Zabriskie, Bradley Embley, Hannah Kharazi, Rachelle Clarke, Grace Templeton, Christopher Hunt, Shawn D. Gale, Dawson W. Hedges
    Folia Parasitologica.2025;[Epub]     CrossRef
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    Pilar Horcajo, Montserrat Coronado, Iván Pastor-Fernández, Esther Collantes-Fernández, Laura Rico-San Román, Armando Reyes-Palomares, Luis-Miguel Ortega-Mora
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Rosuvastatin enhances alterations caused by Toxoplasma gondii in the duodenum of mice
    Nelson Raimundo de Miranda Júnior, Amanda Gubert Alves dos Santos, Andréia Vieira Pereira, Isabela Alessandra Mariano, Ana Lucia Falavigna Guilherme, Priscilla de Laet Santana, Lucimara de Fátima Beletini, Fernanda Ferreira Evangelista, Gessilda de Alcant
    Tissue and Cell.2023; 84: 102194.     CrossRef
  • TNF-α Triggers RIP1/FADD/Caspase-8-Mediated Apoptosis of Astrocytes and RIP3/MLKL-Mediated Necroptosis of Neurons Induced by Angiostrongylus cantonensis Infection
    Hongli Zhou, Minyu Zhou, Yue Hu, Yanin Limpanon, Yubin Ma, Ping Huang, Paron Dekumyoy, Wanchai Maleewong, Zhiyue Lv
    Cellular and Molecular Neurobiology.2022; 42(6): 1841.     CrossRef
  • Exhaled Nitric Oxide Level in Pharynx Angioedema
    Łukasz Moos, Magdalena Zajac, Zenon Brzoza
    Journal of Clinical Medicine.2022; 11(3): 637.     CrossRef
  • Nitric oxide in parasitic infections: a friend or foe?
    Marwa Omar, Heba O. Abdelal
    Journal of Parasitic Diseases.2022; 46(4): 1147.     CrossRef
  • 7,240 View
  • 146 Download
  • 7 Web of Science
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Comparison of Seropositivity to Trichomonas vaginalis between Men with Prostatic Tumor and Normal Men
Jung-Hyun Kim, Hong-Sang Moon, Kyu-Shik Kim, Hwan-Sik Hwang, Jae-Sook Ryu, Sung-Yul Park
Korean J Parasitol 2019;57(1):21-25.
Published online February 26, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.1.21
Trichomoniasis is the most common curable sexually-transmitted infection. Most Trichomonas vaginalis-infected men are asymptomatic and can remain undiagnosed and untreated, and this has been thought to result in chronic persistent prostatic infection. Chronic inflammation is regarded as the major factor in the pathogenesis and progression of benign prostatic hyperplasia (BPH) and prostatic cancer (PCa). The aim of this study is to identify seropositivity to T. vaginalis in men with prostate tumors (BPH or PCa) visited to Hanyang University Hospital. A total of 183 men were enrolled between October 2013 and November 2014. They consisted of 139 with BPH (mean age: 64.0 ± 0.07) and 44 with prostate cancer (mean age: 73.3±0.18). We carried out ELISA to identify the seropositivity to T. vaginalis. Mixed lysate antigen extracted from 8 strains of T. vaginalis was used in the ELISA. Also 58 male outpatients visited to Health Promotion Center in Hanyang University Hospital were evaluated for comparing group. As a results, seropositivity to T. vaginalis in patients with prostatic diseases was 19.7% (BPH: 18.7%, PCa: 22.7%) and it was significantly higher than the 1.7% of the comparing healthy group (P = 0.001). Therefore, prostatic tumor showed higher seropositivity against T. vaginalis than normal men. As far as we know, this is the first report about seroprevalence in prostatic tumor in Korea.

Citations

Citations to this article as recorded by  Crossref logo
  • The Past, Present, and Future in the Diagnosis of a Neglected Sexually Transmitted Infection: Trichomoniasis
    Alexandra Ibáñez-Escribano, Juan José Nogal-Ruiz
    Pathogens.2024; 13(2): 126.     CrossRef
  • Prevalence and Genotype of Trichomonas vaginalis among Men in Xinxiang City, Henan Province, China
    Zhenchao Zhang, Yuhui Sang, Pucheng Wu, Yujia Shang, Lesong Li, Yujuan Duan, Linfei Zhao, Minghui Gao, Lihua Guo, Xiaowei Tian, Zhenke Yang, Shuai Wang, Lixia Hao, Xuefang Mei, Jianbing Mu
    Journal of Tropical Medicine.2023; 2023: 1.     CrossRef
  • Inflammatory responses during trichomoniasis: The role of Toll‐like receptors and inflammasomes
    Abdollah Jafarzadeh, Maryam Nemati, Ehsan Salarkia, Sonal Yadav, Najmeh Aminizadeh, Sara Jafarzadeh, Manisha Yadav
    Parasite Immunology.2023;[Epub]     CrossRef
  • No Association of Trichomonas vaginalis Seropositivity with Advanced Prostate Cancer Risk in the Multiethnic Cohort: A Nested Case-Control Study
    Michelle Nagata, Anne Tome, Kami White, Lynne R. Wilkens, Song-Yi Park, Loïc Le Marchand, Christopher Haiman, Brenda Y. Hernandez
    Cancers.2023; 15(21): 5194.     CrossRef
  • Identification of Signature Genes and Construction of an Artificial Neural Network Model of Prostate Cancer
    Hongye Dong, Xu Wang, Kalidoss Rajakani
    Journal of Healthcare Engineering.2022; 2022: 1.     CrossRef
  • Multiple pathogens and prostate cancer
    James S. Lawson, Wendy K. Glenn
    Infectious Agents and Cancer.2022;[Epub]     CrossRef
  • Trichomonas vaginalis serostatus and prostate cancer risk in Egypt: a case-control study
    Nora E. Saleh, Samar M. Alhusseiny, Wafaa M. El-Zayady, Engy M. Aboelnaga, Wafaa N. El-beshbishi, Yasser M. Saleh, Hala S. Abou-ElWafa, Samar N. El-Beshbishi
    Parasitology Research.2021; 120(4): 1379.     CrossRef
  • The Role of Microbial Factors in Prostate Cancer Development—An Up-to-Date Review
    Karolina Garbas, Piotr Zapała, Łukasz Zapała, Piotr Radziszewski
    Journal of Clinical Medicine.2021; 10(20): 4772.     CrossRef
  • Involvement of Macrophages in Proliferation of Prostate Cancer Cells Infected with Trichomonas vaginalis
    Kyu-Shik Kim, Hong-Sang Moon, Sang-Su Kim, Jae-Sook Ryu
    The Korean Journal of Parasitology.2021; 59(6): 557.     CrossRef
  • Seroprevalence and risk factors of Trichomonas vaginalis among couples in Al-Hamza city-Iraq.
    Musafer H. Al-Ardi
    Al-Kufa University Journal for Biology.2021; 13(1): 26.     CrossRef
  • Is Trichomonas vaginalis a Risk Factor for Prostate Cancer? A Systematic Review and Meta-analysis
    Gianpaolo Perletti, Vittorio Magri, Louise Beckers-Perletti, Alberto Trinchieri, Konstantinos Stamatiou
    Hellenic Urology.2021; 33(1): 12.     CrossRef
  • IL-6 produced by prostate epithelial cells stimulated with Trichomonas vaginalis promotes proliferation of prostate cancer cells by inducing M2 polarization of THP-1-derived macrophages
    Ik-Hwan Han, Hyun-Ouk Song, Jae-Sook Ryu, Michael H. Hsieh
    PLOS Neglected Tropical Diseases.2020; 14(3): e0008126.     CrossRef
  • Development of a convenient detection method for Trichomonas vaginalis based on loop-mediated isothermal amplification targeting adhesion protein 65
    Yuhua Li, Shuai Wang, Haoran Li, Xiaoxiao Song, Hao Zhang, Yujuan Duan, Chengyang Luo, Bingli Wang, Sifan Ji, Qing Xie, Zhenchao Zhang
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?
    Felice Crocetto, Mariarosaria Boccellino, Biagio Barone, Erika Di Zazzo, Antonella Sciarra, Giovanni Galasso, Giuliana Settembre, Lucio Quagliuolo, Ciro Imbimbo, Silvia Boffo, Italo Francesco Angelillo, Marina Di Domenico
    Nutrients.2020; 12(9): 2648.     CrossRef
  • 9,229 View
  • 152 Download
  • 12 Web of Science
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Case Report

A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea
Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong
Korean J Parasitol 2018;56(4):375-378.
Published online August 31, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.4.375
A total of 44 adult or juvenile nutrias were necropsied for disease survey. A large nodule was found in the liver of a nutria. The histopathological specimen of the hepatic nodule was microscopically examined, and sectional worms were found in the bile duct. The worms showed a tegument with spines, highly branches of vitelline glands and intestine. Finally, we histopathologically confirmed fascioliasis in a wild nutria. In the present study, a case of fascioliasis in a wild nutria is first confirmed in Korea.

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  • The use of Glutathione-S-transferase levels as marker of hepatic damage in chronic fasciolosis in cattle
    Al-Hassan Mohammed Mostafa, Gehan Mohammed Sayed, Ali Ali Hassan Al-Ezzi, Alaa Eldin Kamal
    Veterinary Parasitology.2025; 339: 110577.     CrossRef
  • Fasciola hepatica infection in Korean water deer (Hydropotes inermis argyropus)
    Na-Hyeon Kim, Min-Gyeong Seo, Bumseok Kim, Yu Jeong Jeon, In Jung Jung, Il-Hwa Hong
    Parasites, Hosts and Diseases.2025; 63(3): 243.     CrossRef
  • Intestinal parasites of Myocastor coypus (Rodentia, Myocastoridae) on animal farms in Eastern Ukraine
    N. V. Sumakova, A. P. Paliy, O. V. Pavlichenko, R. V. Petrov, B. S. Morozov, V. M. Plys, A. B. Mushynskyi
    Regulatory Mechanisms in Biosystems.2025; 16(3): e25117.     CrossRef
  • Prevalence and hepatic histopathological findings of fascioliasis in sheep slaughtered in Jeddah, Saudi Arabia
    Safinaz J. Ashoor, Majed H. Wakid
    Scientific Reports.2023;[Epub]     CrossRef
  • Climate change induced habitat expansion of nutria (Myocastor coypus) in South Korea
    Pradeep Adhikari, Baek-Jun Kim, Sun-Hee Hong, Do-Hun Lee
    Scientific Reports.2022;[Epub]     CrossRef
  • Genetic diversity and relationships of the liver fluke Fasciola hepatica (Trematoda) with native and introduced definitive and intermediate hosts
    Antonio A. Vázquez, Emeline Sabourin, Pilar Alda, Clémentine Leroy, Carole Leray, Eric Carron, Stephen Mulero, Céline Caty, Sarah Hasfia, Michel Boisseau, Lucas Saugné, Olivier Pineau, Thomas Blanchon, Annia Alba, Dominique Faugère, Marion Vittecoq, Sylvi
    Transboundary and Emerging Diseases.2021; 68(4): 2274.     CrossRef
  • Preputial gland adenoma in a wild nutria (Myocastor coypus): a case report
    Joo-Yeon Kong, Hyo-Seok Kim, Seong-Chan Yeon, Jin-Kyu Park, Kyu-Shik Jeong, Il-Hwa Hong
    Journal of Veterinary Science.2020;[Epub]     CrossRef
  • Preputial gland adenoma in a wild nutria (Myocastor coypus): a case report
    Joo-Yeon Kong, Hyo-Seok Kim, Seong-Chan Yeon, Jin-Kyu Park, Kyu-Shik Jeong, Il-Hwa Hong
    Journal of Veterinary Science.2019;[Epub]     CrossRef
  • 10,019 View
  • 134 Download
  • 8 Web of Science
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Original Article

