Parasites, Hosts and Diseases

"hepatic"

Case Reports

A case of hepatic anisakidosis caused by Anisakis pegreffii mimicking liver cancer: Minoru Yamada, Fumi Murakoshi, Hisashi Ikoma, Osamu Inamori, Akio Yanagisawa, Eiichi Konishi; Parasites Hosts Dis 2023;61(3):292-297.
Published online August 21, 2023; DOI: https://doi.org/10.3347/PHD.23055

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Extra-gastrointestinal anisakidosis is rare. We herein report an Anisakis pegreffii infection in a patient with hepatic anisakidosis diagnosed based on its molecular identification. A 71-year-old male patient had a hepatic tumor presenting as a low-density area of 20 mm in diameter in segment 6 of the liver on abdominal ultrasonography, computed tomography, and magnetic resonance imaging. The surgically resected pathological specimen revealed a necrotizing eosinophilic granuloma containing nematode larvae, possibly an Anisakis larva. Molecular and phylogenetic analysis demonstrated Anisakis larvae belonging to A. pegreffii. The present results will help identify and characterize unknown Anisakis species in histological sections.

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Anisakidae and Anisakidosis: A Public Health Perspective
Diana Nonković, Vanja Tešić, Vida Šimat, Svjetlana Karabuva, Alan Medić, Jerko Hrabar
Pathogens.2025; 14(3): 217. CrossRef
Screening of Anisakis-Related Allergies and Associated Factors in a Mediterranean Community Characterized by High Seafood Consumption
Santo Fruscione, Maria Barrale, Maurizio Zarcone, Davide Alba, Barbara Ravazzolo, Miriam Belluzzo, Rosa Onida, Gaetano Cammilleri, Antonella Costa, Vincenzo Ferrantelli, Alessandra Savatteri, Daniele Domenico De Bella, Salvatore Pipitone, Alida D’Atria, A
Foods.2024; 13(17): 2821. CrossRef

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A Case of Alveolar Echinococcosis Occurring in the Hilar Bile Duct: Jinyu Yang, Zhanxue Zhao, Shuai Li, Hekai Chen; Korean J Parasitol 2019;57(5):517-520.
Published online October 31, 2019; DOI: https://doi.org/10.3347/kjp.2019.57.5.517

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Echinococcosis is a disease caused by the Echinococcus species that parasitizes in humans. Alveolar echinococcosis (AE) which is caused by Echinococcus multilocularis is harmful to humans. AE mainly occurs in the liver and can be transferred to retroperitoneal lymph nodes, lung, brain, bone, spleen and other organs through lymphatic and blood vessels. Cholangiocarcinoma can occur in the intrahepatic and extrahepatic bile ducts and is more common in the hilar. We reported a case of hilar bile duct alveolar echinococcosis which was originally misdiagnosed an cholangiocarcinoma.

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An innovative mathematical approach to the evaluation of susceptibility in liver disorder based on fuzzy parameterized complex fuzzy hypersoft set
Atiqe Ur Rahman, Muhammad Saeed, Mazin Abed Mohammed, Karrar Hameed Abdulkareem, Jan Nedoma, Radek Martinek
Biomedical Signal Processing and Control.2023; 86: 105204. CrossRef
In vivo and in vitro efficacy of crocin against Echinococcus multilocularis
Chuanchuan Liu, Haining Fan, Lu Guan, Ri-li Ge, Lan Ma
Parasites & Vectors.2021;[Epub] CrossRef

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Original Article

Platynosomum fastosum (Trematoda: Dicrocoeliidae) from Cats in Vietnam: Morphological Redescription and Molecular Phylogenetics: Hung Manh Nguyen, Hien Van Hoang, Loan Thi Ho; Korean J Parasitol 2017;55(1):39-45.
Published online February 28, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.1.39

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The present study was performed to reveal the morphological characteristics and molecular phylogenetic position of Platynosomum fastosum Kossack, 1910. A total 167 specimens of P. fastosum were collected in 8 (4.9%) out of 163 sets of gall-bladders and bile ducts of cats. The number of worms was 1-105 per infected cat. This species was characterized by having a long and slender body, slightly larger ventral sucker than the oral sucker, indistinct prepharynx, small pharynx, short esophagus, bifurcation midway between 2 suckers, and ceca extending to the posterior end of the body. The length of the partial sequences of ITS1 and 5.8S rDNA of P. fastosum were 990 bp, GC-rich. AT/GC ratio was 0.9, there were 9 polymorphic sites, and intraspecific variations ranged from 0.1% to 0.9%. Phylogenetic analyses by neighbor-joining phylogram inferred from ITS1 rDNA sequences revealed that the genetic distance between P. fastosum specimens ranged from 0.3 to 1.5% while the smallest interspecific distance among dicrocoeliid species was 20.9 %. The redescription and genetic characters of P. fastosum are taxonomically important to recognize future different species of the genus Platynosomum showing high intraspecific and morphological variability.