Efficient Liquid Media for Encystation of Pathogenic Free-Living Amoebae
Hae-Jin Sohn, Heekyoung Kang, Ga-Eun Seo, Jong-Hyun Kim, Suk-Yul Jung, Ho-Joon Shin
Korean J Parasitol 2017;55(3):233-238.
Published online June 30, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.3.233
Pathogenic Naegleria fowleri, Acanthamoeba castellanii, and Acanthamoeba polyphaga, are distributed worldwide. They are causative agents of primary amoebic meningoencephalitis or acanthamoebic keratitis in humans, respectively. Trophozoites encyst in unfavorable environments, such as exhausted food supply and desiccation. Until recently, the method of N. fowleri encystation used solid non-nutrient agar medium supplemented with heat-inactivated Escherichia coli; however, for the amoebic encystment of Acanthamoeba spp., a defined, slightly modified liquid media is used. In this study, in order to generate pure N. fowleri cysts, a liquid encystment medium (buffer 1) modified from Page’s amoeba saline was applied for encystation of N. fowleri. N. fowleri cysts were well induced after 24 hr with the above defined liquid encystment medium (buffer 1). This was confirmed by observation of a high expression of differential mRNA of nfa1 and actin genes in trophozoites. Thus, this liquid medium can replace the earlier non-nutrient agar medium for obtaining pure N. fowleri cysts. In addition, for cyst formation of Acanthamoeba spp., buffer 2 (adjusted to pH 9.0) was the more efficient medium. To summarize, these liquid encystment media may be useful for further studies which require axenic and pure amoebic cysts.

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    Veterinary World.2025; : 110.     CrossRef
  • Exploring the potential role of soil protists in predicting banana health
    Xiangyu Ren, Chen Liu, Yang Yue, Shuo Sun, Lang Zhao, Chengyuan Tao, Beibei Wang, Wu Xiong, Zongzhuan Shen, Rong Li, Qirong Shen
    Microbiological Research.2025; 295: 128109.     CrossRef
  • Cloning of nf-profilin and intercellular interaction with nf-actin in Naegleria fowleri cysts
    Hae-Jin Sohn, A-Jeong Ham, A-Young Park, Jeong-Heon Lee, Sun Park, Ho-Joon Shin, Jong-Hyun Kim
    Scientific Reports.2025;[Epub]     CrossRef
  • Ouabain, ATPase inhibitor, potentially enhances the effect of polyhexamethylene biguanide on Acanthamoeba castellanii
    Kuang-Yi Shih, Yao-Tsung Chang, Yu-Jen Wang, Jian-Ming Huang
    International Journal for Parasitology: Drugs and Drug Resistance.2024; 25: 100550.     CrossRef
  • Understanding the pathogenicity of Naegleria fowleri in association with N. fowleri antigen-1 (Nfa1)
    Jong-Hyun Kim, Hae-Jin Sohn, Ho-Joon Shin, Stacy E. Walz, Suk-Yul Jung
    Parasites, Hosts and Diseases.2024; 62(4): 385.     CrossRef
  • De Novo Transcriptome Profiling of Naegleria fowleri Trophozoites and Cysts via RNA Sequencing
    Hae-Jin Sohn, Jong-Hyun Kim, Kyongmin Kim, Sun Park, Ho-Joon Shin
    Pathogens.2023; 12(2): 174.     CrossRef
  • An International External Quality Assessment Scheme to Assess the Diagnostic Performance of Polymerase Chain Reaction Detection of Acanthamoeba Keratitis
    Maarten J. Sarink, Rob Koelewijn, Foekje Stelma, Titia Kortbeek, Lisette van Lieshout, Pieter W. Smit, Aloysius G. M. Tielens, Jaap J. van Hellemond
    Cornea.2023; 42(8): 1027.     CrossRef
  • Development of a Machine Learning-Based Cysticidal Assay and Identification of an Amebicidal and Cysticidal Marine Microbial Metabolite against Acanthamoeba
    Brian Shing, Mina Balen, William Fenical, Anjan Debnath, Wei-Hua Chen
    Microbiology Spectrum.2022;[Epub]     CrossRef
  • Curcumin effect on Acanthamoeba triangularis encystation under nutrient starvation
    Rachasak Boonhok, Suthinee Sangkanu, Suganya Phumjan, Ramita Jongboonjua, Nawarat Sangnopparat, Pattamaporn Kwankaew, Aman Tedasen, Chooi Ling Lim, Maria de Lourdes Pereira, Mohammed Rahmatullah, Polrat Wilairatana, Christophe Wiart, Karma G. Dolma, Alok
    PeerJ.2022; 10: e13657.     CrossRef
  • Novel Antiamoebic Tyrocidine-Derived Peptide against Brain-Eating Amoebae
    Noor Akbar, Wendy E. Kaman, Maarten Sarink, Kamran Nazmi, Floris J. Bikker, Naveed Ahmed Khan, Ruqaiyyah Siddiqui
    ACS Omega.2022; 7(33): 28797.     CrossRef
  • Combinatorial treatment with β-glucanase enzyme and chlorhexidine induces cysticidal effects in Acanthamoeba cyst
    Nurhidayana Mohd Rased, Syed Ahmad Tajudin Tuan Johari, Hazlina Ahamad Zakeri, Nyuk Ling Ma, Siti Aisyah Razali, Fatimah Hashim
    Parasitology Research.2022; 121(11): 3105.     CrossRef
  • The Acanthamoeba SBDS, a cytoskeleton-associated gene, is highly expressed during phagocytosis and encystation
    Yu-Jen Wang, Wei-Chen Lin, Ming-Shan He
    Journal of Microbiology, Immunology and Infection.2021; 54(3): 482.     CrossRef
  • RETRACTED ARTICLE: Establishment of an Acanthamoeba keratitis mouse model confirmed by amoebic DNA amplification
    Heekyoung Kang, Hae-Jin Sohn, A-Young Park, A-Jeong Ham, Jeong-Heon Lee, Young-Hwan Oh, Yong-Joon Chwae, Kyongmin Kim, Sun Park, Hongseok Yang, Suk-Yul Jung, Jong-Hyun Kim, Ho-Joon Shin
    Scientific Reports.2021;[Epub]     CrossRef
  • A Novel Cysteine Protease Inhibitor of Naegleria fowleri That Is Specifically Expressed during Encystation and at Mature Cysts
    Hương Giang Lê, A-Jeong Ham, Jung-Mi Kang, Tuấn Cường Võ, Haung Naw, Hae-Jin Sohn, Ho-Joon Shin, Byoung-Kuk Na
    Pathogens.2021; 10(4): 388.     CrossRef
  • Inhibitory Effect of Host Ocular Microenvironmental Factors on Chlorhexidine Digluconate Activity
    Chun-Hsien Chen, Yu-Jen Wang, Jian-Ming Huang, Fu-Chin Huang, Wei-Chen Lin
    Antimicrobial Agents and Chemotherapy.2021;[Epub]     CrossRef
  • Primary Amoebic Meningoencephalitis by Naegleria fowleri: Pathogenesis and Treatments
    Andrea Güémez, Elisa García
    Biomolecules.2021; 11(9): 1320.     CrossRef
  • Evaluation of Amebicidal and Cysticidal Activities of Antifungal Drug Isavuconazonium Sulfate against Acanthamoeba T4 Strains
    Brian Shing, Mina Balen, Anjan Debnath
    Pharmaceuticals.2021; 14(12): 1294.     CrossRef
  • Characterisation of the β-lactam resistance enzyme in Acanthamoeba castellanii
    Chun-Hsien Chen, Chao-Li Huang, Ming-Shan He, Fu-Chin Huang, Wei-Chen Lin
    International Journal of Antimicrobial Agents.2020; 55(2): 105823.     CrossRef
  • Molecular detection of free-living amoebae from Namhangang (southern Han River) in Korea
    Heekyoung Kang, Hae-Jin Sohn, Ga-Eun Seo, Gi-Sang Seong, A-Jeong Ham, A-Young Park, Suk-Yul Jung, Sang-Eun Lee, Shin-Hyeong Cho, Ho-Joon Shin
    Scientific Reports.2020;[Epub]     CrossRef
  • Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro
    Thị Lam Thái, Jung-Mi Kang, Hương Giang Lê, Jinyoung Lee, Won Gi Yoo, Ho-Joon Shin, Woon-Mok Sohn, Byoung-Kuk Na
    Parasites & Vectors.2020;[Epub]     CrossRef
  • The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii
    Brian Shing, Seema Singh, Larissa M. Podust, James H. McKerrow, Anjan Debnath
    Antimicrobial Agents and Chemotherapy.2020;[Epub]     CrossRef
  • Effects of Acanthamoeba castellanii on the dissolved oxygen and the microbial community under the experimental aquatic model
    Chih-Ming Tsai, Jenn-Wei Chen, Wei-Chen Lin
    Experimental Parasitology.2020; 218: 107985.     CrossRef
  • Fate of internalized Campylobacter jejuni and Mycobacterium avium from encysted and excysted Acanthamoeba polyphaga
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    Experimental Parasitology.2019; 199: 104.     CrossRef
  • Cellular characterization of actin gene concerned with contact‐dependent mechanisms in Naegleria fowleri
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    Parasite Immunology.2019;[Epub]     CrossRef
  • Cytopathic Change and Inflammatory Response of Human Corneal Epithelial Cells Induced by Acanthamoeba castellanii Trophozoites and Cysts
    Hae-Jin Sohn, Ga-Eun Seo, Jae-Ho Lee, A-Jeong Ham, Young-Hwan Oh, Heekyoung Kang, Ho-Joon Shin
    The Korean Journal of Parasitology.2019; 57(3): 217.     CrossRef
  • Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri
    Gi-Sang Seong, Hae-Jin Sohn, Heekyoung Kang, Ga-Eun Seo, Jong-Hyun Kim, Ho-Joon Shin
    Experimental Parasitology.2017; 183: 171.     CrossRef
  • 9,737 View
  • 240 Download
  • 27 Web of Science
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Brief Communication

Interaction between Trichomonas vaginalis and the Prostate Epithelium
Jung-Hyun Kim, Ik-Hwan Han, Sang-Su Kim, Soon-Jung Park, Duk-Young Min, Myoung-Hee Ahn, Jae-Sook Ryu
Korean J Parasitol 2017;55(2):213-218.
Published online April 30, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.2.213
Most men infected with Trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. This has been hypothesized to result in chronic persistent prostatic infection. Adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for T. vaginalis infection. Adhesion of T. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by T. vaginalis. The aim of this study was to investigate whether adhesion and cytotoxicity of T. vaginalis are involved in inflammation of prostate epithelial cells. When RWPE-1 cells were infected with T. vaginalis (1:0.4 or 1:4), adhesion of T. vaginalis continuously increased for 24 hr or 3 hr, respectively. The cytotoxicity of prostate epithelial cells infected with T. vaginalis (RWPE-1: T. vaginalis=1:0.4) increased at 9 hr; at an infection ratio of 1:4, cytotoxicity increased after 3 hr. When the RWPE-1 to T. vaginalis ratio was 1:0.4 or 1:4, production of IL-1β, IL-6, CCL2, and CXCL8 also increased. Epithelial-mesenchymal transition (EMT) was verified by measuring decreased E-cadherin and increased vimentin expression at 24 hr and 48 hr. Taken together, the results indicate that T. vaginalis adhered to prostate epithelial cells, causing cytotoxicity, pro-inflammatory cytokine production, and EMT. Our findings suggest for the first time that T. vaginalis may induce inflammation via adhesion to normal prostate epithelial cells.

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  • The Role of Colposcopy in Women with Normal Cytology and High-risk Human Papilloma Virus Positivity, Except for Types 16 and 18
    Necim Yalçın, Aysun Alcı, Mustafa Gökkaya, Mehmet Göksu, Tayfun Toptaş, Işın Üreyen
    Bagcilar Medical Bulletin.2025;[Epub]     CrossRef
  • Point-of-Care Diagnostic for Trichomonas vaginalis, the Most Prevalent, Non-Viral Sexually Transmitted Infection
    John F. Alderete, Hermes Chan
    Pathogens.2023; 12(1): 77.     CrossRef
  • Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia
    Ik-Hwan Han, Jung-Hyun Kim, Jae-Sook Ryu
    Parasites, Hosts and Diseases.2023; 61(1): 2.     CrossRef
  • Inflammatory responses during trichomoniasis: The role of Toll‐like receptors and inflammasomes
    Abdollah Jafarzadeh, Maryam Nemati, Ehsan Salarkia, Sonal Yadav, Najmeh Aminizadeh, Sara Jafarzadeh, Manisha Yadav
    Parasite Immunology.2023;[Epub]     CrossRef
  • Epidemiology, Natural History, Diagnosis, and Treatment of Trichomonas vaginalis in Men
    Olivia T Van Gerwen, Andres F Camino, Jyoti Sharma, Patricia J Kissinger, Christina A Muzny
    Clinical Infectious Diseases.2021; 73(6): 1119.     CrossRef
  • Extracorporeal Shockwave Therapy (ESWT) Alleviates Pain, Enhances Erectile Function and Improves Quality of Life in Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome
    Wen-Ling Wu, Oluwaseun Adebayo Bamodu, Yuan-Hung Wang, Su-Wei Hu, Kai-Yi Tzou, Chi-Tai Yeh, Chia-Chang Wu
    Journal of Clinical Medicine.2021; 10(16): 3602.     CrossRef
  • Prevalence and risk factors for Trichomonas vaginalis infection among adults in the U.S., 2013–2014
    Erin L. Tompkins, Thomas A. Beltran, Elizabeth J. Gelner, Aaron R. Farmer, Ethan Morgan
    PLOS ONE.2020; 15(6): e0234704.     CrossRef
  • Advancing Prevention of STIs by Developing Specific Serodiagnostic Targets: Trichomonas vginalis as a Model
    John F. Alderete
    International Journal of Environmental Research and Public Health.2020; 17(16): 5783.     CrossRef
  • Inflammation as a Driver of Prostate Cancer Metastasis and Therapeutic Resistance
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    Cancers.2020; 12(10): 2984.     CrossRef
  • Prevalence ofTrichomonas vaginalisInfection Among US Males, 2013–2016
    Michael Daugherty, Kendall Glynn, Timothy Byler
    Clinical Infectious Diseases.2019; 68(3): 460.     CrossRef
  • Inflammatory mediators of prostate epithelial cells stimulated with Trichomonas vaginalis promote proliferative and invasive properties of prostate cancer cells
    Ik‐Hwan Han, Jung‐Hyun Kim, Ki‐Seok Jang, Jae‐Sook Ryu
    The Prostate.2019; 79(10): 1133.     CrossRef
  • Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigmEpistemology of the origin of cancer”
    Björn L.D.M. Brücher, Ijaz S. Jamall, Obul R. Bandapalli
    4open.2019; 2: 28.     CrossRef
  • Proliferation of prostate epithelia induced by IL‐6 from stroma reacted with Trichomonas vaginalis
    J.‐H. Kim, I.‐H. Han, Y.‐S. Kim, C.‐S. Noh, J.‐S. Ryu
    Parasite Immunology.2018;[Epub]     CrossRef
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Case Report

Canine Wound Myiasis Caused by Lucilia sericata (Diptera: Calliphoridae) in Korea
Seongjun Choe, Dongmin Lee, Hansol Park, Hyeong-Kyu Jeon, Hakhyun Kim, Ji-Houn Kang, Cha-Ho Jee, Keeseon S. Eom
Korean J Parasitol 2016;54(5):667-671.
Published online October 31, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.5.667
Myiasis is a relatively common infection of animals kept as pets, although only 1 case of canine myiasis has been described so far in the Republic of Korea. In the present study, we report an additional case of canine wound myiasis with identification of its causative agent, Lucilia sericata. An 8-year-old male Siberian husky dog was referred with anorexia, vomiting, and diarrhea to the Chungbuk National University Veterinary Medical Center, Cheongju-si (city), Chungcheongbuk-do (province), Korea in July 2013. Physical examination indicated the patient had a deep wound filled with a maggot swarm as a left gluteal lesion. A total of 216 maggots were removed by forceps, and the wounded area was sponged with gauzes and disinfected with 70% alcohol and a povidone-iodine solution. After daily care and suturing the wound, the patient was discharged at day 19 after admission. Recovered worms possessed morphological characteristics similar to those of L. sericata, namely, a sub-cylindrical body with 6-8 lobed anterior spiracles, round shaped with a button surrounded by a peritremal ring with no gaps, and similar distances between dorsal, median, and outer papillae of the 12th segment. Additionally, cox1 partial sequences (528 bp) obtained in the present study showed 100% identity with those of L. sericata (GenBank no. KT272854.1). L. sericata is indicated as a pathogen of myiasis infection not only in humans, but also in animals kept as pets in Korea.

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  • Traumatic myiasis in animals from Iraq: a five years (2019–2023) survey, and a comprehensive epidemiological overview
    Aws Mohammed, Thamer Alkhafaji, Haydar Al-Rubaye, Moustafa Al-Araby, Salah Abu-Elwafa, Ibrahim Abbas
    Tropical Animal Health and Production.2025;[Epub]     CrossRef
  • Deadly Decomposers: Distinguishing Life History Strategies on the Parasitism‐Saprotrophy Spectrum
    Daniel C. G. Metz, Kelly L. Weinersmith, Alexis S. Beagle, Rudra M. Dixit, Christina G. Fragel, Clayton E. Cressler
    Ecology Letters.2025;[Epub]     CrossRef
  • Incidence of Furuncular Myiasis due to Cordylobia anthropophaga (Blanchard, 1872) Larvae Infestation and Associated Risk Factors on Dogs in Ilorin Metropolis, North Central, Nigeria
    Musa Rabiu, Ridwan Usman Adekola, Shola David Ola-Fadunsin, Isau Aremu Ganiyu, Miftah Olalekan Adeleke, Idiat Modupe Sanda, Ghali-Mohammed Ibraheem, Isyaku Abdulmajeed
    UMYU Scientifica.2025; 4(1): 408.     CrossRef
  • Gut Microbiome Characterisation of Chrysomya megacephala: Isolation, Identification, Antibiotic Profiling, and Initial Documentation of Leclercia adecarboxylata from the Fly
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    In-Yong Lee, Ju Yeong Kim, Jung-Min Park, Ji Ho Seo, Bo-Young Jeon, Tai-Soon Yong, Min Seo
    Parasites, Hosts and Diseases.2023; 61(4): 471.     CrossRef
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    Marco Pezzi, Chiara Scapoli, Milvia Chicca, Marilena Leis, Maria Gabriella Marchetti, Carlo Nicola Francesco Del Zingaro, Chiara Beatrice Vicentini, Elisabetta Mamolini, Annunziata Giangaspero, Teresa Bonacci
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    Sang Eon Shin, Ji Hye Park, Su Jin Jeong, Seong Hwan Park
    Insects.2021; 12(4): 323.     CrossRef
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Brief Communications

New Record of Schistorophus cirripedesmi (Nematoda: Acuariidae) from a Bar-Tailed Godwit, Limosa lapponica baueri (Charadriformes: Scolopacidae) in Korea
Seongjun Choe, Hyun Kim, Junsik Lim, Dongmin Lee, Hansol Park, Hyeong-Kyu Jeon, Heejong Kim, Youngjun Kim, Keeseon S. Eom
Korean J Parasitol 2016;54(3):349-355.
Published online June 30, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.3.349
In July 2014, a nematode species, Schistorophus cirripedesmi Rhizhikov and Khokhlova, 1964, was recovered from a bar-tailed godwit, Limosa lapponica baueri that was stored in a -20˚C freezer in the Chungnam Wild Animal Rescue Center. The bird was collected in 2012 from the coastal region of Pyeongtaek-si (City), Gyeonggi-do (Province) in the Republic of Korea, although the exact date is not clear. At necropsy, 9 nematodes were found in the gizzard of the bird. The parasites had 4 horn-like cephalic cuticular ornamentations. After morphometric comparison and morphological observations, including scanning electron microscopy, the nematodes were identified as S. cirripedesmi. This is the first description of a nematode species in a shorebird in Korea. This is also the first time this genus and species have been found in Korea.
  • 8,760 View
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Three Nematode Species Recovered from Terrestrial Snakes in Republic of Korea
Seongjun Choe, Junsik Lim, Hyun Kim, Youngjun Kim, Heejong Kim, Dongmin Lee, Hansol Park, Hyeong-Kyu Jeon, Keeseon S. Eom
Korean J Parasitol 2016;54(2):205-213.
Published online April 30, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.2.205
The majority of parasitological studies of terrestrial snakes in Korea have focused on zoonotic parasites. However, in the present study, we describe 3 unrecorded nematode species recovered from 5 species of snakes (n=6) in Korea. The examined snakes, all confiscated from illegal hunters, were donated by the Chungnam Wild Animal Rescue Center and Korean Broadcasting System in July 2014 and February 2015. Light and scanning electron microscopies on the shapes of spicules that are either bent or straight (kalicephalids) and the presence of the intestinal cecum (ophidascarids) figured out 3 nematodes; Kalicephalus brachycephalus Maplestone, 1931, Kalicephalus sinensis Hs?, 1934, and Ophidascaris excavata Hs? and Hoeppli, 1934. These 3 species of nematode faunas are recorded for the first time in Korea.