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Giant cell hepatitis with Platynosomum illiciens infection in a Japanese domestic cat
Natsumi Kobayashi, Aya Masuda, Jun Matsumoto, Natsumi Asai, Nobuhiko Hida, Tomoaki Murakami
Journal of Veterinary Diagnostic Investigation.2025; 37(6): 942. CrossRef
Occurrence and Risk Factors Associated with Platynosomum illiciens Infection in Cats with Elevated Liver Enzymes
Pinkarn Chantawong, Jiraporn Potiwong, Natchanon Choochote, Kakanang Piyarungsri, Chakorn Kunkaew, Sahatchai Tangtrongsup, Saruda Tiwananthagorn
Animals.2024; 14(7): 1065. CrossRef
Morphological and molecular data on helminths of Didelphis virginiana and Philander vossi (Mammalia: Didelphidae) from the Yucatán Peninsula, southeast Mexico
JESÚS ALONSO PANTI-MAY, ANYELA JACKELIN CHAN-CASANOVA, ELSY CANCHE-POOL, RAÚL TELLO-MARTÍN, HUGO RUIZ-PIÑA, HENRY CONCHA-GUILLERMO, OSCAR RETANA-GUIASCÓN, PEDRO PABLO MARTÍNEZ VEGA, JUAN CHABLÉ-SANTOS, ERENDIRA ESTRELLA-MARTÍNEZ, WILSON ISAIAS MOGUEL-CHIN
Zootaxa.2024; 5463(1): 1. CrossRef
Survey on the prevalence of intestinal parasites in domestic cats (Felis catus Linnaeus, 1758) in central Nepal
Roshan Babu Adhikari, Madhuri Adhikari Dhakal, Purna Bahadur Ale, Ganga Ram Regmi, Tirth Raj Ghimire
Veterinary Medicine and Science.2023; 9(2): 559. CrossRef
A systematic review and meta-analysis on the global status of Platynosomum sp. (Trematoda – Dicrocoelidae) infecting domestic cats (Felis catus)
Welitânia Inácia Silva, Thais Ferreira Feitosa, Vinícius Longo Ribeiro Vilela
Veterinary Parasitology.2023; 322: 110031. CrossRef
Antigenic components, identification, and characterization of whole worm extract of Platynosomum illiciens
Shin Moe Aoke, Amaya Watthanadirek, Napassorn Poolsawat, Nitipon Srionrod, Pornpiroon Nooroong, Sutthida Minsakorn, Sitthichok Lacharoje, Woraporn Sukhumavasi, Panat Anuracpreeda
Veterinary Parasitology.2022; 310: 109774. CrossRef
Hepatic trematode Platynosomum sp. (Dicrocoeliidae) from a domestic cat in Colombo, Sri Lanka: Case report and molecular identification
Dissanayaka Mudiyanselage Asha Erandhi Ranaraja, Thilini Anupama Nanayakkarawasam Mahakapuge, Dulari Samanthika Thilakarathne, Juliyabaduge Yushika Chamodi Dharmasuriya, Rajapakse Peramune Veddikkarage Jayanthe Rajapakse
Veterinary Parasitology: Regional Studies and Reports.2022; 34: 100762. CrossRef
A first attempt at determining the antibody-specific pattern of Platynosomum fastosum crude antigen and identification of immunoreactive proteins for immunodiagnosis of feline platynosomiasis
Babi Kyi Soe, Poom Adisakwattana, Onrapak Reamtong, Panat Anuracpreeda, Woraporn Sukhumavasi
Veterinary World.2022; : 2029. CrossRef
Platynosomum illiciens (Trematoda: Dicrocoeliidae) in a hybrid marmoset (Callithrix sp.) in the Municipality of Seropédica, RJ, Brazil – Case report
Rayane Christine Pereira de Assis, Diefrey Ribeiro Campos, Debora Azevedo Borges, Barbara Rauta de Avelar, Julia Aline Santos de Mello Pereira, Carlos Alexandre Rey Matias, Carlos Wilson Gomes Lopes, Douglas McIntosh, Fabio Barbour Scott
Revista Brasileira de Parasitologia Veterinária.2021;[Epub] CrossRef
Clinical pathological findings of a cat with chronic cholangitis
A. A. Ikhwan-Saufi, R. Ahmad-Rasul, H. X. Liew, M. Y. Lim, T. Adeline, R. Nuhanim, M. Daarulmuqaamah, A. Amlizawaty, M. Maizatul-Akmal, J. Johaimi, A. Rasedee, M. I. Mahiza, A. A. Azlina, H. Hazilawati
Comparative Clinical Pathology.2020; 29(1): 17. CrossRef
DNA sequences confirm low specificity to definitive host and wide distribution of the cat pathogen Platynosomum illiciens (= P. fastosum) (Trematoda: Dicrocoeliidae)
Hudson A. Pinto, Eduardo A. Pulido-Murillo, Roberta R. Braga, Vitor L. T. Mati, Alan L. Melo, Vasyl V. Tkach
Parasitology Research.2018; 117(6): 1975. CrossRef