Citations

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  • An update on the conservation status and ecology of Korean terrestrial squamates
    Daniel Macias, Yucheol Shin, Amaël Borzée
    Journal for Nature Conservation.2021; 60: 125971.     CrossRef
  • The mitochondrial genome sequence analysis of Ophidascaris baylisi from the Burmese python (Python molurus bivittatus)
    Qi Zhao, Asmaa M.I. Abuzeid, Long He, Tingting Zhuang, Xiu Li, Jumei Liu, Shilan Zhu, Xiaoyu Chen, Guoqing Li
    Parasitology International.2021; 85: 102434.     CrossRef
  • Morphologic and morphometric characteristics of ascaroid worm, Ophidascaris piscatori in Xenochrophis piscator snake in Sidoarjo, Indonesia
    Lucia Tri Suwanti, Inggarsetya Syah Audini, Setiawan Koesdarto, Emmanuel Djoko Poetranto
    Veterinary World.2018; 11(8): 1159.     CrossRef
  • 12,273 View
  • 215 Download
  • 3 Web of Science
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Prevalence of Trichomoniasis by PCR in Women Attending Health Screening in Korea
Seung-Ryong Kim, Jung-Hyun Kim, Na-Yeong Gu, Yong-Suk Kim, Yeon-Chul Hong, Jae-Sook Ryu
Korean J Parasitol 2016;54(2):187-190.
Published online April 30, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.2.187
Trichomoniasis is the most common curable sexually-transmitted infection (STI) worldwide. There are few reports on the prevalence of Trichomonas vaginalis in Korea. The purpose of this study was to examine the prevalence of trichomoniasis by PCR in Guri city, Korea. All adult women who visited Hanyang University Guri Hospital for health screening within the National Health Care Service were invited to participate in the study, and 424 women were enrolled between March and June 2011. PCR was used to detect Trichomonas vaginalis using primers based on a repetitive sequence cloned from T. vaginalis (TV-E650). Fourteen women (3.3%) were found to have T. vaginalis. All were over 50, and they were significantly older on average than the 410 Trichomonas-negative women (mean ages 63.4 vs 55.3 years). It seems that T. vaginalis infection is not rare in women receiving health screening, especially among those over 50.

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  • Molecular diagnosis of Trichomonas vaginalis in liquid-based Papanicolaou samples in Shiraz, southern Iran
    Mohammad Saleh Bahreini, Samaneh Sedghi, Yalda Badalzadeh, Mohammad Hossein Motazedian, Manouchehr Shirani, Sareh Sami Jahromi, Aref Teimouri, Mahmoud Agholi, Qasem Asgari
    BMC Women's Health.2023;[Epub]     CrossRef
  • Construction a novel detection method for Trichomonas vaginalis based on recombinant enzyme polymerase amplification targeting the Actin gene
    Fakun Li, Yangyang Deng, Wanxin Sheng, Xihui Gao, Weijuan Wang, Zhili Chu, Xuefang Mei, Zhenke Yang, Xiaowei Tian, Shuai Wang, Zhenchao Zhang
    Journal of Eukaryotic Microbiology.2023;[Epub]     CrossRef
  • Molecular characterization of Trichomonas infections in women of Ilam City, southwestern Iran
    Maryam Alikhani, Mohammad Akhoundi, Denis Sereno, Jahangir Abdi, Razi Naserifar, Mohammad Reza Mahmoudi, Asad Mirzaei
    Parasitology Research.2022; 121(6): 1631.     CrossRef
  • Status of common parasitic diseases in Korea in 2019
    Sun Huh
    Journal of the Korean Medical Association.2019; 62(8): 437.     CrossRef
  • 8,720 View
  • 105 Download
  • 5 Web of Science
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Original Article

Inflammatory Responses in a Benign Prostatic Hyperplasia Epithelial Cell Line (BPH-1) Infected with Trichomonas vaginalis
Sang-Su Kim, Jung-Hyun Kim, Ik-Hwan Han, Myoung-Hee Ahn, Jae-Sook Ryu
Korean J Parasitol 2016;54(2):123-132.
Published online April 30, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.2.123
Trichomonas vaginalis causes the most prevalent sexually transmitted infection worldwide. Trichomonads have been detected in prostatic tissues from prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer. Chronic prostatic inflammation is known as a risk factor for prostate enlargement, benign prostatic hyperplasia symptoms, and acute urinary retention. Our aim was to investigate whether T. vaginalis could induce inflammatory responses in cells of a benign prostatic hyperplasia epithelial cell line (BPH-1). When BPH-1 cells were infected with T. vaginalis, the protein and mRNA of inflammatory cytokines, such as CXCL8, CCL2, IL-1β, and IL-6, were increased. The activities of TLR4, ROS, MAPK, JAK2/STAT3, and NF-κB were also increased, whereas inhibitors of ROS, MAPK, PI3K, NF-κB, and anti-TLR4 antibody decreased the production of the 4 cytokines although the extent of inhibition differed. However, a JAK2 inhibitor inhibited only IL-6 production. Culture supernatants of the BPH-1 cells that had been incubated with live T. vaginalis (trichomonad-conditioned medium, TCM) contained the 4 cytokines and induced the migration of human monocytes (THP-1 cells) and mast cells (HMC-1 cells). TCM conditioned by BPH-1 cells pretreated with NF-κB inhibitor showed decreased levels of cytokines and induced less migration. Therefore, it is suggested that these cytokines are involved in migration of inflammatory cells. These results suggest that T. vaginalis infection of BPH patients may cause inflammation, which may induce lower urinary tract symptoms (LUTS).

Citations

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  • Immunomodulatory roles of autophagic flux and IFIT in human ectocervical cells upon Trichomonas vaginalis infection
    Ching-Chun Liu, Lichieh Julie Chu, Yuan-Ming Yeh, Hsin-Chung Lin, Lih-Chyang Chen, Ching-Yun Huang, Shu-Fang Chiu, Fang-Wen Cheng, Wei-Ning Lin, Kuo-Yang Huang
    International Immunopharmacology.2025; 155: 114643.     CrossRef
  • Intrinsic and extrinsic factors causing hyperplasia of the prostate
    Yuki Kyoda, Kosuke Shibamori, Tetsuya Shindo, Takeshi Maehana, Kohei Hashimoto, Ko Kobayashi, Toshiaki Tanaka, Fumimasa Fukuta, Naoya Masumori
    International Journal of Urology.2024; 31(7): 705.     CrossRef
  • P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
    Shuang-Ying Wang, Yi Cai, Xiao Hu, Fei Li, Xin-Hang Qian, Ling-Yun Xia, Bo Gao, Lan Wu, Wen-Zhong Xie, Jia-Min Gu, Tong Deng, Cong Zhu, Hai-Chang Jia, Wan-Qi Peng, Jiao Huang, Cheng Fang, Xian-Tao Zeng
    Military Medical Research.2024;[Epub]     CrossRef
  • The correlation between Trichomonas vaginalis infection and reproductive system cancer: a systematic review and meta-analysis
    Zhenchao Zhang, Dongxian Li, Yuhua Li, Rui Zhang, Xianghuan Xie, Yi Yao, Linfei Zhao, Xiaowei Tian, Zhenke Yang, Shuai Wang, Xuejing Yue, Xuefang Mei
    Infectious Agents and Cancer.2023;[Epub]     CrossRef
  • Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia
    Ik-Hwan Han, Jung-Hyun Kim, Jae-Sook Ryu
    Parasites, Hosts and Diseases.2023; 61(1): 2.     CrossRef
  • Trichomoniasis
    Olivia T. Van Gerwen, Skye A. Opsteen, Keonte J. Graves, Christina A. Muzny
    Infectious Disease Clinics of North America.2023; 37(2): 245.     CrossRef
  • Inflammatory responses during trichomoniasis: The role of Toll‐like receptors and inflammasomes
    Abdollah Jafarzadeh, Maryam Nemati, Ehsan Salarkia, Sonal Yadav, Najmeh Aminizadeh, Sara Jafarzadeh, Manisha Yadav
    Parasite Immunology.2023;[Epub]     CrossRef
  • IL-6 Signaling Link between Inflammatory Tumor Microenvironment and Prostatic Tumorigenesis
    Cosmin-Victor Ene, Ilinca Nicolae, Bogdan Geavlete, Petrisor Geavlete, Corina Daniela Ene, Yun Ping Lim
    Analytical Cellular Pathology.2022; 2022: 1.     CrossRef
  • Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3
    Woo Yong Park, Gahee Song, Ja Yeon Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jinbong Park, Jun Hee Lee, Jae-Young Um
    Cell Death & Disease.2022;[Epub]     CrossRef
  • Association between trichomoniasis and prostate and bladder diseases: a population-based case–control study
    Hung-Yi Yang, Ruei-Yu Su, Chi-Hsiang Chung, Kuo-Yang Huang, Hsin-An Lin, Jui-Yang Wang, Chien-Chou Chen, Wu-Chien Chien, Hsin-Chung Lin
    Scientific Reports.2022;[Epub]     CrossRef
  • Increased diagnostic yield of routine multiplex PCR compared to clinician requested testing for detection of Trichomonas vaginalis
    Brooke Webb, Andrea Crampton, Michelle J. Francis, John Hamblin, Tony M. Korman, Maryza Graham
    Pathology.2021; 53(2): 257.     CrossRef
  • Development of a convenient detection method for Trichomonas vaginalis based on loop-mediated isothermal amplification targeting adhesion protein 65
    Yuhua Li, Shuai Wang, Haoran Li, Xiaoxiao Song, Hao Zhang, Yujuan Duan, Chengyang Luo, Bingli Wang, Sifan Ji, Qing Xie, Zhenchao Zhang
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • Inflammatory mediators of prostate epithelial cells stimulated with Trichomonas vaginalis promote proliferative and invasive properties of prostate cancer cells
    Ik‐Hwan Han, Jung‐Hyun Kim, Ki‐Seok Jang, Jae‐Sook Ryu
    The Prostate.2019; 79(10): 1133.     CrossRef
  • Monocyte-derived extracellular trap (MET) formation induces aggregation and affects motility of human spermatozoa in vitro
    Mabel Schulz, Fabiola Zambrano, Hans-Christian Schuppe, Florian Wagenlehner, Anja Taubert, Ulrich Gaertner, Rául Sánchez, Carlos Hermosilla
    Systems Biology in Reproductive Medicine.2019; 65(5): 357.     CrossRef
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    Björn L.D.M. Brücher, Ijaz S. Jamall, Obul R. Bandapalli
    4open.2019; 2: 28.     CrossRef
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    Pei-Ju Sung, Nicolas Rama, Jeromine Imbach, Stephany Fiore, Benjamin Ducarouge, David Neves, Huei-Wen Chen, David Bernard, Pan-Chyr Yang, Agnès Bernet, Stephane Depil, Patrick Mehlen
    Cancer Research.2019; 79(14): 3651.     CrossRef
  • Atractylenolide II Induces Apoptosis of Prostate Cancer Cells through Regulation of AR and JAK2/STAT3 Signaling Pathways
    Jing Wang, Moussa Ide Nasser, Salah Adlat, Ming Ming Jiang, Nan Jiang, Li Gao
    Molecules.2018; 23(12): 3298.     CrossRef
  • Proliferation of prostate epithelia induced by IL‐6 from stroma reacted with Trichomonas vaginalis
    J.‐H. Kim, I.‐H. Han, Y.‐S. Kim, C.‐S. Noh, J.‐S. Ryu
    Parasite Immunology.2018;[Epub]     CrossRef
  • Proliferation of Prostate Stromal Cell Induced by Benign Prostatic Hyperplasia Epithelial Cell Stimulated WithTrichomonas vaginalisvia Crosstalk With Mast Cell
    Jung-Hyun Kim, Sang-Su Kim, Ik-Hwan Han, Seobo Sim, Myoung-Hee Ahn, Jae-Sook Ryu
    The Prostate.2016; 76(15): 1431.     CrossRef
  • Signalling pathways associated with IL‐6 production and epithelial–mesenchymal transition induction in prostate epithelial cells stimulated with Trichomonas vaginalis
    I. H. Han, J. H. Kim, S. S. Kim, M. H. Ahn, J. S. Ryu
    Parasite Immunology.2016; 38(11): 678.     CrossRef
  • 13,911 View
  • 178 Download
  • 22 Web of Science
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Brief Communication

Detection and Molecular Characterization of Cryptosporidium spp. from Wild Rodents and Insectivores in South Korea
Juha Song, C-Yoon Kim, Seo-Na Chang, Tamer Said Abdelkader, Juhee Han, Tae-Hyun Kim, Hanseul Oh, Ji Min Lee, Dong-Su Kim, Jong-Taek Kim, Hong-Shik Oh, Moonsuk Hur, Jae-Hwa Suh, Jae-Hak Park
Korean J Parasitol 2015;53(6):737-743.
Published online December 31, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.6.737
In order to examine the prevalence of Cryptosporidium infection in wild rodents and insectivores of South Korea and to assess their potential role as a source of human cryptosporidiosis, a total of 199 wild rodents and insectivore specimens were collected from 10 regions of South Korea and screened for Cryptosporidium infection over a period of 2 years (2012-2013). A nested-PCR amplification of Cryptosporidium oocyst wall protein (COWP) gene fragment revealed an overall prevalence of 34.2% (68/199). The sequence analysis of 18S rRNA gene locus of Cryptosporidium was performed from the fecal and cecum samples that tested positive by COWP amplification PCR. As a result, we identified 4 species/genotypes; chipmunk genotype I, cervine genotype I, C. muris, and a new genotype which is closely related to the bear genotype. The new genotype isolated from 12 Apodemus agrarius and 2 Apodemus chejuensis was not previously identified as known species or genotype, and therefore, it is supposed to be a novel genotype. In addition, the host spectrum of Cryptosporidium was extended to A. agrarius and Crosidura lasiura, which had not been reported before. In this study, we found that the Korean wild rodents and insectivores were infected with various Cryptosporidium spp. with large intra-genotypic variationa, indicating that they may function as potential reservoirs transmitting zoonotic Cryptosporidium to livestock and humans.

Citations

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  • Prevalence and novel genetic characteristics of Cryptosporidium spp. in wild rodents in the northern foothills of the Dabie Mountains, southeast Henan Province, China
    Mengyao Yang, Yin Fu, Pitambar Dhakal, Zi Yan, Jiashu Lang, Chaofeng Ma, Yuhong Jiang, Congzhou Wang, Longxian Zhang, Lihua Xiao,
    PLOS Neglected Tropical Diseases.2025; 19(5): e0013117.     CrossRef
  • Critters and contamination: Zoonotic protozoans in urban rodents and water quality
    Siobhon Egan, Amanda D. Barbosa, Yaoyu Feng, Lihua Xiao, Una Ryan
    Water Research.2024; 251: 121165.     CrossRef
  • Detection and Molecular Characterization of Giardia and Cryptosporidium spp. Circulating in Wild Small Mammals from Portugal
    Laura Lux, Rainer G. Ulrich, Sérgio Santos-Silva, João Queirós, Christian Imholt, Christian Klotz, Joana Paupério, Ricardo Pita, Hélia Vale-Gonçalves, Paulo Célio Alves, João R. Mesquita
    Animals.2023; 13(3): 515.     CrossRef
  • Outbreak of severe diarrhea due to zoonotic Cryptosporidium parvum and C. xiaoi in goat kids in Chungcheongbuk-do, Korea
    Ah-Young Kim, Badriah Alkathiri, Subin Lee, Kyung-Duk Min, Soochong Kim, Sang-Myeong Lee, Wan-Kyu Lee, Dongmi Kwak, Seung-Hun Lee
    Parasitology Research.2023; 122(9): 2045.     CrossRef
  • Cryptosporidium mortiferum n. sp. (Apicomplexa: Cryptosporidiidae), the species causing lethal cryptosporidiosis in Eurasian red squirrels (Sciurus vulgaris)
    Lenka Tůmová, Jana Ježková, Jitka Prediger, Nikola Holubová, Bohumil Sak, Roman Konečný, Dana Květoňová, Lenka Hlásková, Michael Rost, John McEvoy, Lihua Xiao, Monica Santín, Martin Kváč
    Parasites & Vectors.2023;[Epub]     CrossRef
  • Public health and ecological significance of rodents in Cryptosporidium infections
    Kaihui Zhang, Yin Fu, Junqiang Li, Longxian Zhang
    One Health.2022; 14: 100364.     CrossRef
  • Cryptosporidium rattin. sp. (Apicomplexa: Cryptosporidiidae) and genetic diversity ofCryptosporidiumspp. in brown rats (Rattus norvegicus) in the Czech Republic
    Jana Ježková, Jitka Prediger, Nikola Holubová, Bohumil Sak, Roman Konečný, Yaoyu Feng, Lihua Xiao, Michael Rost, John McEvoy, Martin Kváč
    Parasitology.2021; 148(1): 84.     CrossRef
  • The Role of Peridomestic Rodents as Reservoirs for Zoonotic Foodborne Pathogens
    Nusrat A. Jahan, Laramie L. Lindsey, Peter A. Larsen
    Vector-Borne and Zoonotic Diseases.2021; 21(3): 133.     CrossRef
  • Biodiversity of the Coccidia (Apicomplexa: Conoidasida) in vertebrates: what we know, what we do not know, and what needs to be done
    Donald W. Duszynski
    Folia Parasitologica.2021;[Epub]     CrossRef
  • Genetic characterizations of Cryptosporidium spp. from pet rodents indicate high zoonotic potential of pathogens from chinchillas
    Jia Chen, Weijian Wang, Yu Lin, Lianbei Sun, Na Li, Yaqiong Guo, Martin Kvac, Una Ryan, Yaoyu Feng, Lihua Xiao
    One Health.2021; 13: 100269.     CrossRef
  • Zoonotic Cryptosporidium spp. in Wild Rodents and Shrews
    Rauni Kivistö, Sofia Kämäräinen, Otso Huitu, Jukka Niemimaa, Heikki Henttonen
    Microorganisms.2021; 9(11): 2242.     CrossRef
  • Taxonomy and molecular epidemiology of Cryptosporidium and Giardia – a 50 year perspective (1971–2021)
    Una M. Ryan, Yaoyu Feng, Ronald Fayer, Lihua Xiao
    International Journal for Parasitology.2021; 51(13-14): 1099.     CrossRef
  • Molecular Detection of Cryptosporidium spp. and Enterocytozoon bieneusi Infection in Wild Rodents From Six Provinces in China
    Hong-Bo Ni, Yu-Zhe Sun, Si-Yuan Qin, Yan-Chun Wang, Quan Zhao, Zheng-Yao Sun, Miao Zhang, Ding Yang, Zhi-Hui Feng, Zheng-Hao Guan, Hong-Yu Qiu, Hao-Xian Wang, Nian-Yu Xue, He-Ting Sun
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • Serosurvey and molecular detection of the main zoonotic parasites carried by commensal Rattus norvegicus population in Tehran, Iran
    Taher Azimi, Mohammad Reza Pourmand, Fatemeh Fallah, Abdollah Karimi, Roxana Mansour-Ghanaie, Seyedeh Mahsan Hoseini-Alfatemi, Mehdi Shirdoust, Leila Azimi
    Tropical Medicine and Health.2020;[Epub]     CrossRef
  • Diversity of Cryptosporidium spp. in wild rodents from the Canary Islands, Spain
    Katherine García-Livia, Aarón Martín-Alonso, Pilar Foronda
    Parasites & Vectors.2020;[Epub]     CrossRef
  • Diversity of Cryptosporidium spp. in Apodemus spp. in Europe
    Šárka Čondlová, Michaela Horčičková, Nikola Havrdová, Bohumil Sak, Lenka Hlásková, Agnieszka Perec-Matysiak, Marta Kicia, John McEvoy, Martin Kváč
    European Journal of Protistology.2019; 69: 1.     CrossRef
  • Cryptosporidium apodemi sp. n. and Cryptosporidium ditrichi sp. n. (Apicomplexa: Cryptosporidiidae) in Apodemus spp.
    Šárka Čondlová, Michaela Horčičková, Bohumil Sak, Dana Květoňová, Lenka Hlásková, Roman Konečný, Michal Stanko, John McEvoy, Martin Kváč
    European Journal of Protistology.2018; 63: 1.     CrossRef
  • Molecular characterizations of Cryptosporidium spp. and Enterocytozoon bieneusi in brown rats (Rattus norvegicus) from Heilongjiang Province, China
    Wei Zhao, Jianguang Wang, Guangxu Ren, Ziyin Yang, Fengkun Yang, Weizhe Zhang, Yingchu Xu, Aiqin Liu, Hong Ling
    Parasites & Vectors.2018;[Epub]     CrossRef
  • Subtype analysis of zoonotic pathogen Cryptosporidium skunk genotype
    Wenchao Yan, Kerri Alderisio, Dawn M. Roellig, Kristin Elwin, Rachel M. Chalmers, Fengkun Yang, Yuanfei Wang, Yaoyu Feng, Lihua Xiao
    Infection, Genetics and Evolution.2017; 55: 20.     CrossRef
  • Native and introduced squirrels in Italy host different Cryptosporidium spp.
    Jitka Prediger, Michaela Horčičková, Lada Hofmannová, Bohumil Sak, Nicola Ferrari, Maria Vittoria Mazzamuto, Claudia Romeo, Lucas A. Wauters, John McEvoy, Martin Kváč
    European Journal of Protistology.2017; 61: 64.     CrossRef
  • Cryptosporidium homai n. sp. (Apicomplexa: Cryptosporidiiae) from the guinea pig (Cavia porcellus)
    Alireza Zahedi, Zoey Durmic, Alexander W. Gofton, Susan Kueh, Jill Austen, Malcolm Lawson, Lauren Callahan, John Jardine, Una Ryan
    Veterinary Parasitology.2017; 245: 92.     CrossRef
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  • 134 Download
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Case Reports