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Case Report

Ectopic Human Fasciola hepatica Infection by an Adult Worm in the Mesocolon: Ah Jin Kim, Chang Hwan Choi, Sun Keun Choi, Yong Woon Shin, Yun-Kyu Park, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, In Suh Park; Korean J Parasitol 2015;53(6):725-730.
Published online December 31, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.6.725

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We report here an ectopic case of Fasciola hepatica infection confirmed by recovery of an adult worm in the mesocolon. A 56-year-old female was admitted to our hospital with discomfort and pain in the left lower quadrant of the abdomen. Abdominal CT showed 3 abscesses in the left upper quadrant, mesentery, and pelvic cavity. On surgical exploration, abscess pockets were found in the mesocolon of the sigmoid colon and transverse colon. A leaf-like worm found in the abscess pocket of the mesocolon of the left colon was diagnosed as an adult fluke of F. hepatica. Histologically, numerous eggs of F. hepatica were noted with acute and chronic granulomatous inflammations in the subserosa and pericolic adipose tissues. Conclusively, a rare case of ectopic fascioliasis has been confirmed in this study by the adult worm recovery of F. hepatica in the mesocolon.

Citations

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Molecular identification of Fasciola and Dicrocoelium species isolates in ruminants livestock from Kashan and Arak in center of Iran
Mohsen Arbabi, Hossein Hooshyar, Mahdi Delavari
Journal of Parasitic Diseases.2025; 49(2): 453. CrossRef
Hepatic and Extrahepatic Fascioliasis Mimicking Colon Cancer with Hepatic Metastasis
Youe Ree Kim, Young Hwan Lee, Kwon-Ha Yoon
Korean Journal of Abdominal Radiology.2022; 6(1): 51. CrossRef
Phylogenetic Characteristics of Fasciola hepatica Isolated from a Korean Patient
Mi Jin Jeong, Jae Kyun Park, Hak Sun Yu
The Korean Journal of Parasitology.2022; 60(5): 367. CrossRef
Prevalence of Schistosoma japonicum infection in water buffaloes in selected areas in Davao del Norte and Davao de Oro, the Philippines
Rohani C. Navarro, Aleyla E. de Cadiz, Jordan M. Fronda, Lynnell Alexie D. Ong, Vicente Y. Belizario Jr.
International Journal of One Health.2021; 7(1): 12. CrossRef
Ascariasis Presenting as Hematoma in the Sigmoid Mesocolon: A Case Report
Ji-Eun Kim, Kyung Eun Bae, Hyun-Jung Kim, Byung-Noe Bae, Ji Hae Lee, Mi-Jin Kang, Ji-Young Kim, Jae Hyung Kim
Journal of the Korean Society of Radiology.2020; 81(4): 1013. CrossRef
Parasitological monitoring of European bison (Bison bonasus) from three forests of north-eastern Poland between 2014 and 2016
Michał K. Krzysiak, Aleksander W. Demiaszkiewicz, Magdalena Larska, Jarosław Tomana, Krzysztof Anusz
Journal of Veterinary Research.2020; 64(1): 103. CrossRef
NumerousFasciolaplasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis
J. González-Miguel, M. A. Valero, M. Reguera-Gomez, C. Mas-Bargues, M. D. Bargues, F. Simón, S. Mas-Coma
Parasitology.2019; 146(3): 284. CrossRef
Highlights of human ectopic fascioliasis: a systematic review
Ali Taghipour, Leila Zaki, Ali Rostami, Masoud Foroutan, Fatemeh Ghaffarifar, Atefeh Fathi, Amir Abdoli
Infectious Diseases.2019; 51(11-12): 785. CrossRef
A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess
Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Sik Yoon, Kyung Won Kim, Jaeeun Cho, Jong-Yil Chai, Yong Pil Chong
The Korean Journal of Parasitology.2017; 55(3): 313. CrossRef

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Original Article

Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR: Hwang-Yong Kim, In-Wook Choi, Yeon-Rok Kim, Juan-Hua Quan, Hassan Ahmed Hassan Ahmed Ismail, Guang-Ho Cha, Sung-Jong Hong, Young-Ha Lee; Korean J Parasitol 2014;52(6):645-652.
Published online December 23, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.6.645

Abstract
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Fasciola hepatica is a trematode that causes zoonosis mainly in cattle and sheep and occasionally in humans. Fascioliasis has been reported in Korea; however, determining F. hepatica infection in snails has not been done recently. Thus, using PCR, we evaluated the prevalence of F. hepatica infection in snails at 4 large water-dropwort fields. Among 349 examined snails, F. hepatica-specific internal transcribed space 1 (ITS-1) and/or ITS-2 markers were detected in 12 snails and confirmed using sequence analysis. Morphologically, 213 of 349 collected snails were dextral shelled, which is the same aperture as the lymnaeid snail, the vectorial host for F. hepatica. Among the 12 F. hepatica-infected snails, 6 were known first intermediate hosts in Korea (Lymnaea viridis and L. ollula) and the remaining 6 (Lymnaea sp.) were potentially a new first intermediate host in Korea. It has been shown that the overall prevalence of the snails contaminated with F. hepatica in water-dropwort fields was 3.4%; however, the prevalence varied among the fields. This is the first study to estimate the prevalence of F. hepatica infection using the vectorial capacity of the snails in Korea.