A Case of Ocular Toxocariasis Successfully Treated with Albendazole and Triamcinolon
San Seong, Daruchi Moon, Dong Kyu Lee, Hyung Eun Kim, Hyun Sup Oh, Soon Hyun Kim, Oh Woong Kwon, Yong Sung You
Korean J Parasitol 2014;52(5):537-540.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.537

We present a case of ocular toxocariasis treated successfully with oral albendazole in combination with steroids. A 26-year-old male visited the authors' clinic with the chief complaint of flying flies in his right eye. The fundus photograph showed a whitish epiretinal scar, and the fluorescein angiography revealed a hypofluorescein lesion of the scar and late leakage at the margin. An elevated retinal surface and posterior acoustic shadowing of the scar were observed in the optical coherence tomography, and Toxocara IgG was positive. The patient was diagnosed with toxocariasis, and the condition was treated with albendazole (400 mg twice a day) for a month and oral triamcinolone (16 mg for 2 weeks, once a day, and then 8 mg for 1 week, once a day) from day 13 of the albendazole treatment. The lesions decreased after the treatment. Based on this study, oral albendazole combined with steroids can be a simple and effective regimen for treating ocular toxocariasis.

Citations

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  • Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection
    Katrin Henke, Sotirios Ntovas, Eleni Xourgia, Aristomenis K. Exadaktylos, Jolanta Klukowska-Rötzler, Mairi Ziaka
    International Journal of Environmental Research and Public Health.2023; 20(21): 6972.     CrossRef
  • Toxocariasis ocular simulando un hamartoma retiniano. Reportefide un caso
    Luis R. Michel-Espinoza, Belina Arias-Cabello, Daniel Moreno-Páramo, M. Estela Arroyo-Yllanes
    Revista Mexicana de Oftalmología.2021; 95(6S): 285.     CrossRef
  • Treatment of larva migrans syndrome with long-term administration of albendazole
    Amy Hombu, Ayako Yoshida, Taisei Kikuchi, Eiji Nagayasu, Mika Kuroki, Haruhiko Maruyama
    Journal of Microbiology, Immunology and Infection.2019; 52(1): 100.     CrossRef
  • Ocular toxocariasis in a pediatric patient undergoing a bone marrow transplantation
    Blanca Molina, Marta González-Vicent, Isabel Valls, Miguel Ángel Díaz
    Enfermedades Infecciosas y Microbiología Clínica.2019; 37(9): 617.     CrossRef
  • Ocular toxocariasis: a neglected parasitic disease in Egypt
    Nagwa Mostafa El-Sayed, Nagham Gamal Masoud
    Bulletin of the National Research Centre.2019;[Epub]     CrossRef
  • Ocular toxocariasis in a pediatric patient undergoing a bone marrow transplantation
    Blanca Molina, Marta González-Vicent, Isabel Valls, Miguel Ángel Díaz
    Enfermedades infecciosas y microbiologia clinica (English ed.).2019; 37(9): 618.     CrossRef
  • Toxocariasis: critical analysis of serology in patients attending a public referral center for ophthalmology in Brazil
    Guita Rubinsky-Elefant, Joyce H. Yamamoto, Carlos E. Hirata, Luiz E. Prestes-Carneiro
    Japanese Journal of Ophthalmology.2018; 62(1): 77.     CrossRef
  • 13,218 View
  • 124 Download
  • 5 Web of Science
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A Case of Oral Myiasis Caused by Lucilia sericata (Diptera: Calliphoridae) in Korea
Mun Jang, Seung-Min Ryu, Sang-Chang Kwon, Jun-Ouk Ha, Young-Hoon Kim, Dong-Hyun Kim, Soon-Myung Jung, Soon-Il Lee, Woon-Mok Sohn, Hee-Jae Cha, Meesun Ock
Korean J Parasitol 2013;51(1):119-123.
Published online February 18, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.1.119

We report here a case of oral myiasis in the Republic of Korea. The patient was a 37-year-old man with a 30-year history of Becker's muscular dystrophy. He was intubated due to dyspnea 8 days prior to admission to an intensive care unit (ICU). A few hours after the ICU admission, 43 fly larvae were found during suction of the oral cavity. All maggots were identified as the third instars of Lucilia sericata (Diptera: Calliphoridae) by morphology. We discussed on the characteristics of myiasis acquired in Korea, including the infection risk and predisposing factors.

Citations

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  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Oral and Nasal Myiasis in Two Patients Hospitalized in the Intensive Care Unit: Diagnosis and Clinical Significance of Cases
    Nilgün Savaş, Mehmet Aykur
    Indian Journal of Otolaryngology and Head & Neck Surgery.2024; 76(5): 4677.     CrossRef
  • The Price of Hospital Reshaping: Nasal Myiasis Caused by Flesh Fly (Diptera: Sarcophagidae) in Reallocated COVID-19 Intensive Care Unit
    Vladimir Dolinaj, Jasmina Grujić, Davor Križanović, Aleksandar Potkonjak, Thomas Pape, Pavle Banović
    Healthcare.2023; 11(11): 1533.     CrossRef
  • Oral myiasis: Analysis of cases reported in the English literature from 1990 to 2020
    Juliana Bianchi Souza dos Passos, Luiza Vale Coelho, José Alcides Almeida de Arruda, Leni Verônica de Oliveira Silva, Isabella Bittencourt do Valle, Mariana de Souza Santos, Eugênia Leal de Figueiredo, Lucas Guimarães Abreu, Ricardo Alves Mesquita
    Special Care in Dentistry.2021; 41(1): 20.     CrossRef
  • Aspiration as a Novel Technique to Address Facial and Periocular Myiasis
    Jonathan E. Lu, Sukriti Mohan, Margaret L. Pfeiffer, Bhavishya S. Clark, Jessica R. Chang
    Ophthalmic Plastic & Reconstructive Surgery.2021; 37(5): e172.     CrossRef
  • Orbital myiasis
    Yan-Ling Huang, Lu Liu, Hao Liang, Jian He, Jun Chen, Qiao-Wen Liang, Zhi-Yuan Jiang, Jian-Feng He, Min-Li Huang, Yi Du
    Medicine.2020; 99(4): e18879.     CrossRef
  • Wettability Property In Natural Systems: A Case of Flying Insects
    J. Sackey, B. T. Sone, K. A. Dompreh, M. Maaza
    MRS Advances.2018; 3(42-43): 2697.     CrossRef
  • Oral Myiasis Affecting Gingiva in a Child Patient: An Uncommon Case Report
    Fareedi Mukram Ali, Kishor Patil, Sanjay Kar, Atulkumar A. Patil, Shabeer Ahamed
    Case Reports in Dentistry.2016; 2016: 1.     CrossRef
  • Maggot debridement therapy as primary tool to treat chronic wound of animals
    Vijayata Choudhary, Mukesh Choudhary, Sunanda Pandey, Vandip D. Chauhan, J. J. Hasnani
    Veterinary World.2016; 9(4): 403.     CrossRef
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    Elena Pilli, Alessandro Agostino, Debora Vergani, Elena Salata, Ignazio Ciuna, Andrea Berti, David Caramelli, Simonetta Lambiase
    Forensic Science International.2016; 266: e71.     CrossRef
  • Canine Wound Myiasis Caused by Lucilia sericata (Diptera: Calliphoridae) in Korea
    Seongjun Choe, Dongmin Lee, Hansol Park, Hyeong-Kyu Jeon, Hakhyun Kim, Ji-Houn Kang, Cha-Ho Jee, Keeseon S. Eom
    The Korean Journal of Parasitology.2016; 54(5): 667.     CrossRef
  • A Case of Aural Myiasis in Chronic Alcoholism Patient
    Sung Hoon Jung, Jae Hwan Jung, Seok Hyun Kim, Yang Jae Kim
    Journal of Clinical Otolaryngology Head and Neck Surgery.2016; 27(2): 332.     CrossRef
  • Scanning Electron Microscopy Investigations of Third-Instar Larva of Cordylobia rodhaini (Diptera: Calliphoridae), an Agent of Furuncular Myiasis
    M. Pezzi, R. Cultrera, M. Chicca, M. Leis
    Journal of Medical Entomology.2015; 52(3): 368.     CrossRef
  • A Case of Endoscopic Removal of Nasal Myiasis in Cerebral Infarction Patient
    Jung-Uk Han, Sang Hyok Suk, Jun Sick Im, Bo Young Kim
    Journal of Rhinology.2015; 22(1): 51.     CrossRef
  • Mass Rearing and Life Table Attributes of Two Cyclorrhaphan Flies, Lucilia sericata Meigen (Diptera: Calliphoridae) and Musca domestica L. (Diptera: Muscidae) under Laboratory Conditions
    Vahid Saleh, Aboozar Soltani, Tahere Dabaghmane, Hamzeh Alipour, Kourosh Azizi, Mohammad Djaefar Moemenbell
    Journal of Entomology.2014; 11(5): 291.     CrossRef
  • Flies and the mouth
    Yazan Hassona, Crispian Scully, Miranda Aguida, Oslei Paes de Almeida
    Journal of Investigative and Clinical Dentistry.2014; 5(2): 98.     CrossRef
  • A Case of Nosocomial Nasal Myiasis in Comatose Patient
    Sung Jae Heo, Mi Jin Lee, Chang Mook Park, Jung Soo Kim
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2013; 56(10): 664.     CrossRef
  • 12,509 View
  • 109 Download
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Brief Communications