Citations

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Distribution and Fasciola infection rates of Lymnaea snails and cattle in high-salinity areas of Mekong Delta, Vietnam
Dang Thi LOAN, Lam Thanh NGUYEN, Tran Ngoc BICH, Nguyen Thuy Y VI, Yasunobu MATSUMOTO
Journal of Veterinary Medical Science.2025; 87(3): 291. CrossRef
Susceptibility of lymnaeid snails to Fasciola hepatica and Fasciola gigantica (Digenea: Fasciolidae): a systematic review and meta-analysis
Philile Ignecious Ngcamphalala, Ignore Nyagura, Mokgadi Pulane Malatji, Samson Mukaratirwa
PeerJ.2025; 13: e18976. CrossRef
Green vegetable juice as a potential source of human fascioliasis in Korea
Sungim Choi, Sunghee Park, Sooji Hong, Hyejoo Shin, Bong-Kwang Jung, Min Jae Kim
One Health.2022; 15: 100441. CrossRef
Snail-borne parasitic diseases: an update on global epidemiological distribution, transmission interruption and control methods
Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
Infectious Diseases of Poverty.2018;[Epub] CrossRef
Morphological Characterization of Emerging Cercariae among Lymnaeid Snails from Barangay Cawongan, Padre Garcia, Batangas, Philippines
Gregorio L. Martin I, Esperanza C. Cabrera
Journal of Parasitology Research.2018; 2018: 1. CrossRef
A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea
Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong
The Korean Journal of Parasitology.2018; 56(4): 375. CrossRef
Monitoring of Fasciola Species Contamination in Water Dropwort by COX1 Mitochondrial and ITS-2 rDNA Sequencing Analysis
In-Wook Choi, Hwang-Yong Kim, Juan-Hua Quan, Jae-Gee Ryu, Rubing Sun, Young-Ha Lee
The Korean Journal of Parasitology.2015; 53(5): 641. CrossRef
Ectopic Human <i>Fasciola hepatica</i> Infection by an Adult Worm in the Mesocolon
Ah Jin Kim, Chang Hwan Choi, Sun Keun Choi, Yong Woon Shin, Yun-Kyu Park, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, In Suh Park
The Korean Journal of Parasitology.2015; 53(6): 725. CrossRef

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Case Reports

The First Case of Capillaria hepatica Infection in a Nutria (Myocastor coypus) in Korea: Jae-Hak Park, Meliton N. Novilla, Juha Song, Kyung-Sul Kim, Seo-Na Chang, Ju-Hee Han, Byung Hee Lee, Do-Hun Lee, Hyun-Mac Kim, Young-Ha Kim, Hee-Jeong Youn, Jihyon Kil; Korean J Parasitol 2014;52(5):527-529.
Published online October 22, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.5.527

Abstract
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This study reports the first case of Capillaria hepatica infection in a nutria in Korea. Ten nutrias, captured near the Nakdong River, were submitted to our laboratory for necropsy. White-yellowish nodules were found in the liver of 1 of the nutrias at necropsy. Histologically, the lesions were granulomatous, and infiltrations of lipid-laden macrophages, eosinophils, and several multinucleated giant cells were observed. The lesions consisted of numerous eggs and necrotic hepatocytes. The eggs were lemon-shaped and had polar plugs at the ends of both long sides. The eggs were morphologically identified as those of C. hepatica. Worldwide, C. hepatica infection in nutrias is very rare. Nutrias are a kind of livestock, as well as wildlife; therefore, an epidemiological study for parasitic infections needs to be conducted.

Citations

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Histopathological evaluation of Capillaria hepatica (Bancroft, 1893) in Cricetomys gambianus (Waterhouse, 1840)
Samson Eneojo Abalaka, Sunday Augustine Ejeh
Journal of Parasitic Diseases.2025; 49(1): 186. CrossRef
Intestinal parasites of Myocastor coypus (Rodentia, Myocastoridae) on animal farms in Eastern Ukraine
N. V. Sumakova, A. P. Paliy, O. V. Pavlichenko, R. V. Petrov, B. S. Morozov, V. M. Plys, A. B. Mushynskyi
Regulatory Mechanisms in Biosystems.2025; 16(3): e25117. CrossRef
Population Genomic Insights Into Recent Nutria (Myocastor coypus) Invasion Dynamics
Kristen D. Ahrens, Joshua M. Hallas, Antionette J. Piaggio, Kelly L. Carrothers, Valerie K. Cook, Michael R. Buchalski
Evolutionary Applications.2025;[Epub] CrossRef
Radio Tracking Reveals the Home Range and Activity Patterns of Nutria (Myocastor coypus) in the Macdo Wetland in South Korea
Maniram Banjade, Pradeep Adhikari, Sun-Hee Hong, Do-Hun Lee
Animals.2023; 13(10): 1716. CrossRef
Climate change induced habitat expansion of nutria (Myocastor coypus) in South Korea
Pradeep Adhikari, Baek-Jun Kim, Sun-Hee Hong, Do-Hun Lee
Scientific Reports.2022;[Epub] CrossRef
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M.H. Fugassa
Journal of Helminthology.2020;[Epub] CrossRef
Zoonotic parasites carried by invasive alien species in China
Guang-Li Zhu, Yi-Yang Tang, Yanin Limpanont, Zhong-Dao Wu, Jian Li, Zhi-Yue Lv
Infectious Diseases of Poverty.2019;[Epub] CrossRef
Complete mitochondrial genome of the invasive semi-aquatic mammal, nutria Myocastor coypus (Rodentia; Myocastoridae)
Do-Hun Lee, Moo-Seung Lee, Young-Chae Kim, Il Ryong Kim, Hye Kwon Kim, Dae Gwin Jeong, Jung Ro Lee, Ji Hyung Kim
Conservation Genetics Resources.2018; 10(4): 613. CrossRef
RETROSPECTIVE ANALYSIS OF THE EPIDEMIOLOGIC LITERATURE, 1990–2015, ON WILDLIFE-ASSOCIATED DISEASES FROM THE REPUBLIC OF KOREA
Jusun Hwang, Kyunglee Lee, Young-Jun Kim, Jonathan M. Sleeman, Hang Lee
Journal of Wildlife Diseases.2017; 53(1): 5. CrossRef
Histopathological Study of Hepatic Small Nodular Lesions on Slaughtered Cattle in Hokkaido
Mutsuko SAKUI, Hiroshi OONO, Ayae OONISHI, Yuzaburo OKU
Journal of the Japan Veterinary Medical Association.2016; 69(3): 147. CrossRef
Histopathological findings in wild Nutrias (Myocastor coypus) with Capillaria hepatica infection
Il-Hwa HONG, Sun-Young KANG, Jong-Hyun KIM, Seong-Hoon SEOK, Seong-Kyu LEE, Seong-Jin HONG, Seung-Yong LEE, Se-Jin PARK, Joo-Yeon KONG, Seong-Chan YEON
Journal of Veterinary Medical Science.2016; 78(12): 1887. CrossRef

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A Case of Fasciola hepatica Infection Mimicking Cholangiocarcinoma and ITS-1 Sequencing of the Worm: Bong Kyun Kang, Bong-Kwang Jung, Yoon Suk Lee, In Kyeom Hwang, Hyemi Lim, Jaeeun Cho, Jin-Hyeok Hwang, Jong-Yil Chai; Korean J Parasitol 2014;52(2):193-196.
Published online April 18, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.2.193

Abstract
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Fascioliasis is a zoonotic infection caused by Fasciola hepatica or Fasciola gigantica. We report an 87-year-old Korean male patient with postprandial abdominal pain and discomfort due to F. hepatica infection who was diagnosed and managed by endoscopic retrograde cholangiopancreatography (ERCP) with extraction of 2 worms. At his first visit to the hospital, a gallbladder stone was suspected. CT and magnetic retrograde cholangiopancreatography (MRCP) showed an intraductal mass in the common bile duct (CBD) without proximal duct dilatation. Based on radiological findings, the presumed diagnosis was intraductal cholangiocarcinoma. However, in ERCP which was performed for biliary decompression and tissue diagnosis, movable materials were detected in the CBD. Using a basket, 2 living leaf-like parasites were removed. The worms were morphologically compatible with F. hepatica. To rule out the possibility of the worms to be another morphologically close species, in particular F. gigantica, 1 specimen was processed for genetic analysis of its ITS-1 region. The results showed that the present worms were genetically identical (100%) with F. hepatica but different from F. gigantica.