Detection of Ocular Toxoplasma gondii Infection in Chronic Irregular Recurrent Uveitis by PCR
Sang-Eun Lee, Sung-Hee Hong, Seong-Ho Lee, Young-Il Jeong, Su Jin Lim, Oh Woong Kwon, Sun Hyun Kim, Young Sung You, Shin-Hyeong Cho, Won-Ja Lee
Korean J Parasitol 2012;50(3):229-231.
Published online August 13, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.3.229

Toxoplasma gondii is a zoonotic parasite resulting in human infections and one of the infectious pathogens leading to uveitis and retinochoroiditis. The present study was performed to assess T. gondii infection in 20 ocular patients with chronic irregular recurrent uveitis (20 aqueous humor and 20 peripheral blood samples) using PCR. All samples were analyzed by nested PCR targeting a specific B1 gene of T. gondii. The PCR-positive rate was 25% (5/20), including 5% (1) in blood samples, 25% (5) in aqueous humor samples, and 5% (1) in both sample types. A molecular screening test for T. gondii infection in ocular patients with common clinical findings of an unclear retinal margin and an inflammatory membrane over the retina, as seen by fundus examination, may be helpful for early diagnosis and treatment.

Citations

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  • Molecular diagnosis of toxoplasmosis in immunocompromised patients
    Florence Robert-Gangneux, Sorya Belaz
    Current Opinion in Infectious Diseases.2016; 29(4): 330.     CrossRef
  • IgG Avidity Antibodies against Toxoplasma gondii in High Risk Females of Reproductive Age Group in India
    Naushaba Siddiqui, Fatima Shujatullah, Haris M. Khan, Tamkin Rabbani, Parvez A. Khan
    The Korean Journal of Parasitology.2014; 52(5): 487.     CrossRef
  • Establecimiento de una reacción en cadena de la polimerasa para la detección de bacterias y hongos
    Héctor Javier Pérez-Cano
    Revista Mexicana de Oftalmología.2014; 88(2): 67.     CrossRef
  • PCR-Based Detection of Toxoplasma gondii DNA in Blood and Ocular Samples for Diagnosis of Ocular Toxoplasmosis
    C. Bourdin, A. Busse, E. Kouamou, F. Touafek, B. Bodaghi, P. Le Hoang, D. Mazier, L. Paris, A. Fekkar, M. J. Loeffelholz
    Journal of Clinical Microbiology.2014; 52(11): 3987.     CrossRef
  • Prevalence and Genetic Characterization of Toxoplasma gondii in House Sparrows (Passer domesticus) in Lanzhou, China
    Wei Cong, Si-Yang Huang, Dong-Hui Zhou, Xiao-Xuan Zhang, Nian-Zhang Zhang, Quan Zhao, Xing-Quan Zhu
    The Korean Journal of Parasitology.2013; 51(3): 363.     CrossRef
  • Serologic Survey of Toxoplasmosis in Seoul and Jeju-do, and a Brief Review of Its Seroprevalence in Korea
    Hyemi Lim, Sang-Eun Lee, Bong-Kwang Jung, Min-Ki Kim, Mi Youn Lee, Ho-Woo Nam, Jong-Gyun Shin, Cheong-Ha Yun, Han-Ik Cho, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2012; 50(4): 287.     CrossRef
  • 9,756 View
  • 62 Download
  • Crossref
Naegleria fowleri Lysate Induces Strong Cytopathic Effects and Pro-inflammatory Cytokine Release in Rat Microglial Cells
Yang-Jin Lee, Chang-Eun Park, Jong-Hyun Kim, Hae-Jin Sohn, Jinyoung Lee, Suk-Yul Jung, Ho-Joon Shin
Korean J Parasitol 2011;49(3):285-290.
Published online September 30, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.3.285

Naegleria fowleri, a ubiquitous free-living ameba, causes fatal primary amebic meningoencephalitis in humans. N. fowleri trophozoites are known to induce cytopathic changes upon contact with microglial cells, including necrotic and apoptotic cell death and pro-inflammatory cytokine release. In this study, we treated rat microglial cells with amebic lysate to probe contact-independent mechanisms for cytotoxicity, determining through a combination of light microscopy and scanning and transmission electron microscopy whether N. fowleri lysate could effect on both necrosis and apoptosis on microglia in a time- as well as dose-dependent fashion. A 51Cr release assay demonstrated pronounced lysate induction of cytotoxicity (71.5%) toward microglial cells by 24 hr after its addition to cultures. In an assay of pro-inflammatory cytokine release, microglial cells treated with N. fowleri lysate produced TNF-α, IL-6, and IL-1β, though generation of the former 2 cytokines was reduced with time, and that of the last increased throughout the experimental period. In summary, N. fowleri lysate exerted strong cytopathic effects on microglial cells, and elicited pro-inflammatory cytokine release as a primary immune response.

Citations

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  • Providing an in vitro depiction of microglial cells challenged with immunostimulatory extracellular vesicles of Naegleria fowleri
    Lissette Retana Moreira, Alberto Cornet-Gomez, M. Rosario Sepulveda, Silvia Molina-Castro, Johan Alvarado-Ocampo, Frida Chaves Monge, Mariana Jara Rojas, Antonio Osuna, Elizabeth Abrahams Sandí
    Frontiers in Microbiology.2024;[Epub]     CrossRef
  • Transcriptomic profiling of “brain-eating amoeba” Naegleria fowleri infection in mice: the host and the protozoa perspectives
    Vincent Guerlais, Nina Allouch, E. Ashley Moseman, Alicja W. Wojciechowska, Jakub W. Wojciechowski, Isabel Marcelino
    Frontiers in Cellular and Infection Microbiology.2024;[Epub]     CrossRef
  • Pro-inflammatory cytokine responses to Naegleria fowleri infection
    Ching-wen Chen, E. Ashley Moseman
    Frontiers in Tropical Diseases.2023;[Epub]     CrossRef
  • Naegleria fowleri Extracellular Vesicles Induce Proinflammatory Immune Responses in BV-2 Microglial Cells
    Hương Giang Lê, Jung-Mi Kang, Tuấn Cường Võ, Won Gi Yoo, Byoung-Kuk Na
    International Journal of Molecular Sciences.2023; 24(17): 13623.     CrossRef
  • Three encephalitis-causing amoebae and their distinct interactions with the host
    Maarten J. Sarink, Nadia L. van der Meijs, Kristin Denzer, Leo Koenderman, Aloysius G.M. Tielens, Jaap J. van Hellemond
    Trends in Parasitology.2022; 38(3): 230.     CrossRef
  • Extracellular Vesicles from Naegleria fowleri Induce IL-8 Response in THP-1 Macrophage
    Sakaorat Lertjuthaporn, Jinjuta Somkird, Kittima Lekmanee, Anyapat Atipimonpat, Kasama Sukapirom, Hathai Sawasdipokin, Supathra Tiewcharoen, Kovit Pattanapanyasat, Ladawan Khowawisetsut
    Pathogens.2022; 11(6): 632.     CrossRef
  • Naegleria fowleri Cathepsin B Induces a Pro-Inflammatory Immune Response in BV-2 Microglial Cells via NF-κB and AP-1 Dependent-MAPK Signaling Pathway
    Hương Giang Lê, Jung-Mi Kang, Tuấn Cường Võ, Byoung-Kuk Na
    International Journal of Molecular Sciences.2022; 23(15): 8388.     CrossRef
  • Parasite infections, neuroinflammation, and potential contributions of gut microbiota
    Jérémy Alloo, Ines Leleu, Corinne Grangette, Sylviane Pied
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro
    Thị Lam Thái, Jung-Mi Kang, Hương Giang Lê, Jinyoung Lee, Won Gi Yoo, Ho-Joon Shin, Woon-Mok Sohn, Byoung-Kuk Na
    Parasites & Vectors.2020;[Epub]     CrossRef
  • Toll-like receptors participate in Naegleria fowleri recognition
    Moisés Martínez-Castillo, Leopoldo Santos-Argumedo, José Manuel Galván-Moroyoqui, Jesús Serrano-Luna, Mineko Shibayama
    Parasitology Research.2018; 117(1): 75.     CrossRef
  • Morphological and functional changes of microglia cultured under different oxygen concentrations and the analysis of related mechanisms
    Xing Wu, Tengbo Yu, Hongyan Xu, Xiuming Sun, Dewei Kou, Liping Li
    Experimental and Therapeutic Medicine.2017;[Epub]     CrossRef
  • Biology and pathogenesis of Naegleria fowleri
    Ruqaiyyah Siddiqui, Ibne Karim M. Ali, Jennifer R. Cope, Naveed Ahmed Khan
    Acta Tropica.2016; 164: 375.     CrossRef
  • NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri
    Jong-Hyun Kim, Hae-Jin Sohn, Jong-Kyun Yoo, Heekyoung Kang, Gi-Sang Seong, Yong-Joon Chwae, Kyongmin Kim, Sun Park, Ho-Joon Shin, J. A. Appleton
    Infection and Immunity.2016; 84(9): 2422.     CrossRef
  • Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory–secretory proteins and their biochemical properties
    Jinyoung Lee, Jong-Hyun Kim, Hae-Jin Sohn, Hee-Jong Yang, Byoung-Kuk Na, Yong-Joon Chwae, Sun Park, Kyongmin Kim, Ho-Joon Shin
    Parasitology Research.2014; 113(8): 2765.     CrossRef
  • 10,817 View
  • 103 Download
  • Crossref

Original Article

Contact-Independent Cell Death of Human Microglial Cells due to Pathogenic Naegleria fowleri Trophozoites
Jong-Hyun Kim, Daesik Kim, Ho-Joon Shin
Korean J Parasitol 2008;46(4):217-221.
Published online December 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.4.217

Free-living Naegleria fowleri leads to a fatal infection known as primary amebic meningoencephalitis in humans. Previously, the target cell death could be induced by phagocytic activity of N. fowleri as a contact-dependent mechanism. However, in this study we investigated the target cell death under a non-contact system using a tissue-culture insert. The human microglial cells, U87MG cells, co-cultured with N. fowleri trophozoites for 30 min in a non-contact system showed morphological changes such as the cell membrane destruction and a reduction in the number. By fluorescence-activated cell sorter (FACS) analysis, U87MG cells co-cultured with N. fowleri trophozoites in a non-contact system showed a significant increasse of apoptotic cells (16%) in comparison with that of the control or N. fowleri lysate. When U87MG cells were co-cultured with N. fowleri trophozoites in a non-contact system for 30 min, 2 hr, and 4 hr, the cytotoxicity of amebae against target cells was 40.5, 44.2, and 45.6%, respectively. By contrast, the cytotoxicity of non-pathogenic N. gruberi trophozoites was 10.2, 12.4, and 13.2%, respectively. These results suggest that the molecules released from N. fowleri in a contact-independent manner as well as phagocytosis in a contact-dependent manner may induce the host cell death.

Citations

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  • Cloning of nf-profilin and intercellular interaction with nf-actin in Naegleria fowleri cysts
    Hae-Jin Sohn, A-Jeong Ham, A-Young Park, Jeong-Heon Lee, Sun Park, Ho-Joon Shin, Jong-Hyun Kim
    Scientific Reports.2025;[Epub]     CrossRef
  • Advances in the study of extracellular vesicles of Naegleria fowleri and their role in contact-independent pathogenic mechanisms
    Ismael Castelan-Ramírez, Catalina Flores-Maldonado, Dolores Hernández-Martínez, Lizbeth Salazar-Villatoro, Alberto Daniel Saucedo-Campos, David Segura-Cobos, Adolfo René Méndez-Cruz, Maritza Omaña-Molina
    Parasites & Vectors.2025;[Epub]     CrossRef
  • A comprehensive review on the neurological impact of parasitic infections
    Firooz Shahrivar, Ata Moghimi, Ramin Hosseinzadeh, Mohammad Hasan Kohansal, Ali Mortazavi, Tahereh Mikaeili Galeh, Ehsan Ahmadpour
    Microbial Pathogenesis.2025; 206: 107762.     CrossRef
  • Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba
    N. Datta
    The Journal of V. N. Karazin Kharkiv National University, Series "Biology".2024; (42): 22.     CrossRef
  • Extracellular Vesicles from Naegleria fowleri Induce IL-8 Response in THP-1 Macrophage
    Sakaorat Lertjuthaporn, Jinjuta Somkird, Kittima Lekmanee, Anyapat Atipimonpat, Kasama Sukapirom, Hathai Sawasdipokin, Supathra Tiewcharoen, Kovit Pattanapanyasat, Ladawan Khowawisetsut
    Pathogens.2022; 11(6): 632.     CrossRef
  • Differential Exoproteome and Biochemical Characterisation of Neoparamoeba perurans
    Kerrie Ní Dhufaigh, Natasha Botwright, Eugene Dillon, Ian O’Connor, Eugene MacCarthy, Orla Slattery
    Microorganisms.2021; 9(6): 1258.     CrossRef
  • Naegleria fowleri Induces Jurkat T Cell Death via O-deGlcNAcylation
    Young Ah Lee, Kyeong Ah Kim, Myeong Heon Shin
    The Korean Journal of Parasitology.2021; 59(5): 501.     CrossRef
  • Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro
    Thị Lam Thái, Jung-Mi Kang, Hương Giang Lê, Jinyoung Lee, Won Gi Yoo, Ho-Joon Shin, Woon-Mok Sohn, Byoung-Kuk Na
    Parasites & Vectors.2020;[Epub]     CrossRef
  • Cellular characterization of actin gene concerned with contact‐dependent mechanisms in Naegleria fowleri
    Hae‐Jin Sohn, Kyoung‐Ju Song, Heekyoung Kang, A‐Jeong Ham, Jae‐Ho Lee, Yong‐Joon Chwae, Kyongmin Kim, Sun Park, Jong‐Hyun Kim, Ho‐Joon Shin
    Parasite Immunology.2019;[Epub]     CrossRef
  • Cytopathic Change and Inflammatory Response of Human Corneal Epithelial Cells Induced by Acanthamoeba castellanii Trophozoites and Cysts
    Hae-Jin Sohn, Ga-Eun Seo, Jae-Ho Lee, A-Jeong Ham, Young-Hwan Oh, Heekyoung Kang, Ho-Joon Shin
    The Korean Journal of Parasitology.2019; 57(3): 217.     CrossRef
  • In Vitro Activity of Statins against Naegleria fowleri
    Aitor Rizo-Liendo, Ines Sifaoui, María Reyes-Batlle, Olfa Chiboub, Rubén L. Rodríguez-Expósito, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Edyta B. Hendiger, Atteneri López-Arencibia, Pedro Rocha-Cabrera, José E. Piñero, Jacob Lorenzo-
    Pathogens.2019; 8(3): 122.     CrossRef
  • Excretory and Secretory Proteins of Naegleria fowleri Induce Inflammatory Responses in BV‐2 Microglial Cells
    Jinyoung Lee, Jung‐Mi Kang, Tae Im Kim, Jong‐Hyun Kim, Hae‐Jin Sohn, Byoung‐Kuk Na, Ho‐Joon Shin
    Journal of Eukaryotic Microbiology.2017; 64(2): 183.     CrossRef
  • Amphotericin B induces apoptosis-like programmed cell death in Naegleria fowleri and Naegleria gruberi
    Roberto Cárdenas-Zúñiga, Angélica Silva-Olivares, José D' Artagnan Villalba-Magdaleno, Virginia Sánchez-Monroy, Jesús Serrano-Luna, Mineko Shibayama
    Microbiology.2017; 163(7): 940.     CrossRef
  • Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri
    Gi-Sang Seong, Hae-Jin Sohn, Heekyoung Kang, Ga-Eun Seo, Jong-Hyun Kim, Ho-Joon Shin
    Experimental Parasitology.2017; 183: 171.     CrossRef
  • Biology and pathogenesis of Naegleria fowleri
    Ruqaiyyah Siddiqui, Ibne Karim M. Ali, Jennifer R. Cope, Naveed Ahmed Khan
    Acta Tropica.2016; 164: 375.     CrossRef
  • Naegleria fowleri after 50 years: is it a neglected pathogen?
    Moisés Martínez-Castillo, Roberto Cárdenas-Zúñiga, Daniel Coronado-Velázquez, Anjan Debnath, Jesús Serrano-Luna, Mineko Shibayama
    Journal of Medical Microbiology.2016; 65(9): 885.     CrossRef
  • NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri
    Jong-Hyun Kim, Hae-Jin Sohn, Jong-Kyun Yoo, Heekyoung Kang, Gi-Sang Seong, Yong-Joon Chwae, Kyongmin Kim, Sun Park, Ho-Joon Shin, J. A. Appleton
    Infection and Immunity.2016; 84(9): 2422.     CrossRef
  • Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory–secretory proteins and their biochemical properties
    Jinyoung Lee, Jong-Hyun Kim, Hae-Jin Sohn, Hee-Jong Yang, Byoung-Kuk Na, Yong-Joon Chwae, Sun Park, Kyongmin Kim, Ho-Joon Shin
    Parasitology Research.2014; 113(8): 2765.     CrossRef
  • Naegleria fowleriLysate Induces Strong Cytopathic Effects and Pro-inflammatory Cytokine Release in Rat Microglial Cells
    Yang-Jin Lee, Chang-Eun Park, Jong-Hyun Kim, Hae-Jin Sohn, Jinyoung Lee, Suk-Yul Jung, Ho-Joon Shin
    The Korean Journal of Parasitology.2011; 49(3): 285.     CrossRef
  • Screening of Swiss hot spring resorts for potentially pathogenic free-living amoebae
    Christian Gianinazzi, Marc Schild, Beatrice Zumkehr, Fritz Wüthrich, Irina Nüesch, Regula Ryter, Nadia Schürch, Bruno Gottstein, Norbert Müller
    Experimental Parasitology.2010; 126(1): 45.     CrossRef
  • Immunodominant antigens in Naegleria fowleri excretory–secretory proteins were potential pathogenic factors
    Jong-Hyun Kim, Ae-Hee Yang, Hae-Jin Sohn, Daesik Kim, Kyoung-Ju Song, Ho-Joon Shin
    Parasitology Research.2009; 105(6): 1675.     CrossRef
  • 9,554 View
  • 90 Download
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Brief Communication
Effects of exogenous glucose on survival and infectivity of Schistosoma mansoni cercariae
Bernard Fried, Robert Laterra, Yonghyun Kim
Korean J Parasitol 2002;40(1):55-58.
Published online March 31, 2002
DOI: https://doi.org/10.3347/kjp.2002.40.1.55

The effects of exogenous glucose in artificial spring water (ASW) were studied on the survival and infectivity of Schistosoma mansoni cercariae. The mean percent survival of cercariae maintained in 1% glucose in ASW for 36 and 48hr was significantly greater than that of cercariae maintained identically in ASW. Cercariae maintained in ASW with or without glucose for 24hr, fixed in neutral buffered formalin, and stained in Oil Red O, showed an accumulation of neutral lipid in the tail. Cercariae maintained as described above and stained in periodic acid-Schiff exhibited depleted glycogen, mainly from the tail. Cercariae maintained in ASW with glucose for 24hr did not resynthesize glycogen. Cercariae maintained in ASW with glucose for 24hr were as capable of infecting male FVBN202 mice as were freshly emerged cercariae, and increased the percent of worm recovery. Exogeneous glucose added to ASW prolonged the survival of S. mansoni cercariae and increased infectivity in terms of worm recovery.

Citations

Citations to this article as recorded by  Crossref logo
  • Heads or tails? Differential translational regulation in cercarial heads and tails of schistosome worms
    James R. Hagerty, Emmitt R. Jolly, Salah A. Sheweita
    PLOS ONE.2019; 14(10): e0224358.     CrossRef
  • In Vitro Maintenance of Clonorchis sinensis Adult Worms
    Md. Hafiz Uddin, Shunyu Li, Young Mee Bae, Min-Ho Choi, Sung-Tae Hong
    The Korean Journal of Parasitology.2012; 50(4): 309.     CrossRef
  • Bile components and amino acids affect survival of the newly excysted juvenile Clonorchis sinensis in maintaining media
    Shunyu Li, Tae Im Kim, Won Gi Yoo, Pyo Yun Cho, Tong-Soo Kim, Sung-Jong Hong
    Parasitology Research.2008; 103(5): 1019.     CrossRef
  • Effects of glucose on survival, infectivity and linear movement of the cercariae of Echinostoma caproni
    E.L. Ponder, B. Fried
    Journal of Helminthology.2004; 78(2): 185.     CrossRef
  • Emergence of cercariae of Echinostoma caproni and Schistosoma mansoni from Biomphalaria glabrata under different laboratory conditions
    B. Fried, R. Laterra, Y. Kim
    Journal of Helminthology.2002; 76(4): 369.     CrossRef
  • 7,442 View
  • 102 Download
  • Crossref
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