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A Curious Culprit Behind Biliary Pus: What’s the Diagnosis?
Partha Pal, Uday Kumar Marri, D. Nageshwar Reddy
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Heung Up Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2024; 24(2): 127. CrossRef
Global distribution of zoonotic digenetic trematodes: a scoping review
Yue Hu, Rong-Jian Zhan, Shi-Lin Lu, Yi-Yang Zhang, Min-Yu Zhou, Hui Huang, Ding-Ding Wang, Tao Zhang, Zi-Xin Huang, Yun-Fei Zhou, Zhi-Yue Lv
Infectious Diseases of Poverty.2024;[Epub] CrossRef
General overview of the current status of human foodborne trematodiasis
Jong-Yil Chai, Bong-Kwang Jung
Parasitology.2022; 149(10): 1262. CrossRef
Phylogenetic Characteristics of Fasciola hepatica Isolated from a Korean Patient
Mi Jin Jeong, Jae Kyun Park, Hak Sun Yu
The Korean Journal of Parasitology.2022; 60(5): 367. CrossRef
Fasciola Hepatica Induced Hepatic Abscess Treated with Triclabendazole
Hyun Joon Park, Gil-Soon Choi, Minjung Jung, Sang Uk Lee
The Korean Journal of Gastroenterology.2021; 77(1): 39. CrossRef
Oxysterols of helminth parasites and pathogenesis of foodborne hepatic trematodiasis caused by Opisthorchis and Fasciola species
Nuno Vale, Maria João Gouveia, Fátima Gärtner, Paul J Brindley
Parasitology Research.2020; 119(5): 1443. CrossRef
Prolonged antibiotic use leading to Clostridium difficile colitis in an ill returned traveller with acute fascioliasis
Dylan Kain, Avinash N Mukkala, Andrea K Boggild
Journal of Travel Medicine.2018;[Epub] CrossRef
A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea
Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong
The Korean Journal of Parasitology.2018; 56(4): 375. CrossRef
F-18-FDG PET/BT’de kolanjiosellüler kanseri taklit eden Fasciola hepatica vakası
Hüseyin KAÇMAZ, Elif Tuğba TUNCEL, Berat EBİK, Feyzullah UÇMAK, Muhsin KAYA, Kendal YALÇIN
Endoskopi Gastrointestinal.2018; 26(2): 69. CrossRef
Unexpected hosts: imaging parasitic diseases
Pablo Rodríguez Carnero, Paula Hernández Mateo, Susana Martín-Garre, Ángela García Pérez, Lourdes del Campo
Insights into Imaging.2017; 8(1): 101. CrossRef
Acute biliary obstruction with cholestasis caused by Fasciola hepatica in a patient travelled to Turcmenistan (a case report and literature review)
Alexander M. Bronshteyn, N. A Malyshev, L. V Fedianina, I. V Davydova
Epidemiology and Infectious Diseases.2016; 21(2): 92. CrossRef
Monitoring of Fasciola Species Contamination in Water Dropwort by COX1 Mitochondrial and ITS-2 rDNA Sequencing Analysis
In-Wook Choi, Hwang-Yong Kim, Juan-Hua Quan, Jae-Gee Ryu, Rubing Sun, Young-Ha Lee
The Korean Journal of Parasitology.2015; 53(5): 641. CrossRef
Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis
Ji Su Ha, Hyun Jong Choi, Jong Ho Moon, Yun Nah Lee, Jae Woong Tae, Moon Han Choi, Tae Hoon Lee, Sang-Woo Cha
Clinical Endoscopy.2015; 48(6): 579. CrossRef
Prevalence of Fasciola spp. from cattle in slaughterhouse by macroscopic examination
Bae-Keun Park, Eui-Ju Hong, Si-Yun Ryu, Bae-Dong Jung, Ji-Min Kim, Hyeon-Cheol Kim
Korean Journal of Veterinary Service.2015; 38(4): 227. CrossRef
Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR
Hwang-Yong Kim, In-Wook Choi, Yeon-Rok Kim, Juan-Hua Quan, Hassan Ahmed Hassan Ahmed Ismail, Guang-Ho Cha, Sung-Jong Hong, Young-Ha Lee
The Korean Journal of Parasitology.2014; 52(6): 645. CrossRef

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Original Article

Experimental Murine Fascioliasis Derives Early Immune Suppression with Increased Levels of TGF-β and IL-4: Joon-Yong Chung, Young-An Bae, Doo-Hee Yun, Hyun-Jong Yang, Yoon Kong; Korean J Parasitol 2012;50(4):301-308.
Published online November 26, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.4.301

Abstract
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In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19⁺ B cells was observed as early as week 1 post-infection while CD4⁺/CD8⁺ T cells were down-regulated. Accumulation of Mac1⁺ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes significantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection.

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Immunization of Goats with Recombinant Protein 14-3-3 Isoform 2(rHcftt-2) Induced Moderate Protection against Haemonchus contortus Challenge
Yongqian Bu, Caiwen Jia, Xiaowei Tian, Kalibixiati Aimulajiang, Muhammad Ali Memon, Ruofeng Yan, Xiaokai Song, Lixin Xu, Xiangrui Li
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Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
María Teresa Ruiz-Campillo, Verónica Molina-Hernández, María José Bautista, Isabel L. Pacheco, Rafael Zafra, Leandro Buffoni, Francisco Javier Martínez-Moreno, Alvaro Martínez-Moreno, José Pérez
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Maria João Gouveia, Maria Y. Pakharukova, Gabriel Rinaldi, Viatcheslav A. Mordvinov, Paul J. Brindley, Fátima Gärtner, Nuno Vale, Martin Michaelis
Experimental Results.2020;[Epub] CrossRef
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Transboundary and Emerging Diseases.2018; 65: 199. CrossRef
Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection
Isabel L. Pacheco, Nieves Abril, Rafael Zafra, Verónica Molina-Hernández, Noelia Morales-Prieto, María J. Bautista, María T. Ruiz-Campillo, Raúl Pérez-Caballero, Alvaro Martínez-Moreno, José Pérez
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Claudia Machicado, Jorge D. Machicado, Vicente Maco, Angelica Terashima, Luis A. Marcos, Hector H Garcia
PLOS Neglected Tropical Diseases.2016; 10(9): e0004962. CrossRef

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Brief Communication

Expression of Exogenous Human Hepatic Nuclear Factor-1α by a Lentiviral Vector and Its Interactions with Plasmodium falciparum Subtilisin-Like Protease 2: Shunyao Liao, Yunqiang Liu, Bing Zheng, Pyo Yun Cho, Hyun Ok Song, Yun-Seok Lee, Suk-Yul Jung, Hyun Park; Korean J Parasitol 2011;49(4):431-436.
Published online December 16, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.4.431

Abstract
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The onset, severity, and ultimate outcome of malaria infection are influenced by parasite-expressed virulence factors as well as by individual host responses to these determinants. In both humans and mice, liver injury follows parasite entry, persisting to the erythrocytic stage in the case of infection with the fatal strain of Plasmodium falciparum. Hepatic nuclear factor (HNF)-1α is a master regulator of not only the liver damage and adaptive responses but also diverse metabolic functions. In this study, we analyzed the expression of host HNF-1α in relation to malaria infection and evaluated its interaction with the 5'-untranslated region of subtilisin-like protease 2 (subtilase, Sub2). Recombinant human HNF-1α expressed by a lentiviral vector (LV HNF-1α) was introduced into mice. Interestingly, differences in the activity of the 5'-untranslated region of the Pf-Sub2 promoter were detected in 293T cells, and LV HNF-1α was observed to influence promoter activity, suggesting that host HNF-1α interacts with the Sub2 gene.

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Case Report

Recurrent Hepatic Alveolar Echinococcosis: Report of The First Case in Korea with Unproven Infection Route: Su-Jin Kim, Jong-Han Kim, Sang-Young Han, Young-Hoon Kim, Jin-Han Cho, Jong-Yil Chai, Jin-Sook Jeong; Korean J Parasitol 2011;49(4):413-418.
Published online December 16, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.4.413

Abstract
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Human alveolar echinococcosis (AE), a hepatic disorder that resembles liver cancer, is a highly aggressive and lethal zoonotic infection caused by the larval stage of the fox tapeworm, Echinococcus multilocularis. E. multilocularis is widely distributed in the northern hemisphere; the disease-endemic area stretches from north America through Europe to central and east Asia, including northern parts of Japan, but it has not been reported in Korea. Herein, we represent a first case of AE in Korea. A 41-year-old woman was found to have a large liver mass on routine medical examination. The excised mass showed multinodular, necrotic, and spongiform appearance with small irregular pseudocystic spaces. Microscopically, the mass was composed of chronic granulomatous inflammation with extensive coagulation necrosis and parasite-like structure, which was revealed as parasitic vesicles and laminated layer delineated by periodic acid-Schiff (PAS) stain. Clinical and histologic features were consistent with AE. After 8 years, a new liver mass and multiple metastatic pulmonary nodules were found and the recurred mass showed similar histologic features to the initial mass. She had never visited endemic areas of AE, and thus the exact infection route is unclear.

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Won Jun Choi, Hanna Jin, Hyeon Jae Jo, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Min-Ho Choi
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Bnar S. Hamad, Bushra H. Shnawa, Rafal A. Alrawi, Mukhtar H. Ahmed
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Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
The Korean Journal of Parasitology.2019; 57(4): 429. CrossRef
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Akira Ito, Christine M. Budke
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Kumble S. Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthruimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
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Kumble Seetharama Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthurimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
Current Problems in Diagnostic Radiology.2015; 44(2): 221. CrossRef
Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai
The Korean Journal of Parasitology.2013; 51(5): 595. CrossRef
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Yan Jin, Khikmat Anvarov, Abdukhakim Khajibaev, Samin Hong, Sung-Tae Hong
The Korean Journal of Parasitology.2013; 51(3): 313. CrossRef
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Tatiana Küster, Nadja Kriegel, David W. Boykin, Chad E. Stephens, Andrew Hemphill
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Keun Soo Ahn, Sung-Tae Hong, Yu Na Kang, Jung Hyeok Kwon, Mi Jeong Kim, Tae Jun Park, Yong Hoon Kim, Tae Jin Lim, Koo Jeong Kang
The Korean Journal of Parasitology.2012; 50(4): 357. CrossRef

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Original Articles

Changes in Sonographic Findings after Treatment of Patients with Clonorchiasis in a Heavy Endemic Area: Dongil Choi, Yong Hwan Jeon, Geun-Chan Lee, Min-Ho Choi, Sung-Tae Hong; Korean J Parasitol 2009;47(1):19-23.
Published online March 12, 2009; DOI: https://doi.org/10.3347/kjp.2009.47.1.19

Abstract
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We measured changes in sonographic findings of patients with clonorchiasis after a treatment in a highly endemic area. A total of 347 residents showed positive stool results for Clonorchis sinensis eggs in a village in northeastern China, and were treated with praziquantel. Of them, 132 patients underwent abdominal sonography both before and 1 year after treatment, and the changes in sonographic findings of 83 cured subjects were compared. Diffuse dilatation of intrahepatic bile ducts (DDIHD) was found in 82 patients (98.2%) before and 80 (96.4%) after treatment, which was improved in 3, aggravated in 1, and unchanged in 79 patients. Increased periductal echogenicity (IPDE) was observed in 42 patients (50.6%) before and 45 (54.2%) after treatment, which was improved in 5, aggravated in 8, and unchanged in 70 patients. Floating echogenic foci in the gallbladder (FEFGB) was detected in 32 patients (38.6%) before and 17 (20.5%) after treatment, which was improved in 20, aggravated in 5, and unchanged in 58 patients. Improvement of FEFGB only was statistically significantly (P = 0.004). The present results confirm that DDIHD and IPDE persist but FEFGB decreases significantly at 1 year after treatment. In a heavy endemic area, the sonographic finding of FEFGB may suggest active clonorchiasis 1 year after treatment.

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Men-Bao Qian, Jennifer Keiser, Jürg Utzinger, Xiao-Nong Zhou, Graeme N. Forrest
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World Journal of Meta-Analysis.2021; 9(6): 505. CrossRef
Clonorchiasis
Men-Bao Qian, Jürg Utzinger, Jennifer Keiser, Xiao-Nong Zhou
The Lancet.2016; 387(10020): 800. CrossRef
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Enrico Brunetti, Tom Heller, Joachim Richter, Daniel Kaminstein, Daniel Youkee, Maria Teresa Giordani, Samuel Goblirsch, Francesca Tamarozzi
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Ze-Li Tang, Yan Huang, Xin-Bing Yu
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Hermann Feldmeier, Miklos Hazay, Megumi Sato, Pongvongsa Tiengkham, Futoshi Nishimoto, Hongwei Jiang, Vatsana Sopraseuth, Kazuhiko Moji
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Journal of Hepatology.2012; 57(4): 787. CrossRef
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Sung-Tae Hong, Yueyi Fang
Parasitology International.2012; 61(1): 17. CrossRef
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Chung Hyeon Kim, Jeong-Keun Lee, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong
The Korean Journal of Parasitology.2011; 49(1): 45. CrossRef
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PLoS Neglected Tropical Diseases.2011; 5(10): e1339. CrossRef

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Changes of cytokine mRNA expression and IgG responses in rats infected with Capillaria hepatica: Dong-Kwan Kim, Kyoung-Hwan Joo, Myung-Sook Chung; Korean J Parasitol 2007;45(2):95-102.
Published online June 20, 2007; DOI: https://doi.org/10.3347/kjp.2007.45.2.95

Abstract
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The mRNA expression of several cytokines was evaluated in splenocytes and mesenteric lymph node (MLN) cells of rats infected with Capillaria hepatica by reverse-transcription (RT)-PCR until week 12 after infection. IgG1 and IgG2a, which are associated with Th1 and Th2 response, respectively, were also assessed by ELISA. The results indicated that the majority of cytokines, including the Th1 (IL-2 and IFN-γ) and Th2 cytokines (IL-4, IL-5 and IL-10) were expressed at maximal levels during the early stage of infection (after week 1-2), and the ELISA data also evidenced a similar pattern of changes in IgG1 and IgG2a. Th1 and Th2 cytokines responded in a similar fashion in this rat model. The expression of cytokines in splenocytes was significantly higher than that in MLN cells, thereby indicating that cytokine production is controlled more by spleen than by MLN. In addition, the observation that IFN-γ expression increased unexpectedly at the time of maximal egg production (6 weeks after infection) indicated that IFN-γ is a cytokine reacting against egg production. However, increased IL-5 expression occurring in tandem with worm activity indicated that the activity of C. hepatica might be controlled by IL-5 expression.

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Brief Communication

Usefulness of 8 kDa protein of Fasciola hepatica in diagnosis of fascioliasis: Kwangsig Kim, Hyun Jong Yang, Young-Bae Chung; Korean J Parasitol 2003;41(2):121-123.
Published online June 20, 2003; DOI: https://doi.org/10.3347/kjp.2003.41.2.121

Abstract
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This study was designed to detect and evaluate an antigenicity of low molecular weight proteins of Fasciola hepatica in fascioliasis. Low molecular weight protein of F. hepatica was purified by ammonium sulfate precipitation and Sephacryl S-100 HR gel filtration. The protein obtained was estimated to be 8 kDa on 7.5-15% gradient sodium dodecyl sulfate gel electrophoresis. Immunoblotting studies showed that the 8 kDa protein reacted with human fascioliasis sera, but not other trematodiasis sera. This result suggests that the 8 kDa protein of F. hepatica is one of diagnostic antigens in human fascioliasis without cross-reaction with other human trematodiasis.

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Panat Anuracpreeda, Chaitip Wanichanon, Prasert Sobhon
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Preliminary antigenic characterisation of an adult worm vomit preparation of Fasciola hepatica by infected human sera
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